Inhibition of fatty acid biosynthesis prevents adipocyte lipotoxicity on human osteoblasts in vitro

Journal of Cellular and Molecular Medicine

Volumn 14, Issue 4, 2010, Pages 982-991

  Elbaz, Alexandre ^a   Wu, Xiying ^b   Rivas, Daniel ^a   Gimble, Jeffrey M ^b   Duque, Gustavo ^a,c  

^a MCGILL UNIVERSITY   (Canada)

^b PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Fatty acids; Lipotoxicity, apoptosis; Osteoblastogenesis; Osteoporosis

Indexed keywords

CERULENIN; FATTY ACID; FATTY ACID SYNTHASE; LIPID; PALMITIC ACID; RUNX2 PROTEIN, HUMAN; STEARIC ACID; STEARIC ACID DERIVATIVE; TRANSCRIPTION FACTOR RUNX2;

ADIPOCYTE; ADULT; APOPTOSIS; ARTICLE; BIOSYNTHESIS; BONE MINERALIZATION; CELL DIFFERENTIATION; CELL NUCLEUS; CELL PROLIFERATION; CELL SURVIVAL; COCULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; GENETIC TRANSCRIPTION; GENETICS; HUMAN; MALE; METABOLISM; OSTEOBLAST; PROTEIN BINDING; SECRETION;

ADIPOCYTES; ADULT; APOPTOSIS; CALCIFICATION, PHYSIOLOGIC; CELL DIFFERENTIATION; CELL NUCLEUS; CELL PROLIFERATION; CELL SURVIVAL; CERULENIN; COCULTURE TECHNIQUES; CORE BINDING FACTOR ALPHA 1 SUBUNIT; FATTY ACID SYNTHETASE COMPLEX; FATTY ACIDS; FEMALE; HUMANS; LIPIDS; MALE; OSTEOBLASTS; PALMITIC ACID; PROTEIN BINDING; STEARIC ACIDS; TRANSCRIPTION, GENETIC; YOUNG ADULT;

EID: 77953948509     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2009.00751.x     Document Type: Article

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