Short-term intermittent administration of CXCR4 antagonist AMD3100 facilitates myocardial repair in experimental myocardial infarction

Acta Biochimica et Biophysica Sinica

Volumn 45, Issue 7, 2013, Pages 561-569

  Luo, Yuechen ^a,b   Zhao, Xiaoning ^b   Zhou, Xin ^b   Ji, Wenjie ^b   Zhang, Ling ^b   Luo, Tao ^b   Liu, Hongmei ^b   Huang, Tigang ^a   Jiang, Tiemin ^b   Li, Yuming ^b  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b MEDICAL COLLEGE OF CHINESE PEOPLE'S ARMED POLICE FORCES   (China)

Author keywords

AMD3100; myocardial infarction; tissue repair; ventricular remodeling

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; CXCR4 PROTEIN, RAT; HETEROCYCLIC COMPOUND; PLERIXAFOR; PRIMER DNA;

ANIMAL; ARTICLE; DRUG ANTAGONISM; HEART INFARCTION; HEART VENTRICLE REMODELING; MALE; NUCLEOTIDE SEQUENCE; PATHOLOGY; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE REPAIR; WISTAR RAT;

AMD3100; MYOCARDIAL INFARCTION; TISSUE REPAIR; VENTRICULAR REMODELING;

ANIMALS; BASE SEQUENCE; DNA PRIMERS; HETEROCYCLIC COMPOUNDS; MALE; MYOCARDIAL INFARCTION; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CXCR4; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

RATTUS NORVEGICUS; TRITICUM AESTIVUM;

EID: 84879963562     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1093/abbs/gmt045     Document Type: Article

References (44)

1. Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB and Bravata DM, et al. Heart disease and stroke statistics-2012 update: a report from the American Heart Association. Circulation 2012, 125: e2-e220.
2. Smith-Berdan S, Nguyen A, Hassanein D, Zimmer M, Ugarte F, Ciriza J and Li D, et al. Robo4 cooperates with CXCR4 to specify hematopoietic stem cell localization to bone marrow niches. Cell Stem Cell 2011, 8: 72-83.
3. Cheng Z, Ou L, Zhou X, Li F, Jia X, Zhang Y and Liu X, et al. Targeted migration of mesenchymal stem cells modified with CXCR4 gene to infarcted myocardium improves cardiac performance. Mol Ther 2008, 16: 571-579.
4. Penn MS. Importance of the SDF-1:CXCR4 axis in myocardial repair. Circ Res 2009, 104: 1133-1135.
5. Broxmeyer HE, Orschell CM, Clapp DW, Hangoc G, Cooper S, Plett PA and Liles WC, et al. Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist. J Exp Med 2005, 201: 1307-1318.
6. Jujo K, Hamada H, Iwakura A, Thorne T, Sekiguchi H, Clarke T and Ito A, et al. CXCR4 blockade augments bone marrow progenitor cell recruitment to the neovasculature and reduces mortality after myocardial infarction. Proc Natl Acad Sci USA 2010, 107: 11008-11013.
7. Dai S, Yuan F, Mu J, Li C, Chen N, Guo S and Kingery J, et al. Chronic AMD3100 antagonism of SDF-1alpha-CXCR4 exacerbates cardiac dysfunction and remodeling after myocardial infarction. J Mol Cell Cardiol 2010, 49: 587-597.
8. Datema R, Rabin L, Hincenbergs M, Moreno MB, Warren S, Linquist V and Rosenwirth B, et al. Antiviral efficacy in vivo of the anti-human immunodeficiency virus bicyclam SDZ SID 791 (JM 3100), an inhibitor of infectious cell entry. Antimicrob Agents Chemother 1996, 40: 750-754.
9. Fricker SP, Anastassov V, Cox J, Darkes MC, Grujic O, Idzan SR and Labrecque J, et al. Characterization of the molecular pharmacology of AMD3100: a specific antagonist of the G-protein coupled chemokine receptor, CXCR4. Biochem Pharmacol 2006, 72: 588-596.
10. Liles WC, Broxmeyer HE, Rodger E, Wood B, Hubel K, Cooper S and Hangoc G, et al. Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist. Blood 2003, 102: 2728-2730.
11. Zhou X, Yun JL, Han ZQ, Gao F, Li H, Jiang TM and Li YM. Postinfarction healing dynamics in the mechanically unloaded rat left ventricle. Am J Physiol Heart Circ Physiol 2011, 300: H1863-H1874.
12. Proulx C, El-Helou V, Gosselin H, Clement R, Gillis MA, Villeneuve L and Calderone A. Antagonism of stromal cell-derived factor-1alpha reduces infarct size and improves ventricular function after myocardial infarction. Pflugers Arch 2007, 455: 241-250.
13. Rajamannan NM, Subramaniam M, Rickard D, Stock SR, Donovan J, Springett M and Orszulak T, et al. Human aortic valve calcification is associated with an osteoblast phenotype. Circulation 2003, 107: 2181-2184.
14. Zhou X, Li YM, Ji WJ, Jiang TM, Sun XN, Zhu Y and Shi R. Phenytoin can accelerate the healing process after experimental myocardial infarction? Int J Cardiol 2006, 107: 21-29.
15. Liu HM, Luo T, Zhou X, Cai L, Huang TG, Jiang TM and Li YM. Disassociation between left ventricular mechanical and electrical properties in ischemic rat heart after G-CSF treatment. Cardiovasc Drugs Ther 2011, 25: 203-214.
16. Mohty M, Duarte RF, Croockewit S, Hubel K, Kvalheim G and Russell N. The role of plerixafor in optimizing peripheral blood stem cell mobilization for autologous stem cell transplantation. Leukemia 2011, 25: 1-6.
17. Gnecchi M, Zhang Z, Ni A and Dzau VJ. Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res 2008, 103: 1204-1219.
18. Capoccia BJ, Shepherd RM and Link DC. G-CSF and AMD3100 mobilize monocytes into the blood that stimulate angiogenesis in vivo through a para-crine mechanism. Blood 2006, 108: 2438-2445.
19. Bensinger W, DiPersio JF and McCarty JM. Improving stem cell mobilization strategies: future directions. Bone Marrow Transplant 2009, 43: 181-195.
20. Hu X, Dai S, Wu WJ, Tan W, Zhu X, Mu J and Guo Y, et al. Stromal cell derived factor-1 alpha confers protection against myocardial ischemia/reper-fusion injury: role of the cardiac stromal cell derived factor-1 alpha CXCR4 axis. Circulation 2007, 116: 654-663.
21. Guo Y, Hangoc G, Bian H, Pelus LM and Broxmeyer HE. SDF-1/CXCL12 enhances survival and chemotaxis of murine embryonic stem cells and production of primitive and definitive hematopoietic progenitor cells. Stem Cells 2005, 23: 1324-1332.
22. Abbott JD, Huang Y, Liu D, Hickey R, Krause DS and Giordano FJ. Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury. Circulation 2004, 110: 3300-3305.
23. Ceradini DJ, Kulkarni AR, Callaghan MJ, Tepper OM, Bastidas N, Kleinman ME and Capla JM, et al. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med 2004, 10: 858-864.
24. Ma J, Ge J, Zhang S, Sun A, Shen J, Chen L and Wang K, et al. Time course of myocardial stromal cell-derived factor 1 expression and beneficial effects of intravenously administered bone marrow stem cells in rats with experimental myocardial infarction. Basic Res Cardiol 2005, 100: 217-223.
25. Pillarisetti K and Gupta SK. Cloning and relative expression analysis of rat stromal cell derived factor-1 (SDF-1): SDF-1 alpha mRNA is selectively induced in rat model of myocardial infarction. Inflammation 2001, 25: 293-300.
26. Borders AS, Hersh MA, Getchell ML, van Rooijen N, Cohen DA, Stromberg AJ and Getchell TV. Macrophage-mediated neuroprotection and neurogenesis in the olfactory epithelium. Physiol Genomics 2007, 31: 531-543.
27. Zhang M, Mal N, Kiedrowski M, Chacko M, Askari AT, Popovic ZB and Koc ON, et al. SDF-1 expression by mesenchymal stem cells results in trophic support of cardiac myocytes after myocardial infarction. FASEB J 2007, 21: 3197-3207.
28. Wen J, Zhang JQ, Huang Wand Wang Y. SDF-1a and CXCR4 as therapeutic targets in cardiovascular disease. Am J Cardiovasc Dis 2012, 2: 20-28.
29. Dentelli P, Rosso A, Balsamo A, Colmenares Benedetto S, Zeoli A, Pegoraro M and Camussi G, et al. C-KIT, by interacting with the membrane-bound ligand, recruits endothelial progenitor cells to inflamed endothelium. Blood 2007, 109: 4264-4271.
30. Lyman SD and Jacobsen SE. c-kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities. Blood 1998, 91: 1101-1134.
31. Grunewald M, Avraham I, Dor Y, Bachar-Lustig E, Itin A, Jung S and Chimenti S, et al. VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. Cell 2006, 124: 175-189.
32. 2 cells found in the adult human heart represent a population of endothelial progenitor cells. Basic Res Cardiol 2010, 105: 545-56.
33. + cardiac stem cells derived from adult rat hearts. Stem Cells Dev 2010, 19: 105-116.
34. Murry CE, Soonpaa MH, Reinecke H, Nakajima H, Nakajima HO, Rubart M and Pasumarthi KB, et al. Haematopoietic stem cells do not transdiffer-entiate into cardiac myocytes in myocardial infarcts. Nature 2004, 428: 664-668.
35. Silva GV, Litovsky S, Assad JA, Sousa AL, Martin BJ, Vela D and Coulter SC, et al. Mesenchymal stem cells differentiate into an endothelial pheno-type, enhance vascular density, and improve heart function in a canine chronic ischemia model. Circulation 2005, 111: 150-156.
36. Urbich C and Dimmeler S. Endothelial progenitor cells: characterization and role in vascular biology. Circ Res 2004, 95: 343-353.
37. Creemers EE, Cleutjens JP, Smits JF and Daemen MJ. Matrix metalloprotei-nase inhibition after myocardial infarction: a new approach to prevent heart failure? Circ Res 2001, 89: 201-10.
38. Spinale FG. Matrix metalloproteinases: regulation and dysregulation in the failing heart. Circ Res 2002, 90: 520-530.
39. Lu L, Gunja-Smith Z, Woessner JF, Ursell PC, Nissen T, Galardy RE and Xu Y, et al. Matrix metalloproteinases and collagen ultrastructure in moderate myocardial ischemia and reperfusion in vivo. Am J Physiol Heart Circ Physiol 2000, 279: H601-H609.
40. Cleutjens JP, Kandala JC, Guarda E, Guntaka RV and Weber KT. Regulation of collagen degradation in the rat myocardium after infarction. J Mol Cell Cardiol 1995, 27: 1281-1292.
41. Petit I, Jin D and Rafii S. The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis. Trends Immunol 2007, 28: 299-2307.
42. Minatoguchi S, Takemura G, Chen XH, Wang N, Uno Y, Koda M and Arai M, et al. Acceleration of the healing process and myocardial regeneration may be important as a mechanism of improvement of cardiac function and remodeling by postinfarction granulocyte colony-stimulating factor treatment. Circulation 2004, 109: 2572-2580.
43. Deindl E, Zaruba MM, Brunner S, Huber B, Mehl U, Assmann G and Hoefer IE, et al. G-CSF administration after myocardial infarction in mice attenuates late ischemic cardiomyopathy by enhanced arteriogenesis. FASEB J 2006, 20: 956-958.
44. Bergers G, Brekken R, McMahon G, Vu TH, Itoh T, Tamaki K and Tanzawa K, et al. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol 2000, 2: 737-744.