Excessive Cytokine Response to Rapid Proliferation of Highly Pathogenic Avian Influenza Viruses Leads to Fatal Systemic Capillary Leakage in Chickens

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Kuribayashi, Saya ^a   Sakoda, Yoshihiro ^a   Kawasaki, Takeshi ^b   Tanaka, Tomohisa ^a,e   Yamamoto, Naoki ^a,f   Okamatsu, Masatoshi ^a   Isoda, Norikazu ^a,d   Tsuda, Yoshimi ^a,g   Sunden, Yuji ^a   Umemura, Takashi ^a   Nakajima, Noriko ^c   Hasegawa, Hideki ^c   Kida, Hiroshi ^a,d  

^a HOKKAIDO UNIVERSITY   (Japan)

^b Research Office Concerning the Health of Human and Birds   (Japan)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^d HOKKAIDO UNIVERSITY   (Japan)

^e UNIVERSITY OF YAMANASHI   (Japan)

^f TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^g HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AVIAN INFLUENZA; AVIAN INFLUENZA VIRUS; BRAIN; CAPILLARY LEAK SYNDROME; CAPILLARY PERMEABILITY; CHICKEN; CONTROLLED STUDY; CYTOKINE RESPONSE; FATALITY; INFLUENZA VIRUS A H5N2; INFLUENZA VIRUS A H7N1; INFLUENZA VIRUS A H7N7; MICROGLIA; MULTIPLE ORGAN FAILURE; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; VIRUS VIRULENCE;

ANIMALS; ANTIGENS, VIRAL; BRAIN; CAPILLARY PERMEABILITY; CHICKENS; CYTOKINES; EVANS BLUE; INFLUENZA A VIRUS; INFLUENZA A VIRUS, H5N2 SUBTYPE; INFLUENZA A VIRUS, H7N1 SUBTYPE; INFLUENZA A VIRUS, H7N7 SUBTYPE; INFLUENZA IN BIRDS; VIRUS REPLICATION;

AVES; AVIAN INFLUENZA VIRUS; GALLUS GALLUS; MAMMALIA;

EID: 84879951982     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0068375     Document Type: Article

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