Evaluation of the genisys4, a bench-top preclinical PET Scanner

Journal of Nuclear Medicine

Volumn 54, Issue 7, 2013, Pages 1162-1167

  Herrmann, Ken ^a,b   Dahlbom, Magnus ^a   Nathanson, David ^a   Wei, Liu ^a   Radu, Caius ^a   Chatziioannou, Arion ^a   Czernin, Johannes ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

18F FDG; Preclinical PET; Scanner performance; Tumor models

Indexed keywords

FLUORODEOXYGLUCOSE F 18; GEMCITABINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DRUG BLOOD LEVEL; DRUG TUMOR LEVEL; IMAGE ANALYSIS; IMAGE PROCESSING; IMAGE RECONSTRUCTION; INTERMETHOD COMPARISON; LEUKEMIA CELL; LUNG METASTASIS; LUNG TUMOR; MELANOMA CELL; MOUSE; NONHUMAN; PET SCANNER; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOACTIVITY; RADIOSENSITIVITY; SUBCUTANEOUS NODULE; TREATMENT RESPONSE; TUMOR VOLUME; TUMOR XENOGRAFT;

18F-FDG; PRECLINICAL PET; SCANNER PERFORMANCE; TUMOR MODELS;

ANIMALS; CELL LINE, TUMOR; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; MICE; MICE, SCID; MINIATURIZATION; NEOPLASMS, EXPERIMENTAL; POSITRON-EMISSION TOMOGRAPHY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 84879950265     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.112.114926     Document Type: Article

References (28)

1. Bloomfield PM, Rajeswaran S, Spinks TJ, et al. The design and physical characteristics of a small animal positron emission tomograph. Phys Med Biol. 1995;40:1105-1126.
2. Cherry SR, Shao Y, Silverman RW, et al. MicroPET: a high resolution PET scanner for imaging small animals. IEEE Trans Nucl Sci. 1997;44:1161-1166.
3. Phelps ME. Positron emission tomography provides molecular imaging of biological processes. Proc Natl Acad Sci USA. 2000;97:9226-9233.
4. Herschman HR, MacLaren DC, Iyer M, et al. Seeing is believing: non-invasive, quantitative and repetitive imaging of reporter gene expression in living animals, using positron emission tomography. J Neurosci Res. 2000;59:699-705.
5. Walter MA, Benz MR, Hildebrandt IJ, et al. Metabolic imaging allows early prediction of response to vandetanib. J Nucl Med. 2011;52:231-240.
6. Waldherr C, Mellinghoff IK, Tran C, et al. Monitoring antiproliferative responses to kinase inhibitor therapy in mice with 39-deoxy-39-18F- fluorothymidine PET. J Nucl Med. 2005;46:114-120.
7. Toyohara J, Ishiwata K. Animal tumor models for PET in drug development. Ann Nucl Med. 2011;25:717-731.
8. Aboagye EO. Positron emission tomography imaging of small animals in anticancer drug development. Mol Imaging Biol. 2005;7:53-58.
9. Chen Z, Cheng K, Walton Z, et al. A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response. Nature. 2012;483:613-617.
10. Pysz MA, Gambhir SS, Willmann JK. Molecular imaging: current status and emerging strategies. Clin Radiol. 2010;65:500-516.
11. Zhang H, Vu NT, Bao Q, et al. Performance characteristics of BGO detectors for a low cost preclinical PET scanner. IEEE Trans Nucl Sci. 2010;57:1038-1044.
12. Gu Z, Taschereau R, Vu NT, et al. Design and initial performance of PETbox4, a high sensitivity preclinical imaging tomograph. In: Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). Piscataway, NJ: IEEE; 2011:2328-2331.
13. Bao Q, Newport D, Chen M, Stout DB, Chatziioannou AF. Performance evaluation of the Inveon dedicated PET preclinical tomograph based on the NEMA NU-4 standards. J Nucl Med. 2009;50:401-408.
14. Wang H, Stout DB, Taschereau R, et al. MARS: a mouse atlas registration system based on a planar x-ray projector and an optical camera. Phys Med Biol. 2012;57:6063-6077.
15. Jordheim LP, Cros E, Gouy MH, et al. Characterization of a gemcitabineresistant murine leukemic cell line: reversion of in vitro resistance by a mononucleotide prodrug. Clin Cancer Res. 2004;10:5614-5621.
16. Lee JT, Campbell DO, Satyamurthy N, Czernin J, Radu CG. Stratification of nucleoside analog chemotherapy using 1-(29-deoxy-29-18F-fluoro-beta-D- arabinofuranosyl) cytosine and 1-(29-deoxy-29-18F-fluoro-beta-L- arabinofuranosyl)-5- methylcytosine PET. J Nucl Med. 2012;53:275-280.
17. Laing RE, Walter MA, Campbell DO, et al. Noninvasive prediction of tumor responses to gemcitabine using positron emission tomography. Proc Natl Acad Sci USA. 2009;106:2847-2852.
18. Fueger BJ, Czernin J, Hildebrandt I, et al. Impact of animal handling on the results of 18F-FDG PET studies in mice. J Nucl Med. 2006;47:999-1006.
19. Taschereau R, Chow PL, Chatziioannou AF. Monte Carlo simulations of dose from microCT imaging procedures in a realistic mouse phantom. Med Phys. 2006;33:216-224.
20. Lieberman BP, Ploessl K, Wang L, et al. PET imaging of glutaminolysis in tumors by 18F-(2S,4R)4-fluoroglutamine. J Nucl Med. 2011;52:1947-1955.
21. Fernandes E, Barbosa Z, Clemente G, Alves F, Abrunhosa AJ. Positron emitting tracers in pre-clinical drug development. Curr Radiopharm. 2012;5:90-98.
22. Hurov JB, Huang M, White LS, et al. Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. Proc Natl Acad Sci USA. 2007;104:5680-5685.
23. Bao Q, Chatziioannou AF. Estimation of the minimum detectable activity of preclinical PET imaging systems with an analytical method. Med Phys. 2010; 37:6070-6083.
24. Tomasi G, Turkheimer F, Aboagye E. Importance of quantification for the analysis of PET data in oncology: review of current methods and trends for the future. Mol Imaging Biol. 2012;14:131-146.
25. Huang SC, Phelps ME, Hoffman EJ, Sideris K, Selin CJ, Kuhl DE. Noninvasive determination of local cerebral metabolic rate of glucose in man. Am J Physiol. 1980;238:E69-E82.
26. Dimitrakopoulou-Strauss A, Strauss LG, Egerer G, et al. Impact of dynamic 18FFDG PET on the early prediction of therapy outcome in patients with high-risk soft-tissue sarcomas after neoadjuvant chemotherapy: a feasibility study. J Nucl Med. 2010;51:551-558.
27. Muzi M, Spence AM, O'Sullivan F, et al. Kinetic analysis of 39-deoxy-39-18Ffluorothymidine in patients with gliomas. J Nucl Med. 2006;47:1612-1621.
28. Ferl GZ, Zhang X, Wu HM, Kreissl MC, Huang SC. Estimation of the 18F-FDG input function in mice by use of dynamic small-animal PET and minimal blood sample data. J Nucl Med. 2007;48:2037-2045.