Insulin Receptor-Overexpressing β-Cells Ameliorate Hyperglycemia in Diabetic Rats through Wnt Signaling Activation

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Kim, Mi Hyun ^a   Hong, Seung Hyun ^b   Lee, Moon Kyu ^c  

^a Samsung Medical Center   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CALCIUM; CYCLIN D1; GLUCOKINASE; GLUCOSE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; WNT PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CALCIUM MOBILIZATION; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; GLUCOSE UTILIZATION; HYPERGLYCEMIA; INSULIN RELEASE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PROTEIN PHOSPHORYLATION; RAT; STREPTOZOCIN DIABETES; THYMOMA; VIRUS ONCOGENE; WNT SIGNALING PATHWAY;

ANIMALS; BETA CATENIN; BLOOD GLUCOSE; CELL LINE; CYCLIN D1; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; GENE EXPRESSION; GENE EXPRESSION REGULATION; GLUCOKINASE; HYPERGLYCEMIA; INSULIN; INSULIN-SECRETING CELLS; MALE; RATS; RECEPTOR, INSULIN; TRANSCRIPTION, GENETIC; WNT SIGNALING PATHWAY;

ANIMALIA; MURINAE; RATTUS;

EID: 84879922352     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067802     Document Type: Article

References (46)

1. Berney T, Toso C, (2006) Monitoring of the islet graft. Diabetes Metab 32: 503-512.
2. Garcia-Ocana A, Vasavada RC, Takane KK, Cebrian A, Lopez-Talavera JC, et al. (2001) Using beta-cell growth factors to enhance human pancreatic Islet transplantation. J Clin Endocrinol Metab 86: 984-988.
3. Welters HJ, Kulkarni RN, (2008) Wnt signaling: relevance to beta-cell biology and diabetes. Trends Endocrinol Metab 19: 349-355.
4. Anagnostou SH, Shepherd PR, (2008) Glucose induces an autocrine activation of the Wnt/beta-catenin pathway in macrophage cell lines. Biochem J 416: 211-218.
5. Schinner S, Ulgen F, Papewalis C, Schott M, Woelk A, et al. (2008) Regulation of insulin secretion, glucokinase gene transcription and beta cell proliferation by adipocyte-derived Wnt signalling molecules. Diabetologia 51: 147-154.
6. Tetsu O, McCormick F, (1999) Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398: 422-426.
7. Johnson D, Shepherd RM, Gill D, Gorman T, Smith DM, et al. (2007) Glucose-dependent modulation of insulin secretion and intracellular calcium ions by GKA50, a glucokinase activator. Diabetes 56: 1694-1702.
8. Yi F, Sun J, Lim GE, Fantus IG, Brubaker PL, et al. (2008) Cross talk between the insulin and Wnt signaling pathways: evidence from intestinal endocrine L cells. Endocrinology 149: 2341-2351.
9. Palsgaard J, Emanuelli B, Winnay JN, Sumara G, Karsenty G, et al. (2012) Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5). J Biol Chem 287: 12016-12026.
10. Sun J, Wang D, Jin T, (2010) Insulin alters the expression of components of the Wnt signaling pathway including TCF-4 in the intestinal cells. Biochim Biophys Acta 1800: 344-351.
11. Abiola M, Favier M, Christodoulou-Vafeiadou E, Pichard AL, Martelly I, et al. (2009) Activation of Wnt/β-Catenin Signaling Increases Insulin Sensitivity through a Reciprocal Regulation of Wnt10b and SREBP-1c in Skeletal Muscle Cells. PLoS ONE 4: e8509.
12. Cohen P, Frame S, (2001) The renaissance of GSK3. Nat Rev Mol Cell Biol 2: 769-776.
13. Matschinsky FM, (1990) Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes. Diabetes 39: 647-652.
14. Luciani DS, Johnson JD, (2005) Acute effects of insulin on beta-cells from transplantable human islets. Mol Cell Endocrinol 241: 88-98.
15. Kim HI, Cha JY, Kim SY, Kim JW, Roh KJ, et al. (2002) Peroxisomal proliferator-activated receptor-gamma upregulates glucokinase gene expression in beta-cells. Diabetes 51: 676-685.
16. Cozar-Castellano I, Harb G, Selk K, Takane K, Vasavada R, et al. (2008) Lessons from the first comprehensive molecular characterization of cell cycle control in rodent insulinoma cell lines. Diabetes 57: 3056-3068.
17. Ohsugi M, Cras-Meneur C, Zhou Y, Bernal-Mizrachi E, Johnson JD, et al. (2005) Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion. J Biol Chem 280: 4992-5003.
18. Leibiger IB, Leibiger B, Berggren PO, (2002) Insulin feedback action on pancreatic beta-cell function. FEBS Lett 532: 1-6.
19. Srivastava S, Goren HJ, (2003) Insulin constitutively secreted by beta-cells is necessary for glucose-stimulated insulin secretion. Diabetes 52: 2049-2056.
20. Papadopoulou S, Edlund H, (2005) Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function. Diabetes 54: 2844-2851.
21. Shu L, Sauter NS, Schulthess FT, Matveyenko AV, Oberholzer J, et al. (2008) Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets. Diabetes 57: 645-653.
22. Sutherland C, Leighton IA, Cohen P, (1993) Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling. Biochem J 296 (Pt 1): 15-19.
23. Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA, (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature. 378: 785-789.
24. Bommer GT, Feng Y, Iura A, Giordano TJ, Kuick R, et al. (2010) IRS1 regulation by Wnt/beta-catenin signaling and varied contribution of IRS1 to the neoplastic phenotype. J Biol Chem 285: 1928-1938.
25. Hie M, Iitsuka N, Otsuka T, Tsukamoto I, (2011) Insulin-dependent diabetes mellitus decreases osteoblastogenesis associated with the inhibition of Wnt signaling through increased expression of Sost and Dkk1 and inhibition of Akt activation. Int J Mol Med 28: 455-462.
26. Abiola M, Favier M, Christodoulou-Vafeiadou E, Pichard AL, Martelly I, et al. (2009) Activation of Wnt/beta-catenin signaling increases insulin sensitivity through a reciprocal regulation of Wnt10b and SREBP-1c in skeletal muscle cells. PLoS ONE 4: e8509.
27. Singh R, De Aguiar RB, Naik S, Mani S, Ostadsharif K, et al. (2013) LRP6 Enhances Glucose Metabolism by Promoting TCF7L2-Dependent Insulin Receptor Expression and IGF Receptor Stabilization in Humans. Cell Metab 17: 197-209.
28. Otani K, Kulkarni RN, Baldwin AC, Krutzfeldt J, Ueki K, et al. (2004) Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice. Am J Physiol Endocrinol Metab 286: E41-49.
29. Withers DJ, Burks DJ, Towery HH, Altamuro SL, Flint CL, et al. (1999) Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. Nat Genet 23: 32-40.
30. Pugazhenthi S, Nesterova A, Sable C, Heidenreich KA, Boxer LM, et al. (2000) Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein. J Biol Chem 275: 10761-10766.
31. Kitamura T, Nakae J, Kitamura Y, Kido Y, Biggs WH 3rd, et al (2002) The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest 110: 1839-1847.
32. Schuit FC, Huypens P, Heimberg H, Pipeleers DG, (2001) Glucose sensing in pancreatic beta-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus. Diabetes 50: 1-11.
33. Hattersley AT, Turner RC, Permutt MA, Patel P, Tanizawa Y, et al. (1992) Linkage of type 2 diabetes to the glucokinase gene. Lancet 339: 1307-1310.
34. Bali D, Svetlanov A, Lee HW, Fusco-DeMane D, Leiser M, et al. (1995) Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene. J Biol Chem 270: 21464-21467.
35. Grupe A, Hultgren B, Ryan A, Ma YH, Bauer M, et al. (1995) Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis. Cell 83: 69-78.
36. Jansson EA, Are A, Greicius G, Kuo IC, Kelly D, et al. (2005) The Wnt/beta-catenin signaling pathway targets PPARgamma activity in colon cancer cells. Proc Natl Acad Sci U S A 102: 1460-1465.
37. Sheng M, Thompson MA, Greenberg ME, (1991) CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases. Science 252: 1427-1430.
38. Wang X, Cahill CM, Pineyro MA, Zhou J, Doyle ME, et al. (1999) Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells. Endocrinology 140: 4904-4907.
39. Tuttle RL, Gill NS, Pugh W, Lee JP, Koeberlein B, et al. (2001) Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. Nat Med 7: 1133-1137.
40. Hennige AM, Burks DJ, Ozcan U, Kulkarni RN, Ye J, et al. (2003) Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes. J Clin Invest 112: 1521-1532.
41. Datta SR, Brunet A, Greenberg ME, (1999) Cellular survival: a play in three Akts. Genes Dev 13: 2905-2927.
42. Wrede CE, Dickson LM, Lingohr MK, Briaud I, Rhodes CJ, (2002) Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1). J Biol Chem 277: 49676-49684.
43. Rulifson IC, Karnik SK, Heiser PW, ten Berge D, Chen H, et al. (2007) Wnt signaling regulates pancreatic beta cell proliferation. Proc Natl Acad Sci U S A 104: 6247-6252.
44. Altomare DA, Testa JR, (2005) Perturbations of the AKT signaling pathway in human cancer. Oncogene 24: 7455-7464.
45. Yu J, Berggren PO, Barker CJ, (2007) An autocrine insulin feedback loop maintains pancreatic beta-cell 3-phosphorylated inositol lipids. Mol Endocrinol 21: 2775-2784.
46. Bonner-Weir S, Weir GC, (2005) New sources of pancreatic beta-cells. Nat Biotechnol 23: 857-861.