Differential Regulation of Human 3β-Hydroxysteroid Dehydrogenase Type 2 for Steroid Hormone Biosynthesis by Starvation and Cyclic Amp Stimulation: Studies in the Human Adrenal NCI-H295R Cell Model

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Udhane, Sameer ^a,b   Kempna, Petra ^a,b   Hofer, Gaby ^a,b   Mullis, Primus E ^a,b   Flück, Christa E ^a,b  

^a UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

3 BETA HYDROXYSTEROID DEHYDROGENASE TYPE 2; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE; NUCLEAR RECEPTOR NUR77; STEROID REDUCTASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA; TRANSCRIPTION FACTOR LRH1; TRANSCRIPTION FACTOR SF1; UNCLASSIFIED DRUG;

ACETYLATION; ADENARCHE; ARTICLE; CANCER CELL CULTURE; CELL TYPE; CONTROLLED STUDY; DISEASE SEVERITY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; EPIGENETICS; HORMONAL REGULATION; HUMAN; HUMAN CELL; METHYLATION; OVARY; OVARY POLYCYSTIC DISEASE; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PROCESSING; SEXUAL MATURATION; SIGNAL TRANSDUCTION; STARVATION; STEROIDOGENESIS; TRANSACTIVATION; TRANSCRIPTION REGULATION;

ADRENAL GLANDS; CELL LINE; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA-BINDING PROTEINS; FEMALE; GATA TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; GENE ORDER; GONADAL STEROID HORMONES; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 1; ORGAN SPECIFICITY; PROGESTERONE REDUCTASE; PROMOTER REGIONS, GENETIC; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; STARVATION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 84879906030     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0068691     Document Type: Article

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