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Volumn 29, Issue 4, 2013, Pages 397-404

Moving towards disease modification in inflammatory bowel disease therapy

Author keywords

deep remission; poor prognostic indicators in IBD; treat beyond symptoms

Indexed keywords

AMINOSALICYLIC ACID; AZATHIOPRINE; C REACTIVE PROTEIN; INFLIXIMAB; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 21; INTERLEUKIN 23; INTERLEUKIN 4; INTERLEUKIN 7; INTERLEUKIN 9; JANUS KINASE 1; JANUS KINASE 2; JANUS KINASE 3; MERCAPTOPURINE; METHOTREXATE; PLACEBO; TOFACITINIB; TUMOR NECROSIS FACTOR ALPHA; USTEKINUMAB; VEDOLIZUMAB;

EID: 84879894997     PISSN: 02671379     EISSN: 15317056     Source Type: Journal    
DOI: 10.1097/MOG.0b013e3283622914     Document Type: Review
Times cited : (67)

References (63)
  • 1
    • 77955096659 scopus 로고    scopus 로고
    • Natural history of Crohn'sdisease in a population-based cohortfrom Cardiff (1986-2003): A study ofchanges in medical treatment and surgical resection rates
    • Ramadas AV, Gunesh S, Thomas GA, et al. Natural history of Crohn'sdisease in a population-based cohortfrom Cardiff (1986-2003): a study ofchanges in medical treatment and surgical resection rates. Gut 2010; 59:1200-1206.
    • (2010) Gut , vol.59 , pp. 1200-1206
    • Ramadas, A.V.1    Gunesh, S.2    Thomas, G.A.3
  • 2
    • 79958228566 scopus 로고    scopus 로고
    • Impact of azathioprine and tumour necrosis factor antagonists on the need for surgery in newly diagnosed Crohn's disease
    • Peyrin-Biroulet L, Oussalah A, Williet N, et al. Impact of azathioprine and tumour necrosis factor antagonists on the need for surgery in newly diagnosed Crohn's disease. Gut 2011; 60:930-936.
    • (2011) Gut , vol.60 , pp. 930-936
    • Peyrin-Biroulet, L.1    Oussalah, A.2    Williet, N.3
  • 3
    • 84870857072 scopus 로고    scopus 로고
    • Decreasing colectomy rates for ulcerative colitis: A population-based time trend study
    • Kaplan GG, Seow CH, Ghosh S, et al. Decreasing colectomy rates for ulcerative colitis: a population-based time trend study. Am J Gastroenterol 2012; 107:1879-1887.
    • (2012) Am J Gastroenterol , vol.107 , pp. 1879-1887
    • Kaplan, G.G.1    Seow, C.H.2    Ghosh, S.3
  • 4
    • 55449098725 scopus 로고    scopus 로고
    • Effects of adalimumab therapy on incidence of hospitalization and surgery in Crohn's disease: Results from the CHARM study
    • Feagan BG, Panaccione R, Sandborn WJ, et al. Effects of adalimumab therapy on incidence of hospitalization and surgery in Crohn's disease: results from the CHARM study. Gastroenterology 2008; 135:1493-1499.
    • (2008) Gastroenterology , vol.135 , pp. 1493-1499
    • Feagan, B.G.1    Panaccione, R.2    Sandborn, W.J.3
  • 5
    • 70349418632 scopus 로고    scopus 로고
    • Colectomy rate comparison after treatment of ulcerative colitis with placebo or infliximab
    • Sandborn WJ, Rutgeerts P, Feagan BG, et al. Colectomy rate comparison after treatment of ulcerative colitis with placebo or infliximab. Gastroentero-logy 2009; 137:1250-1260.
    • (2009) Gastroentero-logy , vol.137 , pp. 1250-1260
    • Sandborn, W.J.1    Rutgeerts, P.2    Feagan, B.G.3
  • 6
    • 79953786419 scopus 로고    scopus 로고
    • Loss of response and need for adalimumabdoseintensification inCrohn'sdisease: A systematicreview
    • Billioud V, Sandborn WJ, Peyrin-Biroulet L. Loss of response and need for adalimumabdoseintensification inCrohn'sdisease: a systematicreview. Am J Gastroenterol 2011; 106:674-684.
    • (2011) Am J Gastroenterol , vol.106 , pp. 674-684
    • Billioud, V.1    Sandborn, W.J.2    Peyrin-Biroulet, L.3
  • 7
    • 62049083383 scopus 로고    scopus 로고
    • Loss of response and requirement of infliximab dose intensification in Crohn's disease: A review
    • Gisbert JP, Panes J. Loss of response and requirement of infliximab dose intensification in Crohn's disease: a review. Am J Gastroenterol 2009; 104:760-767.
    • (2009) Am J Gastroenterol , vol.104 , pp. 760-767
    • Gisbert, J.P.1    Panes, J.2
  • 8
    • 79952788410 scopus 로고    scopus 로고
    • Review article: Remission rates achievable by current therapies for inflammatory bowel disease
    • Peyrin-Biroulet L, Lemann M. Review article: remission rates achievable by current therapies for inflammatory bowel disease. Aliment Pharmacol Ther 2011; 33:870-879.
    • (2011) Aliment Pharmacol Ther , vol.33 , pp. 870-879
    • Peyrin-Biroulet, L.1    Lemann, M.2
  • 9
    • 80955178844 scopus 로고    scopus 로고
    • Surgery for adult Crohn's disease: What is the actual risk?
    • Bouguen G, Peyrin-Biroulet L. Surgery for adult Crohn's disease: what is the actual risk? Gut 2011; 60:1178-1181.
    • (2011) Gut , vol.60 , pp. 1178-1181
    • Bouguen, G.1    Peyrin-Biroulet, L.2
  • 10
    • 79952783670 scopus 로고    scopus 로고
    • Does anti-TNF therapy reduce the requirement for surgery in ulcerative colitis? A systematic review
    • Filippi J, Allen PB, Hebuterne X, Peyrin-Biroulet L. Does anti-TNF therapy reduce the requirement for surgery in ulcerative colitis? A systematic review. Curr Drug Targets 2011; 12:1440-1447.
    • (2011) Curr Drug Targets , vol.12 , pp. 1440-1447
    • Filippi, J.1    Allen, P.B.2    Hebuterne, X.3    Peyrin-Biroulet, L.4
  • 11
    • 80053133374 scopus 로고    scopus 로고
    • Results from the 2nd Scientific Workshop of the ECCO. I: Impact of mucosal healing on the course of inflammatory bowel disease
    • Peyrin-Biroulet L, Ferrante M, Magro F, et al. Results from the 2nd Scientific Workshop of the ECCO. I: impact of mucosal healing on the course of inflammatory bowel disease. J Crohns Colitis 2011; 5:477-483.
    • (2011) J Crohns Colitis , vol.5 , pp. 477-483
    • Peyrin-Biroulet, L.1    Ferrante, M.2    Magro, F.3
  • 12
    • 84855216805 scopus 로고    scopus 로고
    • Development of the first disability index for inflammatory bowel disease based on the international classification of functioning, disability and health
    • Peyrin-Biroulet L, Cieza A, Sandborn WJ, et al. Development of the first disability index for inflammatory bowel disease based on the international classification of functioning, disability and health. Gut 2012; 61:241-247.
    • (2012) Gut , vol.61 , pp. 241-247
    • Peyrin-Biroulet, L.1    Cieza, A.2    Sandborn, W.J.3
  • 13
    • 74049136834 scopus 로고    scopus 로고
    • Disability in inflammatory bowel diseases: Developing ICF Core Sets for patients with inflammatory bowel diseases based on the International Classification of Functioning, Disability, and Health
    • Peyrin-Biroulet L, Cieza A, Sandborn WJ, et al. Disability in inflammatory bowel diseases: developing ICF Core Sets for patients with inflammatory bowel diseases based on the International Classification of Functioning, Disability, and Health. Inflamm Bowel Dis 2010; 16:15-22.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 15-22
    • Peyrin-Biroulet, L.1    Cieza, A.2    Sandborn, W.J.3
  • 14
    • 84872680822 scopus 로고    scopus 로고
    • Development and validation of a patient-reported disability measurement tool for patients with inflammatory bowel disease
    • Allen PB, Kamm MA, Peyrin-Biroulet L, et al. Development and validation of a patient-reported disability measurement tool for patients with inflammatory bowel disease. Aliment Pharmacol Ther 2013; 37:438-444.
    • (2013) Aliment Pharmacol Ther , vol.37 , pp. 438-444
    • Allen, P.B.1    Kamm, M.A.2    Peyrin-Biroulet, L.3
  • 15
    • 79960531736 scopus 로고    scopus 로고
    • Gastroenterology review and perspective: The role of cross-sectional imaging in evaluating bowel damage in Crohn disease
    • Epub 2011/06/28
    • Pariente B, Peyrin-Biroulet L, Cohen L, et al. Gastroenterology review and perspective: the role of cross-sectional imaging in evaluating bowel damage in Crohn disease. Am J Roentgenol 2011; 197:42-49; Epub 2011/06/28.
    • (2011) Am J Roentgenol , vol.197 , pp. 42-49
    • Pariente, B.1    Peyrin-Biroulet, L.2    Cohen, L.3
  • 16
    • 79955844087 scopus 로고    scopus 로고
    • Development of the Crohn's disease digestive damage score, the Lemann score
    • Pariente B, Cosnes J, Danese S, et al. Development of the Crohn's disease digestive damage score, the Lemann score. Inflamm Bowel Dis 2011; 17: 1415-1422.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 1415-1422
    • Pariente, B.1    Cosnes, J.2    Danese, S.3
  • 17
    • 84867578354 scopus 로고    scopus 로고
    • High mucosal healing rates in 5-ASA-treated ulcerative colitis patients: Results of a meta-analysis of clinical trials
    • Romkens TE, Kampschreur MT, Drenth JP, et al. High mucosal healing rates in 5-ASA-treated ulcerative colitis patients: results of a meta-analysis of clinical trials. Inflamm Bowel Dis 2012; 18:2190-2198.
    • (2012) Inflamm Bowel Dis , vol.18 , pp. 2190-2198
    • Romkens, T.E.1    Kampschreur, M.T.2    Drenth, J.P.3
  • 19
  • 20
    • 77950988234 scopus 로고    scopus 로고
    • Infliximab azathioprine or combination therapy for Crohn's disease
    • Colombel JF, Sandborn WJ, Reinisch W, et al. Infliximab, azathioprine, or combination therapy for Crohn's disease. N Engl J Med 2010; 362:1383-1395.
    • (2010) N Engl J Med , vol.362 , pp. 1383-1395
    • Colombel, J.F.1    Sandborn, W.J.2    Reinisch, W.3
  • 21
    • 80755136129 scopus 로고    scopus 로고
    • Infliximab, azathioprine, or infliximab + azathioprine for treatment of moderate to severe UC: The UC SUCCESS trial [abstract 835]
    • Chicago, IL
    • Panaccione R, Ghosh S, Middleton S, et al. Infliximab, azathioprine, or infliximab + azathioprine for treatment of moderate to severe UC: the UC SUCCESS trial [abstract 835]. Presented at DDW 2011, Chicago, IL; 2011.
    • (2011) DDW 2011
    • Panaccione, R.1    Ghosh, S.2    Middleton, S.3
  • 22
    • 84872092353 scopus 로고    scopus 로고
    • Clinical riskfactors for complicated disease: How reliable are they?
    • Zallot C, Peyrin-Biroulet L. Clinical riskfactors for complicated disease: how reliable are they? Digest Dis 2012; 30 (Suppl 3):67-72.
    • (2012) Digest Dis , vol.30 , Issue.SUPPL. 3 , pp. 67-72
    • Zallot, C.1    Peyrin-Biroulet, L.2
  • 23
    • 78650751328 scopus 로고    scopus 로고
    • Deep remission predicts long term outcome for adalimumab treated patients with Crohn's disease: Data from EXTEND
    • Colombel JF, Rutgeerts P, Sandborn WJ, et al. Deep remission predicts long term outcome for adalimumab treated patients with Crohn's disease: data from EXTEND. Gut 2010; 132:52-65.
    • (2010) Gut , vol.132 , pp. 52-65
    • Colombel, J.F.1    Rutgeerts, P.2    Sandborn, W.J.3
  • 24
    • 84862164776 scopus 로고    scopus 로고
    • Achievement of early deep remission is associated with lower rates of weekly dosing for adalimumab-treated patients with Crohn's disease: Data from EXTEND
    • Sandborn WJ, Colombel JF, Lomax K, et al. Achievement of early deep remission is associated with lower rates of weekly dosing for adalimumab-treated patients with Crohn's disease: data from EXTEND. Gut 2011; 60:A136-A137.
    • (2011) Gut , vol.60
    • Sandborn, W.J.1    Colombel, J.F.2    Lomax, K.3
  • 25
    • 83555177321 scopus 로고    scopus 로고
    • Mesentericfat as asource of C reactive protein and as a target for bacterial translocation in Crohn's disease
    • Peyrin-Biroulet L, Gonzalez F, Dubuquoy L, et al. Mesentericfat as asource of C reactive protein and as a target for bacterial translocation in Crohn's disease. Gut 2012; 61:78-85.
    • (2012) Gut , vol.61 , pp. 78-85
    • Peyrin-Biroulet, L.1    Gonzalez, F.2    Dubuquoy, L.3
  • 26
    • 84872686554 scopus 로고    scopus 로고
    • Deep remission in inflammatory bowel disease: Looking beyond symptoms
    • Zallot C, Peyrin-Biroulet L. Deep remission in inflammatory bowel disease: looking beyond symptoms. Curr Gastroenterol Rep 2013; 15:315.
    • (2013) Curr Gastroenterol Rep , vol.15 , pp. 315
    • Zallot, C.1    Peyrin-Biroulet, L.2
  • 27
    • 17944393145 scopus 로고    scopus 로고
    • Impact of inflammatory bowel disease on health-related quality of life
    • Casellas F, Lopez-Vivancos J, Vergara M, Malagelada J. Impact of inflammatory bowel disease on health-related quality of life. Digest Dis 1999; 17:208-218.
    • (1999) Digest Dis , vol.17 , pp. 208-218
    • Casellas, F.1    Lopez-Vivancos, J.2    Vergara, M.3    Malagelada, J.4
  • 29
    • 77957346794 scopus 로고    scopus 로고
    • Risk factors associated with progression to intestinal complications of Crohn's disease in a population-based cohort
    • Thia KT, Sandborn WJ, Harmsen WS, et al. Risk factors associated with progression to intestinal complications of Crohn's disease in a population-based cohort. Gastroenterology 2010; 139:1147-1155.
    • (2010) Gastroenterology , vol.139 , pp. 1147-1155
    • Thia, K.T.1    Sandborn, W.J.2    Harmsen, W.S.3
  • 30
    • 0015151774 scopus 로고
    • Methods of scoring the progression of radiologic changes in rheumatoid arthritis: Correlation of radiologic, clinical and laboratory abnormalities
    • Sharp JT, Lidsky MD, Collins LC, Moreland J. Methods of scoring the progression of radiologic changes in rheumatoid arthritis: correlation of radiologic, clinical and laboratory abnormalities. Arthritis Rheum 1971; 14:706-720.
    • (1971) Arthritis Rheum , vol.14 , pp. 706-720
    • Sharp, J.T.1    Lidsky, M.D.2    Collins, L.C.3    Moreland, J.4
  • 31
    • 0020035448 scopus 로고
    • Clinical responses during gold therapy for rheumatoid arthritis: Changes in synovitis, radiologically detectable erosive lesions, serum proteins, and serologic abnormalities
    • Sharp JT, Lidsky MD, Duffy J. Clinical responses during gold therapy for rheumatoid arthritis: changes in synovitis, radiologically detectable erosive lesions, serum proteins, and serologic abnormalities. Arthritis Rheum 1982; 25:540-549.
    • (1982) Arthritis Rheum , vol.25 , pp. 540-549
    • Sharp, J.T.1    Lidsky, M.D.2    Duffy, J.3
  • 32
    • 77954423661 scopus 로고    scopus 로고
    • Increased response and remission rates in short-duration Crohn's disease with subcutaneous certolizumab pegol: An analysis of PRECiSE 2 randomized maintenance trial data
    • Schreiber S, Colombel JF, Bloomfield R, et al. Increased response and remission rates in short-duration Crohn's disease with subcutaneous certolizumab pegol: an analysis of PRECiSE 2 randomized maintenance trial data. Am J Gastroenterol 2010; 105:1574-1582.
    • (2010) Am J Gastroenterol , vol.105 , pp. 1574-1582
    • Schreiber, S.1    Colombel, J.F.2    Bloomfield, R.3
  • 33
    • 84873720197 scopus 로고    scopus 로고
    • Subgroup analysis of the placebo-controlled CHARM trial: Increased remission rates through 3years for adalimumab-treated patients with early Crohn's disease
    • Schreiber S, Reinisch W, Colombel JF, et al. Subgroup analysis of the placebo-controlled CHARM trial: Increased remission rates through 3years for adalimumab-treated patients with early Crohn's disease. J Crohns Colitis 2013; 7:213-221.
    • (2013) J Crohns Colitis , vol.7 , pp. 213-221
    • Schreiber, S.1    Reinisch, W.2    Colombel, J.F.3
  • 34
    • 0042329252 scopus 로고    scopus 로고
    • Response to infliximab is related to disease duration in paediatric Crohn's disease
    • Lionetti P, Bronzini F, Salvestrini C, et al. Response to infliximab is related to disease duration in paediatric Crohn's disease. Aliment Pharmacol Ther 2003; 18:425-431.
    • (2003) Aliment Pharmacol Ther , vol.18 , pp. 425-431
    • Lionetti, P.1    Bronzini, F.2    Salvestrini, C.3
  • 35
    • 84859072629 scopus 로고    scopus 로고
    • Development of the paris definition ofearlyCrohn's diseasefor disease-modification trials: Resultsof an international expert opinion process
    • Peyrin-Biroulet L, Billioud V, D'Haens G, et al. Development of the paris definition ofearlyCrohn's diseasefor disease-modification trials: resultsof an international expert opinion process. Am J Gastroenterol 2012; 107:1770-1776.
    • (2012) Am J Gastroenterol , vol.107 , pp. 1770-1776
    • Peyrin-Biroulet, L.1    Billioud, V.2    D'Haens, G.3
  • 36
    • 36549071038 scopus 로고    scopus 로고
    • Clinical course in Crohn'sdisease: Results of a Norwegian population-based ten-yearfollow-up study
    • Solberg IC, Vatn MH, Hoie O, et al. Clinical course in Crohn'sdisease: results of a Norwegian population-based ten-yearfollow-up study. Clin Gastroenterol Hepatol 2007; 5:1430-1438.
    • (2007) Clin Gastroenterol Hepatol , vol.5 , pp. 1430-1438
    • Solberg, I.C.1    Vatn, M.H.2    Hoie, O.3
  • 37
    • 0033971379 scopus 로고    scopus 로고
    • Risk factors for surgery and postoperative recurrence in Crohn's disease
    • Bernell O, Lapidus A, Hellers G. Risk factors for surgery and postoperative recurrence in Crohn's disease. Ann Surg 2000; 231:38-45.
    • (2000) Ann Surg , vol.231 , pp. 38-45
    • Bernell, O.1    Lapidus, A.2    Hellers, G.3
  • 39
    • 20444441016 scopus 로고    scopus 로고
    • Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease
    • Targan SR, Landers CJ, Yang H, et al. Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease. Gastroenterology 2005; 128:2020-2028.
    • (2005) Gastroenterology , vol.128 , pp. 2020-2028
    • Targan, S.R.1    Landers, C.J.2    Yang, H.3
  • 40
    • 11144266571 scopus 로고    scopus 로고
    • Sero-reactivity to microbial components in Crohn's disease is associated with disease severity and progression, but not NOD2/CARD15 genotype
    • Arnott ID, Landers CJ, Nimmo EJ, et al. Sero-reactivity to microbial components in Crohn's disease is associated with disease severity and progression, but not NOD2/CARD15 genotype. Am J Gastroenterol 2004; 99:2376-2384.
    • (2004) Am J Gastroenterol , vol.99 , pp. 2376-2384
    • Arnott, I.D.1    Landers, C.J.2    Nimmo, E.J.3
  • 41
    • 0033805362 scopus 로고    scopus 로고
    • Markerantibody expression stratifies Crohn's disease into immunologically homogeneous subgroups with distinct clinical characteristics
    • Vasiliauskas EA, Kam LY, Karp LC, et al. Markerantibody expression stratifies Crohn's disease into immunologically homogeneous subgroups with distinct clinical characteristics. Gut 2000; 47:487-496.
    • (2000) Gut , vol.47 , pp. 487-496
    • Vasiliauskas, E.A.1    Kam, L.Y.2    Karp, L.C.3
  • 42
    • 34948854194 scopus 로고    scopus 로고
    • New serological markers in inflammatory bowel disease are associated with complicated disease behaviour
    • Ferrante M, Henckaerts L, Joossens M, et al. New serological markers in inflammatory bowel disease are associated with complicated disease behaviour. Gut 2007; 56:1394-1403.
    • (2007) Gut , vol.56 , pp. 1394-1403
    • Ferrante, M.1    Henckaerts, L.2    Joossens, M.3
  • 43
    • 33644908022 scopus 로고    scopus 로고
    • Serum immune responses predict rapid disease progression among children with Crohn's disease: Immune responses predictdisease progression
    • Dubinsky MC, Lin YC, Dutridge D, et al. Serum immune responses predict rapid disease progression among children with Crohn's disease: immune responses predictdisease progression. Am JGastroenterol 2006; 101:360-367.
    • (2006) Am JGastroenterol , vol.101 , pp. 360-367
    • Dubinsky, M.C.1    Lin, Y.C.2    Dutridge, D.3
  • 44
    • 84858807419 scopus 로고    scopus 로고
    • Serological antibodies in inflammatory bowel disease: A systematic review
    • Prideaux L, De Cruz P, Ng SC, Kamm MA. Serological antibodies in inflammatory bowel disease: a systematic review. Inflamm Bowel Dis 2012; 18:1340-1355.
    • (2012) Inflamm Bowel Dis , vol.18 , pp. 1340-1355
    • Prideaux, L.1    De Cruz, P.2    Ng, S.C.3    Kamm, M.A.4
  • 45
    • 0036725827 scopus 로고    scopus 로고
    • Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease
    • Abreu MT, Taylor KD, Lin YC, et al. Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease. Gastroenterology 2002; 123:679-688.
    • (2002) Gastroenterology , vol.123 , pp. 679-688
    • Abreu, M.T.1    Taylor, K.D.2    Lin, Y.C.3
  • 46
    • 0036202336 scopus 로고    scopus 로고
    • The molecularclassification oftheclinical manifestations of Crohn's disease
    • Ahmad T, Armuzzi A, Bunce M, et al. The molecularclassification oftheclinical manifestations of Crohn's disease. Gastroenterology 2002; 122:854-866.
    • (2002) Gastroenterology , vol.122 , pp. 854-866
    • Ahmad, T.1    Armuzzi, A.2    Bunce, M.3
  • 47
    • 62049085384 scopus 로고    scopus 로고
    • Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort
    • Weersma RK, Stokkers PC, Cleynen I, et al. Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. Am J Gastroenterol 2009; 104:630-638.
    • (2009) Am J Gastroenterol , vol.104 , pp. 630-638
    • Weersma, R.K.1    Stokkers, P.C.2    Cleynen, I.3
  • 48
    • 69249152654 scopus 로고    scopus 로고
    • Genetic risk profiling and prediction of disease course in Crohn's disease patients
    • Henckaerts L, Van Steen K, Verstreken I, et al. Genetic risk profiling and prediction of disease course in Crohn's disease patients. Clin Gastroenterol Hepatol 2009; 7:972-980.
    • (2009) Clin Gastroenterol Hepatol , vol.7 , pp. 972-980
    • Henckaerts, L.1    Van Steen, K.2    Verstreken, I.3
  • 49
    • 80053414769 scopus 로고    scopus 로고
    • Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis
    • Lee JC, Lyons PA, McKinney EF, et al. Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis. J Clin Invest 2011; 121:4170-4179.
    • (2011) J Clin Invest , vol.121 , pp. 4170-4179
    • Lee, J.C.1    Lyons, P.A.2    McKinney, E.F.3
  • 50
    • 84879948030 scopus 로고    scopus 로고
    • Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease phenotype: Results from the IBDchip European Project
    • [Epub 25 December 2012]
    • Cleynen I, Gonzalez JR, Figueroa C, et al. Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease phenotype: results from the IBDchip European Project. Gut 2012. [Epub 25 December 2012].
    • (2012) Gut
    • Cleynen, I.1    Gonzalez, J.R.2    Figueroa, C.3
  • 51
    • 84871894086 scopus 로고    scopus 로고
    • Genotype/phenotype analyses for 53 Crohn's disease associated genetic polymorphisms
    • Jung C, Colombel JF, Lemann M, et al. Genotype/phenotype analyses for 53 Crohn's disease associated genetic polymorphisms. PloS One 2012; 7:e52223.
    • (2012) PloS One , vol.7
    • Jung, C.1    Colombel, J.F.2    Lemann, M.3
  • 52
    • 75149116327 scopus 로고    scopus 로고
    • The second European evidence-based consensus on the diagnosis and management of Crohn's disease: Special situations
    • Van Assche G, Dignass A, Reinisch W, et al. The second European evidence-based consensus on the diagnosis and management of Crohn's disease: special situations. J Crohns Colitis 2010; 4:63-101.
    • (2010) J Crohns Colitis , vol.4 , pp. 63-101
    • Van Assche, G.1    Dignass, A.2    Reinisch, W.3
  • 54
    • 84860557456 scopus 로고    scopus 로고
    • New therapies for inflammatory bowel disease: From the bench to the bedside
    • Danese S. New therapies for inflammatory bowel disease: from the bench to the bedside. Gut 2012; 61:918-932.
    • (2012) Gut , vol.61 , pp. 918-932
    • Danese, S.1
  • 55
    • 53049091561 scopus 로고    scopus 로고
    • A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patientswith moderate-to-severe Crohn's disease
    • Sandborn WJ, Feagan BG, Fedorak RN, et al. A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patientswith moderate-to-severe Crohn's disease. Gastroenterology 2008; 135:1130-1141.
    • (2008) Gastroenterology , vol.135 , pp. 1130-1141
    • Sandborn, W.J.1    Feagan, B.G.2    Fedorak, R.N.3
  • 56
    • 84871701834 scopus 로고    scopus 로고
    • Ustekinumab induction and maintenance therapy in refractory Crohn's disease
    • Sandborn WJ, Gasink C, Gao LL, et al. Ustekinumab induction and maintenance therapy in refractory Crohn's disease. N Engl J Med 2012; 367:1519-1528.
    • (2012) N Engl J Med , vol.367 , pp. 1519-1528
    • Sandborn, W.J.1    Gasink, C.2    Gao, L.L.3
  • 57
    • 84894884164 scopus 로고    scopus 로고
    • Phase 2 study of CP-690, 550, an oral Janus kinase inhibitor, in active ulcerative colitis [Abstract 594]
    • Sandborn WJ, Ghosh S, Panes J, et al. Phase 2 study of CP-690, 550, an oral Janus kinase inhibitor, in active ulcerative colitis [Abstract 594]. DDW 2011.
    • (2011) DDW
    • Sandborn, W.J.1    Ghosh, S.2    Panes, J.3
  • 59
    • 20444469332 scopus 로고    scopus 로고
    • Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin
    • Feagan BG, Greenberg GR, Wild G, et al. Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin. N Engl J Med 2005; 352:2499-2507.
    • (2005) N Engl J Med , vol.352 , pp. 2499-2507
    • Feagan, B.G.1    Greenberg, G.R.2    Wild, G.3
  • 60
    • 57249089077 scopus 로고    scopus 로고
    • Treatment of active Crohn's disease with MLN0002, a humanized antibody to the alpha4beta7 integrin
    • Feagan BG, Greenberg GR, Wild G, et al. Treatment of active Crohn's disease with MLN0002, a humanized antibody to the alpha4beta7 integrin. Clin Gastroenterol Hepatol 2008; 6:1370-1377.
    • (2008) Clin Gastroenterol Hepatol , vol.6 , pp. 1370-1377
    • Feagan, B.G.1    Greenberg, G.R.2    Wild, G.3
  • 61
    • 80054862378 scopus 로고    scopus 로고
    • Increased risk for non-melanoma skin cancers in patients who receive thiopurines for inflammatory bowel disease
    • Peyrin-Biroulet L, Khosrotehrani K, Carrat F, et al. Increased risk for non-melanoma skin cancers in patients who receive thiopurines for inflammatory bowel disease. Gastroenterology 2011; 141:1621-1628.
    • (2011) Gastroenterology , vol.141 , pp. 1621-1628
    • Peyrin-Biroulet, L.1    Khosrotehrani, K.2    Carrat, F.3
  • 62
    • 84872024555 scopus 로고    scopus 로고
    • T-cell non-Hodgkin's lymphomas reported to the FDA AERS with tumor necrosis factor-alpha (TNF-alpha) inhibitors: Results of the REFURBISH Study
    • Deepak P, Sifuentes H, Sherid M, et al. T-cell non-Hodgkin's lymphomas reported to the FDA AERS with tumor necrosis factor-alpha (TNF-alpha) inhibitors: results of the REFURBISH Study. Am J Gastroenterol 2013; 108:99-105.
    • (2013) Am J Gastroenterol , vol.108 , pp. 99-105
    • Deepak, P.1    Sifuentes, H.2    Sherid, M.3
  • 63
    • 84877276662 scopus 로고    scopus 로고
    • Disease-modifying anti-inflammatory bowel disease drugs (DMAIDS): The missing term in the literature
    • press
    • Peyrin Biroulet L. Disease-modifying anti-inflammatory bowel disease drugs (DMAIDS): the missing term in the literature. Am J Gastroenterol 2013. (in press).
    • (2013) Am J Gastroenterol
    • Peyrin Biroulet, L.1


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