Reproductive hormone concentrations in pregnancy and neonates: A systematic review

Reproductive BioMedicine Online

Volumn 27, Issue 1, 2013, Pages 33-63

  Kuijper, E A M ^a   Ket, J C F ^b   Caanen, M R ^a   Lambalk, C B ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

hormones; post partum; pregnancy; serum; singletons; twins

Indexed keywords

ANDROGEN; ANDROSTENEDIONE; ESTRADIOL; ESTRIOL; ESTROGEN; FOLLITROPIN; GONADOTROPIN; INHIBIN; INHIBIN A; INHIBIN B; LUTEINIZING HORMONE; MUELLERIAN INHIBITING FACTOR; PRASTERONE SULFATE; SEX HORMONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

AMNION FLUID; ANDROGEN BLOOD LEVEL; ANDROSTENEDIONE BLOOD LEVEL; ESTRADIOL BLOOD LEVEL; ESTRIOL BLOOD LEVEL; ESTROGEN BLOOD LEVEL; FOLLITROPIN BLOOD LEVEL; GESTATIONAL AGE; GONADOTROPIN BLOOD LEVEL; HUMAN; HYPERTHYROIDISM; INSULIN RESISTANCE; LUTEINIZING HORMONE BLOOD LEVEL; MATERNAL HYPERTENSION; MATERNAL SERUM; NEWBORN PERIOD; PREECLAMPSIA; PREGNANCY; PREMATURITY; PUBERTY; PUERPERIUM; REVIEW; SEX HORMONE DETERMINATION; SYSTEMATIC REVIEW; TESTOSTERONE BLOOD LEVEL; TWIN PREGNANCY; UMBILICAL CORD BLOOD; Y CHROMOSOME;

AMNIOTIC FLUID; ANDROGENS; ESTROGENS; FEMALE; FETAL BLOOD; FETUS; GESTATIONAL AGE; HORMONES; HUMANS; INFANT; INFANT, NEWBORN; INHIBINS; MALE; PREGNANCY; PREGNANCY, TWIN;

EID: 84879890673     PISSN: 14726483     EISSN: 14726491     Source Type: Journal    
DOI: 10.1016/j.rbmo.2013.03.009     Document Type: Review

References (124)

1. L. Aksglaede, K. Sorensen, M. Boas, A. Mouritsen, C.P. Hagen, R.B. Jensen, J.H. Petersen, A. Linneberg, A.M. Andersson, K.M. Main, N.E. Skakkebaek, and A. Juul Changes in anti-Mullerian hormone (AMH) throughout the life span: a population-based study of 1027 healthy males from birth (cord blood) to the age of 69 years J. Clin. Endocrinol. Metab. 95 2010 5357 5364
2. A. Aleyasin, M. Aghahoseini, S. Mokhtar, and P. Fallahi Anti-Mullerian hormone as a predictive factor in assisted reproductive technique of polycystic ovary syndrome patients Acta Med. Iran 49 2011 715 720
3. R. Anand-Ivell, R. Ivell, D. Driscoll, and J. Manson Insulin-like factor 3 levels in amniotic fluid of human male fetuses Hum. Reprod. 23 2008 1180 1186
4. H. Anderson, N. Fogel, S.K. Grebe, R.J. Singh, R.L. Taylor, and A. Dunaif Infants of women with polycystic ovary syndrome have lower cord blood androstenedione and oestradiol levels J. Clin. Endocrinol. Metab. 95 2010 2180 2186
5. A.M. Andersson, J. Toppari, A.M. Haavisto, J.H. Petersen, T. Simell, O. Simell, and N.E. Skakkebaek Longitudinal reproductive hormone profiles in infants: peak of inhibin B levels in infant boys exceeds levels in adult men J. Clin. Endocrinol. Metab. 83 1998 675 681
6. B. Auyeung, S. Baron-Cohen, E. Ashwin, R. Knickmeyer, K. Taylor, G. Hackett, and M. Hines Fetal testosterone predicts sexually differentiated childhood behavior in girls and in boys Psychol. Sci. 20 2009 144 148
7. D.J. Barker The origins of the developmental origins theory J. Intern. Med. 261 2007 412 417
8. J.S. Barthold, J. Manson, V. Regan, X. Si, S.G. Hassink, M.T. Coughlin, and P.A. Lee Reproductive hormone levels in infants with cryptorchidism during postnatal activation of the pituitary-testicular axis J. Urol. 172 2004 1736 1741
9. K. Bay, H.E. Virtanen, S. Hartung, R. Ivell, K.M. Main, N.E. Skakkebaek, A.M. Andersson, and J. Toppari Insulin-like factor 3 levels in cord blood and serum from children: effects of age, postnatal hypothalamic-pituitary-gonadal axis activation, and cryptorchidism J. Clin. Endocrinol. Metab. 92 2007 4020 4027
10. Z. Bazsa-Kassai, I. Takacs, and T. Korosi Importance of the DHEA-sulphate-test in pregnancy Acta Physiol. Hung. 65 1985 497 505
11. F.D. Berg, and E. Kuss Serum concentration and urinary excretion of 'classical' estrogens, catecholestrogens and 2-methoxyestrogens in normal human pregnancy Arch. Gynecol. Obstet. 251 1992 17 27
12. I. Bergada, G.M. Ballerini, S. Ayuso, N.P. Groome, C. Bergada, and S. Campo High serum concentrations of dimeric inhibins A and B in normal newborn girls Fertil. Steril. 77 2002 363 365
13. I. Bergada, C. Milani, P. Bedecarras, L. Andreone, M.G. Ropelato, S. Gottlieb, C. Bergada, S. Campo, and R.A. Rey Time course of the serum gonadotropin surge, inhibins, and anti-Mullerian hormone in normal newborn males during the first month of life J. Clin. Endocrinol. Metab. 91 2006 4092 4098
14. L. Bernstein, R.H. Depue, R.K. Ross, H.L. Judd, M.C. Pike, and B.E. Henderson Higher maternal levels of free oestradiol in first compared to second pregnancy: early gestational differences J. Natl. Cancer Inst. 76 1986 1035 1039
15. M. Boas, K.A. Boisen, H.E. Virtanen, M. Kaleva, A.M. Suomi, I.M. Schmidt, I.N. Damgaard, C.M. Kai, M. Chellakooty, N.E. Skakkebaek, J. Toppari, and K.M. Main Postnatal penile length and growth rate correlate to serum testosterone levels: a longitudinal study of 1962 normal boys Eur. J. Endocrinol. 154 2006 125 129
16. K.A. Boisen, M. Chellakooty, I.M. Schmidt, C.M. Kai, I.N. Damgaard, A.M. Suomi, J. Toppari, N.E. Skakkebaek, and K.M. Main Hypospadias in a cohort of 1072 Danish newborn boys: prevalence and relationship to placental weight, anthropometrical measurements at birth, and reproductive hormone levels at three months of age J. Clin. Endocrinol. Metab. 90 2005 4041 4046
17. F.J. Broekmans, J. Kwee, D.J. Hendriks, B.W. Mol, and C.B. Lambalk A systematic review of tests predicting ovarian reserve and IVF outcome Hum. Reprod. Update 12 2006 685 718
18. E. Buyuk, D.B. Seifer, J. Younger, R.V. Grazi, and H. Lieman Random anti-Mullerian hormone (AMH) is a predictor of ovarian response in women with elevated baseline early follicular follicle-stimulating hormone levels Fertil. Steril. 95 2011 2369 2372
19. S.M. Carlsen, and R. Heimstad Androgen levels are associated with blood pressure in pregnant women after term Acta Obstet. Gynecol. Scand. 91 2011 232 236
20. S.M. Carlsen, P. Romundstad, and G. Jacobsen Early second-trimester maternal hyperandrogenemia and subsequent preeclampsia: a prospective study Acta Obstet. Gynecol. Scand. 84 2005 117 121
21. S.M. Carlsen, G. Jacobsen, and P. Romundstad Maternal testosterone levels during pregnancy are associated with offspring size at birth Eur. J. Endocrinol. 155 2006 365 370
22. S.M. Carlsen, G. Jacobsen, and E. Vanky Mid-pregnancy androgen levels are negatively associated with breastfeeding Acta Obstet. Gynecol. Scand. 89 2010 87 94
23. F.R. Cattrall, B.J. Vollenhoven, and G.C. Weston Anatomical evidence for in utero androgen exposure in women with polycystic ovary syndrome Fertil. Steril. 84 2005 1689 1692
24. P. Cavarzere, M. Vincenzi, R. Gaudino, R. Franceschi, S. Perlini, M. Camilot, F. Teofoli, F. Antoniazzi, and L. Tato Possible andrologic markers in elevated neonatal 17-hydroxyprogesterone Fertil. Steril. 94 2010 2350 2352
25. M. Chellakooty, I.M. Schmidt, A.M. Haavisto, K.A. Boisen, I.N. Damgaard, C. Mau, J.H. Petersen, A. Juul, N.E. Skakkebaek, and K.M. Main Inhibin A, inhibin B, follicle-stimulating hormone, luteinizing hormone, oestradiol, and sex hormone-binding globulin levels in 473 healthy infant girls J. Clin. Endocrinol. Metab. 88 2003 3515 3520
26. P.M. Crofton, A.E. Evans, N.P. Groome, M.R. Taylor, C.V. Holland, and C.J. Kelnar Inhibin B in boys from birth to adulthood: relationship with age, pubertal stage, FSH and testosterone Clin. Endocrinol. (Oxf.) 56 2002 215 221
27. D.A. Damassa, and J.M. Cates Sex hormone-binding globulin and male sexual development Neurosci. Biobehav. Rev. 19 1995 165 175
28. E.J. Davidson, S.C. Riley, S.A. Roberts, C.H. Shearing, N.P. Groome, and C.W. Martin Maternal serum activin, inhibin, human chorionic gonadotrophin and alpha-fetoprotein as second trimester predictors of pre-eclampsia BJOG 110 2003 46 52
29. F. Debieve, S. Beerlandt, C. Hubinont, and K. Thomas Gonadotropins, prolactin, inhibin A, inhibin B, and activin A in human fetal serum from midpregnancy and term pregnancy J. Clin. Endocrinol. Metab. 85 2000 270 274
30. Z. Dong, X. Chen, L. Li, J. Huang, Q. Yin, and D. Yang Free testosterone level correlated with the metabolic abnormalities dependent on central obesity in women with polycystic ovary syndrome Exp. Clin. Endocrinol. Diab. 120 2012 355 360
31. A. Dzaja, R. Wehrle, M. Lancel, and T. Pollmacher Elevated oestradiol plasma levels in women with restless legs during pregnancy Sleep 32 2009 169 174
32. L. Ekelund, and C.B. Laurell The pregnancy zone protein response during gestation: a metabolic challenge Scand. J. Clin. Lab. Invest. 54 1994 623 629
33. D.A. Fisher The unique endocrine milieu of the fetus J. Clin. Invest. 78 1986 603 611
34. M.G. Forest, P.C. Sizonenko, A.M. Cathiard, and J. Bertrand Hypophyso-gonadal function in humans during the first year of life: 1. Evidence for testicular activity in early infancy J. Clin. Invest. 53 1974 819 828
35. S. Fourati, G. Merdassi, M. Khrouf, H. Elloumi, A. Fadhlaoui, I. Brahmi, N. Hammami, S.S. Ben, M.M. Ben, F. Zhioua, and A. Zhioua Basal fsh level is only predictive of the quantitative aspect of the ovarian response Tunis. Med. 90 2012 524 529
36. P.A. Fowler, L.W. Evans, N.P. Groome, A. Templeton, and P.G. Knight A longitudinal study of maternal serum inhibin-A, inhibin-B, activin-A, activin-AB, pro-alphaC and follistatin during pregnancy Hum. Reprod. 13 1998 3530 3536
37. J.M. Garagorri, G. Rodriguez, A.J. Lario-Elboj, J.L. Olivares, A. Lario-Munoz, and I. Orden Reference levels for 17-hydroxyprogesterone, 11-desoxycortisol, cortisol, testosterone, dehydroepiandrosterone sulfate and androstenedione in infants from birth to six months of age Eur. J. Pediatr. 167 2008 647 653
38. M. Gol, S. Altunyurt, D. Cimrin, S. Guclu, M. Bagci, and N. Demir Different maternal serum hCG levels in pregnant women with female and male fetuses: does fetal hypophyseal-adrenal-gonadal axis play a role? J. Perinat. Med. 32 2004 342 345
39. M.C. Gonzalez, H. Reyes, M. Arrese, D. Figueroa, B. Lorca, M. Andresen, N. Segovia, C. Molina, and S. Arce Intrahepatic cholestasis of pregnancy in twin pregnancies J. Hepatol. 9 1989 84 90
40. R.F. Greaves, R.W. Hunt, A.S. Chiriano, and M.R. Zacharin Luteinizing hormone and follicle-stimulating hormone levels in extreme prematurity: development of reference intervals Pediatrics 121 2008 e574 e580
41. D.R. Grow Metabolism of endogenous and exogenous reproductive hormones Obstet. Gynecol. Clin. North Am. 29 2002 425 436
42. C.P. Hagen, L. Aksglaede, K. Sorensen, K.M. Main, M. Boas, L. Cleemann, K. Holm, C.H. Gravholt, A.M. Andersson, A.T. Pedersen, J.H. Petersen, A. Linneberg, S. Kjaergaard, and A. Juul Serum levels of anti-Mullerian hormone as a marker of ovarian function in 926 healthy females from birth to adulthood and in 172 Turner syndrome patients J. Clin. Endocrinol. Metab. 95 2010 5003 5010
43. M. Hazewinkel Encyclopedia of Mathematics 2002 Springer-Verlag Heidelberg, New York
44. M. Hickey, D.A. Doherty, R. Hart, R.J. Norman, E. Mattes, H.C. Atkinson, and D.M. Sloboda Maternal and umbilical cord androgen levels do not predict digit ratio (2D:4D) in girls: a prospective cohort study Psychoneuroendocrinology 35 2010 1235 1244
45. M. Hohlagschwandtner, P. Husslein, C. Klier, and B. Ulm Correlation between serum testosterone levels and peripartal mood states Acta Obstet. Gynecol. Scand. 80 2001 326 330
46. L. Ibanez, C. Valls, M. Cols, A. Ferrer, M.V. Marcos, and Z.F. De Hypersecretion of FSH in infant boys and girls born small for gestational age J. Clin. Endocrinol. Metab. 87 2002 1986 1988
47. K. Iwata, H. Matsuzaki, T. Miyachi, C. Shimmura, S. Suda, K.J. Tsuchiya, K. Matsumoto, K. Suzuki, Y. Iwata, K. Nakamura, M. Tsujii, T. Sugiyama, K. Sato, and N. Mori Investigation of the serum levels of anterior pituitary hormones in male children with autism Mol. Autism 2 2011 16
48. R.B. Jaffe Fetoplacental endocrine and metabolic physiology Clin. Perinatol. 10 1983 669 693
49. F. Janse, M.J. Eijkemans, A.J. Goverde, E.G. Lentjes, A. Hoek, C.B. Lambalk, T.E. Hickey, B.C. Fauser, and R.J. Norman Assessment of androgen concentration in women: liquid chromatography-tandem mass spectrometry and extraction RIA show comparable results Eur. J. Endocrinol. 165 2011 925 933
50. N. Janzen, M. Peter, S. Sander, U. Steuerwald, M. Terhardt, U. Holtkamp, and J. Sander Newborn screening for congenital adrenal hyperplasia: additional steroid profile using liquid chromatography-tandem mass spectrometry J. Clin. Endocrinol. Metab. 92 2007 2581 2589
51. J.A. Keelan, E. Mattes, H. Tan, A. Dinan, J.P. Newnham, A.J. Whitehouse, P. Jacoby, and M. Hickey Androgen concentrations in umbilical cord blood and their association with maternal, fetal and obstetric factors PLoS ONE 7 2012 e42827
52. V. Kerlan, K. Nahoul, M.T. Le Martelot, and J.P. Bercovici Longitudinal study of maternal plasma bioavailable testosterone and androstanediol glucuronide levels during pregnancy Clin. Endocrinol. (Oxf.) 40 1994 263 267
53. E.A. Kuijper, J. van Kooten, J.I. Verbeke, R.M. van, and C.B. Lambalk Ultrasonographically measured testicular volumes in 0- to 6-year-old boys Hum. Reprod. 23 2008 792 796
54. T. Kuiri-Hanninen, S. Kallio, R. Seuri, E. Tyrvainen, A. Liakka, J. Tapanainen, U. Sankilampi, and L. Dunkel Postnatal developmental changes in the pituitary-ovarian axis in preterm and term infant girls J. Clin. Endocrinol. Metab. 96 2011 3432 3439
55. J. Kwee, R. Schats, J. McDonnell, A. Themmen, J.F. de, and C. Lambalk Evaluation of anti-Mullerian hormone as a test for the prediction of ovarian reserve Fertil. Steril. 90 2008 737 743
56. P. Lagiou, R. Tamimi, L.A. Mucci, D. Trichopoulos, H.O. Adami, and C.C. Hsieh Nausea and vomiting in pregnancy in relation to prolactin, estrogens, and progesterone: a prospective study Obstet. Gynecol. 101 2003 639 644
57. P. Lagiou, A. Lagiou, E. Samoli, C.C. Hsieh, H.O. Adami, and D. Trichopoulos Diet during pregnancy and levels of maternal pregnancy hormones in relation to the risk of breast cancer in the offspring Eur. J. Cancer Prev. 15 2006 20 26
58. N. Lahlou, I. Fennoy, J.C. Carel, and M. Roger Inhibin B and anti-Mullerian hormone, but not testosterone levels, are normal in infants with nonmosaic Klinefelter syndrome J. Clin. Endocrinol. Metab. 89 2004 1864 1868
59. Y.H. Lam, and M.H. Tang Second-trimester maternal serum inhibin-A screening for fetal Down syndrome in Asian women Prenat. Diagn. 19 1999 463 467
60. A. La Marca, S. Giulini, R. Orvieto, V. De Leo, and A. Volpe Anti-Mullerian hormone concentrations in maternal serum during pregnancy Hum. Reprod. 20 2005 1569 1572
61. M.M. Lee, P.K. Donahoe, T. Hasegawa, B. Silverman, G.B. Crist, S. Best, Y. Hasegawa, R.A. Noto, D. Schoenfeld, and D.T. MacLaughlin Mullerian inhibiting substance in humans: normal levels from infancy to adulthood J. Clin. Endocrinol. Metab. 81 1996 571 576
62. H.W. Li, P.W. Hui, M.H. Tang, E.T. Lau, W.S. Yeung, P.C. Ho, and E.H. Ng Maternal serum anti-Mullerian hormone level is not superior to chronological age in predicting Down syndrome pregnancies Prenat. Diagn. 30 2010 320 324
63. A. Liberati, D.G. Altman, J. Tetzlaff, C. Mulrow, P.C. Gotzsche, J.P. Ioannidis, M. Clarke, P.J. Devereaux, J. Kleijnen, and D. Moher The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration BMJ 339 2009 b2700
64. E.E. Maccoby, C.H. Doering, C.N. Jacklin, and H. Kraemer Concentrations of sex hormones in umbilical-cord blood: their relation to sex and birth order of infants Child Dev. 50 1979 632 642
65. K.M. Main, J. Toppari, A.M. Suomi, M. Kaleva, M. Chellakooty, I.M. Schmidt, H.E. Virtanen, K.A. Boisen, C.M. Kai, I.N. Damgaard, and N.E. Skakkebaek Larger testes and higher inhibin B levels in Finnish than in Danish newborn boys J. Clin. Endocrinol. Metab. 91 2006 2732 2737
66. C.R. Marrs, D.P. Ferraro, and C.L. Cross Salivary hormones and parturition in healthy, primigravid women Int. J. Gynaecol. Obstet. 99 2007 59 60
67. K.C. Mau, K.M. Main, A.N. Andersen, A. Loft, N.E. Skakkebaek, and A. Juul Reduced serum testosterone levels in infant boys conceived by intracytoplasmic sperm injection J. Clin. Endocrinol. Metab. 92 2007 2598 2603
68. K.A. McGlynn, B.I. Graubard, J.M. Nam, F.Z. Stanczyk, M.P. Longnecker, and M.A. Klebanoff Maternal hormone levels and risk of cryptorchism among populations at high and low risk of testicular germ cell tumors Cancer Epidemiol. Biomarkers Prev. 14 2005 1732 1737
69. L.A. Mucci, P. Lagiou, R.M. Tamimi, C.C. Hsieh, H.O. Adami, and D. Trichopoulos Pregnancy estriol, oestradiol, progesterone and prolactin in relation to birth weight and other birth size variables (United States) Cancer Causes Control 14 2003 311 318
70. S. Muttukrishna Role of inhibin in normal and high-risk pregnancy Semin. Reprod. Med. 22 2004 227 234
71. C. Nagata, S. Iwasa, M. Shiraki, and H. Shimizu Estrogen and alpha-fetoprotein levels in maternal and umbilical cord blood samples in relation to birth weight Cancer Epidemiol. Biomarkers Prev. 15 2006 1469 1472
72. S.M. Nelson, F. Stewart, R. Fleming, and D.J. Freeman Longitudinal assessment of antiMullerian hormone during pregnancy-relationship with maternal adiposity, insulin, and adiponectin Fertil. Steril. 93 2010 1356 1358
73. E.R. Norwitz, J.N. Robinson, and J.R. Challis The control of labor N. Engl. J. Med. 341 1999 660 666
74. P. Ocal, S. Sahmay, M. Cetin, T. Irez, O. Guralp, and I. Cepni Serum anti-Mullerian hormone and antral follicle count as predictive markers of OHSS in ART cycles J. Assist. Reprod. Genet. 28 2011 1197 1203
75. K. Panagiotopoulou, K. Katsouyanni, E. Petridou, Y. Garas, A. Tzonou, and D. Trichopoulos Maternal age, parity, and pregnancy estrogens Cancer Causes Control 1 1990 119 124
76. M. Peter, H.G. Dorr, and W.G. Sippell Changes in the concentrations of dehydroepiandrosterone sulfate and estriol in maternal plasma during pregnancy: a longitudinal study in healthy women throughout gestation and at term Horm. Res. 42 1994 278 281
77. F. Petraglia, S. Angioni, G. Coukos, E. Uccelli, P. DiDomenica, B.M. De Ramundo, A.D. Genazzani, G.C. Garuti, and A. Segre Neuroendocrine mechanisms regulating placental hormone production Contrib. Gynecol. Obstet. 18 1991 147 156
78. F. Petraglia, S. Luisi, C. Benedetto, M. Zonca, P. Florio, E. Casarosa, A. Volpe, S. Bernasconi, and A.R. Genazzani Changes of dimeric inhibin B levels in maternal serum throughout healthy gestation and in women with gestational diseases J. Clin. Endocrinol. Metab. 82 1997 2991 2995
79. V. Phupong, T. Hanprasertpong, and S. Honsawek First trimester serum inhibin A in normal pregnant women Arch. Gynecol. Obstet. 277 2008 307 310
80. F.H. Pierik, J.A. Deddens, A. Burdorf, S.M. de Muinck Keizer-Schrama, F.H. Jong, and R.F. Weber The hypothalamus-pituitary-testis axis in boys during the first six months of life: a comparison of cryptorchidism and hypospadias cases with controls Int. J. Androl. 32 2009 453 461
81. M.P. Plevyak, G.M. Lambert-Messerlian, A. Farina, N.P. Groome, J.A. Canick, and H.M. Silver Concentrations of serum total activin A and inhibin A in preterm and term labor patients: a cross-sectional study J. Soc. Gynecol. Invest. 10 2003 231 236
82. N. Potischman, R. Troisi, R. Thadhani, R.N. Hoover, K. Dodd, W.W. Davis, P.M. Sluss, C.C. Hsieh, and R. Ballard-Barbash Pregnancy hormone concentrations across ethnic groups: implications for later cancer risk Cancer Epidemiol. Biomarkers Prev. 14 2005 1514 1520
83. T. Raivio, J. Toppari, M. Kaleva, H. Virtanen, A.M. Haavisto, L. Dunkel, and O.A. Janne Serum androgen bioactivity in cryptorchid and noncryptorchid boys during the postnatal reproductive hormone surge J. Clin. Endocrinol. Metab. 88 2003 2597 2599
84. A. Reddy, S. Suri, I.L. Sargent, C.W. Redman, and S. Muttukrishna Maternal circulating levels of activin A, inhibin A, sFlt-1 and endoglin at parturition in normal pregnancy and pre-eclampsia PLoS ONE 4 2009 e4453
85. L.K. Rogers, and M. Velten Maternal inflammation, growth retardation, and preterm birth: insights into adult cardiovascular disease Life Sci. 89 2011 417 421
86. L.M. Sakai, L.A. Baker, C.N. Jacklin, and I. Shulman Sex steroids at birth: genetic and environmental variation and covariation Dev. Psychobiol. 24 1991 559 570
87. J.T. Sanderson Placental and fetal steroidogenesis Methods Mol. Biol. 550 2009 127 136
88. N. Sattar, I.A. Greer, A. Rumley, G. Stewart, J. Shepherd, C.J. Packard, and G.D. Lowe A longitudinal study of the relationships between haemostatic, lipid, and oestradiol changes during normal human pregnancy Thromb. Haemost. 81 1999 71 75
89. I.M. Schmidt, M. Chellakooty, A.M. Haavisto, K.A. Boisen, I.N. Damgaard, U. Steendahl, J. Toppari, N.E. Skakkebaek, and K.M. Main Gender difference in breast tissue size in infancy: correlation with serum oestradiol Pediatr. Res. 52 2002 682 686
90. H. Schmidt, and H.P. Schwarz Serum concentrations of LH and FSH in the healthy newborn Eur. J. Endocrinol. 143 2000 213 215
91. C. Schubring, P. Englaro, T. Siebler, W.F. Blum, T. Demirakca, J. Kratzsch, and W. Kiess Longitudinal analysis of maternal serum leptin levels during pregnancy, at birth and up to six weeks after birth: relation to body mass index, skinfolds, sex steroids and umbilical cord blood leptin levels Horm. Res. 50 1998 276 283
92. I.S. Serin, M. Kula, M. Basbug, K. Unluhizarci, S. Gucer, and M. Tayyar Androgen levels of preeclamptic patients in the third trimester of pregnancy and six weeks after delivery Acta Obstet. Gynecol. Scand. 80 2001 1009 1013
93. D. Simmons Interrelation between umbilical cord serum sex hormones, sex hormone-binding globulin, insulin-like growth factor I, and insulin in neonates from normal pregnancies and pregnancies complicated by diabetes J. Clin. Endocrinol. Metab. 80 1995 2217 2221
94. T. Sir-Petermann, E. Codner, M. Maliqueo, B. Echiburu, C. Hitschfeld, N. Crisosto, F. Perez-Bravo, S.E. Recabarren, and F. Cassorla Increased anti-Mullerian hormone serum concentrations in prepubertal daughters of women with polycystic ovary syndrome J. Clin. Endocrinol. Metab. 91 2006 3105 3109
95. K.V. Smirnakis, A. Plati, M. Wolf, R. Thadhani, and J.L. Ecker Predicting gestational diabetes: choosing the optimal early serum marker Am. J. Obstet. Gynecol. 196 2007 410 416
96. R. Smith, J.I. Smith, X. Shen, P.J. Engel, M.E. Bowman, S.A. McGrath, A.M. Bisits, P. McElduff, W.B. Giles, and D.W. Smith Patterns of plasma corticotropin-releasing hormone, progesterone, oestradiol, and estriol change and the onset of human labor J. Clin. Endocrinol. Metab. 94 2009 2066 2074
97. O.P. Soldin, T. Guo, E. Weiderpass, R.E. Tractenberg, L. Hilakivi-Clarke, and S.J. Soldin Steroid hormone levels in pregnancy and 1 year postpartum using isotope dilution tandem mass spectrometry Fertil. Steril. 84 2005 701 710
98. K. Spencer, C.K. Yu, G. Rembouskos, R. Bindra, and K.H. Nicolaides First trimester sex hormone-binding globulin and subsequent development of preeclampsia or other adverse pregnancy outcomes Hypertens. Pregnancy 24 2005 303 311
99. K. Spencer, N.J. Cowans, and K.H. Nicolaides Maternal serum inhibin-A and activin-A levels in the first trimester of pregnancies developing pre-eclampsia Ultrasound Obstet. Gynecol. 32 2008 622 626
100. Speroff, L., Fritz, M.A., 2005. Clinical Gynecologic Endocrinology and Infertility, seventh ed. Lippincott Williams & Wilkins.
101. A.J. Swerdlow, B.L. De Stavola, M.A. Swanwick, and N.E. Maconochie Risks of breast and testicular cancers in young adult twins in England and Wales: evidence on prenatal and genetic aetiology Lancet 350 1997 1723 1728
102. N. Tagawa, Y. Hidaka, T. Takano, Y. Shimaoka, Y. Kobayashi, and N. Amino Serum concentrations of dehydroepiandrosterone and dehydroepiandrosterone sulfate and their relation to cytokine production during and after normal pregnancy Clin. Chim. Acta 340 2004 187 193
103. J. Tapanainen, M. Koivisto, R. Vihko, and I. Huhtaniemi Enhanced activity of the pituitary-gonadal axis in premature human infants J. Clin. Endocrinol. Metab. 52 1981 235 238
104. A.L. Tapp, M.T. Maybery, and A.J. Whitehouse Evaluating the twin testosterone transfer hypothesis: a review of the empirical evidence Horm. Behav. 60 2011 713 722
105. H.V. Thomas, M.F. Murphy, T.J. Key, I.S. Fentiman, D.S. Allen, and L.J. Kinlen Pregnancy and menstrual hormone levels in mothers of twins compared to mothers of singletons Ann. Hum. Biol. 25 1998 69 75
106. C. Tomlinson, H. Macintyre, C.A. Dorrian, S.F. Ahmed, and A.M. Wallace Testosterone measurements in early infancy Arch. Dis. Child. Fetal Neonatal Ed. 89 2004 F558 F559
107. M. Torricelli, C. Voltolini, L. Galleri, G. Biliotti, A. Giovannelli, B.M. De, P.F. De, G. Centini, and F. Petraglia Amniotic fluid urocortin, CRF, oestriol, dehydroepiandrosterone sulfate and cortisol concentrations at mid-trimester: putative relationship with preterm delivery Eur. J. Obstet. Gynecol. Reprod. Biol. 146 2009 169 173
108. D. Trichopoulos Hypothesis: does breast cancer originate in utero? Lancet 335 1990 939 940
109. R. Troisi, N. Potischman, C.N. Johnson, J.M. Roberts, D. Lykins, G. Harger, N. Markovic, P. Siiteri, and R.N. Hoover Estrogen and androgen concentrations are not lower in the umbilical cord serum of pre-eclamptic pregnancies Cancer Epidemiol. Biomarkers Prev. 12 2003 1268 1270
110. R. Troisi, N. Potischman, J. Roberts, P. Siiteri, A. Daftary, C. Sims, and R.N. Hoover Associations of maternal and umbilical cord hormone concentrations with maternal, gestational and neonatal factors (United States) Cancer Causes Control 14 2003 347 355
111. R. Troisi, N. Potischman, J.M. Roberts, G. Harger, N. Markovic, B. Cole, D. Lykins, P. Siiteri, and R.N. Hoover Correlation of serum hormone concentrations in maternal and umbilical cord samples Cancer Epidemiol. Biomarkers Prev. 12 2003 452 456
112. R. Troisi, N. Potischman, J.M. Roberts, R. Ness, W. Crombleholme, D. Lykins, P. Siiteri, and R.N. Hoover Maternal serum oestrogen and androgen concentrations in preeclamptic and uncomplicated pregnancies Int. J. Epidemiol. 32 2003 455 460
113. D. Tulchinsky, R. Osathanondh, and A. Finn Dehydroepiandrosterone sulfate loading test in the diagnosis of complicated pregnancies N. Engl. J. Med. 294 1976 517 522
114. E.K. Tuutti, E.K. Hamalainen, S.M. Sainio, V.K. Hiilesmaa, U.L. Turpeinen, H.V. Alfthan, and U.H. Stenman Serum testosterone levels during early pregnancy in patients developing preeclampsia Scand. J. Clin. Lab. Invest. 71 2011 413 418
115. C. van de Beek, J.H. Thijssen, P.T. Cohen-Kettenis, S.H. van Goozen, and J.K. Buitelaar Relationships between sex hormones assessed in amniotic fluid, and maternal and umbilical cord serum: what is the best source of information to investigate the effects of fetal hormonal exposure? Horm. Behav. 46 2004 663 669
116. C. van de Beek, S.H. van Goozen, J.K. Buitelaar, and P.T. Cohen-Kettenis Prenatal sex hormones (maternal and amniotic fluid) and gender-related play behavior in 13-month-old infants Arch. Sex. Behav. 38 2009 6 15
117. S.M. Veltman-Verhulst, T.W. van Haeften, M.J. Eijkemans, H.W. de Valk, B.C. Fauser, and A.J. Goverde Sex hormone-binding globulin concentrations before conception as a predictor for gestational diabetes in women with polycystic ovary syndrome Hum. Reprod. 25 2010 3123 3128
118. E.M. Wallace, I.A. Swanston, A.S. McNeilly, J.P. Ashby, G. Blundell, A.A. Calder, and N.P. Groome Second trimester screening for Down's syndrome using maternal serum dimeric inhibin A Clin. Endocrinol. (Oxf.) 44 1996 17 21
119. E.M. Wallace, S.C. Riley, J.A. Crossley, S.C. Ritoe, A. Horne, M. Shade, P.M. Ellis, D.A. Aitken, and N.P. Groome Dimeric inhibins in amniotic fluid, maternal serum, and fetal serum in human pregnancy J. Clin. Endocrinol. Metab. 82 1997 218 222
120. E.M. Wallace, J.A. Crossley, S.C. Riley, C. Balfour, N.P. Groome, and D.A. Aitken Inhibin-B and pro-alphaC-containing inhibins in amniotic fluid from chromosomally normal and Down syndrome pregnancies Prenat. Diagn. 18 1998 213 217
121. E.M. Wallace, D. D'Antona, C. Shearing, L.W. Evans, P. Thirunavukarasu, J.P. Ashby, M. Shade, and N.P. Groome Amniotic fluid levels of dimeric inhibins, pro-alpha C inhibin, activin A and follistatin in Down's syndrome Clin. Endocrinol. (Oxf.) 50 1999 669 673
122. A.J. Whitehouse, M.T. Maybery, R. Hart, E. Mattes, J.P. Newnham, D.M. Sloboda, F.J. Stanley, and M. Hickey Fetal androgen exposure and pragmatic language ability of girls in middle childhood: implications for the extreme male-brain theory of autism Psychoneuroendocrinology 35 2010 1259 1264
123. P. Wood Salivary steroid assays - research or routine? Ann. Clin. Biochem. 46 2009 183 196
124. C.K. Yu, A.T. Papageorghiou, R. Bindra, K. Spencer, and K.H. Nicolaides Second-trimester sex hormone-binding globulin and subsequent development of pre-eclampsia J. Matern. Fetal Neonatal Med. 16 2004 158 162