Second trimester screening for Down's syndrome using maternal serum dimeric inhibin A

Clinical Endocrinology

Volumn 44, Issue 1, 1996, Pages 17-21

  Wallace, Euan M ^a   Swanston, Ian A ^a   McNeilly, Alan S ^a   Peter Ashby, J ^b   Blundell, Gillian ^b   Calder, Andrew A ^a   Groome, Nigel P ^c  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b NHS LOTHIAN   (United Kingdom)

^c OXFORD BROOKES UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INHIBIN;

ADULT; ARTICLE; CONTROLLED STUDY; DOWN SYNDROME; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

EID: 0030068664     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.1996.544368.x     Document Type: Article

References (19)

1. Abe, Y., Hasegawa, Y., Miyamoto, K., Yamaguchi, A., Ibuki, Y. & Igarashi, M. (1990) High concentrations of plasma immunoreactive inhibin during normal pregnancy in women. Journal of Clinical Endocrinology and Metabolism, 71, 133-137.
2. Benacerraf, B.R., Frigoletto, F.D. & Laboda, L.A. (1985) Sonographic diagnosis of Down's syndrome in the second trimester. American Journal of Obstetrics Gynecology, 153, 49-52.
3. Cuckle, H.S., Wald, N.J., Goodburn, S.F., Sneddon, J., Arness J.A.C. & Dunn, S.C. (1990) Measurement of activity of urea-resistant neutrophil alkaline phosphatase as an antenatal screening test for Down's syndrome. British Medical Journal, 301, 1024-1026.
4. Cuckle, H.S., Holding, S. & Jones, R. (1994) Maternal serum inhibin levels in second-trimester Down's syndrome pregnancies. Prenatal Diagnosis, 14, 387-390.
5. Groome, N.P. & O'Brien, M. (1993) Two-site immunoassays for inhibin and its subunits. Further applications of the synthetic peptide approach. Journal of Immunological Methods, 165, 167-176.
6. Groome, N.P., Illingworth, P.J., O'Brien, M., Cooke, I., Ganesan, T.S., Baird, D.T. & McNeilly, A.S. (1994) Detection of dimeric inhibin throughout the human menstrual cycle by two-site enzyme immunoassay. Clinical Endocrinology, 40, 717-723.
7. Macintosh, M.C.M. & Chard, T. (1993) Biochemical screening for Down's syndrome in the first trimester of pregnancy. Fetal and Maternal Medicine Reviews, 5, 181-190,
8. Robertson, D.M., Sullivan, J. & Cahir, N. (1995) Inhibin forms in human plasma. Journal of Endocrinology, 144, 261-269.
9. Royal College of Obstetricians and Gynaecologists (1993) Report of the RCOG Working Party on Biochemical Markers and the Detection of Down's Syndrome. RCOG Press, London.
10. Schneyer, A.L., Mason, A.J., Barton, L.E., Ziegner, J.R. & Crowley, W.F. (1990) Immunoreactive inhibin α-subunit in human serum: implications for radioimmunoassay. Journal of Clinical Endocrinology and Metabolism, 70, 1208-1212.
11. Spencer, K., Wood, P.J. & Anthony, F.W. (1993) Elevated levels of maternal serum inhibin immunoreactivity in second trimester pregnancies affected by Down's syndrome. Annals of Clinical Biochemistry, 30, 219-220.
12. Studd, J.W.W., Blainey, J.D. & Bailey, D.E. (1970) A study of serum protein changes in late pregnancy and identification of the pregnancy zone protein using antigen antibody crossed immunoelectrophoresis. Journal of Obstetrics and Gynaecology of the British Commonwealth, 77, 42-51.
13. Tabor, A., Philip, J., Madser, M., Bang, J., Obel, E.B. & Norgaard-Pedersen, B. (1986) Randomised controlled trial of genetic amniocentesis in 4606 low risk women. Lancet, i, 1287-1289.
14. Tovanabutra, S., Illingworth, P.J., Ledger, W.L., Glasier, A.F. & Baird, D.T. (1993) The relationship between peripheral immunactive inhibin, human chorionic gonadotrophin, oestradiol and progesterone during human pregnancy. Clinical Endocrinology, 38, 101-107.
15. Van Lith, J.M.M., Pratt, J.J., Beekhuis, J.R. & Mantingh, A. (1992) Second-trimester maternal serum immunoreactive inhibin as a marker for fetal Down's syndrome. Prenatal Diagnosis, 12, 801-806.
16. Van Lith, J.M.M., Mantingh, A. & Pratt, J.J. (1994) First-trimester maternal serum immunoreactive inhibin in chromosomally normal and abnormal pregnancies. Obstetrics and Gynecology, 83, 661-664.
17. 2-macroglobulin is a binding protein of inhibin and activin. Endocrinology, 132, 2038-2050.
18. Wallace, E.M., Harkness, L.M., Burns, S. & Liston, W.A. (1994) Evaluation of maternal serum immunoreactive inhibin as a first trimester marker of Down's syndrome. Clinical Endocrinology, 41, 483-486.
19. Wallace, E.M., Grant, V.F., Swanston, I.A. & Groome, N.P. (1995) Evaluation of maternal serum dimeric inhibin A as a first tri-mester marker of Down's syndrome. Prenatal Diagnosis, 15, 359-362.