Assessment of androgen concentration in women: Liquid chromatography-tandem mass spectrometry and extraction RIA show comparable results

European Journal of Endocrinology

Volumn 165, Issue 6, 2011, Pages 925-933

  Janse, Femi ^a   Eijkemans, Martinus J C ^a   Goverde, Angelique J ^a   Lentjes, Eef G W M ^a   Hoek, Annemieke ^b   Lambalk, Cornelius B ^c   Hickey, Theresa E ^d   Fauser, Bart C J M ^a   Norman, Robert J ^d  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTENEDIONE; PRASTERONE; TESTOSTERONE;

ADULT; ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; CORRELATION COEFFICIENT; CROSS-SECTIONAL STUDY; FEMALE; HORMONE DETERMINATION; HUMAN; INTERMETHOD COMPARISON; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; OVARY INSUFFICIENCY; OVARY POLYCYSTIC DISEASE; PHENOTYPE; PRIORITY JOURNAL; RADIOIMMUNOASSAY; TANDEM MASS SPECTROMETRY;

ADOLESCENT; ADULT; ANDROGENS; BIOLOGICAL MARKERS; CHROMATOGRAPHY, LIQUID; CROSS-SECTIONAL STUDIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; MIDDLE AGED; RADIOIMMUNOASSAY; RANDOM ALLOCATION; TANDEM MASS SPECTROMETRY; YOUNG ADULT;

EID: 81555195441     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-11-0482     Document Type: Article

References (43)

1. Rosner W, Auchus RJ, Azziz R, Sluss PM & Raff H. Position statement: utility, limitations, and pitfalls in measuring testosterone: an Endocrine Society position statement. Journal of Clinical Endocrinology and Metabolism 2007 92 405-413. (doi:10.1210/ jc.2006-1864)
2. Vermeulen A, Verdonck L & Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. Journal of Clinical Endocrinology and Metabolism 1999 84 3666-3672. (doi:10.1210/jc.84.10.3666)
3. Herold DA & Fitzgerald RL. Immunoassays for testosterone in women: better than a guess? Clinical Chemistry 2003 49 1250-1251. (doi:10.1373/49.8. 1250)
4. Longcope C. Adrenal and gonadal androgen secretion in normal females. Clinics in Endocrinology and Metabolism 1986 15 213-228. (doi:10.1016/S0300- 595X(86)80021-4)
5. Burger HG. Androgen production in women. Fertility and Sterility 2002 77 3-5. (doi:10.1016/S0015-0282(02)02985-0)
6. Dunn JF, Nisula BC & Rodbard D. Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma. Journal of Clinical Endocrinology and Metabolism 1981 53 58-68. (doi:10.1210/jcem-53-1-58)
7. Stanczyk FZ, Cho MM, Endres DB, Morrison JL, Patel S & Paulson RJ. Limitations of direct estradiol and testosterone immunoassay kits. Steroids 2003 68 1173-1178. (doi:10.1016/ j.steroids.2003.08.012)
8. Taieb J, Mathian B, Millot F, Patricot MC, Mathieu E, Queyrel N, Lacroix I, Somma-Delpero C & Boudou P. Testosterone measured by 10 immunoassays and by isotope-dilution gas chromatography-mass spectrometry in sera from 116 men, women, and children. Clinical Chemistry 2003 49 1381-1395. (doi:10.1373/ 49.8.1381)
9. Boots LR, Potter S, Potter D & Azziz R. Measurement of total serum testosterone levels using commercially available kits: high degree of between-kit variability. Fertility and Sterility 1998 69 286-292. (doi:10.1016/S0015-0282(97)00464-0)
10. Rosner W & Vesper H. Toward excellence in testosterone testing: a consensus statement. Journal of Clinical Endocrinology and Metabolism 2010 95 4542-4548. (doi:10.1210/jc.2010-1314)
11. Stanczyk FZ. Measurement of androgens in women. Seminars in Reproductive Medicine 2006 24 78-85. (doi:10.1055/s-2006- 939566)
12. Vesper HW, Botelho JC, Shacklady C, Smith A & Myers GL. CDC project on standardizing steroid hormone measurements. Steroids 2008 73 1286-1292. (doi:10.1016/j.steroids.2008.09.008)
13. Shifren JL. Androgen deficiency in the oophorectomized woman. Fertility and Sterility 2002 77 60-62. (doi:10.1016/S0015- 0282(02)02970-9)
14. van der Stege JG, Groen H, van Zadelhoff SJ, Lambalk CB, Braat DD, van Kasteren YM, van Santbrink EJ, Apperloo MJ, Weijmar Schultz WC & Hoek A. Decreased androgen concentrations and diminished general and sexual well-being in women with premature ovarian failure. Menopause 2008 15 23-31. (doi:10.1097/gme.0b013e3180f6108c)
15. Davison SL, Bell R, Donath S, Montalto JG & Davis SR. Androgen levels in adult females: changes with age, menopause, and oophorectomy. Journal of Clinical Endocrinology and Metabolism 2005 90 3847-3853. (doi:10.1210/jc.2005- 0212)
16. Chang WY, Knochenhauer ES, Bartolucci AA & Azziz R. Phenotypic spectrum of polycystic ovary syndrome: clinical and biochemical characterization of the three major clinical subgroups. Fertility and Sterility 2005 83 1717-1723. (doi:10.1016/ j.fertnstert.2005.01.096)
17. Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and longterm health risks related to polycystic ovary syndrome (PCOS). Human Reproduction 2004 19 41-47. (doi:10.1093/humrep/ deh098)
18. Bachmann G, Bancroft J, Braunstein G, Burger H, Davis S, Dennerstein L, Goldstein I, Guay A, Leiblum S, Lobo R, Notelovitz M, Rosen R, Sarrel P, Sherwin B, Simon J, Simpson E, Shifren J, Spark R & Traish A. Female androgen insufficiency: the princeton consensus statement on definition, classification, and assessment. Fertility and Sterility 2002 77 660-665. (doi:10. 1016/S0015-0282(02)02969-2)
19. Goverde AJ, van Koert AJ, Eijkemans MJ, Knauff EA, Westerveld HE, Fauser BC & Broekmans FJ. Indicators for metabolic disturbances in anovulatory women with polycystic ovary syndrome diagnosed according to the Rotterdam consensus criteria. Human Reproduction 2009 24 710-717. (doi:10.1093/ humrep/den433)
20. Janse F, Knauff EA, Niermeijer MF, Eijkemans MJ, Laven JS, Lambalk CB, Fauser BC & Goverde AJ. Similar phenotype characteristics comparing familial and sporadic premature ovarian failure. Menopause 2010 17 758-765. (doi:10.1097/ gme.0b013e3181cf8521)
21. Coulam CB, Adamson SC & Annegers JF. Incidence of premature ovarian failure. Obstetrics and Gynecology 1986 67 604-606. (Pubitemid 16116286)
22. Knauff EAH, Eijkemans MJC, Lambalk CB, ten Kate-Booij MJ, Hoek A, Beerendonk CCM, Laven JSE, Goverde AJ, Broekmans FJM, Themmen APN, de Jong FH, Fauser BCJM & on behalf of the Dutch Premature Ovarian Failure Consortium. Anti-Mullerian hormone, inhibin B, and antral follicle count in young women with ovarian failure. Journal of Clinical Endocrinology and Metabolism 2009 94 786-792. (doi:10.1210/jc.2008-1818)
23. Thienpont LM, Van Uytfanghe K, Blincko S, Ramsay CS, Xie H, Doss RC, Keevil BG, Owen LJ, Rockwood AL, Kushnir MM, Chun KY, Chandler DW, Field HP & Sluss PM. State-of-the-art of serum testosterone measurement by isotope dilution-liquid chromatography-tandem mass spectrometry. Clinical Chemistry 2008 54 1290-1297. (doi:10.1373/clinchem.2008.105841)
24. Carter GD, Holland SM, Alaghband-Zadeh J, Rayman G, Dorrington-Ward P & Wise PH. Investigation of hirsutism: testosterone is not enough. Annals of Clinical Biochemistry 1983 20 262-263. (Pubitemid 14244990)
25. Shrout PE & Fleiss JL. Intraclass correlations: uses in assessing rater reliability. Psychological Bulletin 1979 86 420-428. (doi:10. 1037/0033-2909.86.2.420)
26. Stener-Victorin E, Holm G, Labrie F, Nilsson L, Janson PO & Ohlsson C. Are there any sensitive and specific sex steroid markers for polycystic ovary syndrome? Journal of Clinical Endocrinology and Metabolism 2010 95 810-819. (doi:10.1210/jc.2009-1908)
27. Barth JH, Field HP, Yasmin E & Balen AH. Defining hyperandrogenism in polycystic ovary syndrome: measurement of testosterone and androstenedione by liquid chromatography-tandem mass spectrometry and analysis by receiver operator characteristic plots. European Journal of Endocrinology 2010 162 611-615. (doi:10.1530/EJE-09-0741)
28. Helsel DR. Nondetects and Data Analysis: Statistics for Censored Environmental Data, edn 1. Eds M Scott & V Barnett. Hoboken, NJ: John Wiley & Sons, Inc., 2005.
29. Kalantaridou SN, Calis KA, Vanderhoof VH, Bakalov VK, Corrigan EC, Troendle JF & Nelson LM. Testosterone deficiency in young women with 46,XX spontaneous premature ovarian failure. Fertility and Sterility 2006 86 1475-1482. (doi:10.1016/ j.fertnstert.2006.04.028)
30. Benetti-Pinto CL, Bedone AJ & Magna LA. Evaluation of serum androgen levels in women with premature ovarian failure. Fertility and Sterility 2005 83 508-510. (doi:10.1016/j.fertnstert.2004. 09.015)
31. Duignan NM, Shaw RW, Glass MR, Butt WR & Edwards RL. Sex hormone levels and gonadotrophin release in premature ovarian failure. British Journal of Obstetrics and Gynaecology 1978 85 862-867. (doi:10.1111/j.1471-0528.1978. tb15844.x)
32. Falsetti L, Scalchi S, Villani MT & Bugari G. Premature ovarian failure. Gynecological Endocrinology 1999 13 189-195. (doi:10. 3109/09513599909167554)
33. Bernardi F, Hartmann B, Casarosa E, Luisi S, Stomati M, Fadalti M, Florio P, Santuz M, Luisi M, Petraglia F & Genazzani AR. High levels of serum allopregnanolone in women with premature ovarian failure. Gynecological Endocrinology 1998 12 339-345. (doi:10.3109/09513599809012836)
34. Elias AN, Pandian MR & Rojas FJ. Serum levels of androstenedione, testosterone and dehydroepiandrosterone sulfate in patients with premature ovarian failure to age-matched menstruating controls. Gynecologic and Obstetric Investigation 1997 43 47-48. (doi:10. 1159/000291817)
35. Parker CR Jr, Slayden SM, Azziz R, Crabbe SL, Hines GA, Boots LR & Bae S. Effects of aging on adrenal function in the human: responsiveness and sensitivity of adrenal androgens and cortisol to adrenocorticotropin in premenopausal and postmenopausal women. Journal of Clinical Endocrinology and Metabolism 2000 85 48-54. (doi:10.1210/jc.85.1.48)
36. Wang C, Catlin DH, Demers LM, Starcevic B & Swerdloff RS. Measurement of total serum testosterone in adult men: comparison of current laboratory methods versus liquid chromatography-tandem mass spectrometry. Journal of Clinical Endocrinology and Metabolism 2004 89 534-543. (doi:10.1210/jc.2003- 031287)
37. Moal V, Mathieu E, Reynier P, Malthiery Y & Gallois Y. Low serum testosterone assayed by liquid chromatography-tandem mass spectrometry. Comparison with five immunoassay techniques. Clinica Chimica Acta 2007 386 12-19. (doi:10.1016/j.cca.2007. 07.013)
38. Owen WE, Rawlins ML & Roberts WL. Selected performance characteristics of the Roche Elecsys testosterone II assay on the Modular analytics E 170 analyzer. Clinica Chimica Acta 2010 411 1073-1079. (doi:10.1016/j.cca.2010.03.041)
39. Dorgan JF, Fears TR, McMahon RP, Aronson FL, Patterson BH & Greenhut SF. Measurement of steroid sex hormones in serum: a comparison of radioimmunoassay and mass spectrometry. Steroids 2002 67 151-158. (doi:10.1016/S0039-128X(01) 00147-7)
40. Legro RS, Schlaff WD, Diamond MP, Coutifaris C, Casson PR, Brzyski RG, Christman GM, Trussell JC, Krawetz SA, Snyder PJ, Ohl D, Carson SA, Steinkampf MP, Carr BR, McGovern PG, Cataldo NA, Gosman GG, Nestler JE, Myers ER, Santoro N, Eisenberg E, Zhang M & Zhang H. Total testosterone assays in women with polycystic ovary syndrome: precision and correlation with hirsutism. Journal of Clinical Endocrinology and Metabolism 2010 95 5305-5313. (doi:10.1210/jc.2010- 1123)
41. Rivera-Woll LM, Papalia M, Davis SR & Burger HG. Androgen insufficiency in women: diagnostic and therapeutic implications. Human Reproduction Update 2004 10 421-432. (doi:10.1093/ humupd/dmh037)
42. Mueller A, Cupisti S, Binder H, Hoffmann I, Kiesewetter F, Beckmann MW & Dittrich R. Endocrinological markers for assessment of hyperandrogenemia in hirsute women. Hormone Research 2007 67 35-41. (doi:10.1159/000096036)
43. BolelliG,Muti P,Micheli A, SciajnoR, Franceschetti F,Krogh V, Pisani P & Berrino F. Validity for epidemiological studies of long-term cryoconservation of steroid and protein hormones in serum and plasma.CancerEpidemiology,Biomarkers&Prevention19954509-513.