Anatomical evidence for in utero androgen exposure in women with polycystic ovary syndrome

Fertility and Sterility

Volumn 84, Issue 6, 2005, Pages 1689-1692

  Cattrall, Fleur R ^a,b   Vollenhoven, Beverley J ^a   Weston, Gareth C ^a  

^a MONASH UNIVERSITY   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Fetal programming; Finger length ratio; In utero androgen exposure; Polycystic ovarian syndrome

Indexed keywords

ANDROGEN;

ADULT; ANATOMICAL VARIATION; ANDROGEN BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; FEMALE; FERTILIZATION IN VITRO; FINGER; HORMONE DETERMINATION; HUMAN; MAJOR CLINICAL STUDY; MASCULINITY; OVARY POLYCYSTIC DISEASE; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; SEX DIFFERENCE; SEX HORMONE DETERMINATION; UNIVERSITY HOSPITAL; VIRILIZATION;

ADOLESCENT; ADULT; ANDROGENS; BODY MASS INDEX; CASE-CONTROL STUDIES; FEMALE; FINGERS; FUNCTIONAL LATERALITY; HUMANS; POLYCYSTIC OVARY SYNDROME; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; SEX CHARACTERISTICS;

EID: 28944451229     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2005.05.061     Document Type: Article

References (24)

1. A. Ecker Some remarks about a varying character in the hands of humans Arch Anthropol 8 1875 68 74
2. J.T. Manning, D. Scutt, J. Wilson, D.I. Lewis-Jones The ratio of 2nd to 4th digit length a predictor of sperm numbers and concentrations of testosterone, luteinizing hormone oestrogen Hum Reprod 13 1998 3000 3004
3. W.M. Brown, M. Hines, B.A. Fane, S.M. Breedlove Masculinized finger length patterns in human males and females with congenital adrenal hyperplasia Horm Behav 42 2002 380 386
4. R.J. Norman Hyperandrogenaemia and the ovary Mol Cell Endocrinol 191 2002 113 119
5. D.H. Abbott, D.A. Dumesic, S. Franks Developmental origin of polycystic ovary syndrome - a hypothesis J Endocrinol 174 2002 1 5
6. S.M. Garn, A.R. Burdi, W.J. Babler, S. Stinson Early prenatal attainment of adult metacarpal-phalangeal rank and proportions Am J Phys Anthropol 43 1975 327 332
7. S. Lutchmaya, S. Baron-Cohen, P. Raggatt, R. Knickmeyer, J. Manning 2nd to 4th digit ratios, fetal testosterone and estradiol Early Hum Dev 77 2004 23 28
8. J.T. Manning, P.E. Bundred, B.F. Flanagan The ratio of 2nd to 4th digit length a proxy for transactivation activity of the androgen receptor gene? Med Hypotheses 59 2002 334 336
9. C.S. Jamison, P.L. Jamison, R.J. Meier Effect of prenatal testosterone administration on palmar dermatoglyphic intercore ridge counts of rhesus monkeys (Macaca mulatta) Am J Phys Anthropol 94 1994 409 419
10. J.R. Roney, J.C. Whitham, M. Leoni, A. Bellem, N. Wielebnowski, D. Maestripieri Relative digit lengths and testosterone levels in Guinea baboons Horm Behav 45 2004 285 290
11. R. Barnes, R. Rosenfield, D. Ehrmann, J. Cara, L. Cuttler, L. Levitsky Ovarian hyperandrogenism as a result of congenital adrenal virilizing disorders evidence for perinatal masculinization of neuroendocrine function in women J Clin Endocrinology and Metabolism 79 1994 1328 1333
12. T.J. Williams, M.E. Pepitone, E. Scott, B.M. Christensen, A.D. Cooke Finger-length ratios and sexual orientation Nature 404 2000 455
13. R. Agrawal, S. Sharma, J. Bekir, G. Conway, J. Bailey, A. Balen Prevalence of polycystic ovaries and polycystic ovary syndrome in lesbian women compared with heterosexual women Fertil Steril 82 2004 1352 1357
14. L.S. Hall, C.T. Love Finger-length ratios in female monozygotic twins discordant for sexual orientation Arch Sex Behav 32 2003 23 28
15. P.G. Crosignani, A.E. Nicolosi Polycystic ovarian disease heritability and heterogeneity Hum Reprod Update 7 2001 3 7
16. S. Jahanfar, J.A. Eden, P. Warren, M. Seppala, T.V. Nguyen A twin study of polycystic ovary syndrome Fertil Steril 63 1995 478 485
17. D.A. Dumesic, D.H. Abbott, J.R. Eisner, R.W. Goy Prenatal exposure of female rhesus monkeys to testosterone propionate increases serum luteinizing hormone levels in adulthood Fertil Steril 67 1997 155 163
18. J.F. Strauss, J.R. Wood, L.K. Christenson, J.M. McAllister Strategies to elucidate the mechanism of excessive theca cell androgen production in PCOS Mol Cell Endocrinol 186 2002 183 188
19. F.R. Goodman Limb malformation and the human HOX genes Am J Med Genet 112 2002 256 265
20. J. Manning, M. Callow, P.E. Bundred Finger and toe ratios in humans and mice implications for the aetiology of diseases influenced by HOX genes Med Hypotheses 60 2003 340 343
21. J.K. Zawadski, A. Dunaif Diagnostic criteria for polycystic ovary syndrome; towards a rational approach A. Dunaif J.R. Givens F. Haseltine Polycystic ovary syndrome 1992 Blackwell Scientific Boston 377 384
22. The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome Fertil Steril 81 2004 19 25
23. J. Buck, R. Williams, I. Hughes, C. Acerini In-utero androgen exposure and 2nd to 4th digit length ratio, comparisons between healthy controls and females with classical congenital adrenal hyperplasia Hum Reprod 18 2003 976 979
24. D. Kimura, M.W. Carson Dermatoglyphic asymmetry relation to sex handedness and cognitive pattern Person Individ Diff 19 1995 471 478