A longitudinal study of maternal serum inhibin-A inhibin-B, activin-A activin-AB, pro-αC and follistatin during pregnancy

Human Reproduction

Volumn 13, Issue 12, 1998, Pages 3530-3536

  Fowler, Paul A ^a   Evans, Lee W ^b   Groome, Nigel P ^b   Templeton, Allan ^a   Knight, Philip G ^c  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b OXFORD BROOKES UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF READING   (United Kingdom)

Author keywords

Activin; Follistatin; Gestation; Inhibin; Steroids

Indexed keywords

ACTIVIN; ACTIVIN A; FOLLISTATIN; GONADOTROPIN; INHIBIN; INHIBIN A; STEROID;

ADULT; ARTICLE; ARTIFICIAL INSEMINATION; BLOOD LEVEL; FEMALE; FOLLICULAR PHASE; GESTATIONAL AGE; GONADOTROPIN BLOOD LEVEL; HORMONE BLOOD LEVEL; HUMAN; MATERNAL SERUM; NORMAL HUMAN; PREGNANCY; STEROID BLOOD LEVEL;

EID: 0032436312     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/13.12.3530     Document Type: Article

References (33)

1. Birdsall, M., Ledger, W., Groome, N. et al. (1997) Inhibin A and activin A in the first trimester of human pregnancy. J. Clin. Endocrinol. Metab., 82, 1557-1560.
2. Byrne, B., Fowler, P.A. and Templeton, A. (1996) The effects of steroidal and non-steroidal ovarian hormones on pituitary responsiveness to gonadotrophin surge-attenuating factor (GnSAF). J. Endocrinol., 150, 413-422.
3. de Kretser, D.M. (1995) Inhibin in pregnancy. Clin. Endocrinol., 42, 389.
4. de Kretser, D.M., Foulds, L.M., Hancock, M. and Robertson, D.M. (1994) Partial characterization of inhibin, activin, and follistatin in the term human placenta. J. Clin. Endocrinol. Metab., 79, 502-507.
5. Evans, L.W., Muttukrishna, S., Knight, P.G. and Groome, N.P. (1997) Development, validation and application of a two-site enzyme-linked immunosorbent assay for activin-AB. J. Endocrinol., 153, 221-230.
6. Evans, L.W., Muttukrishna, S. and Groome, N.P. (1998) Development, validation and application of an ultra-sensitive two-site enzyme immunoassay for human follistatin. J. Endocrinol., 156, 275-282.
7. Groome, N.P., Illingworth, P.J., O'Brien, M. et al. (1995) Quantification of inhibin pro-alpha c-containing forms in human serum by a new ultrasensitive two-site enzyme-linked immunosorbent assay. J. Clin. Endocrinol. Metab., 80, 2926-2932.
8. Illingworth, P.J., Groome, N.P., Duncan, W.C. et al. (1996) Measurement of circulating inhibin forms during the establishment of pregnancy. J. Clin. Endocrinol. Metab., 81, 1471-1475.
9. Knight, P.G. (1997) Roles of inhibin, activins and follistatin in the female reproductive system. Front. NeuroEndocrinol., 17, 476-509.
10. Knight, P.G., Muttukrishna, S. and Groome, N.P. (1996) Development and application of a two-site enzyme immunoassay for the determination of 'total' activin-a concentrations in serum and follicular fluid. J. Endocrinol., 148, 267-279.
11. Lockwood, G.M., Muttukrishna, S., Groome, N.P. et al. (1996) Circulating inhibins and activin A during GnRH-analogue down-regulation and ovarian hyperstimulation with recombinant FSH for in-vitro fertilization-embryo transfer. Clin. Endocrinol., 45, 741-748.
12. Lockwood, G.M., Ledger, W.L., Barlow, D.H. et al. (1997) Measurement of inhibin and activin in early human pregnancy: demonstration of feto-placental origin and role in prediction of early pregnancy outcome. Biol. Reprod., 57, 1490-1494.
13. Mathews, L.S. (1994) Activin receptors and cellular signaling by the receptor serine kinase family. Endocr. Rev., 15, 310-325.
14. Muttukrishna, S., Fowler, P.A., Groome, N. et al. (1994) Serum concentrations of dimeric inhibin during the spontaneous human menstrual cycle and after treatment with exogenous gonadotrophin. Hum. Reprod., 9, 1634-1642.
15. Muttukrishna, S., George, L., Fowler, P.A. et al. (1995) Measurement of serum concentrations of dimeric inhibin during human pregnancy. Clin. Endocrinol., 42, 391-397.
16. Muttukrishna, S., Fowler, P.A., George, L. et al. (1996) Changes in peripheral serum concentrations of total activin-A during the human menstrual cycle and pregnancy. J. Clin. Endocrinol. Metab., 81, 3328-3334.
17. Muttukrishna, S., Child, T.J., Groome, N.P. and Ledger, W.L. (1997a) Source of circulating concentrations of inhibin-A, pro alpha C-containing inhibins and activin-A in early pregnancy. Hum. Reprod., 12, 1089-1093.
18. Muttukrishna, S., Knight, P.G., Groome, N.P. et al. (1997b) Activin A and inhibin A as possible endocrine markers for pre-eclampsia. Lancet, 349, 1285-1288.
19. Petraglia, F., Sawchenko, P., Lim, A.T.W. et al. (1987) Localisation, secretion and action of inhibin in the human placenta. Science, 237, 187-189.
20. Petraglia, F., Aneschi, M.M. and Calza, L. (1993) Inhibin and activin in human fetal membranes: evidence for a local effect on prostaglandin release. J. Clin. Endocrinol. Metab., 77, 542-548.
21. Petraglia, F., Gallinelli, A., Grande, A. et al. (1994) Local production and action of follistatin in human placenta. J. Clin. Endocrinol. Metab., 78, 205-210.
22. Petraglia, F., de Vita, D., Gallinelli, A. et al. (1995) Abnormal concentrations of maternal serum activin-A in gestational diseases. J. Clin. Endocrinol. Metab., 80, 558-561.
23. Petraglia, F., Luisi, C., Benedetto, C. et al. (1997) Changes in dimeric inhibin B concentrations in maternal serum throughout healthy gestation and in women with gestational disease. J. Clin. Endocrinol. Metab., 82, 2991-2995.
24. Qu, J. and Thomas, K. (1995) Inhibin and activin production in human placenta. Endocr. Rev., 16, 485-507.
25. Riley, S.C., Wathen, N.C., Chard, T. et al. (1996) Inhibin in extra-embryonic coelomic and amniotic fluids and maternal serum in early pregnancy. Hum. Reprod., 11, 2772-2776.
26. Robertson, D.M., Cahir, N., Findlay, J.K. et al. (1997) The biological and immunological characterisation of inhibin A and inhibin B forms in human follicular fluid and plasma. J. Clin. Endocrinol. Metab., 82, 889-896.
27. Shimonaka, M., Inouye, S. and Ling, N. (1991) Follistatin binds both activin and inhibin through the common beta-subunit. Endocrinology, 128, 3313-3315.
28. Vihko, K.K., Blauer, M., Kujansuu, E. et al. (1998) Activin B: detection by an immunoenzymometric assay in human serum during ovarian stimulation and late pregnancy. Hum. Reprod., 13, 841-846.
29. Wallace, E.M., Riley, S.C., Crossley, J.A. et al. (1997) Dimeric inhibins in amniotic fluid, maternal serum, and fetal serum in human pregnancy. J. Clin. Endocrinol. Metab., 82, 218-222.
30. Webley, G.E., Knight, P.G., Given, A. and Hodges, J.K. (1991) Increased concentrations of immunoreactive inhibin during conception cycles in the marmoset monkey: suppression with an LHRH antagonist and cloprostenol. J. Endocrinol., 128, 465-473.
31. Woodruff, T.K., Sluss, P., Wang, E. et al. (1997) Activin A and follistatin are dynamically regulated during human pregnancy. J. Endocrinol., 152, 167-174.
32. Ying, S-Y. (1988) Inhibins, activins, and follistatins: gonadal proteins modulating the secretion of follicle-stimulating hormone. Endocr. Rev., 9, 267-293.
33. Yokoyama, Y., Nakamura, T., Nakamura, R. et al. (1995) Identification of activins and follistatin proteins in human follicular fluid and placenta. J. Clin. Endocrinol. Metab., 80, 915-921.