Antioxidant, N-acetyl-L-cysteine inhibits the expression of the collagen α2 (I) promoter in the activated human hepatic stellate cell line in the absence as well as the presence of transforming growth factor-β

Hepatology Research

Volumn 24, Issue 3, 2002, Pages 305-315

  Segawa, Makoto ^a   Kayano, Kozo ^a   Sakaguchi, Eiki ^a   Okamoto, Mariko ^a   Sakaida, Isao ^a   Okita, Kiwamu ^a  

^a YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

COL1A2 promoter; Hepatic stellate cell; LI90; Liver fibrosis; N acetyl L cysteine

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; COLLAGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR SP1; TRANSFORMING GROWTH FACTOR BETA;

ANTIOXIDANT ACTIVITY; ARTICLE; BINDING SITE; CELL ACTIVATION; CELL LINE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE DELETION; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIVER CELL; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; STELLATE CELL;

EID: 0036847417     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1386-6346(02)00089-X     Document Type: Article

References (37)

1. Friedman SL. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N Engl J Med 1993;328:1827-35.
2. Olaso E, Friedman SL. Molecular regulation of hepatic fibrogenesis. J Hepatol 1998;29:836-47.
3. Friedman SL. Cellular networks in hepatic fibrosis. Digestion 1998;59:368-71.
4. Bissel DM. Hepatic fibrosis as wound repair: a progress report. J Gastroenterol 1998;33:295-302.
5. Friedman SL. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 2000;275:2247-50.
6. Rojkind M, Giambrone MA, Biempica L. Collagen types in normal and cirrhotic liver. Gastroenterology 1979;76:710-9.
7. Gressner AM, Bachem MG. Cellular sources of noncollagenous matrix proteins: role of fat-storing cells in fibrogenesis. Semin Liver Dis 1990;10:30-46.
8. Ramadori G. The stellate cell (Ito-cell, fat-storing cell, lipocyte, perisinusoidal cell) of the liver. New insights into pathophysiology of an intriguing cell. Virchows Arch 1991;61:147-58.
9. Pinzani M. Novel insights into the biology and physiology of the Ito cell. Pharmacol Ther 1995;66:387-412.
10. Friedman SL, Roll FJ, Boyles J, Arenson DM, Bissel DM. Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix. J Biol Chem 1989;264:10756-62.
11. Geerts A, Lazou JM, Bleser PD, Wisse E. Tissue distribution, quantitation and tetrachloride-induced rat liver. Hepatology 1990;13:1193-202.
12. Maher JJ, McGuire RF. Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo. J Clin Invest 1990;86:1641-8.
13. Davis BH, Kramer RT, Davidson NO. Retinoic acid modulates rat Ito cell proliferation, collagen and transforming growth factor β production. J Clin Invest 1990;86:2062-70.
14. Rocky DC, Maher JJ, Jarnagin WR, Gabbiani G, Friedman SL. Inhibition of rat hepatic lipocyte activation in culture by interferon-γ. Hepatology 1992;16:776-84.
15. Baroni GS, Ambrosio LD, Curto P, et al. Interferon gamma decreases hepatic stellate cell activation and extracellular matrix deposition in rat liver fibrosis. Hepatology 1996;23:1189-99.
16. Matsuda Y, Matsumoto K, Yamada A, et al. Preventive and therapeutic effects in rats of hepatocyte growth factor infusion on liver fibrosis/cirrhosis. Hepatology 1997;26:81-9.
17. Sakaida I, Matsumura Y, Akiyama S, Hayashi K, Ishige A, Okita K. Herbal medicine Sho-saiko-to (TJ-9) prevents liver fibrosis and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet. J Hepatol 1998;28:298-306.
18. Sakaida I, Matsumura Y, Kubota M, Kayano K, Takenaka K, Okita K. The prolyl 4-hydroxylase inhibitor HOE 077 prevents activation of Ito cells, reducing procollagen gene expression in rat liver fibrosis induced by choline deficient L-amino acid-defined diet. Hepatology 1996;23:755-63.
19. Matsumura Y, Sakaida I, Uchida K, Kimura T, Ishihara T, Okita K. Prolyl 4-hydroxylase inhibitor (HOE 077) inhibits pig serum-induced rat liver fibrosis by preventing stellate cell activation. J Hepatol 1997;27:185-92.
20. Sakaida I, Uchida K, Matsumura Y, Okita K. Interferon gamma treatment prevents procollagen gene expression without affecting TGF-β1 expression in pig serum-induced rat liver fibrosis in vivo. J Hepatol 1998;84:1786-93.
21. Sakaida I, Hironaka K, Uchida K, Suzuki C, Kayano K, Okita K. Interferon γ- but not α-treatment prevents fibrosis by inhibiting procollagen and tissue inhibitor of metalloproteinase-1 gene expression in pig serum-induced rat liver fibrosis in vivo. Hepatol Res 1998;12:59-67.
22. Kayano K, Sakaida I, Uchida K, Okita K. Inhibitory effects of the herbal medicine sho-saiko-to (TJ-9) on cell proliferation and procollagen gene expressions in cultured rat hepatic stellate cells. J Hepatol 1998;29:642-9.
23. Casini A, Cunningham M, Rojkind M, Lieber CS. Acetaldehyde increases procollagen type I and fibronectin gene transcription in cultured rat fat-storing cells through a protein synthesis-dependent mechanism. Hepatology 1991;13:758-65.
24. Parola M, Pinzani M, Casini A, et al. Stimulation of lipid peroxidation or 4-hydroxynoneal treatment increases pro-collagen α1 (I) gene expression in human liver fat-storing cells. Biochem Biophys Res Commun 1993;194:1044-50.
25. Bedossa P, Houglum K, Trautwein C, Holstege A, Chojkier M. Stimulation of collagen α1 (I) gene expression is associated with lipid peroxidation in hepatocellular injury: a link to tissue fibrosis? Hepatology 1994;19:1262-71.
26. Lee KS, Buck M, Houglum K, Chojkier M. Activation of hepatic stellate cells by TGF-α and collagen type I is mediated by oxidative stress through c-myb expression. J Clin Invest 1995;96:2461-8.
27. Shimizu I, Ma YR, Mizobuchi Y, et al. Effects of Sho-saiko-to, a Japanese herbal medicine on hepatic fibrosis in rats. Hepatology 1999;29:149-60.
28. Kawada N, Seki S, Inoue M, Kuroki T. Effect of antioxidants, resveratrol, quercetin, and N-acetylcysteine, on the functions of cultured rat hepatic stellate cells and Kupffer cells. Hepatology 1998;27:1265-74.
29. Murakami K, Abe T, Miyazawa M, et al. Establishment of a new human cell line, LI90, exhibiting characteristics of hepatic Ito (fat-storing) cells. Lab Invest 1995;72:731-9.
30. Boast S, Su M-W, Ramirez F, Sanchez M, Avvedimento EV. Functional analysis of cis-acting DNA sequences controlling transcription of the human type I collagen genes. J Biol Chem 1990;265:13351-6.
31. Chung K-Y, Agarwal A, Uitto J, Mauviel A. An AP-1 binding sequence is essential for regulation of the human α2 (I) collagen (COL1A2) promoter activity by transforming growth factor-β. J Biol Chem 1996;271:3272-8.
32. Bass DA, Parce JW, Dechatelet LR, Szejda P, Seeds MC, Thomas M. Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation. J Immunol 1983;130:1910-7.
33. Ohba M, Shibanuma M, Kuroki T, Nose K. Production of hydrogen peroxide by transforming growth factor-β1 and its involvement in induction of egr-1 in mouse osteoblastic cells. J Cell Biol 1994;126:1079-88.
34. Gasso M, Rubio M, Varela G, Cabre M, Caballeria J, Alonso E, et al. Effects of S-adenosylmethionine on lipid peroxidation and liver fibrogenesis in carbon tetrachloride-induced cirrhosis. J Hepatol 1996;25:200-5.
35. Vendemiale G, Grattagliano I, Caruso ML, Serviddio G, Valentini AM, Pirrelli M, et al. Increased oxidative stress in dimethylnitrosamine-induced liver fibrosis in the rat: effect of N-acetylcysteine and interferon-α. Toxicol Appl Pharmacol 2001;175:130-9.
36. Garcia-Trevijano ER, Iraburu MJ, Fontana L, Dominguez-Rosales JA, Auster A, Covarrubias-Pinedo A, et al. Transforming growth factor β1 induces the expression of α1 (I) procollagen mRNA by a hydrogen peroxide-C/EBPβ-dependent mechanism in rat hepatic stellate cells. Hepatology 1999;29:960-70.
37. Fox ES, Brower JS, Bellezzo JM, Leingang KA. N-acetylcysteine and α-tocopherol reverse the inflammatory response in activated rat Kupffer cells. J Immunol 1997;158:5418-23.