Synthesis of 4-thiophen-2′-yl-1,4-dihydropyridines as potentiators of the CFTR chloride channel

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 23, 2009, Pages 7894-7903

  Cateni, Francesca ^a   Zacchigna, Marina ^a   Pedemonte, Nicoletta ^b   Galietta, Luis J V ^b   Mazzei, Marco T ^c   Fossa, Paola ^c   Giampieri, Michele ^c   Mazzei, Mauro ^c  

^a UNIVERSITY OF TRIESTE   (Italy)

^b G GASLINI INSTITUTE   (Italy)

^c Department of Experimental Medicine ^*  (Italy)

Author keywords

CFTR; CoMFA; Cystic fibrosis; Dihydropyridine; Potentiators

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 4 (3' METHYL 2 THIOACETATETHIOPHEN 2' YL)PYRIDINE 3 CARBOXYLIC ACID BENZYL ESTER, 5 CARBOXYLIC ACID ETHYL ESTER; 1,4 DIHYDRO 2,6 DIMETHYL 4 (3' METHYL 2 THIOACETATETHIOPHEN 2' YL)PYRIDINE 3,5 DICARBOXYLIC ACID DIBENZYL ESTER; 1,4 DIHYDRO 2,6 DIMETHYL 4 (3' METHYLTHIOPHEN 2' YL)PYRIDINE 3 CARBOXYLIC ACID ALLYL ESTER, 5 CARBOXYLIC ACID ETHYL ESTER; 1,4 DIHYDRO 2,6 DIMETHYL 4 (3' METHYLTHIOPHEN 2' YL)PYRIDINE 3 CARBOXYLIC ACID BENZYL ESTER, 5 CARBOXYLIC ACID ETHYL ESTER; 1,4 DIHYDRO 2,6 DIMETHYL 4 (3' METHYLTHIOPHEN 2' YL)PYRIDINE 3,5 DICARBOXYLIC ACID DIALLYL ESTER; 1,4 DIHYDRO 2,6 DIMETHYL 4 (3' METHYLTHIOPHEN 2' YL)PYRIDINE 3,5 DICARBOXYLIC ACID DIBENZYL ESTER; 1,4 DIHYDROPYRIDINE DERIVATIVE; THIOPHENE DERIVATIVE; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG; YELLOW FLUORESCENT PROTEIN;

ANIMAL CELL; ARTICLE; CHANNEL GATING; COMPARATIVE MOLECULAR FIELD ANALYSIS; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; NONHUMAN; RAT;

ANIMALS; CELL LINE; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DIHYDROPYRIDINES; HUMANS; ION CHANNEL GATING; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICROSCOPY, FLUORESCENCE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; THIOPHENES;

EID: 71849085822     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.10.028     Document Type: Article

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