Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Ca2+ channels CaV1.3 and CaV1.2

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 9, 2010, Pages 3147-3158

  Chang, Che Chien ^a   Cao, Song ^a,d   Kang, Soosung ^a   Kai, Li ^b   Tian, Xinyong ^b   Pandey, Prativa ^a   Dunne, Sara Fernandez ^c   Luan, Chi Hao ^c   Surmeier, D James ^b   Silverman, Richard B ^a  

^a Center for Molecular Innovation and Drug Discovery ^*  (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Antagonism; CaV1.2 Ca+2 channel; CaV1.3 Ca+2 channel; Dihydropyridines; Dopamine neurons; FLIPR (Fluorometric imaging plate reader); Parkinson's disease; Selective antagonists

Indexed keywords

1,4 DIHYDROPYRIDINE; 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLIC ACID DERIVATIVE; CALCIUM CHANNEL CAV1.3; CALCIUM CHANNEL CAV1.4; CALCIUM CHANNEL L TYPE; DIETHYL 2 METHYL 6 N PROPYL 4 (3 NITROPHENYL) 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLATE; DIETHYL 2,6 DIMETHYL 4 (3 NITROPHENYL) 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLATE; DIMETHYL 2,6 DIMETHYL 4 (2 METHYLTHIOPHENYL) 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLATE; ETHYL METHOXYETHYL 2,6 DIMETHYL 4 (3 NITROPHENYL) 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLATE; ETHYL N PENTYL 2,6 DIMETHYL 4 (3 NITROPHENYL) 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLATE; ISRADIPINE; METHYL CYANOETHYL 2,6 DIMETHYL 4 (3 NITROPHENYL) 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLATE; METHYL ETHYL 2,6 DIMETHYL 4 (2 NITROPHENYL) 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLATE; NIFEDIPINE; NIMODIPINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; IC 50; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; STRUCTURE ACTIVITY RELATION;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CALCIUM CHANNELS, L-TYPE; CELL LINE; DICARBOXYLIC ACIDS; DIHYDROPYRIDINES; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; NIFEDIPINE;

ANIMALIA; MAMMALIA;

EID: 77951295326     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.03.038     Document Type: Article

References (25)

1. Zamponi G.W. Voltage-Gated Calcium Channels (2005), Kluwer Academic, New York
2. Catterall W.A., Striessnig J., Snutch T.P., and Perez-Reyes E. Pharmacol. Rev. 55 (2003) 579
3. Striessnig J. Cell Physiol. Biochem. 9 (1999) 242
4. Eisenberg M.J., Brox A., and Bestawros A.N. Am. J. Med. 116 (2004) 35
5. Helton T.D., Xu W., and Lipscombe D. J. Neurosci. 25 (2005) 10247
6. Moosmang S., Schulla V., Welling A., Feil R., Feil S., Wegener J.W., Hofmann F., and Klugbauer N. EMBO J. 22 (2003) 6027
7. Epstein B.J., Vogel K., and Palmer B.F. Drugs 67 (2007) 1309
8. Chan C.Savio., Guzman J.N., Ilijic Ema., Mercer J.N., Rick Caroline., Tkatch Tatiana., Meredith G.E., and Surmeier D.James. Nature 447 (2007) 1081
9. Brevetti G., Bonaduce D., Breglio R., Perna S., Simonelli P., Marconi R., and Campanella G. Clin. Cardiol. 13 (1990) 474
10. Sinnegger-Brauns M.J., Huber I.G., Koschak A., Wild C., Obermair G.J., Einzinger U., Hoda J.-C., Sartori S.B., and Striessnig J. Mol. Pharmacol. 75 (2009) 407
11. Xu W., and Lipscombe D. J. Neurosci. 21 (2001) 5944
12. Striessnig J., Koschak A., Sinnegger-brauns M.J., Hetzenauer A., Nguyen N.K., Busquet P., Pelster G., and Singewald N. Biochem. Soc. Trans. 34 (2006) 903
13. Zolfigol M.A., and Safaiee M. Synlett 5 (2004) 827
14. van Rhee A.M., Jiang J.-L., Melman N., Olah M.E., Stiles G.L., and Jacobson K.A. J. Med. Chem. 39 (1996) 2980
15. Lee, L. F. Eur. Patent 135,491, 1985.
16. Harper J.L., Camerini-Otero C.S., Li A.-H., Kim S.-A., Jacobson K.A., and Daly J.W. Biochem. Pharmacol. 65 (2003) 329
17. Satoh Y., Ichihashi M., and Okumura K. Chem. Pharm. Bull. 39 (1991) 3189
18. Goldmann S., and Stoltefuss J. Angew. Chem., Int. Ed. Engl. 30 (1991) 1559
19. Corey E.J., and Choi S. Tetrahedron Lett. 34 (1993) 6969
20. Ogawa T., Hatayama K., Maeda H., and Kita Y. Chem. Pharm. Bull. 42 (1994) 1579
21. Goldmann S., Born L., Kazda S., Pittel B., and Schramm M. J. Med. Chem. 33 (1990) 1413
22. Urbahns K., Horváth E., Stasch J.-P., and Mauler F. Bioorg. Med. Chem. Lett. 13 (2003) 2637
23. Wu X.-Y., Hu A.-X., and Cao G. Acta Crystallogr., Sect. E 63 (2007) o4578
24. Ismail F.M.D. J. Fluorine Chem. 118 (2002) 27
25. Böhm H.-J., Banner D., Bendels S., Kansy M., Kuhn B., Müller K., Obst-Stander U., and Stahl M. ChemBioChem 5 (2004) 637