The Hsp90 inhibitor SNX-2112, induces apoptosis in multidrug resistant K562/ADR cells through suppression of Akt/NF-κB and disruption of mitochondria-dependent pathways

Chemico-Biological Interactions

Volumn 205, Issue 1, 2013, Pages 1-10

  Wang, Rui ^a,b   Shao, Fangyuan ^a,c   Liu, Zhong ^a   Zhang, Jiaxuan ^a   Wang, Shaoxiang ^a   Liu, Jinyun ^d   Liu, Hui ^a   Chen, Hongyuan ^a,c   Liu, Kaisheng ^a   Xia, Min ^a   Wang, Yifei ^a  

^a JINAN UNIVERSITY   (China)

^b Reproduction Center of Zaozhuang Maternity and Child Care Hospital   (China)

^c GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

^d Yunnan Research Institute of Tobacco Science   (China)

Author keywords

Apoptosis; Hsp90; Leukemia; Mitochondrial dysfunction; SNX 2112

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; DOXORUBICIN; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; HEAT SHOCK PROTEIN 90 INHIBITOR; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MULTIDRUG RESISTANCE PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; PROTEIN KINASE B; SNX 2112; TANESPIMYCIN; TRAP1 PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER RESISTANCE; CELL STRAIN K 562; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; DOWN REGULATION; G1 PHASE CELL CYCLE CHECKPOINT; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MULTIDRUG RESISTANCE; PROTEIN EXPRESSION;

17-(ALLYLAMINO)-17-DEMETHOXYGELDANMYCIN; 17-AAG; 3-[4,5-DIMETHYLTHIAZOL-2-YL]-2,5-DIPHENYL-TETRAZOLIUM BROMIDE; 4,6-DIAMIDINO-2-PHENYLINDOLE; 5,5′,6,6′-TETRACHLORO-1,1′,3,3′-TETRAETHYLBENZIMIDAZOLYLCARBOCYANINE IODIDE; ANOVA; APOPTOSIS; BCA; BICINCHONINIC ACID; CHRONIC MYELOID LEUKEMIA; CML; DAPI; DIMETHYLSULFOXIDE; DMSO; FBS; FETAL BOVINE SERUM; FITC; FLUORESCEIN ISOTHIOCYANATE; HEAT SHOCK PROTEIN 90; HSP90; JC-1; LEUKEMIA; MDR; MITOCHONDRIAL DYSFUNCTION; MITOCHONDRIAL TRANSMEMBRANE POTENTIAL; MMP; MTT; MULTIDRUG RESISTANCE; ONE-WAY ANALYSIS OF VARIANCE AND COVARIANCE; P-GLYCOPROTEIN; P-GP; PBS; PHOSPHATE-BUFFERED SALINE; PI; POLYVINYL DIFLUORIDE; PROPIDIUM IODIDE; PVDF; SNX-2112; TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE-MEDIATED DUTP NICK-END-LABELING; TUNEL;

ADENOSINE TRIPHOSPHATE; APOPTOSIS; CASPASES; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; HEAT-SHOCK PROTEINS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; K562 CELLS; MITOCHONDRIA; NF-KAPPA B; P-GLYCOPROTEIN; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION;

EID: 84879814437     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2013.06.007     Document Type: Article

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