Nicotine suppresses tunicamycin-induced, but not thapsigargin-induced, expression of GRP78 during ER stress-mediated apoptosis in PC12 cells

Journal of Biochemistry

Volumn 144, Issue 2, 2008, Pages 251-257

  Sasaya, Harue ^a   Utsumi, Takahiro ^a   Shimoke, Koji ^a   Nakayama, Hitoshi ^b   Matsumura, Yoshinobu ^a   Fukunaga, Kenji ^a   Ikeuchi, Toshihiko ^a  

^a KANSAI UNIVERSITY   (Japan)

^b NARA MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis; ER stress; Glucose regulated protein 78; Nicotine; PC12 cell

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; ALPHA BUNGAROTOXIN; CASPASE 12; DILTIAZEM; GLUCOSE REGULATED PROTEIN 78; MESSENGER RNA; NICOTINE; NIFEDIPINE; PROTEIN IRE1; THAPSIGARGIN; TUBOCURARINE CHLORIDE; TUNICAMYCIN; X BOX BINDING PROTEIN 1;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STRAIN; CELL VIABILITY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RNA SPLICING;

ACTIVATING TRANSCRIPTION FACTOR 6; ANIMALS; APOPTOSIS; CASPASES; CELL SURVIVAL; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM; HEAT-SHOCK PROTEINS; MOLECULAR CHAPERONES; NICOTINE; PC12 CELLS; RATS; RNA SPLICING; THAPSIGARGIN; TRANSCRIPTION FACTORS; TUNICAMYCIN;

EID: 48749112854     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvn063     Document Type: Article

References (27)

1. O'Neill, M.J., Murray, T.K., Lakics, V., Visanji, N.P., and Duty, S. (2002) The role of neuronal nicotinic acetylcholine receptors in acute and chronic neurodegeneration. Curr. Drug Targets CNS Neurol. Disord. 1, 399-411
2. Dajas-Bailador, F. and Wonnacott, S. (2004) Nicotinic acetylcholine receptors and the regulation of neuronal signalling. Trends Pharmacol. Sci. 25, 317-324
3. Messi, M.L., Renganathan, M., Grigorenko, E., and Delbono, O. (1997) Activation of alpha7 nicotinic acetylcholine receptor promotes survival of spinal cord motoneurons. FEBS Lett. 411, 32-38
4. Fucile, S., Renzi, M., Lauro, C., Limatola, C., Ciotti, T., and Eusebi, F. (2004) Nicotinic cholinergic stimulation promotes survival and reduces motility of cultured rat cerebellar granule cells. Neuroscience 127, 53-61
5. Kihara, T., Shimohama, S., Urushitani, M., Sawada, H., Kimura, J., Kume, T., Maeda, T., and Akaike, A. (1998) Stimulation of alpha4beta2 nicotinic acetylcholine receptors inhibits beta-amyloid toxicity. Brain Res. 792, 331-334
6. Kihara, T., Shimohama, S., Sawada, H., Honda, K., Nakamizo, T., Shibasaki, H., Kume, T., and Akaike, A. (2001) Alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity. J. Biol. Chem. 276, 13541-13546
7. Ren, K., Puig, V., Papke, R.L., Itoh, Y., Hughes, J.A., and Meyer, E.M. (2005) Multiple calcium channels and kinases mediate alpha7 nicotinic receptor neuroprotection in PC12 cells. J. Neurochem. 94, 926-933
8. Li, Y., King, M.A., and Meyer, E.M. (2000) Alpha7 nicotinic receptor-mediated protection against ethanol-induced oxidative stress and cytotoxicity in PC12 cells. Brain Res. 861, 165-167
9. Jin, Z., Gao, F., Flagg, T., and Deng, X. (2004) Nicotine induces multi-site phosphorylation of Bad in association with suppression of apoptosis. J. Biol. Chem. 279, 23837-23844
10. Mai, H., May, W.S., Gao, F., Jin, Z., and Deng, X. (2003) A functional role for nicotine in Bcl2 phosphorylation and suppression of apoptosis. J. Biol. Chem. 278, 1886-1891
11. Stevens, T.R., Krueger, S.R., Fitzsimonds, R.M., and Picciotto, M.R. (2003) Neuroprotection by nicotine in mouse primary cortical cultures involves activation of calcineurin and L-type calcium channel inactivation. J. Neurosci. 23, 10093-10099
12. Xin, M. and Deng, X. (2005) Nicotine inactivation of the proapoptotic function of Bax through phosphorylation. J. Biol. Chem. 280, 10781-10789
13. Rao, R.V. and Bredesen, D.E. (2004) Misfolded proteins, endoplasmic reticulum stress and neurodegeneration. Curr. Opin. Cell Biol. 16, 653-662
14. Nakagawa, T., Zhu, H., Morishima, N., Li, E., Xu, J., Yankner, B.A., and Yuan, J. (2000) Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403, 98-103
15. Nishitoh, H., Matsuzawa, A., Tobiume, K., Saegusa, K., Takeda, K., Inoue, K., Hori, S., Kakizuka, A., and Ichijo, H. (2002) ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes. Dev. 16, 1345-1355
16. Kaufman, R.J. (1999) Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes. Dev. 13, 1211-1233
17. Kaufman, R.J. (2002) Orchestrating the unfolded protein response in health and disease. J. Clin. Invest. 110, 1389-1398
18. Imaizumi, K., Miyoshi, K., Katayama, T., Yoneda, T., Taniguchi, M., Kudo, T., and Tohyama, M. (2001) The unfolded protein response and Alzheimer's disease. Biochim. Biophys. Acta 1536, 85-96
19. Yoshida, H., Haze, K., Yanagi, H., Yura, T., and Mori, K. (1998) Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors. J. Biol. Chem. 273, 33741-33749
20. Morishima, N., Nakanishi, K., Takenouchi, H., Shibata, T., and Yasuhiko, Y. (2002) An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J. Biol. Chem. 277, 34287-34294
21. Utsumi, T., Shimoke, K., Kishi, S., Sasaya, H., Ikeuchi, T., and Nakayama, H. (2004) Protective effect of nicotine on tunicamycin-induced apoptosis of PC12h cell. Neurosci. Lett. 370, 244-247
22. Shimoke, K., Kishi, S., Utsumi, T., Shimamura, Y., Sasaya, H., Oikawa, T., Uesato, S., and Ikeuchi, T. (2005) NGF-induced phosphatidylinositol 3-kinase signaling pathway prevents thapsigargin-triggered ER stress-mediated apoptosis in PC12 cells. Neurosci. Lett. 389, 124-128
23. Shimoke, K., Amano, H., Kishi, S., Uchida, H., Kudo, M., and Ikeuchi, T. (2004) Nerve growth factor attenuates endoplasmic reticulum stress-mediated apoptosis via suppression of caspase-12 activity. J. Biochem. 135, 439-446
24. Haze, K., Yoshida, H., Yanagi, H., Yura, T., and Mori, K. (1999) Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol. Biol. Cell. 10, 3787-3799
25. Kane, J.K., Konu, O., Ma, J.Z., and Li, M.D. (2004) Nicotine coregulates multiple pathways involved in protein modification/degradation in rat brain. Mol. Brain Res. 132, 181-191
26. Rezvani, K., Teng, Y., Shim, D., and De Biasi, M. (2007) Nicotine regulates multiple synaptic proteins by inhibiting proteasomal activity. J. Neurosci. 27, 10508-10519
27. Nakayama, H., Numakawa, T., and Ikeuchi, T. (2002) Nicotine-induced phosphorylation of Akt through epidermal growth factor receptor and Src in PC12h cells. J. Neurochem. 83, 1372-1379