Acceleration of Bone Repair in NOD/SCID Mice by Human Monoosteophils, Novel LL-37-Activated Monocytes

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Zhang, Zhifang ^a   Shively, John E ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE BONE ISOENZYME; CALCIUM; CARBON; CARTILAGE GLYCOPROTEIN 39; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CHITINASE; MACROPHAGE DERIVED CHEMOKINE; MATRILYSIN; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 13; OSTEOACTIVIN; OSTEOPONTIN; PHOSPHORUS; SODIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE REMODELING; CATALYSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; MALE; MONOCYTE; MONOOSTEOPHIL; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; ROENTGEN SPECTROSCOPY; SCANNING ELECTRON MICROSCOPY; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ANTIGENS, SURFACE; ANTIMICROBIAL CATIONIC PEPTIDES; BONE REGENERATION; CALCIFICATION, PHYSIOLOGIC; CELL DIFFERENTIATION; CELL PROLIFERATION; CHEMOKINE CCL22; CHITINASE; EYE PROTEINS; GENE EXPRESSION PROFILING; HUMANS; IMMUNOPHENOTYPING; MACROPHAGES; MALE; MATRIX METALLOPROTEINASE 7; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, SCID; MITOGEN-ACTIVATED PROTEIN KINASE 13; MONOCYTES; OSTEOCLASTS; OSTEOCYTES; OSTEOPONTIN; SIGNAL TRANSDUCTION;

ANIMALIA; MUS;

EID: 84879769368     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067649     Document Type: Article

References (45)

1. Seeman E, Delmas PD, (2006) Bone quality-the material and structural basis of bone strength and fragility. N Engl J Med 354: 2250-2261.
2. Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, et al. (1998) Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93: 165-176.
3. Quinn JM, Elliott J, Gillespie MT, Martin TJ, (1998) A combination of osteoclast differentiation factor and macrophage-colony stimulating factor is sufficient for both human and mouse osteoclast formation in vitro. Endocrinology 139: 4424-4427.
4. Khan AN, Al-Jahdali HH, Allen CM, Irion KL, Al Ghanem S, et al. (2010) The calcified lung nodule: What does it mean? Ann Thorac Med 5: 67-79.
5. Sage AP, Tintut Y, Demer LL, (2010) Regulatory mechanisms in vascular calcification. Nat Rev Cardiol 7: 528-536.
6. Pignolo RJ, Kassem M, (2011) Circulating osteogenic cells: implications for injury, repair, and regeneration. J Bone Miner Res 26: 1685-1693.
7. Fadini GP, Rattazzi M, Matsumoto T, Asahara T, Khosla S, (2012) Emerging role of circulating calcifying cells in the bone-vascular axis. Circulation 125: 2772-2781.
8. Kuwana M, Okazaki Y, Kodama H, Izumi K, Yasuoka H, et al. (2003) Human circulating CD14+ monocytes as a source of progenitors that exhibit mesenchymal cell differentiation. J Leukoc Biol 74: 833-845.
9. Eghbali-Fatourechi GZ, Lamsam J, Fraser D, Nagel D, Riggs BL, et al. (2005) Circulating osteoblast-lineage cells in humans. N Engl J Med 352: 1959-1966.
10. Choi YH, Burdick MD, Strieter RM, (2010) Human circulating fibrocytes have the capacity to differentiate osteoblasts and chondrocytes. Int J Biochem Cell Biol 42: 662-671.
11. Suda RK, Billings PC, Egan KP, Kim JH, McCarrick-Walmsley R, et al. (2009) Circulating osteogenic precursor cells in heterotopic bone formation. Stem Cells 27: 2209-2219.
12. Zhang Z, Shively JE, (2010) Generation of novel bone forming cells (monoosteophils) from the cathelicidin-derived peptide LL-37 treated monocytes. PLoS One 5: e13985.
13. Fadini GP, Albiero M, Menegazzo L, Boscaro E, Vigili de Kreutzenberg S, et al. (2011) Widespread increase in myeloid calcifying cells contributes to ectopic vascular calcification in type 2 diabetes. Circ Res 108: 1112-1121.
14. Lehrer RI, Ganz T, (2002) Cathelicidins: a family of endogenous antimicrobial peptides. Curr Opin Hematol 9: 18-22.
15. De Y, Chen Q, Schmidt AP, Anderson GM, Wang JM, et al. (2000) LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J Exp Med 192: 1069-1074.
16. Nizet V, Ohtake T, Lauth X, Trowbridge J, Rudisill J, et al. (2001) Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature 414: 454-457.
17. Kreidberg JA, (2000) Functions of alpha3beta1 integrin. Curr Opin Cell Biol 12: 548-553.
18. Standal T, Borset M, Sundan A, (2004) Role of osteopontin in adhesion, migration, cell survival and bone remodeling. Exp Oncol 26: 179-184.
19. Safadi FF, Xu J, Smock SL, Rico MC, Owen TA, et al. (2001) Cloning and characterization of osteoactivin, a novel cDNA expressed in osteoblasts. J Cell Biochem 84: 12-26.
20. Abdelmagid SM, Barbe MF, Arango-Hisijara I, Owen TA, Popoff SN, et al. (2007) Osteoactivin acts as downstream mediator of BMP-2 effects on osteoblast function. J Cell Physiol 210: 26-37.
21. Bateman JP, Safadi FF, Susin C, Wikesjo UM, (2012) Exploratory study on the effect of osteoactivin on bone formation in the rat critical-size calvarial defect model. J Periodontal Res 47: 243-247.
22. Recklies AD, Ling H, White C, Bernier SM, (2005) Inflammatory cytokines induce production of CHI3L1 by articular chondrocytes. J Biol Chem 280: 41213-41221.
23. Nyirkos P, Golds EE, (1990) Human synovial cells secrete a 39 kDa protein similar to a bovine mammary protein expressed during the non-lactating period. Biochem J 269: 265-268.
24. Krause SW, Rehli M, Kreutz M, Schwarzfischer L, Paulauskis JD, et al. (1996) Differential screening identifies genetic markers of monocyte to macrophage maturation. J Leukoc Biol 60: 540-545.
25. Johansen JS, Stoltenberg M, Hansen M, Florescu A, Horslev-Petersen K, et al. (1999) Serum YKL-40 concentrations in patients with rheumatoid arthritis: relation to disease activity. Rheumatology (Oxford) 38: 618-626.
26. Krane SM, Inada M, (2008) Matrix metalloproteinases and bone. Bone 43: 7-18.
27. Laguna JC, Alegret M, (2012) Regulation of gene expression in atherosclerosis: insights from microarray studies in monocytes/macrophages. Pharmacogenomics 13: 477-495.
28. Doring Y, Drechsler M, Wantha S, Kemmerich K, Lievens D, et al. (2012) Lack of neutrophil-derived CRAMP reduces atherosclerosis in mice. Circ Res 110: 1052-1056.
29. Benjamin M, Ralphs JR, (2004) Biology of fibrocartilage cells. Int Rev Cytol 233: 1-45.
30. Zuo C, Huang Y, Bajis R, Sahih M, Li YP, et al. (2012) Osteoblastogenesis regulation signals in bone remodeling. Osteoporos Int 23: 1653-1663.
31. Katagiri T, Takahashi N, (2002) Regulatory mechanisms of osteoblast and osteoclast differentiation. Oral Dis 8: 147-159.
32. Shalhoub V, Shatzen EM, Ward SC, Young JI, Boedigheimer M, et al. (2010) Chondro/osteoblastic and cardiovascular gene modulation in human artery smooth muscle cells that calcify in the presence of phosphate and calcitriol or paricalcitol. J Cell Biochem 111: 911-921.
33. Sumara G, Formentini I, Collins S, Sumara I, Windak R, et al. (2009) Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis. Cell 136: 235-248.
34. Monfoulet L, Rabier B, Chassande O, Fricain JC, (2010) Drilled hole defects in mouse femur as models of intramembranous cortical and cancellous bone regeneration. Calcif Tissue Int 86: 72-81.
35. Eghbali-Fatourechi GZ, Modder UI, Charatcharoenwitthaya N, Sanyal A, Undale AH, et al. (2007) Characterization of circulating osteoblast lineage cells in humans. Bone 40: 1370-1377.
36. Gossl M, Modder UI, Gulati R, Rihal CS, Prasad A, et al. (2010) Coronary endothelial dysfunction in humans is associated with coronary retention of osteogenic endothelial progenitor cells. Eur Heart J 31: 2909-2914.
37. Matsumoto T, Kawamoto A, Kuroda R, Ishikawa M, Mifune Y, et al. (2006) Therapeutic potential of vasculogenesis and osteogenesis promoted by peripheral blood CD34-positive cells for functional bone healing. Am J Pathol 169: 1440-1457.
38. Asahara T, Masuda H, Takahashi T, Kalka C, Pastore C, et al. (1999) Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res 85: 221-228.
39. Bucala R, Spiegel LA, Chesney J, Hogan M, Cerami A, (1994) Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Mol Med 1: 71-81.
40. Seta N, Kuwana M, (2007) Human circulating monocytes as multipotential progenitors. Keio J Med 56: 41-47.
41. Gronthos S, Simmons PJ, Graves SE, Robey PG, (2001) Integrin-mediated interactions between human bone marrow stromal precursor cells and the extracellular matrix. Bone 28: 174-181.
42. Lundstrom A, Holmbom J, Lindqvist C, Nordstrom T, (1998) The role of alpha2 beta1 and alpha3 beta1 integrin receptors in the initial anchoring of MDA-MB-231 human breast cancer cells to cortical bone matrix. Biochem Biophys Res Commun 250: 735-740.
43. Nakai M, Mundy GR, Williams PJ, Boyce B, Yoneda T, (1992) A synthetic antagonist to laminin inhibits the formation of osteolytic metastases by human melanoma cells in nude mice. Cancer Res 52: 5395-5399.
44. Sabio G, Arthur JS, Kuma Y, Peggie M, Carr J, et al. (2005) p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP. Embo J 24: 1134-1145.
45. Schindler EM, Hindes A, Gribben EL, Burns CJ, Yin Y, et al. (2009) p38delta Mitogen-activated protein kinase is essential for skin tumor development in mice. Cancer Res 69: 4648-4655.