The calcified lung nodule: What does it mean

Annals of Thoracic Medicine

Volumn 5, Issue 2, 2010, Pages 67-79

  Khan, Ali Nawaz ^a   Al Jahdali, Hamdan H ^b   Allen, Carolyn M ^a   Irion, Klaus L ^c   Al Ghanem, Sarah ^b   Koteyar, Shyam Sunder ^a  

^a NORTH MANCHESTER GENERAL HOSPITAL   (United Kingdom)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Benign pulmonary nodules; calcification; malignant pulmonary nodules

Indexed keywords

ACRYLIC CEMENT; AMIODARONE; BARIUM SULFATE; IODINATED POPPYSEED OIL; IRON; MERCURY; THORIUM DIOXIDE;

AMYLOIDOSIS; BENIGN TUMOR; BRONCHUS CARCINOID; CALCIFYING FIBROUS PSEUDOTUMOR; CANCER SURGERY; CARCINOID; CARNEY COMPLEX; CHONDROSARCOMA; COMPUTER ASSISTED TOMOGRAPHY; DENDRIFORM PULMONARY OSSIFICATION; DIFFERENTIAL DIAGNOSIS; EWING SARCOMA; FEASIBILITY STUDY; FIBROSARCOMA; FOLLOW UP; GRANULOMA; HAMARTOMA; HEMOSIDEROSIS; HIGH RESOLUTION COMPUTER TOMOGRAPHY; HISTOPATHOLOGY; HISTOPLASMA CAPSULATUM; HUMAN; LUNG CALCIFICATION; LUNG CARCINOMA; LUNG DISEASE; LUNG EMBOLISM; LUNG FIBROSIS; LUNG GRANULOMA; LUNG HEMORRHAGE; LUNG INFECTION; LUNG METASTASIS; LUNG MICROLITHIASIS; LUNG NODULE; LUNG PSEUDOTUMOR; LUNG SEQUESTRATION; MALIGNANT FIBROUS HISTIOCYTOMA; MALIGNANT NEOPLASTIC DISEASE; NEUROECTODERM TUMOR; OSTEOSARCOMA; PATHOGENESIS; PNEUMOCONIOSIS; PRIMARY TUMOR; RELIABILITY; REVIEW; SARCOMA; SENSITIVITY AND SPECIFICITY; SURVIVAL RATE; SYNOVIAL SARCOMA; TALC PNEUMOCONIOSIS; THORAX RADIOGRAPHY; THORAX TUMOR; TUMOR VOLUME;

EID: 77956018365     PISSN: 18171737     EISSN: 19983557     Source Type: Journal    
DOI: 10.4103/1817-1737.62469     Document Type: Review

References (72)

1. Grewal RG, Austin JH. CT demonstration of calcification in carcinoma of the lung. J Comput Assist Tomogr 1994; 18:867-871
2. Caskey CI, Templeton PA, Zerhouni EA. Current evaluation of the solitary pulmonary nodule. Radiol Clin North Am 1990;28:511-520
3. Mahoney MC, Shipley RT, Corcoran HL, Dickson BA. CT demonstration of calcification in carcinoma of the lung. AJR Am J Roentgenol 1990;154:255-258
4. Siegelman SS, Khouri NF, Scott WW Jr, Leo FP, Hamper UM, Fishman EK, et al. Pulmonary hamartoma: CT findings. Radiology 1986;160:313-317
5. Oldham HN Jr, Young WG Jr, Sealy WC. Hamartoma of the lung. J Thorac Cardiovasc Surg 1967;53:735-742
6. Ledor K, Fish B, Chaise L, Ledor S. CT diagnosis of pulmonary hamartomas. J Comput Assist Tomogr 1981;5:343-344
7. Khouri NF, Meziane MA, Zerhouni EA, Fishman EK, Siegelman SS. The solitary pulmonary nodule. Chest 1987;91:128-133
8. Zerhouni EA, Stitik FP, Siegelman SS, Naidich DP, Sagel SS, Proto AV, et al. CT of the pulmonary nodule: A cooperative study. Radiology 1986;160:319-327
9. Siegelman SS, Khouri NF, Leo FP, Fishman EK, Braverman RM, Zerhouni EA. Solitary pulmonary nodules: CT assessment. Radiology 1986;160:307-312
10. Brown K, Mund DF, Aberle DR, Batra P, Young DA. Intrathoracic calcifications: Radiographic features and differential diagnoses. RadioGraphics 1994;14:1247-1261
11. Chan ED, Morales DV, Welsh CH, McDermott MT, Swarz MI. Calcium deposition with or without bone formation in the lung. Am J Respir Crit Care Med 2002;165:1654-1669
12. Theros EG. 1976 Caldwell Lecture: Varying manifestation of peripheral pulmonary neoplasms: A radiologic-pathologic correlative study. AJR Am J Roentgenol 1977;128:893-914.
13. Kurihara Y, Nakajima Y, Ishikawa T, Kurisu S, Taira Y, Yokote K, et al. The prevalence and pattern of calcification in primary lung carcinoma as demonstrated by computed tomography. Hai Gan 1993;33:1037-1044
14. O'Keefe ME, Good CA, McDonald JR. Calcification in solitary nodules of the lung. AJR Am J Roentgenol 1957;77:1023-1033
15. Webb WR. Radiologic evaluation of the solitary pulmonary nodule. AJR Am J Roentgenol 1990;154:701-708
16. Ost D, Fein AM, Feinsilver SH. The solitary pulmonary nodule. N Engl J Med 2003;348:2535-2542
17. Jacob S, Mohapatra D, Verghese M. Massive chondroid hamartoma of the lung clinically masquerading as bronchogenic carcinoma. Indian J Pathol Microbiol 2008;51:61-62
18. Hayward RH, Carabasi RJ. Malignant hamartoma of the lung: Fact or fiction? J Thorac Cardiovasc Surg 1967;53:457-466
19. Zheng RH, Chou DH, Shi MX. Hamartoma lung: An analysis of 24 cases Zhonghua Jie He Hu Xi Za Zhi 1994;17:86-7,126.
20. Seemann MD, Beinert T, Dienemann H. Identification of characteristics for malignancy of solitary pulmonary nodules using high-resolution computed tomography. Eur J Med Res 1996;1:371-376
21. Shady K, Siegel MJ, Glazer HS. CT of focal pulmonary masses in childhood. Radiographics 1992;12:505-514
22. d'Alessandro MP, Kozakewich HP, Cooke KR. Radiologic-pathologic conference of Children''s Hospital Boston: New pulmonary nodules in a child undergoing treatment for a solid malignancy. Pediatr Radiol 1996;26:19-21.
23. Bennett LL, Lesar MS, Tellis CJ. Multiple calcified chondrohamartomas of the lung: CT appearance. J Comput Assist Tomogr 1985;9:180-182
24. Saqi A, Shaham D, Scognamiglio T, Murray MP, Henschke CI, Yankelevitz D, et al. Incidence and cytological features of pulmonary hamartomas indeterminate on CT scan. Cytopathology 2008;19:185-191
25. Gaerte SC, Meyer CA, Winer-Muram HT, Tarver RD, Conces DJ Jr. Fat containing tumors of the chest. Radiographics 2002;22:S61-78.
26. Kanauchi T, Hoshi T, Kato A. CT findings of pulmonary hamartoma with special reference to epithelial-lined clefts and connection with pulmonary arteries. Nippon Igaku Hoshasen Gakkai Zasshi 2004;64:300-304
27. Park KY, Kim SJ, Noh TW, Cho SH, Lee DY, Paik HC, et al. Diagnostic efficacy and characteristic features of MRI in pulmonary hamartoma: Comparison with CT, MRI and pathology. J Comput Assist Tomogr 2008;32:919-925
28. Guo W, Zhao YP, Jiang YG, Wang RW, Ma Z. Surgical treatment and outcome of pulmonary hamartoma: Retrospective study of 20-year experience. J Exp Clin Cancer Res 2008;27:8.
29. Zakharov V, Schinstine M. Hamartoma of the lung. Diagn Cytopathol 2008;36:331-332
30. Jin MS, Ha HJ, Baek HJ, Lee JC, Koh JS. Adenomyomatous hamartoma of lung mimicking benign mucinous tumor in fine needle aspiration biopsy: A case report. Acta Cytol 2008;52:357-360
31. Wood B, Swarbrick N, Frost F. Diagnosis of pulmonary hamartoma by fine needle biopsy. Acta Cytol 2008;52:412-417
32. Lien YC, Hsu HS, Li WY, Wu YC, Hsu WH, Wang LS, et al. Pulmonary hamartoma. J Chin Med Assoc 2004;67:21-26
33. De Cicco C, Bellomi M, Bartolomei M, Carbone G, Pelosi G, Giulia Veronesi G, et al Imaging of lung hamartomas by multidetector computed tomography and positron emission tomography. Ann Thorac Surg 2008;86:1769-1772
34. Gurney JW, Conces DJ. Pulmonary histoplasmosis: State of the art. Radiology 1996;199:297-306.
35. Rubin SA, Winer-Muram HT. Thoracic histoplasmosis. J Thorac Imaging 1992;7:39-50.
36. Abbasi AA, Chemplavi JK, Farah S, Muller BF, Arnstein AR. Hypercalcemia in active pulmonary tuberculosis. Ann Intern Med 1979;90:324-328
37. Murray JJ, Heim CR. Hypercalcemia in disseminated histoplasmosis: Aggravation by vitamin D. Am J Med 1985;78:881-884
38. Stern PH, DeOlazzabal J, Bell NH. Evidence for abnormal regulation of circulating 1,25-dihydroxyvitamin D in patients with sarcoidosis and normal calcium metabolism. J Clin Invest 1980;66:852-855
39. Batra P. Pulmonary coccidioidomycosis. J Thorac Imaging 1992;7:29-38.
40. Roussos A, Lagogianni I, Gonis A, Ilias I, Kazi D, Patsopoulos D, et al. Hypercalcaemia in Greek patients with tuberculosis before the initiation of anti-tuberculosis treatment. Respir Med 2001;95:187-190
41. Katz S, Stanton J, McCormick G. Miliary calcification of the lungs after treated miliary tuberculosis. N Engl J Med 1955;253:135-137
42. Chawalparit O, Charoensak A, Chierakul N HRCT of pulmonary tuberculosis mimics malignancy: A preliminary report. J Med Assoc Thai 2006;89:190-195
43. Weinstein DS. Pulmonary sarcoidosis: Calcified micronodular pattern simulating pulmonary alveolar microlithiasis. J Thorac Imaging 1999;14:218-220
44. Goldstein MS, Rush M, Johnson P, Sprung CL. A calcified adenocarcinoma of the lung with very high CT numbers. Radiology 1984;150:785-786
45. Takamochi K, Yokose T, Yoshida J, Nishimura M, Ohmatsu H, Nagai K, et al. Calcification in large cell neuroendocrine carcinoma of the lung. Jpn J Clin Oncol 2003;33:10-13
46. XVII European Symposium on Calcified Tissues 11 - 14 April 1983 Davos, Switzerland abstracts.
47. Kaltreider HB, Baum GL, Bogaty G, McCoy MD, Tucker M. So-called "metastatic" calcification of the lung. Am J Med 1969;46:188-196
48. Kennedy A. The diagnosis of pulmonary carcinoid tumours. Br J Dis Chest 1979;73:71-80.
49. Zwiebel BR, Austin JH, Grimes MM. Bronchial carcinoid tumors: Assessment with CT of location and intratumoral calcification in 31 patients. Radiology 1991;179:483-486
50. Hillerdal G, Elmberger G. Malignant mediastinal tumor with bone formation-mesothelioma or sarcoma? J Thorac Oncol 2007;2:983-984
51. Gladish GW, Sabloff BM, Munden RF, Truong MT, Erasmus JJ, Chasen MH. Primary thoracic sarcomas. Radiographics 2002;22:621-637
52. Samuels T, Kerenyi N, Hamilton P. Cystosarcoma phylloides: Calcified pulmonary metastases detected by computed tomography. Can Assoc Radiol J 1990;41:217-218
53. Maile CW, Rodan BA, Godwin JD, Chen JT, Ravin CE. Calcification in pulmonary metastases. Br J Radiol 1982;55:108-113
54. Pinkard NB, Wilson RW, Lawless N, Dodd LG, McAdams HP, Koss MN, et al. Calcifying fibrous pseudotumor of pleura: A report of three cases of a newly described entity involving the pleura. Am J Clin Pathol 1996;105:189-194
55. Coblentz CL, Chen JT, Bernhardt P, Roggli V. Calcified intralobar sequestration. Can Assoc Radiol J 1988;39:290-292
56. Urban BA, Fishman EK, Goldman SM, Scott WW Jr, Jones B, Humphrey RL, et al. CT evaluation of amyloidosis: Spectrum of disease. RadioGraphics 1993;13:1295-1308
57. Hartman TE, Müller NL, Primack SL, Johkoh T, Takeuchi N, Ikezoe J, et al. Metastatic pulmonary calcification in patients with hypercalcemia: Findings on chest radiographs and CT scans. AJR Am J Roentgenol 1994;162:799-802.
58. Chung MJ, Lee KS, Franquet T, Müller NL, Han J, Kwon OJ. Metabolic lung disease: Imaging and histopathologic findings. Eur J Radiol 2005;54:233-245
59. Bendayan D, Barziv Y, Kramer MR. Pulmonary calcifications: A review. Respir Med 2000;94:190-193
60. Greenberg S, Suster B. Metastatic pulmonary calcification: Appearance on high resolution CT. J Comput Assist Tomogr 1994;18:497-499
61. Kang EH, Kim ES, Kim CH, Ham SY, Oh YW. Atypical radiological manifestation of pulmonary metastatic calcification. Korean J Radiol 2008;9:186-189
62. Moran CA, Suster S. Unusual non-neoplastic lesions of the lung. Semin Diagn Pathol 2007;24:199-208.
63. Rodriguez FJ, Aubry MC, Tazelaar HD, Slezak J, Carney JA. Pulmonary chondroma: A tumor associated with Carney triad and different from pulmonary hamartoma. Am J Surg Pathol 2007;31:1844-1853
64. Lee JY, Lee KS, Jung KJ, Han J, Kwon OJ, Kim J, et al. Pulmonary tuberculosis: CT and pathologic correlation. J Comput Assist Tomogr 2000;24:691-698
65. Marchiori E, Souza AS Jr, Franquet T, Müller N. Diffuse high-attenuation pulmonary abnormalities: A pattern-oriented diagnostic approach on high-resolution CT. AJR Am J Roentgenol 2005;184:273-282
66. Ward S, Heyneman LE, Reittner P, Kazerooni EA, Godwin JD, Müller NL. Talcosis associated with IV abuse of oral medications: CT findings. AJR Am J Roentgenol 2000;174:789-793
67. Cotton A, Boutry N, Cortet B. Percutaneous vertebroplasty: State of the art. RadioGraphics 1998;18:311-320
68. Kanne JP, Godwin JD, Takasugi JE, Schmidt RA, Stern EJ. Diffuse pulmonary ossification. J Thorac Imaging 2004;19:98-102.
69. Ellis SJ, Cleverley JR, Müller NL. Drug-induced lung disease: High-resolution CT findings. AJR Am J Roentgenol 2000;175:1019-1024
70. Chung JW, Park JH, Han JK, Han MC. Pulmonary oil embolism after transcatheter oily chemoembolization of hepatocellular carcinoma. Radiology 1993;187:689-693
71. Kaul A, Muth H. Thorotrast kinetics and radiation dose: Results from studies in thorotrast patients and from animal experiments. Radiat Environ Biophys 1978;15:241-259
72. Levy DW, Rindsberg S, Friedman AC, Fishman EK, Ros PR, Radecki PD, et al. Thorotrast-induced hepatosplenic neoplasia: CT identification. AJR Am J Roentgenol 1986;150:997-1004.