Liver microRNA hsa-miR-125a-5p in HBV Chronic Infection: Correlation with HBV Replication and Disease Progression

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Coppola, Nicola ^a   Potenza, Nicoletta ^a   Pisaturo, Mariantonietta ^a   Mosca, Nicola ^a   Tonziello, Gilda ^a   Signoriello, Giuseppe ^a   Messina, Vincenzo ^b   Sagnelli, Caterina ^a   Russo, Aniello ^a   Sagnelli, Evangelista ^a,b  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b Division of Infectious Diseases   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; HEMOGLOBIN BETA CHAIN; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIBODY; HSA MICRORNA 125A 5P; MICRORNA; UNCLASSIFIED DRUG; VIRUS DNA;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL CONSUMPTION; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CAUCASIAN; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DELTA AGENT HEPATITIS; DISEASE COURSE; DISEASE SEVERITY; FEMALE; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC ASSOCIATION; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS C; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; ISHAK SCORING SYSTEM; LIVER FIBROSIS; LIVER NECROSIS; MALE; PATHOPHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SCORING SYSTEM; VIRUS LOAD; VIRUS REPLICATION;

ADULT; DISEASE PROGRESSION; DNA, VIRAL; FEMALE; GENE EXPRESSION; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; LIVER; LIVER CIRRHOSIS; MALE; MICRORNAS; MIDDLE AGED; RISK FACTORS; VIRAL LOAD; VIRUS REPLICATION;

HEPATITIS B VIRUS; HEPATITIS C VIRUS;

EID: 84879762339     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065336     Document Type: Article

References (38)

1. Lavanchy D, (2004) Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat 11: 97-107.
2. McMahon BJ, (2005) Epidemiology and natural history of hepatitis B. Semin Liver Dis. 25(Suppl 1): 3-8.
3. Sagnelli E, Stroffolini T, Mele A, Imparato M, (2008) Almasio PL; Italian Hospitals' Collaborating Group (2008) Chronic hepatitis B in Italy: new features of an old disease- approaching the universal prevalence of hepatitis B e antigen-negative cases and the eradication of hepatitis D infection. Clin Infect Dis. 46: 110-3.
4. Ganem D, Prince AM, (2004) Hepatitis B virus infection - natural history and clinical consequences. N Engl J Med 350: 1118-1129.
5. Dienstag JL, (2008) Hepatitis B virus infection. N Engl J Med 359: 1486-1500.
6. Chu CM, Liaw YF, (2006) Hepatitis B virus-related cirrhosis: natural history and treatment. Semin Liver Dis 26: 142-152.
7. Fattovich G, Olivari N, Pasino M, D'Onofrio M, Martone E, et al. (2008) Long-term outcome of chronic hepatitis B in Caucasian patients: mortality after 25 years. Gut 57: 84-90.
8. McMahon (2009) The natural history of chronic hepatitis B virus infection. Hepatology 49: S45-S55.
9. Hadziyannis SJ, (2011) Natural history of chronic hepatitis B in Euro-Mediterranean and African countries. J Hepatol 55: 183-91.
10. Sagnelli E, Coppola N, Scolastico C, Filippini P, Santantonio T, et al. (2000) Virologic and clinical expressions of reciprocal inhibitory effect of hepatitis B, C, and delta viruses in patients with chronic hepatitis. Hepatology 32: 1106-10.
11. Kao JH, Chen PJ, Lai MY, Chen DS, (2003) Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers. Gastroenterology 124: 327-334.
12. Iloeje UH, Yang HI, Jen CL, You SL, Chen CJ, (2006) Predicting cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology 130: 678-686.
13. Chen CJ, Yang HI, Su J, Jen CL, You SL, et al. (2006) Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA 295: 65-73.
14. Puoti M, Torti C, Bruno R, Filice G, Carosi G, (2006) Natural history of chronic hepatitis B in co-infected patients. J Hepatol 44: S65-S70.
15. Hoffmann CJ, Thio CL, (2007) Clinical implications of HIV and hepatitis B co-infection in Asia and Africa. Lancet Infect Dis 7: 402-409.
16. Fattovich G, Bortolotti F, Donato F, (2008) Natural history of chronic hepatitis B: special emphasis on disease progression and prognostic factors. J Hepatol 48: 335-352.
17. Kim BK, Revill PA, Ahn SH, (2011) HBV genotypes: relevance to natural history, pathogenesis and treatment of chronic hepatitis B. Antivir Ther. 16: 1169-86.
18. Thursz M, Yee L, Khakoo S, (2011) Understanding the host genetics of chronic hepatitis B and C. Semin Liver Dis. 31: 115-27.
19. Dandri M, Locarnini S, (2012) New insight in the pathobiology of hepatitis B virus infection. Gut 61Suppl 1: i6-17.
20. Ambros V (2004). The functions of animal microRNAs. Nature: 431, 350-355.
21. Guo H, Ingolia NT, Weissman JS, Bartel DP (2010). Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature: 12, 835-840.
22. Bartel DP (2004). MicroRNAs: genomics, biogenesis, mechanism, and function. Cell; 116, 281-297.
23. Wienholds E, Plasterk RH (2005). MicroRNA function in animal development. FEBS Lett; 579, 5911-5922.
24. Tarantino C, Paolella G, Cozzuto L, Minopoli G, Pastore L, et al. (2010) miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J 24: 3255-63.
25. Umbach JL, Cullen BR (2009). The role of RNAi and microRNAs in animal virus replication and antiviral immunity. Genes Dev; 23, 1151-64.
26. Russo A, Potenza N (2011). Antiviral effects of human microRNAs and conservation of their target sites. FEBS Letters; 585, 2551-2555.
27. Potenza N, Papa U, Mosca N, Zerbini F, Nobile V, et al. (2011). Human microRNA hsa-miR-125a-5p interferes with expression of hepatitis B virus surface antigen. Nucleic Acids Res; 39, 5157-5163.
28. Park SO, Kumar M, Gupta S (2012). TGF-ß and Iron Differently Alter HBV Replication in Human Hepatocytes through TGF-ß/BMP Signaling and Cellular MicroRNA Expression. PLoS One; 7, e39276.
29. Sagnelli E, Imparato M, Coppola N, Pisapia R, Sagnelli C, et al. (2008) Diagnosis and clinical impact of occult hepatitis B infection in patients with biopsy proven hepatitis C: a multicenter study. J Med Virol 80: 1547-53.
30. Coppola N, Pisapia R, Tonziello G, Martini S, Imparato M, et al. (2008) Virological pattern in plasma, peripheral blood mononuclear cells and liver tissue and clinical outcome in chronic hepatitis B and C virus coinfection. Antivir Ther 13: 307-18.
31. Ishak K, Baptista A, Binachi L, Callea F, De Groote J, et al. (1995) Histological grading and staging of chronic hepatitis. J Hepatol 22: 696-699.
32. Coppola N, Tonziello G, Pisaturo M, Messina V, Guastafierro S, et al. (2011) Reactivation of overt and occult hepatitis B infection in various immunosuppressive settings. J Med Virol 83: 1909-1916.
33. Coppola N, Masiello A, Tonziello G, Pisapia R, Pisaturo M, et al. (2010) Factors affecting the changes in molecular epidemiology of acute hepatitis B in a Southern Italian area. J Viral Hepat 17: 493-500.
34. Schmittgen TD, Livak VJ (2008). Analyzing real-time PCR data by the comparation Ct method. Nature Protocols: 3, 1101-1108.
35. Zhang GL, Li YX, Zheng SQ, Liu M, Li X, et al. (2010). Suppression of hepatitis B virus replication by microRNA-199a-3p and microRNA-210. Antiviral Res: 88, 169-175.
36. LiuY, Zhao JJ, Wang CM, Li MY, Han P, et al. (2009). Altered expression profiles of microRNAs in a stable hepatitis B virus-expressing cell line. Chin Med J, 122, 10-14.
37. Wang Y, Lu Y, Toh ST, Sung W, Tan P, et al. (2010). Lethal-7 is down-regulated by the hepatitis B virus X protein and targets 50 signal transducer and activator of transcription 3. J Hepatol; 53, 57-66.
38. Huang J, Wang F, Argyris E, Chen K, Liang Z, et al. (2007). Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes. Nat Med; 13, 1241-1247.