Microfluidic perfusion for regulating diffusible signaling in stem cells

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Blagovic, Katarina ^a   Kim, Lily Y ^a,c   Voldman, Joel ^a,b  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b USA   (United States)

^c Decision Resources Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 4; GROWTH FACTOR; FGF4 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; AUTOCRINE EFFECT; CELL DIFFERENTIATION; CELL GROWTH; CELL SECRETION; CONTROLLED STUDY; CULTURE MEDIUM; DEPLETION; DOWN REGULATION; EMBRYONIC STEM CELL; EXTRACELLULAR MATRIX; MICROFLUIDIC PERFUSION; MOUSE; NEUROECTODERM; NONHUMAN; PARACRINE SIGNALING; PERFUSION; SHEAR STRESS; SIGNAL TRANSDUCTION; ANIMAL; CYTOLOGY; METABOLISM; MICROFLUIDICS;

ANIMALS; CULTURE MEDIA; EMBRYONIC STEM CELLS; FIBROBLAST GROWTH FACTOR 4; MICE; MICROFLUIDICS; SIGNAL TRANSDUCTION;

EID: 79961146650     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022892     Document Type: Article

References (51)

1. Yu H, Jove R, (2004) The STATs of cancer- new molecular targets come of age. Nat Rev Cancer 4: 97-105.
2. Freeman M, (2000) Feedback control of intercellular signalling in development. Nature 408: 313-319.
3. Freeman M, Gurdon JB, (2002) REGULATORY PRINCIPLES OF DEVELOPMENTAL SIGNALING. Annual Review of Cell and Developmental Biology 18: 515-539.
4. Davey RE, Onishi K, Mahdavi A, Zandstra PW, (2007) LIF-mediated control of embryonic stem cell self-renewal emerges due to an autoregulatory loop. The FASEB Journal 21: 1-13.
5. Ying Q-L, Stavridis M, Griffiths D, Li M, Smith A, (2003) Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture. Nat Biotech 21: 4.
6. Shvartsman SY, Wiley HS, Deen WM, Lauffenburger DA, (2001) Spatial Range of Autocrine Signaling: Modeling and Computational Analysis. Biophysical Journal 81: 1854-1867.
7. Zandstra H-VL PW, Daley GQ, Griffith LG, Lauffenburger DA, (2000) Leukemia inhibitory factor (LIF) concentration modulates embryonic stem cell self-renewal and differentiation independently of proliferation. Biotechnology and Bioengineering 69: 607-617.
8. Bansal R, Magge S, Winkler S, (2003) Specific Inhibitor of FGF Receptor Signaling: FGF-2-Mediated Effects on Proliferation, Differentiation, and MAPK Activation Are Inhibited by PD173074 in Oligodendrocyte-Lineage Cells. Journal of Neuroscience Research 74: 486-493.
9. Dani C, Chambers I, Johnstone S, Robertson M, Ebrahimi B, et al. (1998) Paracrine Induction of Stem Cell Renewal by LIF-Deficient Cells: A New ES Cell Regulatory Pathway. Developmental Biology 203: 149-162.
10. Kunath T, Saba-El-Leil MK, Almousailleakh M, Wray J, Meloche S, et al. (2007) FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment. Development 134: 2895-2902.
11. Voorhoeve PM, Agami R, (2003) Knockdown stands up. Trends in Biotechnology 21: 2-4.
12. Tropepe V, Hitoshi S, Sirard C, Mak TW, Rossant J, et al. (2001) Direct Neural Fate Specification from Embryonic Stem Cells: A Primitive Mammalian Neural Stem Cell Stage Acquired through a Default Mechanism. Neuron 30: 65-78.
13. Peerani R, Rao BM, Bauwens C, Yin T, Wood GA, et al. (2007) Niche-mediated control of human embryonic stem cell self-renewal and differentiation. EMBO J 26: 4744-4755.
14. Domenech M, Yu H, Warrick J, Badders NM, Meyvantsson I, et al. (2009) Cellular observations enabled by microculture: paracrine signaling and population demographics. Integrative Biology 1: 267-274.
15. Squires TM, Messinger RJ, Manalis SR, (2008) Making it stick: convection, reaction and diffusion in surface-based biosensors. Nat Biotech 26: 417-426.
16. Atencia J, Beebe DJ, (2005) Controlled microfluidic interfaces. Nature 437: 648-655.
17. Discher DE, Mooney DJ, Zandstra PW, (2009) Growth Factors, Matrices, and Forces Combine and Control Stem Cells. Science 324: 1673-1677.
18. Gupta K, Kim D-H, Ellison D, Smith C, Kundu A, et al. (2010) Lab-on-a-chip devices as an emerging platform for stem cell biology. Lab on a Chip 10: 2019-2031.
19. Toh Y-C, Blagovic K, Voldman J, (2010) Advancing stem cell research with microtechnologies: opportunities and challenges. Integrative Biology 2: 305-325.
20. Tourovskaia A, Figueroa-Masot X, Folch A, (2005) Differentiation-on-a-chip: A microfluidic platform for long-term cell culture studies. Lab on a Chip 5: 14-19.
21. Chung BG, Flanagan LA, Rhee SW, Schwartz PH, Lee AP, et al. (2005) Human neural stem cell growth and differentiation in a gradient-generating microfluidic device. Lab on a Chip 5: 401-406.
22. Ellison D, Munden A, Levchenko A, (2009) Computational model and microfluidic platform for the investigation of paracrine and autocrine signaling in mouse embryonic stem cells. Molecular BioSystems 5: 1004-1012.
23. Mehta K, Linderman JJ, (2006) Model-based analysis and design of a microchannel reactor for tissue engineering. Biotechnology and Bioengineering 94: 596-609.
24. Bain G, Kitchens D, Yao M, Huettner JE, Gottlieb DI, (1995) Embryonic Stem Cells Express Neuronal Properties in Vitro. Developmental Biology 168: 342-357.
25. Wichterle H, Lieberam I, Porter JA, Jessell TM, (2002) Directed Differentiation of Embryonic Stem Cells into Motor Neurons. Cell 110: 385-397.
26. Stavridis MP, Lunn JS, Collins BJ, Storey KG, (2007) A discrete period of FGF-induced Erk1/2 signalling is required for vertebrate neural specification. Development 134: 2889-2894.
27. Ying Q-L, Smith AG, Wassarman PM, Keller GM, (2003) Defined Conditions for Neural Commitment and Differentiation. pp. 327-341 Methods in Enzymology: Academic Press.
28. Irimia D, Toner M, (2006) Cell handling using microstructured membranes. Lab on a Chip 6: 345-352.
29. Skelley AM, Voldman J, (2008) An active bubble trap and debubbler for microfluidic systems. Lab on a Chip 8: 1733-1737.
30. Kim L, Vahey MD, Lee H-Y, Voldman J, (2006) Microfluidic arrays for logarithmically perfused embryonic stem cell culture. Lab on a Chip 6: 394-406.
31. Catchpole JP, Fulford G, (1966) DIMENSIONLESS GROUPS. Industrial & Engineering Chemistry 58: 46-60.
32. Tanford C, (1961) Physical Chemistry of Macromolecules John Wiley and Sons Ltd.
33. Gaver DP Iii, Kute SM, (1998) A Theoretical Model Study of the Influence of Fluid Stresses on a Cell Adhering to a Microchannel Wall. Biophysical Journal 75: 721-733.
34. Fok EYL, Zandstra PW, (2005) Shear-Controlled Single-Step Mouse Embryonic Stem Cell Expansion and Embryoid Body-Based Differentiation. Stem Cells 23: 1333-1342.
35. Wang H, Riha GM, Yan S, Li M, Chai H, et al. (2005) Shear Stress Induces Endothelial Differentiation From a Murine Embryonic Mesenchymal Progenitor Cell Line. Arterioscler Thromb Vasc Biol 25: 1817-1823.
36. Yamamoto K, Sokabe T, Watabe T, Miyazono K, Yamashita JK, et al. (2005) Fluid shear stress induces differentiation of Flk-1-positive embryonic stem cells into vascular endothelial cells in vitro. Am J Physiol Heart Circ Physiol 288: H1915-1924.
37. Bradley BOlwin, Stephen DHauschka, (1989) Cell type and tissue distribution of the fibroblast growth factor receptor. Journal of Cellular Biochemistry 39: 443-454.
38. Dowd CJ, Cooney CL, Nugent MA, (1999) Heparan Sulfate Mediates bFGF Transport through Basement Membrane by Diffusion with Rapid Reversible Binding. J Biol Chem 274: 5236-5244.
39. Ibrahimi OA, Yeh BK, Eliseenkova AV, Zhang F, Olsen SK, et al. (2005) Analysis of Mutations in Fibroblast Growth Factor (FGF) and a Pathogenic Mutation in FGF Receptor (FGFR) Provides Direct Evidence for the Symmetric Two-End Model for FGFR Dimerization. Mol Cell Biol 25: 671-684.
40. Olsen SK, Ibrahimi OA, Raucci A, Zhang F, Eliseenkova AV, et al. (2004) Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity. Proceedings of the National Academy of Sciences of the United States of America 101: 935-940.
41. Wood HB, Episkopou V, (1999) Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages. Mechanisms of Development 86: 197-201.
42. Ying QL, Nichols J, Chambers I, Smith A, (2003) BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 115: 281-292.
43. Zhang K, Li L, Huang C, Shen C, Tan F, et al. (2010) Distinct functions of BMP4 during different stages of mouse ES cell neural commitment. Development 137: 2095-2105.
44. Brons IGM, Smithers LE, Trotter MWB, Rugg-Gunn P, Sun B, et al. (2007) Derivation of pluripotent epiblast stem cells from mammalian embryos. Nature 448: 191-195.
45. Hall VJ, Jacobsen JV, Rasmussen MA, Hyttel P, (2010) Ultrastructural and molecular distinctions between the porcine inner cell mass and epiblast reveal unique pluripotent cell states. Developmental Dynamics 239: 2911-2920.
46. Hirasawa R, Sasaki H, (2009) Dynamic transition of Dnmt3b expression in mouse pre- and early post-implantation embryos. Gene Expression Patterns 9: 27-30.
47. Tesar PJ, Chenoweth JG, Brook FA, Davies TJ, Evans EP, et al. (2007) New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature 448: 196-199.
48. Watanabe D, Suetake I, Tada T, Tajima S, (2002) Stage- and cell-specific expression of Dnmt3a and Dnmt3b during embryogenesis. Mechanisms of Development 118: 187-190.
49. Young EWK, Beebe DJ, (2010) Fundamentals of microfluidic cell culture in controlled microenvironments. Chemical Society Reviews 39: 1036-1048.
50. Wilder PJ, Kelly D, Brigman K, Peterson CL, Nowling T, et al. (1997) Inactivation of the FGF-4 Gene in Embryonic Stem Cells Alters the Growth and/or the Survival of Their Early Differentiated Progeny. Developmental Biology 192: 614-629.
51. Lanner F, Rossant J, (2010) The role of FGF/Erk signaling in pluripotent cells. Development 137: 3351-3360.