MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 27, 2013, Pages 10994-10999

  Fan, Chengpeng ^a   Rajasekaran, Deepa ^a   Syed, Mansoor Ali ^a   Leng, Lin ^a   Loria, J Patrick ^b   Bhandari, Vineet ^a   Bucala, Richard ^a,c   Lolis, Elias J ^a,c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY   (United States)

^c YALE CANCER CENTER   (United States)

Author keywords

ERK 1 2 activation; Mechanism; Thermostable variant

Indexed keywords

CD74 ANTIGEN; CYSTEINE; MACROPHAGE MIGRATION INHIBITION FACTOR; OLIGOMER;

ANIMAL CELL; ARTICLE; BETA SHEET; BINDING KINETICS; BIOACCUMULATION; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISULFIDE BOND; ENZYME ACTIVITY; GEL PERMEATION CHROMATOGRAPHY; LIGHT SCATTERING; LUNG ALVEOLUS CELL; MOUSE; NEUTROPHIL; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN STRUCTURE; PROTEIN SUBUNIT; RECEPTOR BINDING; WILD TYPE;

ERK-1/2 ACTIVATION; MECHANISM; THERMOSTABLE VARIANT;

ANIMALS; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; CRYSTALLOGRAPHY, X-RAY; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STABILITY; PROTEIN STRUCTURE, QUATERNARY; PROTEIN SUBUNITS; RECEPTORS, IMMUNOLOGIC;

EID: 84879733913     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1221817110     Document Type: Article

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