Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor

Journal of Biological Chemistry

Volumn 282, Issue 32, 2007, Pages 23089-23095

  Crichlow, Gregg V ^a   Kai, Fan Cheng ^b   Dabideen, Darrin ^b   Ochani, Mahendar ^b   Aljabari, Bayan ^b   Pavlov, Valentin A ^b   Miller, Edmund J ^b   Lolis, Elias ^a   Al Abed, Yousef ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL SCAFFOLDS; MACROPHAGE MIGRATION INHIBITORY FACTORS; THERAPEUTIC POTENCY;

DRUG PRODUCTS; PROTEINS; STRUCTURE (COMPOSITION);

MACROPHAGES;

3 (4 HYDROXYPHENYL) 4,5 DIHYDRO 5 ISOXAZOLE ACETIC ACID METHYL ESTER; 4 HYDROXYBENZALDEHYDE O CYCLOHEXANECARBONYLOXIME; 4 HYDROXYPHENYLPYRUVIC ACID; ACETIC ACID DERIVATIVE; GLUCOCORTICOID; MIGRATION INHIBITION FACTOR; OXIM 11; OXIME DERIVATIVE; PYRUVIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG RESEARCH; DRUG STRUCTURE; ENZYME INHIBITION; GEL MOBILITY SHIFT ASSAY; MOUSE; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; SEPSIS; X RAY CRYSTALLOGRAPHY;

ANTI-INFLAMMATORY AGENTS; BINDING SITES; CARBON; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; GLUCOCORTICOIDS; HUMANS; LEUKOCYTES, MONONUCLEAR; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MODELS, CHEMICAL; NF-KAPPA B; OXIMES; PROTEIN BINDING; RECOMBINANT PROTEINS;

MUS;

EID: 34548188996     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M701825200     Document Type: Article

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