Reduced fractional anisotropy in the uncinate fasciculus in patients with major depression carrying the met-allele of the Val66Met brain-derived neurotrophic factor genotype

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 159 B, Issue 5, 2012, Pages 537-548

  Carballedo, A ^a   Amico, F ^a   Ugwu, I ^a   Fagan, A J ^b   Fahey, C ^a   Morris, D ^a   Meaney, J F ^b   Leemans, A ^c   Frodl, T ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b ST JAMES S HOSPITAL   (Ireland)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Cingulum; Diffusion tensor imaging (DTI); Fornix; Major depression (MDD); Neurogenetics; Uncinate fasciculus; Val66Met brain derived neurotrophic factor (BDNF) genotype

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

ADULT; AGED; ALLELE; AMYGDALOID NUCLEUS; ARTICLE; BRAIN FORNIX; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; DIFFUSION TENSOR IMAGING; FEMALE; FRACTIONAL ANISOTROPY; GENETIC POLYMORPHISM; GENOTYPE; HEMISPHERE; HETEROZYGOTE; HIPPOCAMPUS; HUMAN; MAJOR DEPRESSION; MALE; PREFRONTAL CORTEX; PRIORITY JOURNAL; UNCINATE FASCICULUS; WHITE MATTER;

ADOLESCENT; ADULT; AGED; ALLELES; ANISOTROPY; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CASE-CONTROL STUDIES; DEMOGRAPHY; DEPRESSIVE DISORDER, MAJOR; DIFFUSION TENSOR IMAGING; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; YOUNG ADULT;

EID: 84861957030     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.32060     Document Type: Article

References (106)

1. Abe O, Yamasue H, Kasai K, Yamada H, Aoki S, Inoue H, Takei K, Suga M, Matsuo K, Kato T, et al. 2010. Voxel-based analyses of gray/white matter volume and diffusion tensor data in major depression. Psychiatry Res 181(1): 64-70.
2. Alderson RF, Curtis R, Alterman AL, Lindsay RM, DiStefano PS. 2000. Truncated TrkB mediates the endocytosis and release of BDNF and neurotrophin-4/5 by rat astrocytes and schwann cells in vitro. Brain Res 871(2): 210-222.
3. Alexopoulos GS, Kiosses DN, Choi SJ, Murphy CF, Lim KO. 2002. Frontal white matter microstructure and treatment response of late-life depression: A preliminary study. Am J Psychiatry 159(11): 1929-1932.
4. Alexopoulos GS, Murphy CF, Gunning-Dixon FM, Glatt CE, Latoussakis V, Kelly RE Jr, Kanellopoulos D, Klimstra S, Lim KO, Young RC, et al. 2009. Serotonin transporter polymorphisms, microstructural white matter abnormalities and remission of geriatric depression. J Affect Disord 119(1-3): 132-141.
5. Anand A, Li Y, Wang Y, Wu J, Gao S, Bukhari L, Mathews VP, Kalnin A, Lowe MJ. 2005. Activity and connectivity of brain mood regulating circuit in depression: A functional magnetic resonance study. Biol Psychiatry 57(10): 1079-1088.
6. Bae JN, MacFall JR, Krishnan KRR, Payne ME, Steffens DC, Taylor WD. 2006. Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depression. Biol Psychiatry 60(12): 1356-1363.
7. Bailey RK, Patel TC, Avenido J, Patel M, Jaleel M, Barker NC, Khan JA, Ali S, Jabeen S. 2011. Suicide: Current trends. J Natl Med Assoc 103(7): 614-617.
8. Basser PJ, Mattiello J, LeBihan D. 1994. MR diffusion tensor spectroscopy and imaging. Biophys J 66(1): 259-267.
9. Basser PJ, Pajevic S, Pierpaoli C, Duda J, Aldroubi A. 2000. In vivo fiber tractography using DT-MRI data. Magn Reson Med 44(4): 625-632.
10. Beaulieu C. 2002. The basis of anisotropic water diffusion in the nervous system-A technical review. NMR Biomed 15(7-8): 435-455.
11. Beck AT, Steer RA, Brown GK. 1996. BDI-II manual. San Antonio, TX: Harcourt Brace and Company.
12. Behrens TE, Berg HJ, Jbabdi S, Rushworth MF, Woolrich MW. 2007. Probabilistic diffusion tractography with multiple fibre orientations: What can we gain? Neuroimage 34(1): 144-155.
13. Benjamin S, McQuoid DR, Potter GG, Payne ME, MacFall JR, Steffens DC, Taylor WD. 2010. The brain-derived neurotrophic factor Val66Met polymorphism, hippocampal volume, and cognitive function in geriatric depression. Am J Geriatr Psychiatry 18(4): 323-331.
14. Blood AJ, Iosifescu DV, Makris N, Perlis RH, Kennedy DN, Dougherty DD, Kim BW, Lee MJ, Wu S, Lee S, et al. 2010. Microstructural abnormalities in subcortical reward circuitry of subjects with major depressive disorder. PLoS ONE 5(11): e13945.
15. Bueller JA, Aftab M, Sen S, Gomez-Hassan D, Burmeister M, Zubieta JK. 2006. BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects. Biol Psychiatry 59(9): 812-815.
16. Chang LC, Jones DK, Pierpaoli C. 2005. RESTORE: Robust estimation of tensors by outlier rejection. Magn Reson Med 53(5): 1088-1095.
17. Chen CH, Suckling J, Ooi C, Fu CH, Williams SC, Walsh ND, Mitterschiffthaler MT, Pich EM, Bullmore E. 2008. Functional coupling of the amygdala in depressed patients treated with antidepressant medication. Neuropsychopharmacology 33(8): 1909-1918.
18. Chiang MC, Barysheva M, Toga AW, Medland SE, Hansell NK, James MR, McMahon KL, de Zubicaray GI, Martin NG, Wright MJ, et al. 2011. BDNF gene effects on brain circuitry replicated in 455 twins. Neuroimage 55(2): 448-454.
19. Cole J, Weinberger DR, Mattay VS, Cheng X, Toga AW, Thompson PM, Powell-Smith G, Cohen-Woods S, Simmons A, McGuffin P, et al. 2011. No effect of 5HTTLPR or BDNF Val66Met polymorphism on hippocampal morphology in major depression. Genes Brain Behav 10(7): 756-764.
20. Concha L, Gross DW, Beaulieu C. 2005. Diffusion tensor tractography of the limbic system. AJNR Am J Neuroradiol 26(9): 2267-2274.
21. Coplan J, Abdallah C, Tang C, Mathew S, Martinez J, Hof P, Smith E, Dwork A, Perera T, Pantol G. 2010. The role of early life stress in development of the anterior limb of the internal capsule in non-human primates. Neurosci Lett 480(2): 93-96.
22. Cullen K, Klimes-Dougan B, Muetzel R, Mueller B, Camchong J, Houri A, Kurma S, Lim K. 2010. Altered white matter microstructure in adolescents with major depression: A preliminary study. J Am Acad Child Adolesc Psychiatry 49(2): 173-183.
23. Dannlowski U, Ohrmann P, Konrad C, Domschke K, Bauer J, Kugel H, Hohoff C, Schoning S, Kersting A, Baune BT, et al. 2009. Reduced amygdala-prefrontal coupling in major depression: Association with MAOA genotype and illness severity. Int J Neuropsychopharmacol 12(1): 11-22.
24. Dennis KE, Levitt P. 2005. Regional expression of brain derived neurotrophic factor (BDNF) is correlated with dynamic patterns of promoter methylation in the developing mouse forebrain. Brain Res Mol Brain Res 140(1-2): 1-9.
25. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, Zaitsev E, Gold B, Goldman D, Dean M, et al. 2003. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112(2): 257-269.
26. Erickson KI, Miller DL, Roecklein KA. 2011. The aging hippocampus: Interactions between exercise, depression, and BDNF. Neuroscientist 18(1): 82-97.
27. Forlenza OV, Diniz BS, Teixeira AL, Ojopi EB, Talib LL, Mendonca VA, Izzo G, Gattaz WF. 2010. Effect of brain-derived neurotrophic factor Val66Met polymorphism and serum levels on the progression of mild cognitive impairment. World J Biol Psychiatry 11(6): 774-780.
28. Frodl T, Schule C, Schmitt G, Born C, Baghai T, Zill P, Bottlender R, Rupprecht R, Bondy B, Reiser M, et al. 2007. Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression. Arch Gen Psychiatry 64(4): 410-416.
29. Frodl T, Reinhold E, Koutsouleris N, Donohoe G, Reiser M, Moeller H-J, Meisenzahl E. 2010. Childhood stress, serotonin transporter gene and brain structures in major depression. Neuropsychopharmacology 35(6): 1383-1390.
30. Gerritsen L, Tendolkar I, Franke B, Vasquez AA, Kooijman S, Buitelaar J, Fernandez G, Rijpkema M. 2011. BDNF Val66Met genotype modulates the effect of childhood adversity on subgenual anterior cingulate cortex volume in healthy subjects. Mol Psychiatry (in press), DOI:10.1038/mp.2011.51.
31. Gonca Akbulut K, Akbulut H, Akgun N, Gonul B. 2011. Melatonin decreases apoptosis in gastric mucosa during aging. Aging Clin Exp Res (in press).
32. Gonul AS, Kitis O, Eker MC, Eker OD, Ozan E, Coburn K. 2011. Association of the brain-derived neurotrophic factor Val66Met polymorphism with hippocampus volumes in drug-free depressed patients. World J Biol Psychiatry 12(2): 110-118.
33. Grande I, Fries GR, Kunz M, Kapczinski F. 2010. The role of BDNF as a mediator of neuroplasticity in bipolar disorder. Psychiatry Investig 7(4): 243-250.
34. Hamilton M. 1969. Standardised assessment and recording of depressive symptoms. Psychiatr Neurol Neurochir 72(2): 201-205.
35. Hasan KM, Iftikhar A, Kamali A, Kramer LA, Ashtari M, Cirino PT, Papanicolaou AC, Fletcher JM, Ewing-Cobbs L. 2009. Development and aging of the healthy human brain uncinate fasciculus across the lifespan using diffusion tensor tractography. Brain Res 1276: 67-76.
36. Isacsson G. 2000. Suicide prevention-A medical breakthrough? Acta Psychiatr Scand 102(2): 113-117.
37. Jessen F, Schuhmacher A, von Widdern O, Guttenthaler V, Hofels S, Suliman H, Scheef L, Block W, Urbach H, Maier W, et al. 2009. No association of the Val66Met polymorphism of the brain-derived neurotrophic factor with hippocampal volume in major depression. Psychiatr Genet 19(2): 99-101.
38. Jeurissen B, Leemans A, Jones DK, Tournier JD, Sijbers J. 2011. Probabilistic fiber tracking using the residual bootstrap with constrained spherical deconvolution. Hum Brain Mapp 32(3): 461-479.
39. Joffe RT, Gatt JM, Kemp AH, Grieve S, Dobson-Stone C, Kuan SA, Schofield PR, Gordon E, Williams LM. 2009. Brain derived neurotrophic factor Val66Met polymorphism, the five factor model of personality and hippocampal volume: Implications for depressive illness. Hum Brain Mapp 30(4): 1246-1256.
40. Jones DK, Symms MR, Cercignani M, Howard RJ. 2005. The effect of filter size on VBM analyses of DT-MRI data. Neuroimage 26(2): 546-554.
41. Kanellopoulos D, Gunning FM, Morimoto SS, Hoptman MJ, Murphy CF, Kelly RE, Glatt C, Lim KO, Alexopoulos GS. 2011. Hippocampal volumes and the brain-derived neurotrophic factor val66met polymorphism in geriatric major depression. Am J Geriatr Psychiatry 19(1): 13-22.
42. Karnik MS, Wang L, Barch DM, Morris JC, Csernansky JG. 2010. BDNF polymorphism rs6265 and hippocampal structure and memory performance in healthy control subjects. Psychiatry Res 178(2): 425-429.
43. Kaspar BK, Frost LM, Christian L, Umapathi P, Gage FH. 2005. Synergy of insulin-like growth factor-1 and exercise in amyotrophic lateral sclerosis. Ann Neurol 57(5): 649-655.
44. Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, Rush AJ, Walters EE, Wang PS. 2003. The epidemiology of major depressive disorder: Results from the national comorbidity survey replication (NCS-R). JAMA 289(23): 3095-3105.
45. Klein S, Staring M, Murphy K, Viergever MA, Pluim JP. 2010. Elastix: A toolbox for intensity-based medical image registration. IEEE Trans Med Imaging 29(1): 196-205.
46. Kumar A, Sundaram SK, Sivaswamy L, Behen ME, Makki MI, Ager J, Janisse J, Chugani HT, Chugani DC. 2010. Alterations in frontal lobe tracts and corpus callosum in young children with autism spectrum disorder. Cereb Cortex 20(9): 2103-2113.
47. Le Bihan D. 2003. Looking into the functional architecture of the brain with diffusion MRI. Nat Rev Neurosci 4(6): 469-480.
48. Leemans A, Jones DK. 2009. The B-matrix must be rotated when correcting for subject motion in DTI data. Magn Reson Med 61(6): 1336-1349.
49. Leemans A, Sijbers J, De Backer S, Vandervliet E, Parizel PM, 2005. Affine coregistration of diffusion tensor magnetic resonance images using mutual information, Vol. 3708. Antwerp, Belgium: IEEE Advanced Concepts for Intelligent Vision Systems (ACIVS) - Lecture Notes in Computer Science. pp 523-530.
50. Leemans A, Jeurissen B, Sijbers J, Jones DK. 2009. ExploreDTI: A graphical toolbox for processing, analyzing, and visualizing diffusion MR data. In: 17th Annual Meeting of Intl Soc Mag Reson Med, Hawaii, USA, Proc. Intl. Soc. Mag. Reson. Med. 17, p 3537.
51. Levine B, Black SE, Cabeza R, Sinden M, McIntosh AR, Toth JP, Tulving E, Stuss DT. 1998. Episodic memory and the self in a case of isolated retrograde amnesia. Brain 121( Pt 10): 1951-1973.
52. Li L, Ma N, Li Z, Tan L, Liu J, Gong G, Shu N, He Z, Jiang T, Xu L. 2007. Prefrontal white matter abnormalities in young adult with major depressive disorder: A diffusion tensor imaging study. Brain Res 1168: 124-128.
53. Licinio J, Dong C, Wong ML. 2009. Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response. Arch Gen Psychiatry 66(5): 488-497.
54. Liu QR, Walther D, Drgon T, Polesskaya O, Lesnick TG, Strain KJ, de Andrade M, Bower JH, Maraganore DM, Uhl GR. 2005. Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease. Am J Med Genet Part B 134B(1): 93-103.
55. Lu B, Gottschalk W. 2000. Modulation of hippocampal synaptic transmission and plasticity by neurotrophins. Prog Brain Res 128: 231-241.
56. Lu C, Teng S, Wang P, Yeh T, Su T, Hsieh J. 2010. A neuronal fiber tracking study for major depressive disorder using MR diffusion tensor imaging with fiber tractography. International Conference on Bioinformatics and Biomedical Technology (ICBBT), 16-18, April 2010. Piscataway, NJ: IEEE. pp 106-110.
57. Luck D, Buchy L, Czechowska Y, Bodnar M, Pike GB, Campbell JS, Achim A, Malla A, Joober R, Lepage M. 2011. Fronto-temporal disconnectivity and clinical short-term outcome in first episode psychosis: A DTI-tractography study. J Psychiatr Res 45(3): 369-377.
58. Ma N, Li L, Shu N, Liu J, Gong G, He Z, Li Z, Tan L, Stone WS, Zhang Z, et al. 2007. White matter abnormalities in first-episode, treatment-naive young adults with major depressive disorder. Am J Psychiatry 164(5): 823-826.
59. Mabbott DJ, Rovet J, Noseworthy MD, Smith ML, Rockel C. 2009. The relations between white matter and declarative memory in older children and adolescents. Brain Res 1294: 80-90.
60. MacQueen G, Frodl T. 2011. The hippocampus in major depression: Evidence for the convergence of the bench and bedside in psychiatric research? Mol Psychiatry 16(3): 252-264.
61. Malykhin N, Concha L, Seres P, Beaulieu C, Coupland NJ. 2008. Diffusion tensor imaging tractography and reliability analysis for limbic and paralimbic white matter tracts. Psychiatry Res 164(2): 132-142.
62. McKenzie K, Serfaty M, Crawford M. 2003. Suicide in ethnic minority groups. Br J Psychiatry 183: 100-101.
63. Montag C, Weber B, Fliessbach K, Elger C, Reuter M. 2009. The BDNF Val66Met polymorphism impacts parahippocampal and amygdala volume in healthy humans: Incremental support for a genetic risk factor for depression. Psychol Med 39(11): 1831-1839.
64. Montag C, Schoene-Bake JC, Faber J, Reuter M, Weber B. 2010. Genetic variation on the BDNF gene is not associated with differences in white matter tracts in healthy humans measured by tract-based spatial statistics. Genes Brain Behav 9(8): 886-891.
65. Montgomery SA, Asberg M. 1979. A new depression scale designed to be sensitive to change. Br J Psychiatry 134: 382-389.
66. Mori S, Zhang J. 2006. Principles of diffusion tensor imaging and its applications to basic neuroscience research. Neuron 51(5): 527-539.
67. Mori S, Crain BJ, Chacko VP, van Zijl PC. 1999. Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging. Ann Neurol 45(2): 265-269.
68. Mori S, Oishi K, Jiang H, Jiang L, Li X, Akhter K, Hua K, Faria AV, Mahmood A, Woods R, et al. 2008. Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM template. Neuroimage 40(2): 570-582.
69. Murphy ML, Frodl T. 2011. Meta-analysis of diffusion tensor imaging (DTI) studies shows altered fractional anisotropy occurring in distinct brain areas in association with depression. Biol Mood Anxiety Disord 1: 3.
70. Murphy CF, Gunning-Dixon FM, Hoptman MJ, Lim KO, Ardekani B, Shields JK, Hrabe J, Kanellopoulos D, Shanmugham BR, Alexopoulos GS. 2007. White-matter integrity predicts stroop performance in patients with geriatric depression. Biol Psychiatry 61(8): 1007-1010.
71. Nobuhara K, Okugawa G, Sugimoto T, Minami T, Tamagaki C, Takase K, Saito Y, Sawada S, Kinoshita T. 2006a. Frontal white matter anisotropy and symptom severity of late-life depression: A magnetic resonance diffusion tensor imaging study. J Neurol Neurosurg Psychiatry 77(1): 120-122.
72. Nobuhara K, Okugawa G, Sugimoto T, Minami T, Tamagaki C, Takase K, Saito Y, Sawada S, Kinoshita T. 2006b. Frontal white matter anisotropy and symptom severity of late-life depression: A magnetic resonance diffusion tensor imaging study. J Neurol Neurosurg Psychiatry 77(1): 120.
73. Pacheco J, Beevers CG, Benavides C, McGeary J, Stice E, Schnyer DM. 2009. Frontal-limbic white matter pathway associations with the serotonin transporter gene promoter region (5-HTTLPR) polymorphism. J Neurosci 29(19): 6229-6233.
74. Pang PT, Lu B. 2004. Regulation of late-phase LTP and long-term memory in normal and aging hippocampus: Role of secreted proteins tPA and BDNF. Ageing Res Rev 3(4): 407-430.
75. Pierpaoli C, Basser PJ. 1996. Toward a quantitative assessment of diffusion anisotropy. Magn Reson Med 36(6): 893-906.
76. Prince M, Patel V, Saxena S, Maj M, Maselko J, Phillips MR, Rahman A. 2007. No health without mental health. Lancet 370(9590): 859-877.
77. Réus GZ, Stringari RB, Ribeiro KF, Cipriano AL, Panizzutti BS, Stertz L, Lersch C, Kapczinski F, Quevedo J. 2011. Maternal deprivation induces depressive-like behaviour and alters neurotrophin levels in the rat brain. Neurochem Res 36: 460-466.
78. Richter-Schmidinger T, Alexopoulos P, Horn M, Maus S, Reichel M, Rhein C, Lewczuk P, Sidiropoulos C, Kneib T, Perneczky R, et al. 2011. Influence of brain-derived neurotrophic-factor and apolipoprotein E genetic variants on hippocampal volume and memory performance in healthy young adults. J Neural Transm 118(2): 249-257.
79. Rohde GK, Barnett AS, Basser PJ, Marenco S, Pierpaoli C. 2004. Comprehensive approach for correction of motion and distortion in diffusion-weighted MRI. Magn Reson Med 51(1): 103-114.
80. Sage CA, Van Hecke W, Peeters R, Sijbers J, Robberecht W, Parizel P, Marchal G, Leemans A, Sunaert S. 2009. Quantitative diffusion tensor imaging in amyotrophic lateral sclerosis: Revisited. Hum Brain Mapp 30(11): 3657-3675.
81. Serretti A, Kato M, De Ronchi D, Kinoshita T. 2007. Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with selective serotonin reuptake inhibitor efficacy in depressed patients. Mol Psychiatry 12(3): 247-257.
82. Sexton C, Mackay C, Ebmeier K. 2009. A systematic review of diffusion tensor imaging studies in affective disorders. Biol Psychiatry 66(9): 814-823.
83. Shimony JS, Sheline YI, D'Angelo G, Epstein AA, Benzinger TLS, Mintun MA, McKinstry RC, Snyder AZ. 2009. Diffuse microstructural abnormalities of normal appearing white matter in late life depression: A diffusion tensor imaging study. Biol Psychiatry 66(3): 245.
84. Soliman F, Glatt CE, Bath KG, Levita L, Jones RM, Pattwell SS, Jing D, Tottenham N, Amso D, Somerville LH, et al. 2010. A genetic variant BDNF polymorphism alters extinction learning in both mouse and human. Science 327(5967): 863-866.
85. Spitzer RL, Williams JB, Gibbon M, First MB. 1992. The structured clinical interview for DSM-III-R (SCID). I: History, rationale, and description. Arch Gen Psychiatry 49(8): 624-629.
86. Sullivan PF, Neale MC, Kendler KS. 2000. Genetic epidemiology of major depression: Review and meta-analysis. Am J Psychiatry 157(10): 1552-1562.
87. Taylor WD, MacFall JR, Payne ME, McQuoid DR, Provenzale JM, Steffens DC, Krishnan KR. 2004. Late-life depression and microstructural abnormalities in dorsolateral prefrontal cortex white matter. Am J Psychiatry 161(7): 1293-1296.
88. Taylor WD, Macfall JR, Gerig G, Krishnan RR. 2007. Structural integrity of the uncinate fasciculus in geriatric depression: Relationship with age of onset. Neuropsychiatr Dis Treat 3(5): 669-674.
89. Taylor WD, MacFall JR, Boyd B, Payne ME, Sheline YI, Krishnan RR, Doraiswamy PM. 2010. One-year change in anterior cingulate cortex white matter microstructure: Relationship with late-life depression outcomes. Am J Geriatr Psychiatry.
90. Thomson W. 2012. Long term follow up of suicide in a clinically depressed community sample. J Affect Disord.
91. Tournier JD, Mori S, Leemans A. 2011. Diffusion tensor imaging and beyond. Magn Reson Med 65(6): 1532-1556.
92. Tuch DS, Reese TG, Wiegell MR, Makris N, Belliveau JW, Wedeen VJ. 2002. High angular resolution diffusion imaging reveals intravoxel white matter fiber heterogeneity. Magn Reson Med 48(4): 577-582.
93. Uher R. 2009. The role of genetic variation in the causation of mental illness: An evolution-informed framework. Mol Psychiatry 14(12): 1072-1082.
94. Van Hecke W, Sijbers J, D'Agostino E, Maes F, De Backer S, Vandervliet E, Parizel PM, Leemans A. 2008. On the construction of an inter-subject diffusion tensor magnetic resonance atlas of the healthy human brain. Neuroimage 43(1): 69-80.
95. Van Hecke W, Sijbers J, De Backer S, Poot D, Parizel PM, Leemans A. 2009. On the construction of a ground truth framework for evaluating voxel-based diffusion tensor MRI analysis methods. Neuroimage 46(3): 692-707.
96. Van Hecke W, Leemans A, De Backer S, Jeurissen B, Parizel PM, Sijbers J. 2010. Comparing isotropic and anisotropic smoothing for voxel-based DTI analyses: A simulation study. Hum Brain Mapp 31(1): 98-114.
97. Van Hecke W, Leemans A, Sage CA, Emsell L, Veraart J, Sijbers J, Sunaert S, Parizel PM. 2011. The effect of template selection on diffusion tensor voxel-based analysis results. Neuroimage 55(2): 566-573.
98. van Wingen G, Rijpkema M, Franke B, van Eijndhoven P, Tendolkar I, Verkes RJ, Buitelaar J, Fernandez G. 2010. The brain-derived neurotrophic factor Val66Met polymorphism affects memory formation and retrieval of biologically salient stimuli. Neuroimage 50(3): 1212-1218.
99. Verhagen M, van der Meij A, van Deurzen PA, Janzing JG, Arias-Vasquez A, Buitelaar JK, Franke B. 2010. Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: Effects of gender and ethnicity. Mol Psychiatry 15(3): 260-271.
100. Voineskos AN, Lerch JP, Felsky D, Shaikh S, Rajji TK, Miranda D, Lobaugh NJ, Mulsant BH, Pollock BG, Kennedy JL. 2011. The brain-derived neurotrophic factor Val66Met polymorphism and prediction of neural risk for Alzheimer disease. Arch Gen Psychiatry 68(2): 198-206.
101. Vos SB, Jones DK, Jeurissen B, Viergever MA, Leemans A. 2011a. The influence of complex white matter architecture on the mean diffusivity in diffusion tensor MRI of the human brain. Neuroimage.
102. Vos SB, Jones DK, Viergever MA, Leemans A. 2011b. Partial volume effect as a hidden covariate in DTI analyses. Neuroimage 55(4): 1566-1576.
103. Wheeler-Kingshott CA, Cercignani M. 2009. About "axial" and "radial" diffusivities. Magn Reson Med 61(5): 1255-1260.
104. Williams JB, Gibbon M, First MB, Spitzer RL, Davies M, Borus J, Howes MJ, Kane J, Pope HG Jr, Rounsaville B, et al. 1992. The structured clinical interview for DSM-III-R (SCID). II. Multisite test-retest reliability. Arch Gen Psychiatry 49(8): 630-636.
105. Wobrock T, Ecker UK, Scherk H, Schneider-Axmann T, Falkai P, Gruber O. 2009. Cognitive impairment of executive function as a core symptom of schizophrenia. World J Biol Psychiatry 10( 4 Pt 2): 442-451.
106. Yang Q, Huang X, Hong N, Yu X. 2007. White matter microstructural abnormalities in late-life depression. Int Psychogeriatr 19(4): 757-766.