IKK epsilon kinase is crucial for viral G protein-coupled receptor tumorigenesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 27, 2013, Pages 11139-11144

  Wang, Yi ^a   Lu, Xiaolu ^a   Zhu, Lining ^a   Shen, Yan ^a   Chengedza, Shylet ^a   Feng, Hao ^b   Wang, Laiyee ^a   Jung, Jae U ^a   Gutkind, Julio S ^c   Feng, Pinghui ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b HUNAN NORMAL UNIVERSITY   (China)

^c NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

Inflammation associated; Sarcomagenesis

Indexed keywords

G PROTEIN COUPLED RECEPTOR; I KAPPA B KINASE EPSILON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR RELA;

ARTICLE; CARCINOGENESIS; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN HERPESVIRUS 8; KAPOSI SARCOMA; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; VIRUS GENOME; VIRUS MUTANT;

INFLAMMATION ASSOCIATED; SARCOMAGENESIS;

ANIMALS; ENZYME ACTIVATION; HEK293 CELLS; HERPESVIRUS 8, HUMAN; HOST-PATHOGEN INTERACTIONS; HUMANS; I-KAPPA B KINASE; MICE; MICE, NUDE; PARACRINE COMMUNICATION; RECEPTORS, CHEMOKINE; SARCOMA, KAPOSI; TRANSCRIPTION FACTOR RELA; TRANSPLANTATION, HETEROLOGOUS; UP-REGULATION; VIRAL PROTEINS;

HERPESVIRIDAE; HUMAN HERPESVIRUS 8; MUS;

EID: 84879715851     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1219829110     Document Type: Article

References (39)

1. Soulier J, et al. (1995) Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood 86(4):1276-1280.
2. Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM (1995) Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med 332(18):1186-1191.
3. Chang Y, et al. (1994) Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266(5192):1865-1869.
4. Nador RG, Cesarman E, Knowles DM, Said JW (1995) Herpes-like DNA sequences in a body-cavity-based lymphoma in an HIV-negative patient. N Engl J Med 333(14):943.
5. Rezza G, et al. (1999) Human herpesvirus 8 seropositivity and risk of Kaposi's sarcoma and other acquired immunodefi ciency syndrome-related diseases. J Natl Cancer Inst 91(17):1468-1474. (Pubitemid 29424551)
6. Moore PS, Chang Y (2001) Molecular virology of Kaposi's sarcoma-associated herpesvirus. Philos Trans R Soc Lond B Biol Sci 356(1408):499-516. (Pubitemid 32442749)
7. Montaner S, et al. (2003) Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes. Cancer Cell 3(1):23-36. (Pubitemid 37443889)
8. Sun R, et al. (1999) Kinetics of Kaposi's sarcoma-associated herpesvirus gene expression. J Virol 73(3):2232-2242. (Pubitemid 29098128)
9. Yang TY, et al. (2000) Transgenic expression of the chemokine receptor encoded by human herpesvirus 8 induces an angioproliferative disease resembling Kaposi's sarcoma. J Exp Med 191(3):445-454.
10. Wess J (1997) G-protein-coupled receptors: Molecular mechanisms involved in receptor activation and selectivity of G-protein recognition. FASEB J 11(5):346-354.
11. Pierce KL, Premont RT, Lefkowitz RJ (2002) Seven-transmembrane receptors. Nat Rev Mol Cell Biol 3(9):639-650. (Pubitemid 34987785)
12. Arvanitakis L, Geras-Raaka E, Varma A, Gershengorn MC, Cesarman E (1997) Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation. Nature 385(6614):347-350.
13. Dorsam RT, Gutkind JS (2007) G-protein-coupled receptors and cancer. Nat Rev Cancer 7(2):79-94. (Pubitemid 46164746)
14. Sodhi A, et al. (2006) The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. Cancer Cell 10(2):133-143. (Pubitemid 44175903)
15. Martin D, et al. (2011) PI3Kγ mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis. Cancer Cell 19(6):805-813.
16. Martin D, Galisteo R, Ji Y, Montaner S, Gutkind JS (2008) An NF-kappaB gene expression signature contributes to Kaposi's sarcoma virus vGPCR-induced direct and paracrine neoplasia. Oncogene 27(13):1844-1852. (Pubitemid 351430813)
17. Chen ZJ (2005) Ubiquitin signalling in the NF-kappaB pathway. Nat Cell Biol 7(8):758-765.
18. Häcker H, Karin M (2006) Regulation and function of IKK and IKK-related kinases. Sci STKE 2006(357):re13.
19. Perkins ND (2007) Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol 8(1):49-62.
20. Hayden MS, Ghosh S (2008) Shared principles in NF-kappaB signaling. Cell 132(3):344-362.
21. Siebenlist U, Franzoso G, Brown K (1994) Structure, regulation and function of NFkappa B. Annu Rev Cell Biol 10:405-455.
22. Verma IM, Stevenson JK, Schwarz EM, Van Antwerp D, Miyamoto S (1995) Rel/NF-kappa B/I kappa B family: Intimate tales of association and dissociation. Genes Dev 9(22):2723-2735. (Pubitemid 3009952)
23. Hanahan D, Weinberg RA (2011) Hallmarks of cancer: The next generation. Cell 144(5):646-674.
24. Sharma S, et al. (2003) Triggering the interferon antiviral response through an IKK-related pathway. Science 300(5622):1148-1151. (Pubitemid 36583100)
25. Fitzgerald KA, et al. (2003) IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol 4(5):491-496. (Pubitemid 36592443)
26. Shimada T, et al. (1999) IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases. Int Immunol 11(8):1357-1362. (Pubitemid 29355675)
27. Tenoever BR, et al. (2007) Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity. Science 315(5816):1274-1278.
28. Boehm JS, et al. (2007) Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell 129(6):1065-1079. (Pubitemid 46891036)
29. Clément JF, Meloche S, Servant MJ (2008) The IKK-related kinases: From innate immunity to oncogenesis. Cell Res 18(9):889-899.
30. Hayward GS (2003) Initiation of angiogenic Kaposi's sarcoma lesions. Cancer Cell 3(1):1-3.
31. Cesarman E, Mesri EA, Gershengorn MC (2000) Viral G protein-coupled receptor and Kaposi's sarcoma: A model of paracrine neoplasia? J Exp Med 191(3):417-422.
32. Moreno R, Sobotzik JM, Schultz C, Schmitz ML (2010) Specification of the NF-kappaB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKK epsilon. Nucleic Acids Res 38(18):6029-6044.
33. Mattioli I, et al. (2006) Inducible phosphorylation of NF-kappa B p65 at serine 468 by T cell costimulation is mediated by IKK epsilon. J Biol Chem 281(10):6175-6183. (Pubitemid 43847547)
34. Guasparri I, Keller SA, Cesarman E (2004) KSHV vFLIP is essential for the survival of infected lymphoma cells. J Exp Med 199(7):993-1003. (Pubitemid 38481090)
35. Reilly SM, et al. (2013) An inhibitor of the protein kinases TBK1 and IKK-varepsilon improves obesity-related metabolic dysfunctions in mice. Nat Med 19(3):313-321.
36. Ben-Neriah Y, Karin M (2011) Inflammation meets cancer, with NF-κB as the matchmaker. Nat Immunol 12(8):715-723.
37. Dong X, et al. (2012) Murine gammaherpesvirus 68 evades host cytokine production via replication transactivator-induced RelA degradation. J Virol 86(4):1930-1941.
38. Mao X, et al. (2009) GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelA. Genes Dev 23(7):849-861.
39. Dong X, Feng P (2011) Murine gamma herpesvirus 68 hijacks MAVS and IKKβ to abrogate NF-κB activation and antiviral cytokine production. PLoS Pathog 7(11):e1002336.