Murine gammaherpesvirus 68 evades host cytokine production via replication transactivator-induced RelA degradation

Journal of Virology

Volumn 86, Issue 4, 2012, Pages 1930-1941

  Dong, Xiaonan ^a   He, Zhiheng ^b   Durakoglugil, Deniz ^a   Arneson, Lisa ^a   Shen, Yan ^a   Feng, Pinghui ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; REPLICATION TRANSACTIVATOR; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR RELA; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA VIRUS INFECTION; GAMMAHERPESVIRINAE; MOUSE; MURINE GAMMAHERPESVIRUS 68; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UBIQUITINATION; VIRUS RECOMBINANT; WILD TYPE;

ANIMALS; CELL LINE; CYTOKINES; FEMALE; HERPESVIRIDAE INFECTIONS; HUMANS; IMMEDIATE-EARLY PROTEINS; IMMUNE EVASION; MALE; MICE; MICE, INBRED C57BL; PROTEIN BINDING; RHADINOVIRUS; RODENT DISEASES; TRANSCRIPTION FACTOR RELA; VIRAL PROTEINS;

MURINAE;

EID: 84857070553     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.06127-11     Document Type: Article

References (41)

1. Akira S, Uematsu S, Takeuchi O. 2006. Pathogen recognition and innate immunity. Cell 124:783- 801.
2. Ben-Neriah Y, Karin M. 2011. Inflammation meets cancer, with NFkappaB as the matchmaker. Nat. Immunol. 12:715-723.
3. Borst EM, Crnkovic-Mertens I, Messerle M. 2004. Cloning of betaherpesvirus genomes as bacterial artificial chromosomes. Methods Mol. Biol. 256:221-239.
4. Brown HJ, et al. 2003. NF-kappaB inhibits gammaherpesvirus lytic replication. J. Virol. 77:8532-8540.
5. Carbone A, Cesarman E, Spina M, Gloghini A, Schulz TF. 2009. HIV-associated lymphomas and gamma-herpesviruses. Blood 113:1213- 1224.
6. Chang Y, et al. 1994. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266:1865-1869.
7. Chaudhary PM, Jasmin A, Eby MT, Hood L. 1999. Modulation of the NF-kappa B pathway by virally encoded death effector domainscontaining proteins. Oncogene 18:5738-5746.
8. Chen LF, Greene WC. 2004. Shaping the nuclear action of NF-kappaB. Nat. Rev. Mol. Cell Biol. 5:392-401.
9. Chen ZJ, Parent L, Maniatis T. 1996. Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity. Cell 84:853-862.
10. Dong X, et al. 2010. Murine gamma-herpesvirus 68 hijacks MAVS and IKKbeta to initiate lytic replication. PLoS Pathog. 6:e1001001.
11. Dong X, Feng P. 2011. Dissecting host-virus interaction in lytic replication of a model herpesvirus. J. Vis. Exp. 2011(56):pii=3140. doi:10.3791/3140.
12. Dong X, Feng P. 2011. Murine gamma herpesvirus 68 hijacks MAVS and IKKbeta to abrogate NFkappaB activation and antiviral cytokine production. PLoS Pathog. 7:e1002336.
13. Feng P, et al. 2007. A novel inhibitory mechanism of mitochondriondependent apoptosis by a herpesviral protein. PLoS Pathog. 3:e174.
14. Geng H, Wittwer T, Dittrich-Breiholz O, Kracht M, Schmitz ML. 2009. Phosphorylation of NF-kappaB p65 at Ser468 controls its COMMD1- dependent ubiquitination and target gene-specific proteasomal elimination. EMBO Rep. 10:381-386.
15. Gould F, Harrison SM, Hewitt EW, Whitehouse A. 2009. Kaposi's sarcoma-associated herpesvirus RTA promotes degradation of the Hey1 repressor protein through the ubiquitin proteasome pathway. J. Virol. 83:6727- 6738.
16. Hammarskjöld ML, Simurda MCMC. 1992. Epstein-Barr virus latent membrane protein transactivates the human immunodeficiency virus type 1 long terminal repeat through induction of NF-kappa B activity. J. Virol. 66:6496-6501.
17. Hirt B. 1967. Selective extraction of polyoma DNA from infected mouse cell cultures. J. Mol. Biol. 26:365-369.
18. Kawai T, Akira S. 2010. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 11:373- 384.
19. Krug LT, Moser JM, Dickerson SM, Speck SH. 2007. Inhibition of NF-kappaB activation in vivo impairs establishment of gammaherpesvirus latency. PLoS Pathog. 3:e11.
20. Li X, Liang D, Lin X, Robertson ES, Lan K. 2011. Kaposi's sarcomaassociated herpesvirus-encoded latency-associated nuclear antigen reduces interleukin-8 expression in endothelial cells and impairs neutrophil chemotaxis by degrading nuclear p65. J. Virol. 85:8606-8615.
21. Maine GN, Mao X, Komarck CM, Burstein E. 2007. COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullincontaining ubiquitin ligase. EMBO J. 26:436-447.
22. Mao X, et al. 2009. GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelA. Genes Dev. 23:849-861.
23. Matta H, Chaudhary PM. 2004. Activation of alternative NF-kappa B pathway by human herpes virus 8-encoded Fas-associated death domainlike IL-1 beta-converting enzyme inhibitory protein (vFLIP). Proc. Natl. Acad. Sci. U. S. A. 101:9399 -9404.
24. Medzhitov R. 2007. Recognition of microorganisms and activation of the immune response. Nature 449:819-826.
25. Mercurio F, et al. 1997. IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. Science 278:860-866.
26. Paludan SR, Bowie AG, Horan KA, Fitzgerald KA. 2011. Recognition of herpesviruses by the innate immune system. Nat. Rev. Immunol. 11:143- 154.
27. Perkins ND. 2006. Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway. Oncogene 25:6717- 6730.
28. Rodrigues L, et al. 2009. Termination of NF-kappaB activity through a gammaherpesvirus protein that assembles an EC5S ubiquitin-ligase. EMBO J. 28:1283-1295.
29. Ryo A, et al. 2003. Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Mol. Cell 12:1413-1426.
30. Siebenlist U, Franzoso G, Brown K. 1994. Structure, regulation and function of NF-kappa B. Annu. Rev. Cell Biol. 10:405- 455.
31. Song MJ, et al. 2005. Identification of viral genes essential for replication of murine gamma-herpesvirus 68 using signature-tagged mutagenesis. Proc. Natl. Acad. Sci. U. S. A. 102:3805-3810.
32. Speck SH, Ganem D. 2010. Viral latency and its regulation: lessons from the gamma-herpesviruses. Cell Host Microbe 8:100 -115.
33. Speck SH, Virgin HW. 1999. Host and viral genetics of chronic infection: a mouse model of gamma-herpesvirus pathogenesis. Curr. Opin. Microbiol. 2:403- 409.
34. Strebovsky J, Walker P, Lang R, Dalpke AH. 2011. Suppressor of cytokine signaling 1 (SOCS1) limits NFkappaB signaling by decreasing p65 stability within the cell nucleus. FASEB J. 25:863- 874.
35. Tanaka T, Grusby MJ, Kaisho T. 2007. PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit. Nat. Immunol. 8:584 -591.
36. Thoms HC, et al. 2010. Nucleolar targeting of RelA(p65) is regulated by COMMD1-dependent ubiquitination. Cancer Res. 70:139 -149.
37. Verma IM, Stevenson JK, Schwarz EM, Van Antwerp D, Miyamoto S. 1995. Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev. 9:2723-2735.
38. Yada K, et al. 2006. KSHV RTA induces a transcriptional repressor, HEY1 that represses rta promoter. Biochem. Biophys. Res. Commun. 345:410- 418.
39. Yang Z, Yan Z, Wood C. 2008. Kaposi's sarcoma-associated herpesvirus transactivator RTA promotes degradation of the repressors to regulate viral lytic replication. J. Virol. 82:3590 -3603.
40. Yu Y, Hayward GS. 2010. The ubiquitin E3 ligase RAUL negatively regulates type I interferon through ubiquitination of the transcription factors IRF7 and IRF3. Immunity 33:863-877.
41. Yu Y, Wang SE, Hayward GS. 2005. The KSHV immediate-early transcription factor RTA encodes ubiquitin E3 ligase activity that targets IRF7 for proteosome-mediated degradation. Immunity 22:59 -70.