Mono-carbonyl curcumin analogues as 11β-hydroxysteroid dehydrogenase 1 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 15, 2013, Pages 4362-4366

  Lin, Han ^a,b   Hu, Guo Xin ^a   Guo, Jingjing ^a   Ge, Yufei ^b   Liang, Guang ^a   Lian, Qing Quan ^a   Chu, Yanhui ^c   Yuan, Xiaohuan ^c   Huang, Ping ^d   Ge, Ren Shan ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b ROCKEFELLER UNIVERSITY   (United States)

^c MUDANJIANG MEDICAL UNIVERSITY   (China)

^d Tongde Hospital of Zhejiang Province   (China)

Author keywords

11 HSD1; 11 HSD2; Inhibitors; Mono carbonyl curcumin analogues

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; 11BETA HYDROXYSTEROID DEHYDROGENASE 1 INHIBITOR; CARBONYL DERIVATIVE; CURCUMIN; CYCLOHEXANONE DERIVATIVE; CYCLOPENTANONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; MICROSOME; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; ANIMALS; CURCUMIN; ENZYME INHIBITORS; HUMANS; MICROSOMES; PROTEIN BINDING; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 84879696196     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.05.080     Document Type: Article

References (23)

1. R.C. Andrews, and B.R. Walker Clin. Sci (Lond.) 96 1999 513
2. B.S. McEwen J. Clin. Endocrinol. Metab. 2002 1947 87
3. J.W. Tomlinson, E.A. Walker, I.J. Bujalska, N. Draper, G.G. Lavery, M.S. Cooper, M. Hewison, and P.M. Stewart Endocr. Rev. 25 2004 831
4. P.C. White, T. Mune, and A.K. Agarwal Endocr. Rev. 18 1997 135
5. R. Ge, Y. Huang, G. Liang, and X. Li Curr. Med. Chem 17 5 2010 412 422
6. H. Masuzaki, J. Paterson, H. Shinyama, N.M. Morton, J.J. Mullins, J.R. Seckl, and J.S. Flier Science 294 2001 2166
7. N.M. Morton, M.C. Holmes, C. Fievet, B. Staels, A. Tailleux, J.J. Mullins, and J.R. Seckl J. Biol. Chem. 276 2001 41293
8. N. Vicker, X. Su, D. Ganeshapillai, A. Smith, A. Purohit, M.J. Reed, and B.V. Potter J. Steroid Biochem. Mol. Biol. 104 2007 123
9. K.A. Hughes, S.P. Webster, and B.R. Walker Expert Opin. Investig. Drugs 17 2008 481
10. I.J. Bujalska, L.L. Gathercole, J.W. Tomlinson, C. Darimont, J. Ermolieff, A.N. Fanjul, P.A. Rejto, and P.M. Stewart J. Endocrinol. 197 2008 297
11. A. Goel, A.B. Kunnumakkara, and B.B. Aggarwal Biochem. Pharmacol. 75 2008 787
12. G. Liang, X. Li, L. Chen, S. Yang, X. Wu, E. Studer, E. Gurley, P.B. Hylemon, F. Ye, Y. Li, and H. Zhou Bioorg. Med. Chem. Lett. 18 2008 1525
13. G. Liang, H. Zhou, Y. Wang, E.C. Gurley, B. Feng, L. Chen, J. Xiao, S. Yang, and X. Li J. Cell Mol. Med. 13 9B 2009 3370 3379
14. G. Liang, L. Shao, Y. Wang, C. Zhao, Y. Chu, J. Xiao, Y. Zhao, X. Li, and S. Yang Bioorg. Med. Chem. 17 2009 2623
15. G. Liang, S. Yang, L. Jiang, Y. Zhao, L. Shao, J. Xiao, F. Ye, Y. Li, and X. Li Chem. Pharm. Bull. (Tokyo) 56 2008 162
16. J. Guo, X. Yuan, L. Qiu, W. Zhu, C. Wang, G. Hu, Y. Chu, L. Ye, Y. Xu, and R.S. Ge Toxicol. Lett. 215 2012 126
17. C. Monder, P.M. Stewart, V. Lakshmi, R. Valentino, D. Burt, and C.R. Edwards Endocrinology 125 1989 1046
18. R.S. Ge, H.B. Gao, V.L. Nacharaju, G.L. Gunsalus, and M.P. Hardy Endocrinology 138 1997 2435
19. R.S. Ge, and M.P. Hardy Endocrinology 139 1998 3787
20. R.S. Ge, and M.P. Hardy J. Androl. 21 2000 303
21. R.-S. Ge, Q. Dong, E.-m. Niu, C.M. Sottas, D.O. Hardy, J.F. Catterall, S.A. Latif, D.J. Morris, and M.P. Hardy Endocrinology 146 2005 2657
22. G. Liang, S.L. Yang, L.L. Shao, C.G. Zhao, J. Xiao, Y.X. Lv, J. Yang, Y. Zhao, and X.K. Li J. Asian Nat. Prod. Res. 10 2008 957
23. G.X. Hu, G. Liang, Y. Chu, X. Li, Q.Q. Lian, H. Lin, Y. He, Y. Huang, D.O. Hardy, and R.S. Ge Bioorg. Med. Chem. Lett. 20 2010 2549