Simple synthesis of carbon-11-labeled chromen-4-one derivatives as new potential PET agents for imaging of DNA-dependent protein kinase (DNA-PK) in cancer

Applied Radiation and Isotopes

Volumn 70, Issue 8, 2012, Pages 1558-1563

  Gao, Mingzhang ^a   Wang, Min ^a   Miller, Kathy D ^a   Zheng, Qi Huang ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer; Carbon 11 labeled chromen 4 one derivatives; DNA dependent protein kinase (DNA PK); Positron emission tomography (PET); Radiosynthesis

Indexed keywords

CANCER; DNA-DEPENDENT PROTEIN KINASE; DNA-REPAIR ENZYMES; RADIOCHEMICAL YIELD; RADIOSYNTHESIS; SOLID PHASE EXTRACTION METHOD; SPECIFIC ACTIVITY;

ALKYLATION; BIOSYNTHESIS; CARBON; CARBON DIOXIDE; DISEASES; ENZYMES; POSITRON EMISSION TOMOGRAPHY; PROTEINS;

DNA;

1 (2 HYDROXY 3 METHOXYPHENYL) 3 MORPHOLINOPROPANE 1,3 DIONE; 1 (2 HYDROXY 4 METHOXYPHENYL) 3 MORPHOLINOPROPANE 1,3 DIONE; 1 (2 HYDROXY 5 METHOXYPHENYL) 3 MORPHOLINOPROPANE 1,3 DIONE; 1 (2 HYDROXY 6 METHOXYPHENYL) 3 MORPHOLINOPROPANE 1,3 DIONE; 5 HYDROXY 2 MORPHOLINO 4H CHROMEN 4 ONE; 5 METHOXY 2 MORPHOLINO 4H CHROMEN 4 ONE; 5 METHOXY 2 MORPHOLINO 4H CHROMEN 4 ONE C 11; 6 HYDROXY 2 MORPHOLINO 4H CHROMEN 4 ONE; 6 METHOXY 2 MORPHOLINO 4H CHROMEN 4 ONE; 6 METHOXY 2 MORPHOLINO 4H CHROMEN 4 ONE C 11; 7 HYDROXY 2 MORPHOLINO 4H CHROMEN 4 ONE; 7 METHOXY 2 MORPHOLINO 4H CHROMEN 4 ONE; 7 METHOXY 2 MORPHOLINO 4H CHROMEN 4 ONE C 11; 8 HYDROXY 2 MORPHOLINO 4H CHROMEN 4 ONE; 8 METHOXY 2 MORPHOLINO 4H CHROMEN 4 ONE; 8 METHOXY 2 MORPHOLINO 4H CHROMEN 4 ONE C 11; CARBON 11; CHROMEN 4 ONE C 11 DERIVATIVE; CHROMEN 4 ONE DERIVATIVE; DNA DEPENDENT PROTEIN KINASE; HYDROXY 2 MORPHOLINO 4H CHROMEN 4 ONE DERIVATIVE; METHOXY 2 MORPHOLINO 4H CHROMEN 4 ONE C 11 DERIVATIVE; METHYL 2 HYDROXY 3 METHOXYBENZOIC ACID; METHYL 2 HYDROXY 4 METHOXYBENZOIC ACID; METHYL 2 HYDROXY 5 METHOXYBENZOIC ACID; METHYL 2 HYDROXY 6 METHOXYBENZOIC ACID; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ARTICLE; DNA REPAIR; DRUG DESIGN; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; END OF BOMBARDMENT; END OF SYNTHESIS; ENZYME ANALYSIS; ISOTOPE LABELING; MALIGNANT NEOPLASTIC DISEASE; METHYLATION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOACTIVITY; RADIOGRAPHY; RADIOISOTOPE DECAY; RADIOLOGICAL PARAMETERS; SOLID PHASE EXTRACTION;

BENZOPYRANS; CARBON RADIOISOTOPES; DNA-ACTIVATED PROTEIN KINASE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84862627487     PISSN: 09698043     EISSN: 18729800     Source Type: Journal    
DOI: 10.1016/j.apradiso.2012.04.023     Document Type: Article

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