Selective inhibition of human acetylcholinesterase by xanthine derivatives: In vitro inhibition and molecular modeling investigations

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 15, 2013, Pages 4336-4341

  Mohamed, Tarek ^a   Osman, Wesseem ^a   Tin, Gary ^a   Rao, Praveen P N ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

Author keywords

Acetylcholine (ACh); Acetylcholinesterase (AChE); Alzheimer's disease (AD); Butyrylcholinesterase (BuChE); Central nervous system (CNS); Cholinesterase inhibitors (ChEIs); Peripheral anionic site (PAS)

Indexed keywords

ACETYLCHOLINESTERASE; CAFFEINE; CHOLINESTERASE; DONEPEZIL; PENTOXIFYLLINE; PROPENTOFYLLINE; TACRINE; XANTHINE;

ARTICLE; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME INHIBITION; IC 50; IN VITRO STUDY; MOLECULAR MODEL;

ACETYLCHOLINESTERASE; BINDING SITES; BUTYRYLCHOLINESTERASE; CAFFEINE; CATALYTIC DOMAIN; CHOLINESTERASE INHIBITORS; HUMANS; HYDROGEN BONDING; MOLECULAR DOCKING SIMULATION; PENTOXIFYLLINE; PROTEIN BINDING; THERMODYNAMICS; XANTHINE; XANTHINES;

EID: 84879690631     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.05.092     Document Type: Article

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