Passage-dependent cancerous transformation of human mesenchymal stem cells under carcinogenic hypoxia

FASEB Journal

Volumn 27, Issue 7, 2013, Pages 2788-2798

  Crowder, Spencer W ^a,b   Horton, Linda W ^b,d   Lee, Sue Hyun ^a   McClain, Colt M ^c   Hawkins, Oriana E ^b,d   Palmer, Amanda M ^a   Bae, Hojae ^e   Richmond, Ann ^b,d   Sung, Hak Joon ^a,b,e  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^d DEPARTMENT OF VETERANS AFFAIRS   (United States)

^e Kyung Hee University   (South Korea)

Author keywords

Aging; Experimental models; p53; Reactive oxygen species

Indexed keywords

MYC PROTEIN; NICKEL; PROTEIN P53; REACTIVE OXYGEN METABOLITE; TUMOR SUPPRESSOR PROTEIN;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CARCINOGENESIS; CARCINOGENICITY; CELL DIVISION; CELL HYPOXIA; CELL PROLIFERATION; DISEASE COURSE; HUMAN; HUMAN CELL; IN VIVO STUDY; MESENCHYMAL STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SENESCENCE;

AGING; EXPERIMENTAL MODELS; P53; REACTIVE OXYGEN SPECIES;

ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL HYPOXIA; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; DNA-BINDING PROTEINS; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MESENCHYMAL STROMAL CELLS; MICE; MICE, KNOCKOUT; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; NICKEL; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSPLANTATION, HETEROLOGOUS; TUMOR BURDEN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84879650632     PISSN: None     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.13-228288     Document Type: Article

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