PARG dysfunction enhances DNA double strand break formation in S-phase after alkylation DNA damage and augments different cell death pathways

Cell Death and Disease

Volumn 4, Issue 6, 2013, Pages

  Shirai, H ^a   Poetsch, A R ^a   Gunji, A ^a   Maeda, D ^a   Fujimori, H ^a   Fujihara, H ^a   Yoshida, T ^a   Ogino, H ^a   Masutani, M ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

alkylating agent; cell death pathway; DNA strand break; PARG; S phase arrest

Indexed keywords

CALPAIN; CASPASE; GENOMIC DNA; GLYCOSIDASE; HISTONE H2AX; MESYLIC ACID METHYL ESTER; POLY(ADENOSINE DIPHOSPHATE RIBOSE); POLY(ADENOSINE DIPHOSPHATE RIBOSE)GLYCOHYDROLASE; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE S PHASE; CELL DEATH; CELL MEMBRANE; CHEMOSENSITIZATION; CONTROLLED STUDY; DNA ALKYLATION; DNA DAMAGE; DNA FRAGMENTATION; DOUBLE STRANDED DNA BREAK; ENZYME ACTIVITY; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN INDUCTION;

EID: 84879641430     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.133     Document Type: Article

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