Synergistic cytotoxicity of N-methyl-N′-nitro-N-nitrosoguanidine and absence of poly(ADP-ribose) glycohydrolase involves chromatin decondensation

International Journal of Oncology

Volumn 39, Issue 1, 2011, Pages 121-127

  Zhou, Yiran ^a   Feng, Xiaoxing ^a   Koh, David W ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

Chromatin decondensation; Histones; PAR; PARG; PARP; Poly(ADP ribose)

Indexed keywords

6 O METHYLGUANINE; GENOMIC DNA; HISTONE H1; HISTONE H2B; METHYLNITRONITROSOGUANIDINE; NICOTINAMIDE ADENINE DINUCLEOTIDE NUCLEOSIDASE; POLY(ADENOSINE DIPHOSPHATE RIBOSE);

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMATIN CONDENSATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA ALKYLATION; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG POTENTIATION; EMBRYO; EMBRYONIC STEM CELL; ENZYME INHIBITION; HISTONE MODIFICATION; MOUSE; NONHUMAN; NULL ALLELE; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; TROPHOBLAST; TUMOR CELL DESTRUCTION; WILD TYPE;

ALKYLATING AGENTS; ALKYLATION; ANIMALS; CELL DEATH; CELLS, CULTURED; CHROMATIN; DNA; DRUG SYNERGISM; EMBRYONIC STEM CELLS; GLYCOSIDE HYDROLASES; HISTONES; HUMANS; MICE; NITROSOGUANIDINES;

EID: 79956021767     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2011.1013     Document Type: Article

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