Effect of pantoprazole on human gastric adenocarcinoma SGC7901 cells through regulation of phospho-LRP6 expression in Wnt/β-catenin signaling

Oncology Reports

Volumn 30, Issue 2, 2013, Pages 851-855

  Shen, Weidong ^a   Zou, Xiaoping ^b   Chen, Min ^b   Shen, Yonghua ^b   Huang, Shuling ^b   Guo, Huimin ^b   Zhang, Lili ^b   Liu, Pengfei ^a  

^a SOUTHEAST UNIVERSITY   (China)

^b NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Gastric cancer; Pantoprazole; Signaling; Vacuolar ATPases; Wnt catenin

Indexed keywords

BETA CATENIN; CYCLIN D1; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; PANTOPRAZOLE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; WNT PROTEIN;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; CYCLIN D1 GENE; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; STOMACH ADENOCARCINOMA; WESTERN BLOTTING; WNT SIGNALING PATHWAY;

2-PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES; ADENOCARCINOMA; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN D1; HUMANS; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-6; NEOPLASM INVASIVENESS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-MYC; STOMACH NEOPLASMS; TUMOR MICROENVIRONMENT; VACUOLAR PROTON-TRANSLOCATING ATPASES; WNT SIGNALING PATHWAY;

EID: 84879640580     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2524     Document Type: Article

References (33)

1. Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin 55: 74-108, 2005. (Pubitemid 40372904)
2. Chiche J, Brahimi-Horn MC and Pouysségur J: Tumor hypoxia induces a metatloic shift causing acidosis: a common feature in cancer. J Cell Mol Med 14: 771-794, 2010.
3. Trédan O, Galmarini CM, Patel K and Tannock IF: Drug resistance and the solid tumor microenvironment. J Natl Cancer Inst 99: 1441-1454, 2007.
4. Subarsky P and Hill RP: The hypoxic tumour microenvironment and metastatic progression. Clin Exp Metastasis 20: 237-250, 2003. (Pubitemid 36513228)
5. +-ATPase in human breast cancer cells with distinct metastatic potential: distribution and functional activity. Am J Physiol Cell Physiol 286: 1443-1452, 2004.
6. Lu X, Qin W, Li J, et al: The growth and metastasis of human hepatocellular carcinoma xenografts are inhibited by small interfering RNA targeting to the subunit ATP6L of proton pump. Cancer Res 65: 6843-6849, 2005. (Pubitemid 41060723)
7. Martinez-Zaguilan R, Lynch RM, Martinez GM and Gillies RJ: Vacuolar-type H(+)-ATPases are functionally expressed in the plasma membranes of human tumor cells. Am J Physiol 265: C1015-C1029, 1993.
8. +-ATPases as a new strategy against cancer. Cancer Res 67: 10627-10630, 2007.
9. Barrison AF, Jarboe LA, Weinberg BM, et al: Patterns of proton pump inhibitor use in clinical practice. Am J Med 111: 469-473, 2011.
10. Chen M, Zou XP, Luo HS, et al: Effects and mechanisms of proton pump inhibitors as a novel chemosensitizer on human gastric adenocarcinoma (SGC7901) cells. Cell Biol Int 33: 1008-1019, 2009.
11. Peifer M and Polakis P: Wnt signaling in oncogenesis and embryogenesis - a look outside the nucleus. Science 287: 1606-1609, 2000. (Pubitemid 30127755)
12. Nishi T and Forgac M: The vacuolar (H+)-ATPases - nature's most versatile proton pumps. Nat Rev Mol Cell Biol 3: 94-103, 2002.
13. Swietach P, Vaughan-Jones RD and Harris AL: Regulation of tumor pH and the role of carbonic anhydrase 9. Cancer Metastasis Rev 26: 299-310, 2007. (Pubitemid 47101667)
14. +-ATPase in cancer biology. Cell Biochem Biophys 40: 185-206, 2004.
15. De Milito A, Canese R, Marino ML, et al: pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity. Int J Cancer 127: 207-219, 2009.
16. Luciani F, Spada M, De Milito A, et al: Effect of proton pump inhibitor pretreatment on resistance of solid tumors to cytotoxic drugs. J Natl Cancer Inst 96: 1702-1713, 2004. (Pubitemid 39585639)
17. Yeo M, Kim DK, Kim YB, et al: Selective induction of apoptosis with proton pump inhibitor in gastric cancer cells. Clin Cancer Res 10: 8687-8696, 2004. (Pubitemid 40053438)
18. De Milito A, Iessi E, Logozzi M, et al: Proton pump inhibitors induce apoptosis of human B-cell tumors through a caspase-independent mechanism involving reactive oxygen species. Cancer Res 67: 5408-5417, 2007. (Pubitemid 46997281)
19. Bowman EJ, Siebers A and Altendorf K: Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. Proc Natl Acad Sci USA 85: 7972-7976, 1998.
20. Melikova MS, Blagoveshchenskaia AD, Nikol'skiǐ NN and Kornilova ES: Effect of an vacuolar proton pump inhibitor bafilomycin A1 on the intracellular processing of markers for receptor-mediated and liquid phase endocytosis. Tsitologiia 44: 807-816, 2002 (In Russian).
21. +-ATPase inhibitor on cell and tumor response to camptothecins. J Pharmacol Exp Ther 318: 939-946, 2006.
22. Niikura K: Effect of a V-ATPase inhibitor, FR202126, in syngeneic mouse model of experimental bone metastasis. Cancer Chemother Pharmacol 60: 555-562, 2007.
23. Hesselink RW, Fedorov A, Hemminga MA and Prieto M: Membrane-bound peptides from V-ATPases subunit a do not interact with an indole-type inhibitor. J Pept Sci 14: 383-388, 2008. (Pubitemid 351540895)
24. Polakis P: Wnt signaling and cancer. Genes Dev 14: 1837-1851, 2000.
25. Korinek V, Barker N, Morin PJ, et al: Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-/-colon carcinoma. Science 275: 1784-1787, 1997. (Pubitemid 27136714)
26. Rubinfeld B, Robbins P, El-Gamil M, et al: Stabilization of β-catenin by genetic defects in melanoma cell lines. Science 275: 1790-1792, 1997. (Pubitemid 27136716)
27. Satoh S, Daigo Y, Furukawa Y, et al: AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus mediated transfer of AXIN1. Nat Genet 24: 245-250, 2002. (Pubitemid 30132191)
28. de La Coste A, Romagnolo B, Billuart P, et al: Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas. Proc Natl Acad Sci USA 95: 8847-8851, 1998. (Pubitemid 28350577)
29. Merle P, de la Monte S, Kim M, et al: Functional consequences of frizzled-7 receptor overexpression in human hepatocellular carcinoma. Gastroenterology 127: 1110-1122, 2004. (Pubitemid 39345880)
30. +-ATPase-mediated acidification for Wnt signaling. Science 327: 459-463, 2010.
31. Blitzer JT and Nusse R: A critical role for endocytosis in Wnt signaling. BMC Cell Biol 7: 28, 2006.
32. Yamamoto H, Komekado H and Kikuchi A: Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of β-catenin. Dev Cell 11: 213-223, 2006. (Pubitemid 44138502)
33. Wang J, Wang X, Gong W, et al: Increased expression of β-catenin, phosphorylated glycogen synthase kinase 3β, cyclin D1, and c-myc in laterally spreading colorectal tumors. J Histochem Cytochem 57: 363-371, 2009.