In vitro anticancer activity, toxicity and structure-activity relationships of phyllostictine A, a natural oxazatricycloalkenone produced by the fungus Phyllosticta cirsii

Toxicology and Applied Pharmacology

Volumn 254, Issue 1, 2011, Pages 8-17

  Le Calvé, Benjamin ^a   Lallemand, Benjamin ^a   Perrone, Carmen ^b   Lenglet, Gaëlle ^c   Depauw, Sabine ^c   Van Goietsenoven, Gwendoline ^a   Bury, Marina ^a   Vurro, Maurizio ^d   Herphelin, Françoise ^e   Andolfi, Anna ^b   Zonno, Maria Chiara ^d   Mathieu, Véronique ^a   Dufrasne, François ^a   Van Antwerpen, Pierre ^a   Poumay, Yves ^e   David Cordonnier, Marie Hélène ^c   Evidente, Antonio ^b   Kiss, Robert ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c JEAN PIERRE AUBERT RESEARCH CENTER   (France)

^d INSTITUTE OF SCIENCES OF FOOD PRODUCTION   (Italy)

^e UNIVERSITY OF NAMUR   (Belgium)

Author keywords

Apoptosis; Cancer cells; Cell death; Cell proliferation; Chemical stability; Hemisyntheses; In vitro; Normal cells; Phyllostictines; Videomicroscopy

Indexed keywords

ACRYLAMIDE; ANTINEOPLASTIC AGENT; DNA; GLUTATHIONE; PHYLLOSTICTINE A; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CHEMICAL BOND; CONTROLLED STUDY; CYTOTOXICITY; FUNGUS; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PHYLLOSTICTA CIRSII; STRUCTURE ACTIVITY RELATION;

ALKYLATION; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; ASCOMYCOTA; CELL CYCLE; CELL LINE; CELL LINE, TUMOR; DNA; GLUTATHIONE; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; MICROSCOPY, VIDEO; NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP;

FUNGI; PHYLLOSTICTA;

EID: 79958006806     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.03.027     Document Type: Article

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