Vinblastine-induced apoptosis of melanoma cells is mediated by Ras homologous A protein (Rho A) via mitochondrial and non-mitochondrial-dependent mechanisms

Apoptosis

Volumn 18, Issue 8, 2013, Pages 980-997

  Selimovic, Denis ^a,b   Badura, Helene E ^c   El Khattouti, Abdelouahid ^d   Soell, Martine ^a,b   Porzig, Benjamin B O W ^c   Spernger, Achim ^c   Ghanjati, Foued ^c   Santourlidis, Simeon ^c   Haikel, Youssef ^a,b   Hassan, Mohamed ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^d UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

Apoptosis; ER stress; MAP kinase; Mitochondrial dysregulation; Rho A; Vinblastine

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; APOPTOSIS INDUCING FACTOR; APOPTOSIS SIGNAL REGULATING KINASE 1; CALCIUM; CASPASE 3; CASPASE 9; CYTOCHROME C; HEAT SHOCK PROTEIN 70; HEAT SHOCK TRANSCRIPTION FACTOR 1; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INOSITOL; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR AP 1; VINBLASTINE;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MELANOMA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

APOPTOSIS; CALCIUM; CELL LINE, TUMOR; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE KINASE 5; MELANOMA; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; RHOA GTP-BINDING PROTEIN; VINBLASTINE;

EID: 84879602996     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-013-0844-4     Document Type: Article

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