메뉴 건너뛰기




Volumn 305, Issue 1, 2013, Pages

Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways

Author keywords

Hepatic steatosis; Insulin resistance; Thyroid hormone receptor agonists

Indexed keywords

EPROTIROME; GLUCOSE; SOBETIROME; THYROID HORMONE RECEPTOR BETA; TRIACYLGLYCEROL;

EID: 84879596112     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00573.2012     Document Type: Article
Times cited : (86)

References (57)
  • 1
    • 64049099095 scopus 로고    scopus 로고
    • Thyroid hormone mimetics: Potential applications in atherosclerosis, obesity and type 2 diabetes
    • Baxter JD, Webb P. Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes. Nat Rev Drug discovery 8: 308-320, 2009.
    • (2009) Nat Rev Drug discovery , vol.8 , pp. 308-320
    • Baxter, J.D.1    Webb, P.2
  • 2
    • 1942453725 scopus 로고    scopus 로고
    • Selective activation of thyroid hormone signaling pathways by GC-1: A new approach to controlling cholesterol and body weight
    • Baxter JD, Webb P, Grover G, Scanlan TS. Selective activation of thyroid hormone signaling pathways by GC-1: a new approach to controlling cholesterol and body weight. Trends Endocrinol Metab 15: 154-157, 2004.
    • (2004) Trends Endocrinol Metab , vol.15 , pp. 154-157
    • Baxter, J.D.1    Webb, P.2    Grover, G.3    Scanlan, T.S.4
  • 4
    • 84861890085 scopus 로고    scopus 로고
    • Regulation of glucose transporter translocation in health and diabetes
    • Bogan JS. Regulation of glucose transporter translocation in health and diabetes. Ann Rev Biochem 81: 507-532, 2012.
    • (2012) Ann Rev Biochem , vol.81 , pp. 507-532
    • Bogan, J.S.1
  • 5
    • 0142184334 scopus 로고    scopus 로고
    • Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking
    • Bogan JS, Hendon N, McKee AE, Tsao TS, Lodish HF. Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking. Nature 425: 727-733, 2003.
    • (2003) Nature , vol.425 , pp. 727-733
    • Bogan, J.S.1    Hendon, N.2    McKee, A.E.3    Tsao, T.S.4    Lodish, H.F.5
  • 6
    • 77955051874 scopus 로고    scopus 로고
    • Biogenesis and regulation of insulin-responsive vesicles containing GLUT4
    • Bogan JS, Kandror KV. Biogenesis and regulation of insulin-responsive vesicles containing GLUT4. Curr Opin Cell Biol 22: 506-512, 2010.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 506-512
    • Bogan, J.S.1    Kandror, K.V.2
  • 8
    • 0024419846 scopus 로고
    • Differential expression of alpha and beta thyroid hormone receptor genes in rat brain and pituitary
    • USA
    • Bradley DJ, Young WS, 3rd, Weinberger C. Differential expression of alpha and beta thyroid hormone receptor genes in rat brain and pituitary. Proc Natl Acad Sci USA 86: 7250-7254, 1989.
    • (1989) Proc Natl Acad Sci , vol.86 , pp. 7250-7254
    • Bradley, D.J.1    Young III, W.S.2    Weinberger, C.3
  • 10
    • 77953639982 scopus 로고    scopus 로고
    • Molecular aspects of thyroid hormone actions
    • Cheng SY, Leonard JL, Davis PJ. Molecular aspects of thyroid hormone actions. Endocr Rev 31: 139-170, 2010.
    • (2010) Endocr Rev , vol.31 , pp. 139-170
    • Cheng, S.Y.1    Leonard, J.L.2    Davis, P.J.3
  • 13
    • 0022403385 scopus 로고
    • Tissue-specific regulation of two functional malic enzyme mRNAs by triiodothyronine
    • Dozin B, Magnuson MA, Nikodem VM. Tissue-specific regulation of two functional malic enzyme mRNAs by triiodothyronine. Biochemistry 24: 5581-5586, 1985.
    • (1985) Biochemistry , vol.24 , pp. 5581-5586
    • Dozin, B.1    Magnuson, M.A.2    Nikodem, V.M.3
  • 14
    • 33747590148 scopus 로고    scopus 로고
    • Tissuespecific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice
    • Dumitrescu AM, Liao XH, Weiss RE, Millen K, Refetoff S. Tissuespecific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice. Endocrinology 147: 4036-4043, 2006.
    • (2006) Endocrinology , vol.147 , pp. 4036-4043
    • Dumitrescu, A.M.1    Liao, X.H.2    Weiss, R.E.3    Millen, K.4    Refetoff, S.5
  • 16
    • 0034464045 scopus 로고    scopus 로고
    • Thyroid hormone regulation of hepatic genes in vivo detected by complementary DNA microarray
    • Feng X, Jiang Y, Meltzer P, Yen PM. Thyroid hormone regulation of hepatic genes in vivo detected by complementary DNA microarray. Mol Endocrinol 14: 947-955, 2000.
    • (2000) Mol Endocrinol , vol.14 , pp. 947-955
    • Feng, X.1    Jiang, Y.2    Meltzer, P.3    Yen, P.M.4
  • 18
    • 33747591214 scopus 로고    scopus 로고
    • Mouse sterol response element binding protein-1c gene expression is negatively regulated by thyroid hormone
    • Hashimoto K, Yamada M, Matsumoto S, Monden T, Satoh T, Mori M. Mouse sterol response element binding protein-1c gene expression is negatively regulated by thyroid hormone. Endocrinology 147: 4292-4302, 2006.
    • (2006) Endocrinology , vol.147 , pp. 4292-4302
    • Hashimoto, K.1    Yamada, M.2    Matsumoto, S.3    Monden, T.4    Satoh, T.5    Mori, M.6
  • 19
    • 0025021268 scopus 로고
    • Differential and tissue-specific regulation of the multiple rat c-erbA messenger RNA species by thyroid hormone
    • Hodin RA, Lazar MA, Chin WW. Differential and tissue-specific regulation of the multiple rat c-erbA messenger RNA species by thyroid hormone. J Clin Invest 85: 101-105, 1990.
    • (1990) J Clin Invest , vol.85 , pp. 101-105
    • Hodin, R.A.1    Lazar, M.A.2    Chin, W.W.3
  • 20
    • 22644432001 scopus 로고    scopus 로고
    • Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice
    • USA
    • Johansson L, Rudling M, Scanlan TS, Lundasen T, Webb P, Baxter J, Angelin B, Parini P. Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc Natl Acad Sci USA 102: 10297-10302, 2005.
    • (2005) Proc Natl Acad Sci , vol.102 , pp. 10297-10302
    • Johansson, L.1    Rudling, M.2    Scanlan, T.S.3    Lundasen, T.4    Webb, P.5    Baxter, J.6    Angelin, B.7    Parini, P.8
  • 21
    • 39449085830 scopus 로고    scopus 로고
    • Thyroid hormone as a determinant of energy expenditure and the basal metabolic rate
    • Kim B. Thyroid hormone as a determinant of energy expenditure and the basal metabolic rate. Thyroid 18: 141-144, 2008.
    • (2008) Thyroid , vol.18 , pp. 141-144
    • Kim, B.1
  • 26
    • 0027416347 scopus 로고
    • Thyroid hormone receptors: Multiple forms, multiple possibilities
    • Lazar MA. Thyroid hormone receptors: multiple forms, multiple possibilities. Endocr Rev 14: 184-193, 1993.
    • (1993) Endocr Rev , vol.14 , pp. 184-193
    • Lazar, M.A.1
  • 27
    • 0023691049 scopus 로고
    • Identification of a rat c-erbA alpha-related protein which binds deoxyribonucleic acid but does not bind thyroid hormone
    • Lazar MA, Hodin RA, Darling DS, Chin WW. Identification of a rat c-erbA alpha-related protein which binds deoxyribonucleic acid but does not bind thyroid hormone. Mol Endocrinol 2: 893-901, 1988.
    • (1988) Mol Endocrinol , vol.2 , pp. 893-901
    • Lazar, M.A.1    Hodin, R.A.2    Darling, D.S.3    Chin, W.W.4
  • 28
    • 77949329263 scopus 로고    scopus 로고
    • Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation
    • Liu YY, Brent GA. Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation. Trends Endocrinol Metab 21: 166-173, 2010.
    • (2010) Trends Endocrinol Metab , vol.21 , pp. 166-173
    • Liu, Y.Y.1    Brent, G.A.2
  • 30
    • 0027504359 scopus 로고
    • Pretranslational regulation of type I 5=-deiodinase by thyroid hormones and in fasted and diabetic rats
    • O'Mara BA, Dittrich W, Lauterio TJ, St Germain DL. Pretranslational regulation of type I 5=-deiodinase by thyroid hormones and in fasted and diabetic rats. Endocrinology 133: 1715-1723, 1993.
    • (1993) Endocrinology , vol.133 , pp. 1715-1723
    • O'Mara, B.A.1    Dittrich, W.2    Lauterio, T.J.3    St Germain, D.L.4
  • 31
    • 0036936394 scopus 로고    scopus 로고
    • Insight into the physiological actions of thyroid hormone receptors from genetically modified mice
    • O'Shea PJ, Williams GR. Insight into the physiological actions of thyroid hormone receptors from genetically modified mice. J Endocrinol 175: 553-570, 2002.
    • (2002) J Endocrinol , vol.175 , pp. 553-570
    • O'Shea, P.J.1    Williams, G.R.2
  • 32
    • 0014599987 scopus 로고
    • Pyruvate carboxylase in Rhodopseudomonas spheroides
    • Payne J, Morris JG. Pyruvate carboxylase in Rhodopseudomonas spheroides. J Gen Microbiol 59: 97-101, 1969.
    • (1969) J Gen Microbiol , vol.59 , pp. 97-101
    • Payne, J.1    Morris, J.G.2
  • 34
    • 0029556146 scopus 로고
    • Triiodothyronine treatment increases substrate cycling between pyruvate carboxylase and malic enzyme in perfused rat liver
    • Petersen KF, Blair JB, Shulman GI. Triiodothyronine treatment increases substrate cycling between pyruvate carboxylase and malic enzyme in perfused rat liver. Metab Clin Exp 44: 1380-1383, 1995.
    • (1995) Metab Clin Exp , vol.44 , pp. 1380-1383
    • Petersen, K.F.1    Blair, J.B.2    Shulman, G.I.3
  • 35
    • 0028121599 scopus 로고
    • Substrate cycling between pyruvate and oxaloacetate in awake normal and 3,3=-5-triiodo-Lthyronine-treated rats
    • Petersen KF, Cline GW, Blair JB, Shulman GI. Substrate cycling between pyruvate and oxaloacetate in awake normal and 3,3=-5-triiodo-Lthyronine-treated rats. Am J Physiol Endocrinol Metab 267: E273-E277, 1994.
    • (1994) Am J Physiol Endocrinol Metab , vol.267
    • Petersen, K.F.1    Cline, G.W.2    Blair, J.B.3    Shulman, G.I.4
  • 36
    • 14644435731 scopus 로고    scopus 로고
    • Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes
    • Petersen KF, Dufour S, Befroy D, Lehrke M, Hendler RE, Shulman GI. Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes. Diabetes 54: 603-608, 2005.
    • (2005) Diabetes , vol.54 , pp. 603-608
    • Petersen, K.F.1    Dufour, S.2    Befroy, D.3    Lehrke, M.4    Hendler, R.E.5    Shulman, G.I.6
  • 38
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR (Abstract)
    • Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR (Abstract). Nucleic Acids Res 29: e45, 2001.
    • (2001) Nucleic Acids Res , vol.29
    • Pfaffl, M.W.1
  • 39
    • 0033396462 scopus 로고    scopus 로고
    • Improved radioimmunoassay for measurement of mouse thyrotropin in serum: Strain differences in thyrotropin concentration and thyrotroph sensitivity to thyroid hormone
    • Pohlenz J, Maqueem A, Cua K, Weiss RE, Van Sande J, Refetoff S. Improved radioimmunoassay for measurement of mouse thyrotropin in serum: strain differences in thyrotropin concentration and thyrotroph sensitivity to thyroid hormone. Thyroid 9: 1265-1271, 1999.
    • (1999) Thyroid , vol.9 , pp. 1265-1271
    • Pohlenz, J.1    Maqueem, A.2    Cua, K.3    Weiss, R.E.4    van Sande, J.5    Refetoff, S.6
  • 40
    • 0032810949 scopus 로고    scopus 로고
    • A critical evaluation of mass isotopomer distribution analysis of gluconeogenesis in vivo
    • Previs SF, Cline GW, Shulman GI. A critical evaluation of mass isotopomer distribution analysis of gluconeogenesis in vivo. Am J Physiol Endocrinol Metab 277: E154-E160, 1999.
    • (1999) Am J Physiol Endocrinol Metab , vol.277
    • Previs, S.F.1    Cline, G.W.2    Shulman, G.I.3
  • 43
    • 84857861919 scopus 로고    scopus 로고
    • Mechanisms for insulin resistance: Common threads and missing links
    • Samuel VT, Shulman GI. Mechanisms for insulin resistance: common threads and missing links. Cell 148: 852-871, 2012.
    • (2012) Cell , vol.148 , pp. 852-871
    • Samuel, V.T.1    Shulman, G.I.2
  • 44
    • 0035941085 scopus 로고    scopus 로고
    • A novel functional co-operation between MyoD, MEF2 and TRalpha1 is sufficient for the induction of GLUT4 gene transcription
    • Santalucia T, Moreno H, Palacin M, Yacoub MH, Brand NJ, Zorzano A. A novel functional co-operation between MyoD, MEF2 and TRalpha1 is sufficient for the induction of GLUT4 gene transcription. J Mol Biol 314: 195-204, 2001.
    • (2001) J Mol Biol , vol.314 , pp. 195-204
    • Santalucia, T.1    Moreno, H.2    Palacin, M.3    Yacoub, M.H.4    Brand, N.J.5    Zorzano, A.6
  • 45
    • 0141706620 scopus 로고    scopus 로고
    • Thyroid hormone regulation and cholesterol metabolism are connected through Sterol Regulatory Element-Binding Protein-2 (SREBP-2)
    • Shin DJ, Osborne TF. Thyroid hormone regulation and cholesterol metabolism are connected through Sterol Regulatory Element-Binding Protein-2 (SREBP-2). J Biol Chem 278: 34114-34118, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 34114-34118
    • Shin, D.J.1    Osborne, T.F.2
  • 46
    • 0021837050 scopus 로고
    • Substrate cycling between gluconeogenesis and glycolysis in euthyroid, hypothyroid, and hyperthyroid man
    • Shulman GI, Ladenson PW, Wolfe MH, Ridgway EC, Wolfe RR. Substrate cycling between gluconeogenesis and glycolysis in euthyroid, hypothyroid, and hyperthyroid man. J Clin Invest 76: 757-764, 1985.
    • (1985) J Clin Invest , vol.76 , pp. 757-764
    • Shulman, G.I.1    Ladenson, P.W.2    Wolfe, M.H.3    Ridgway, E.C.4    Wolfe, R.R.5
  • 48
    • 70350374347 scopus 로고    scopus 로고
    • Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion
    • Stark R, Pasquel F, Turcu A, Pongratz RL, Roden M, Cline GW, Shulman GI, Kibbey RG. Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion. J Biol Chem 284: 26578-26590, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 26578-26590
    • Stark, R.1    Pasquel, F.2    Turcu, A.3    Pongratz, R.L.4    Roden, M.5    Cline, G.W.6    Shulman, G.I.7    Kibbey, R.G.8
  • 49
    • 0029848197 scopus 로고    scopus 로고
    • Thyroid hormone-responsive genes in developing cerebellum include a novel synaptotagmin and a hairless homolog
    • Thompson CC. Thyroid hormone-responsive genes in developing cerebellum include a novel synaptotagmin and a hairless homolog. J Neurosci 16: 7832-7840, 1996.
    • (1996) J Neurosci , vol.16 , pp. 7832-7840
    • Thompson, C.C.1
  • 50
    • 0031039395 scopus 로고    scopus 로고
    • Effects of thyroid hormone on GLUT4 glucose transporter gene expression and NIDDM in rats
    • Torrance CJ, Devente JE, Jones JP, Dohm GL. Effects of thyroid hormone on GLUT4 glucose transporter gene expression and NIDDM in rats. Endocrinology 138: 1204-1214, 1997.
    • (1997) Endocrinology , vol.138 , pp. 1204-1214
    • Torrance, C.J.1    Devente, J.E.2    Jones, J.P.3    Dohm, G.L.4
  • 54
    • 2642588897 scopus 로고    scopus 로고
    • Selective activators of thyroid hormone receptors
    • Webb P. Selective activators of thyroid hormone receptors. Exp Opinion Invest Drugs 13: 489-500, 2004.
    • (2004) Exp Opinion Invest Drugs , vol.13 , pp. 489-500
    • Webb, P.1
  • 55
    • 0036146423 scopus 로고    scopus 로고
    • Thyroid function and effect of aging in combined hetero/ homozygous mice deficient in thyroid hormone receptors alpha and beta genes
    • Weiss RE, Chassande O, Koo EK, Macchia PE, Cua K, Samarut J, Refetoff S. Thyroid function and effect of aging in combined hetero/ homozygous mice deficient in thyroid hormone receptors alpha and beta genes. J Endocrinol 172: 177-185, 2002.
    • (2002) J Endocrinol , vol.172 , pp. 177-185
    • Weiss, R.E.1    Chassande, O.2    Koo, E.K.3    Macchia, P.E.4    Cua, K.5    Samarut, J.6    Refetoff, S.7
  • 56
    • 0022631232 scopus 로고
    • Hepatic glucose production and splanchnic glucose exchange in hyperthyroidism
    • Wennlund A, Felig P, Hagenfeldt L, Wahren J. Hepatic glucose production and splanchnic glucose exchange in hyperthyroidism. J Clin Endocrinol Metab 62: 174-180, 1986.
    • (1986) J Clin Endocrinol Metab , vol.62 , pp. 174-180
    • Wennlund, A.1    Felig, P.2    Hagenfeldt, L.3    Wahren, J.4
  • 57
    • 33947592425 scopus 로고    scopus 로고
    • The glucose transporter 4-regulating protein TUG is essential for highly insulin-responsive glucose uptake in 3T3-L1 adipocytes
    • Yu C, Cresswell J, Loffler MG, Bogan JS. The glucose transporter 4-regulating protein TUG is essential for highly insulin-responsive glucose uptake in 3T3-L1 adipocytes. J Biol Chem 282: 7710-7722, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 7710-7722
    • Yu, C.1    Cresswell, J.2    Loffler, M.G.3    Bogan, J.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.