Modeling reveals that dynamic regulation of c-FLIP levels determines cell-to-cell distribution of CD95-mediated apoptosis

Journal of Biological Chemistry

Volumn 286, Issue 21, 2011, Pages 18375-18382

  Toivonen, Hannu T ^a   Meinander, Annika ^a   Asaoka, Tomoko ^a   Westerlund, Mia ^a   Pettersson, Frank ^a   Mikhailov, Andrey ^a   Eriksson, John E ^a   Saxén, Henrik ^a  

^a ÅBO AKADEMI UNIVERSITY   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; APOPTOTIC; APOPTOTIC SIGNALING; CELL POPULATIONS; CONCENTRATION DISTRIBUTIONS; DEATH-INDUCING SIGNALING COMPLEXES; DEATH-RECEPTOR; DEVELOPED MODEL; DYNAMIC REGULATION; EMPIRICAL DATA; EXPERIMENTAL STUDIES; EXPRESSION LEVELS; INDIVIDUAL CELLS; ISOFORMS; KEY DETERMINANTS; LIMITING FACTORS; MATHEMATICAL SIMULATIONS; MODELING APPROACH; MONTE CARLO SIMULATION; SIGNALING PROCESS; SINGLE CELLS; WHOLE CELL;

CELL CULTURE; CELL PROLIFERATION; MATHEMATICAL MODELS; POPULATION STATISTICS; SIGNALING;

CELL DEATH;

DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEIN; DEATH RECEPTOR; FAS ANTIGEN; FLICE INHIBITORY PROTEIN;

APOPTOSIS; ARTICLE; CELL POPULATION; CELLULAR DISTRIBUTION; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; MONTE CARLO METHOD; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

ANTIGENS, CD95; APOPTOSIS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CELL COMMUNICATION; CELL LINE, TUMOR; HUMANS; MODELS, BIOLOGICAL; MONTE CARLO METHOD; SIGNAL TRANSDUCTION;

EID: 79956323684     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.177097     Document Type: Article

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