Insulin-like growth factor (IGF) binding protein-3 inhibits type 1 IGF receptor activation independently of its IGF binding affinity

Endocrinology

Volumn 142, Issue 1, 2001, Pages 108-113

  Ricort, Jean Marc ^a   Binoux, Michel ^a  

^a HÔPITAL SAINT ANTOINE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN RECEPTOR; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C RECEPTOR;

ARTICLE; AUTOPHOSPHORYLATION; BINDING AFFINITY; COMPETITIVE INHIBITION; CONFORMATIONAL TRANSITION; CROSS LINKING; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INSULIN LIKE ACTIVITY; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

EID: 0035115056     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.142.1.7915     Document Type: Article

References (13)

1. Molecular and cellular aspects of the insulin-like growth factor I receptor
2. IGF binding proteins as modulators of IGF action
3. Insulin-like growth factor (IGF)-independent action of IGF-binding protein-3 in Hs578T human breast cancer cells
4. The human insulin-like growth factor (IGF) binding protein-3 inhibits the growth of fibroblasts with a targeted disruption of the IGF-I receptor gene
5. Insulin-like growth factor-binding prorein-3 induces apoptosis and mediates the effects of transforming growth factor-β1 on programmed cell death through a p53- and IGF-independent mechanism
6. Insulin-like growth factor (IGF) binding protein-3 interacts with the type 1 IGF receptor, reducing the affinity of the receptor for its ligand: An alternative mechanism in the regulation of IGF action
7. Cross-talk between the platelet-derived growth factor and the insulin signaling pathways in 3T3-L1 adipocytes
8. Characterization of the affinities of insulin-like growth factor (IGF)-binding proteins 1-4 for IGF-I, IGF-II, IGF-I/insulin hybrid, and IGF-I analogs
9. Insulin receptor substrate-1 is the predominant signaling molecule activated by insulin-like growth factor-I, insulin, and interleukin-4 in estrogen receptor-positive human breast cancer cells
10. Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2, -3, -4, -5 and -6)
11. IGF-independent actions of the IGF binding proteins
12. Differential signaling to glycogen synthesis by the intracellular domain of the insulin versus the insulin-like growth factor-1 receptor. Evidence from studies of TrkC-chimeras
13. Tyrosine residues in the C-terminal domain of the insulin-like growth factor-I receptor mediate mitogenic and tumorigenic signals