Anti-insulin-like growth factor 1 receptor antibody EM164 (murine AVE1642) exhibits anti-tumour activity alone and in combination with temozolomide against neuroblastoma

European Journal of Cancer

Volumn 46, Issue 18, 2010, Pages 3251-3262

  Geoerger, Birgit ^a   Brasme, Jean Franois ^a   Daudigeos Dubus, Estelle ^a   Opolon, Paule ^b   Venot, Corinne ^c   Debussche, Laurent ^c   Vrignaud, Patricia ^c   Vassal, Gilles ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b CNRS   (France)

^c SANOFI   (France)

Author keywords

Alkylating agents; Insulin like growth factor pathway; Monoclonal antibodies therapeutic use; Pediatric cancer; Retinoid acid; Sympathic nervous system tumours

Indexed keywords

ANTINEOPLASTIC AGENT; EM 164; PROTEIN KINASE B; SOMATOMEDIN B; SOMATOMEDIN C RECEPTOR; TEMOZOLOMIDE; UNCLASSIFIED DRUG;

ADVANCED CANCER; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER STAGING; CELL PROLIFERATION; CHILDHOOD CANCER; DRUG MEGADOSE; DRUG POTENTIATION; DRUG RESEARCH; DRUG SCREENING; DRUG SENSITIVITY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VIVO STUDY; MAXIMUM TOLERATED DOSE; NEUROBLASTOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; TUMOR GROWTH; TUMOR REGRESSION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS, ALKYLATING; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CELL LINE, TUMOR; CELL PROLIFERATION; DACARBAZINE; FEMALE; HUMANS; MICE; MICE, NUDE; MITOGEN-ACTIVATED PROTEIN KINASES; NEUROBLASTOMA; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, IGF TYPE 1; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 78649636617     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2010.06.005     Document Type: Article

References (50)

1. M.N. Pollak, E.S. Schernhammer, and S.E. Hankinson Insulin-like growth factors and neoplasia Nat Rev Cancer 4 7 2004 505 518
2. R. Baserga, F. Peruzzi, and K. Reiss The IGF-1 receptor in cancer biology Int J Cancer 107 6 2003 873 877
3. F.M. Barlaskar, A.C. Spalding, and J.H. Heaton Preclinical targeting of the type I insulin-like growth factor receptor in adrenocortical carcinoma J Clin Endocrinol Metab 94 1 2009 204 212
4. S.R. Datta, A. Brunet, and M.E. Greenberg Cellular survival: a play in three Akts Genes Dev 13 22 1999 2905 2927
5. H. Zhang, and D. Yee The therapeutic potential of agents targeting the type I insulin-like growth factor receptor Expert Opin Invest Drugs 13 12 2004 1569 1577 (Pubitemid 39625142)
6. R. Schumacher, M.A. Soos, and J. Schlessinger Signaling-competent receptor chimeras allow mapping of major insulin receptor binding domain determinants J Biol Chem 268 2 1993 1087 1094
7. E.K. Maloney, J.L. McLaughlin, and N.E. Dagdigian An anti-insulin-like growth factor I receptor antibody that is a potent inhibitor of cancer cell proliferation Cancer Res 63 16 2003 5073 5083
8. J.P. Liu, J. Baker, A.S. Perkins, E.J. Robertson, and A. Efstratiadis Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r) Cell 75 1 1993 59 72
9. O.M. El-Badry, J.A. Romanus, and L.J. Helman Autonomous growth of a human neuroblastoma cell line is mediated by insulin-like growth factor II J Clin Invest 84 3 1989 829 839
10. V.P. Castle, K.P. Heidelberger, and J. Bromberg Expression of the apoptosis-suppressing protein bcl-2, in neuroblastoma is associated with unfavorable histology and N-myc amplification Am J Pathol 143 6 1993 1543 1550
11. A. Puglianiello, D. Germani, P. Rossi, and S. Cianfarani IGF-I stimulates chemotaxis of human neuroblasts. Involvement of type 1 IGF receptor, IGF binding proteins, phosphatidylinositol-3 kinase pathway and plasmin system J Endocrinol 165 1 2000 123 131
12. C.M. van Golen, T.S. Schwab, and B. Kim Insulin-like growth factor-I receptor expression regulates neuroblastoma metastasis to bone Cancer Res 66 13 2006 6570 6578
13. A. Weber, C. Huesken, and E. Bergmann Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas Clin Cancer Res 9 15 2003 5683 5692
14. C.M. van Golen, V.P. Castle, and E.L. Feldman IGF-I receptor activation and BCL-2 overexpression prevent early apoptotic events in human neuroblastoma Cell Death Differ 7 7 2000 654 665
15. D. Chambery, S. Mohseni-Zadeh, B. de Galle, and S. Babajko N-myc regulation of type I insulin-like growth factor receptor in a human neuroblastoma cell line Cancer Res 59 12 1999 2898 2902
16. Coulter DW, Blatt J, D'Ercole AJ, Moats-Staats BM. IGF-I receptor inhibition combined with rapamycin or temsirolimus inhibits neuroblastoma cell growth. Anticancer Res 2008;28(3A):1509-16.
17. Liu X, Turbyville T, Fritz A, Whitesell L. Inhibition of insulin-like growth factor I receptor expression in neuroblastoma cells induces the regression of established tumors in mice. Cancer Res 1998;58(23):5432-8.
18. G.E. Meyer, L. Chesler, and D. Liu Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells J Cell Biochem 102 6 2007 1529 1541
19. D.W. Coulter, M.B. Wilkie, and B.M. Moats-Staats Inhibition of IGF-I receptor signaling in combination with rapamycin or temsirolimus increases MYC-N phosphorylation Anticancer Res 29 6 2009 1943 1949
20. B. Tanno, C. Mancini, and R. Vitali Down-regulation of insulin-like growth factor I receptor activity by NVP-AEW541 has an antitumor effect on neuroblastoma cells in vitro and in vivo Clin Cancer Res 12 22 2006 6772 6780
21. P. Haluska, J.M. Carboni, and D.A. Loegering In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417 Cancer Res 66 1 2006 362 371
22. G. Vassal, M.J. Terrier-Lacombe, and M.C. Bissery Therapeutic activity of CPT-11, a DNA-topoisomerase I inhibitor, against peripheral primitive neuroectodermal tumour and neuroblastoma xenografts Brit J Cancer 74 4 1996 537 545
23. E. Ferrandis, J. Da Silva, G. Riou, and I. Benard Coactivation of the MDR1 and MYCN genes in human neuroblastoma cells during the metastatic process in the nude mouse Cancer Res 54 8 1994 2256 2261
24. G. Descamps, P. Gomez-Bougie, and C. Venot A humanised anti-IGF-1R monoclonal antibody (AVE1642) enhances Bortezomib-induced apoptosis in myeloma cells lacking CD45 Brit J Cancer 100 2 2009 366 369
25. Y. Shang, Y. Mao, and J. Batson Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake Mol Cancer Ther 7 9 2008 2599 2608
26. K. Scotlandi, M.C. Manara, and G. Nicoletti Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors Cancer Res 65 9 2005 3868 3876
27. M.C. Manara, L. Landuzzi, and P. Nanni Preclinical in vivo study of new insulin-like growth factor-I receptor - specific inhibitor in Ewing's sarcoma Clin Cancer Res 13 4 2007 1322 1330
28. R. Baserga The insulin-like growth factor-I receptor as a target for cancer therapy Expert Opin Ther Targets 9 4 2005 753 768
29. D. Burtrum, Z. Zhu, and D. Lu A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo Cancer Res 63 24 2003 8912 8921
30. F. Huang, A. Greer, and W. Hurlburt The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors Cancer Res 69 1 2009 161 170
31. H. Werner, E. Karnieli, F.J. Rauscher, and D. LeRoith Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene Proc Natl Acad Sci USA 93 16 1996 8318 8323
32. H. Werner, C.T. Roberts Jr., F.J. Rauscher III, and D. LeRoith Regulation of insulin-like growth factor I receptor gene expression by the Wilms' tumor suppressor WT1 J Mol Neurosci 7 2 1996 111 123
33. S. Abramovitch, T. Glaser, T. Ouchi, and H. Werner BRCA1-Sp1 interactions in transcriptional regulation of the IGF-IR gene FEBS Lett 541 1-3 2003 149 154 (Pubitemid 36428934)
34. B. Kim, C.M. van Golen, and E.L. Feldman Insulin-like growth factor-I signaling in human neuroblastoma cells Oncogene 23 1 2004 130 141
35. A.P. Feinberg The epigenetics of cancer etiology Semin Cancer Biol 14 6 2004 427 432
36. A. Ullrich, A. Gray, and A.W. Tam Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity EMBO J 5 10 1986 2503 2512
37. D. Sachdev, R. Singh, Y. Fujita-Yamaguchi, and D. Yee Down-regulation of insulin receptor by antibodies against the type I insulin-like growth factor receptor: implications for anti-insulin-like growth factor therapy in breast cancer Cancer Res 66 4 2006 2391 2402
38. Q.S. Ji, M.J. Mulvihill, and M. Rosenfeld-Franklin A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo Mol Cancer Ther 6 8 2007 2158 2167
39. Y. Lu, X. Zi, Y. Zhao, D. Mascarenhas, and M. Pollak Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin) J Natl Cancer Inst 93 24 2001 1852 1857
40. A. Chakravarti, J.S. Loeffler, and N.J. Dyson Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling Cancer Res 62 1 2002 200 207
41. Camirand A, Lu Y, Pollak M. Co-targeting HER2/ErbB2 and insulin-like growth factor-1 receptors causes synergistic inhibition of growth in HER2-overexpressing breast cancer cells. Med Sci Monit 2002;8(12):BR521-6.
42. B.D. Cohen, D.A. Baker, and C. Soderstrom Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751, 871 Clin Cancer Res 11 5 2005 2063 2073
43. D. Lu, H. Zhang, and H. Koo A fully human recombinant IgG-like bispecific antibody to both the epidermal growth factor receptor and the insulin-like growth factor receptor for enhanced antitumor activity J Biol Chem 280 20 2005 19665 19672
44. A.S. Martins, J.L. Ordonez, and A. Garcia-Sanchez A pivotal role for heat shock protein 90 in Ewing sarcoma resistance to anti-insulin-like growth factor 1 receptor treatment: in vitro and in vivo study Cancer Res 68 15 2008 6260 6270
45. H. Rubie, J. Chisholm, and A.S. D7efachelles Phase II study of temozolomide in relapsed or refractory high-risk neuroblastoma: a joint Societe Francaise des Cancers de l'Enfant and United Kingdom Children Cancer Study Group-New Agents Group Study J Clin Oncol 24 33 2006 5259 5264
46. E.K. Rowinsky, H. Youssoufian, and J.R. Tonra IMC-A12, a human IgG1 monoclonal antibody to the insulin-like growth factor I receptor Clin Cancer Res 13 18 Pt 2 2007 5549s 5555s
47. N.A. Dallas, L. Xia, and F. Fan Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition Cancer Res 69 5 2009 1951 1957
48. S. Babajko, and M. Binoux Modulation by retinoic acid of insulin-like growth factor (IGF) and IGF binding protein expression in human SK-N-SH neuroblastoma cells Eur J Endocrinol 134 4 1996 474 480
49. K. Matsumoto, E. Lucarelli, C. Minniti, C. Gaetano, and C.J. Thiele Signals transduced via insulin-like growth factor I receptor (IGF(R)) mediate resistance to retinoic acid-induced cell growth arrest in a human neuroblastoma cell line Cell Death Differ 1 1 1994 49 58
50. C. Gaetano, K. Matsumoto, and C.J. Thiele Retinoic acid resistant neuroblastoma cells and the expression of insulin-like growth factor-II Prog Clin Biol Res 366 1991 165 172