The transport effect of submicron emulsions on 5-flurouracil topical application

Journal of Microencapsulation

Volumn 30, Issue 5, 2013, Pages 425-431

  Huang, Yaw Bin ^a   Huang, Chi Te ^a   Tsou, Hsin Yeh ^a   Fu, Li Tse ^a   Fu, Yaw Sya ^a   Tsai, Yi Hung ^a   Wu, Pao Chu ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

5 fluorouracil; Deposition amount in skin; Submicron emulsion; Surfactant; Topical application

Indexed keywords

FLUOROURACIL; SURFACTANT;

AQUEOUS SOLUTION; ARTICLE; DERMIS; DRUG DELIVERY SYSTEM; DRUG TRANSPORT; EPIDERMIS; HYDROPHILICITY; LIPOPHILICITY; MICROEMULSION; NONHUMAN; PHYSICAL CHEMISTRY; STRATUM CORNEUM; VISCOSITY;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; DRUG CARRIERS; EMULSIONS; FLUOROURACIL; RATS; RATS, SPRAGUE-DAWLEY; SKIN; SKIN ABSORPTION;

EID: 84879584830     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.3109/02652048.2012.746748     Document Type: Article

References (37)

1. Alany RG, Rades T, Agatonovic-Kustrin S, Davies NM, Tucker IG. Effects of alcohols and diols on the phase behaviour of quaternary systems. Int J Pharm, 2000;196:141-5. (Pubitemid 30105730)
2. Bargman H, Hochman J. Topical treatment of Bowen's disease with 5- Fluorouracil. J Cutan Med Surg, 2003;7:101-5. (Pubitemid 36506157)
3. Barichello JM, Handa H, Kisyuku M, Shibata T, Ishida T, Kiwada H. Inducing effect of liposomalization on the transdermal delivery of hydrocortisone: Creation of a drug supersaturated state. J Control Release, 2006;115:94-102. (Pubitemid 44415078)
4. Beall HD, Sloan KB. Topical delivery of 5-fluorouracil (5-Fu) by 3-alkylcarbonyl- 5-Fu prodrugs. Int J Pharm, 2001;217:127-37. (Pubitemid 32268640)
5. Chen H, Chang X, Weng T, Zhao X, Gao Z, Yang Y, Xu H, Yang X. A study of microemulsion systems for transdermal delivery of triptolide. J Control Release, 2004;98:427-36. (Pubitemid 39093953)
6. De Paula D, Martins CA, Bentley MV. Development and validation of HPLC method for imiquimod determination in skin penetration studies. Biomed Chromatogr, 2008;22:1416-23.
7. Diasio RB, Harris BE. Clinical pharmacology of 5-fluorouracil. Clin Pharmacokinet, 1989;16:215-37. (Pubitemid 19114713)
8. Diasio RB, Johnson MR. The role of pharmacogenetics and pharmacogenomics in cancer chemotherapy with 5-fluorouracil. Pharmacology, 2000;61:199-203.
9. El Maghraby GM. Transdermal delivery of hydrocortisone from eucalyptus oil microemulsion: Effects of cosurfactants. Int J Pharm, 2008;355:285-92.
10. Falkson G, Schulz EJ. Skin changes in patients treated with 5-fluorouracil. Br J Dermatol, 1962;74:229-36.
11. Fang JY, Hung CF, Fang YP, Chan TF. Transdermal iontophoresis of 5- fluorouracil combined with electroporation and laser treatment. Int J Pharm, 2004;270:241-9.
12. Gullapalli RP, Sheth BB. Influence of an optimized non-ionic emulsifier blend on properties of oil-in-water emulsions. Eur J Pharm Biopharm, 1999;48:233-8. (Pubitemid 29509790)
13. Gupta RR, Jain SK, Varshney M. AOT water-in-oil microemulsions as a penetration enhancer in transdermal drug delivery of 5-fluorouracil. Colloids Surf B Biointerf, 2005;41:25-32. (Pubitemid 40215481)
14. Kibbe AH. 2000. Handbook of pharmaceutical excipients, 3rd edn. London: Pharmaceutical Press
15. Kreilgaard M. Influence of microemulsions on cutaneous drug delivery. Adv Drug Deliv Rev, 2002;54(Suppl 1):S77-S98. (Pubitemid 35379956)
16. Lademann J, Jacobi U, Surber C, Weigmann HJ, Fluhr JW. The tape stripping procedure - Evaluation of some critical parameters. Eur J Pharm Biopharm, 2009;72:317-23.
17. Lopes LB, Ferreira DA, de Paula D, Garcia MT, Thomazini JA, Fantini MC, Bentley MV. Reverse hexagonal phase nanodispersion of monoolein and oleic acid for topical delivery of peptides: In vitro and in vivo skin penetration of cyclosporin A. Pharm Res, 2006;23:1332-42. (Pubitemid 43946155)
18. Meidan VM, Walmsley AD, Docker MF, Irwin WJ. Ultrasound-enhanced diffusion into coupling gel during phonophoresis of 5-fluorouracil. Int J Pharm, 1999;185:205-13. (Pubitemid 29392907)
19. Merino V, Lopez A, Kalia YN, Guy RH. Electrorepulsion versus electroosmosis: Effect of pH on the iontophoretic flux of 5-fluorouracil. Pharm Res, 1999;16:758-61. (Pubitemid 29227108)
20. Pasquali RC, Taurozzi MP, Bregni C. Some considerations about the hydrophilic- lipophilic balance system. Int J Pharm, 2008;356:44-51.
21. Piemi MP, Korner D, Benita S, Marty JP. Positively and negatively charged submicron emulsions for enhanced topical delivery of antifungal drugs. J Control Release, 1999;58:177-87. (Pubitemid 29112888)
22. Raza K, Negi P, Takyar S, Shukla A, Amarji B, Katare OP. Novel dithranol phospholipid microemulsion for topical application: Development, characterization and percutaneous absorption studies. J Microencapsul, 2011;28:190-9.
23. Rhee YS, Choi JG, Park ES, Chi SC. Transdermal delivery of ketoprofen using microemulsions. Int J Pharm, 2001;228:161-70.
24. Roberts WJ, Sloan KB. Topical delivery of 5-fluorouracil (5-FU) by 3-alkylcarbonyloxymethyl- 5-FU prodrugs. J Pharm Sci, 2003;92:1028-36. (Pubitemid 36523448)
25. Robins P, Gupta AK. The use of topical fluorouracil to treat actinic keratosis. Cutis, 2002;70:4-7.
26. Singh BN, Singh RB, Singh J. Effects of ionization and penetration enhancers on the transdermal delivery of 5-fluorouracil through excised human stratum corneum. Int J Pharm, 2005;298:98-107. (Pubitemid 40828331)
27. Sinico C, Caddeo C, Valenti D, Fadda AM, Bilia AR, Vincieri FF. Liposomes as carriers for verbascoside: Stability and skin permeation studies. J Liposome Res, 2008;18:83-90. (Pubitemid 351414948)
28. Skov MJ, Quigley JW, Bucks DA. Topical delivery system for tretinoin: Research and clinical implications. J Pharm Sci, 1997;86:1138-43. (Pubitemid 27430919)
29. Sloan KB, Wasdo S, Ezike-Mkparu U, Murray T, Nickels D, Singh S, Shanks T, Tovar J, Ulmer K, Waranis R. Topical delivery of 5-fluorouracil and 6-mercaptopurine by their alkylcarbonyloxymethyl prodrugs from water: Vehicle effects on design of prodrugs. Pharm Res, 2003;20:639-45. (Pubitemid 36438909)
30. Spernath A, Aserin A, Ziserman L, Danino D, Garti N. Phosphatidylcholine embedded microemulsions: Physical properties and improved Caco-2 cell permeability. J Control Release, 2007;119:279-90. (Pubitemid 46770876)
31. Tenjarla S. Microemulsions: An overview and pharmaceutical applications. Crit Rev Ther Drug Carrier Syst, 1999;16:461-521. (Pubitemid 30004629)
32. Tsai YH, Chang JT, Chang JS, Huang CT, Huang YB, Wu PC. The effect of component of microemulsions on transdermal delivery of buspirone hydrochloride. J Pharm Sci, 2011a;100:2358-65.
33. Tsai YH, Fu LT, Huang CT, Chang JS, Huang YB, Wu PC. Formulation optimization of estradiol microemulsion using response surface methodology. J Pharm Sci, 2011b;100:4383-9.
34. Vicentini FT, Simi TR, Del Ciampo JO, Wolga NO, Pitol DL, Iyomasa MM, Bentley MV, Fonseca MJ. Quercetin in w/o microemulsion: In vitro and in vivo skin penetration and efficacy against UVB-induced skin damages evaluated in vivo. Eur J Pharm Biopharm, 2008;69:948-57.
35. Wei ZG, Li GX, Huang XC, Zhen L, Yu J, Deng HJ, Qing SH, Zhang C. Pharmacokinetics and tissue distribution of intraperitoneal 5-fluorouracil with a novel carrier solution in rats. World J Gastroenterol, 2008;14:2179-86.
36. Wu H, Ramachandran C, Weiner ND, Roessler BJ. Topical transport of hydrophilic compounds using water-in-oil nanoemulsions. Int J Pharm, 2001;220:63-75. (Pubitemid 32476842)
37. Yuan Y, Li SM, Mo FK, Zhong DF. Investigation of microemulsion system for transdermal delivery of meloxicam. Int J Pharm, 2006;321:117-23.