Ultrasound-enhanced diffusion into coupling gel during phonophoresis of 5-fluorouracil

International Journal of Pharmaceutics

Volumn 185, Issue 2, 1999, Pages 205-213

  Meidan, V M ^a   Walmsley, A D ^b   Docker, M F ^c   Irwin, W J ^a  

^a ASTON UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c BIRMINGHAM WOMEN S HOSPITAL   (United Kingdom)

Author keywords

5 Fluorouracil; Azone; Coupling gel; Enhancement; Percutaneous absorption; Phonophoresis

Indexed keywords

FLUOROURACIL; LAUROCAPRAM; PENETRATION ENHANCING AGENT;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSIMETRY; DRUG DIFFUSION; DRUG FORMULATION; DRUG PENETRATION; GEL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN ABSORPTION; TOPICAL DRUG ADMINISTRATION; ULTRASOUND;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; AZEPINES; BIOLOGICAL TRANSPORT; CELL MEMBRANE PERMEABILITY; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, THIN LAYER; DIFFUSION; FLUOROURACIL; GELS; MALE; PHONOPHORESIS; RADIOMETRY; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; SKIN ABSORPTION; SKIN TEMPERATURE; ULTRASONICS; VEHICLES;

EID: 0032810202     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00168-4     Document Type: Article

References (18)

1. Bronaugh R., Stewart R., Congdon E. Methods for in vitro percutaneous absorption studies 2. Animal models for human skin. Toxicol. Appl. Pharmacol. 62:1982;481-488.
2. Chivers R.C. Fundamentals of ultrasonic propagation. Preston R.C. Output Measurements for Medical Ultrasound. 1991;Springer, London.
3. Davidson F. Ultrasonic power balances. Preston R.C. Output Measurements for Medical Ultrasound. 1991;Springer, London.
4. Franz T.J. Percutaneous absorption. On the relevance of in vitro data. J. Invest. Dermatol. 64:1975;190-195.
5. Hofmann D., Moll F. The effect of ultrasound on in vivo penetration of benzyl nicotinate. J. Control. Release. 27:1993;185-192.
6. Martindale, 1982. The Extra Pharmacopoeia, 28th ed. The Pharmaceutical Press, UK, pp. 209-211.
7. Meidan V.M., 1996. PhD Thesis, Aston University.
8. Meidan V.M., Walmsley A.D., Irwin W.J. Phonophoresis - is it a reality? Int. J. Pharm. 118:1995;129-149.
9. Meidan V.M., Walmsley A.D., Irwin W.J. Low intensity ultrasound as a probe to elucidate the relative follicular contribution to total transdermal absorption. Pharm. Res. 15:1998;86-93.
10. Meidan V.M., Docker M.F., Walmsley A.D., Irwin W.J. Phonophoresis of hydrocortisone with enhancers: an acoustically defined model. Int. J. Pharm. 170:1998;157-168.
11. Mollgaard B., Hoelgaard A., Bundgaard H. Prodrugs as drug delivery systems. 23. Improved dermal delivery of 5-fluorouracil through human skin via n-acyloxymethyl pro-drug derivatives. Int. J. Pharm. 12:1982;153-162.
12. Newell J.A. A radiation pressure balance for the absolute measurement of ultrasonic power. Phys. Med. Biol. 8:1963;215-221.
13. Philips C.A., Michniak B.B. Transdermal delivery of drugs with differing lipophilicities using Azone analogs as dermal penetration enhancers. J. Pharm. Sci. 84:1995;1427-1433.
14. Singh S., Singh J. Transdermal delivery of drugs by phonophoresis. A review. Drug Des. Del. 5:1990;259-265.
15. Sugibayashi K., Hosoya K.I., Morimoto Y., Higuchi W.I. Effect of the absorption enhancer Azone on the transport of 5-fluorouracil across hairless rat skin. J. Pharm. Pharmacol. 37:1985;578-580.
16. Touitou E., Abed L. Effect of propylene glycol, Azone and n-decylmethylsulphoxide on skin permeation kinetics of 5-fluorouracil. Int. J. Pharm. 27:1985;89-98.
17. Welch M.L., Grabski W.J., McCollough M.L. et al. 5-Fluorouracil iontophoretic therapy for Bowen's disease. J. Am. Acad. Dermatol. 36:1997;956-958.
18. Williams A.R. Ultrasound: Biological Effects and Potential Hazards. 1983;Academic Press, London.