Novel dithranol phospholipid microemulsion for topical application: Development, characterization and percutaneous absorption studies

Journal of Microencapsulation

Volumn 28, Issue 3, 2011, Pages 190-199

  Raza, Kaisar ^a   Negi, Poonam ^a   Takyar, Shweta ^a   Shukla, Anshuman ^a   Amarji, Basant ^a   Katare, O P ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

anthralin; colloidal delivery; Dermal delivery; phase diagrams; surfactant; topical

Indexed keywords

ALCOHOL; ALPHA TOCOPHEROL; DITHRANOL; MYRISTIC ACID ISOPROPYL ESTER; OLIVE OIL; PHOSPHOLIPID; POLYSORBATE 20; POLYSORBATE 80; SOYBEAN OIL; ANTIOXIDANT; DERMATOLOGICAL AGENT; EMULSION; MYRISTIC ACID DERIVATIVE; OIL; POLYSORBATE; SURFACTANT; TOCOPHEROL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CENTRIFUGATION; DRUG ABSORPTION; DRUG DESIGN; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; FREEZE THAWING; MICROEMULSION; MOUSE; NONHUMAN; PARTICLE SIZE; REFRACTION INDEX; SKIN PENETRATION; SKIN PERMEABILITY; VISCOSITY; ZETA POTENTIAL; ANIMAL; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; EMULSION; INTRADERMAL DRUG ADMINISTRATION; PERMEABILITY; SKIN ABSORPTION;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTHRALIN; ANTIOXIDANTS; DERMATOLOGIC AGENTS; DRUG EVALUATION, PRECLINICAL; EMULSIONS; MICE; MYRISTATES; OILS; PERMEABILITY; PHOSPHOLIPIDS; POLYSORBATES; SKIN ABSORPTION; SURFACE-ACTIVE AGENTS; TOCOPHEROLS; VISCOSITY;

EID: 79953051360     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.3109/02652048.2010.546435     Document Type: Article

References (39)

1. Aboofazeli R, Lawrence CB, Wicks SR, Lawrence MJ. Investigations into the formation and characterization of phospholipid microemulsions. III. Pseudo-ternary phase diagrams of systems containing water-lecithin- IPM and either an alkanoic acid, amine, alkanediol, polyethylene glycol alkyl ether or alcohol as cosurfactant. Int J Pharm, 1994;111:63-72.
2. Agarwal R, Katare OP, Vyas SP. Preparation and in vitro evaluation of liposomal/ niosomal delivery systems for antipsoriatic drug dithranol. Int J Pharm, 2001;228:43-52. (Pubitemid 32905364)
3. Azeem A, Khan ZI, Aqil M, Ahmad FJ, Khar RK, Talegaonkar S. Microemulsions as a surrogate carrier for dermal drug delivery. Drug Dev Ind Pharm, 2009;35:525-47.
4. Changez M, Varshney M. Aerosol-OT microemulsions as transdermal carriers of tetracaine hydrochloride. Drug Dev Ind Pharm, 2000;26:507-12. (Pubitemid 30225628)
5. Cilek A, Celebi N, Tirnaksiz F. Lecithin-based microemulsion of a peptide for oral administration: Preparation, characterization, and physical stability of the formulation. Drug Delivery, 2006;13:19-24. (Pubitemid 43087616)
6. Craig DQM, Barker SA, Banning D, Booth SW. An investigation into the mechanisms of self-emulsification using particle size analysis and low frequency dielectric spectroscopy. Int J Pharm, 1995;114:103-10. (Pubitemid 24377034)
7. Delgado-Charro MB, Iglesias-Vilas G, Blanco-Méndez J, López Quintela MA, Marty JP, Guy RH. Delivery of a hydrophilic solute through the skin from novel microemulsion systems. Eur J Pharm Biopharm, 1997;43:37-42. (Pubitemid 28298808)
8. Gasco MR, 1997. Microemulsions in the pharmaceutical: Industrial applications of microemulsions. New York, USA: Marcel Dekker Inc.
9. Heuschkel S, Wohlrab J, Schmaus G, Neubert RHH. Modulation of dihydroavenanthramide D release and skin penetration by 1,2-alkanediols. Eur J Pharm Biopharm, 2008;70:239-47.
10. Hiller C, Campbell C, Smeaton I. How stable is dithranol? An investigation into the degradation of different dithranol formulations. Pharm Pract, 1995;5:428-31.
11. Hua L, Weisan P, Jiayu L. Preparation, evaluation and NMR characterization of vinpocetine microemulsion for transdermal delivery. Drug Dev Ind Pharm, 2004;30:657-66. (Pubitemid 38924636)
12. Kawakami K, Yoshikawa T, Moroto EK, Takahashi K, Nishihara Y, Masuda K. Microemulsion formulation for enhanced absorption of poorly soluble drugs I. Prescription design, J Controlled Release, 2002;81:65-74. (Pubitemid 34454850)
13. Kelmann RG, Kuminek G, Teixeira HF, Koester LS. Carbamazepine parenteral nanoemulsions prepared by spontaneous emulsification process. Int J Pharm, 2007;342:231-39. (Pubitemid 47271896)
14. Kogan A, Garti N. Microemulsions as transdermal drug delivery vehicles. Adv Colloid Interface Sci, 2006;123-126:369-85. (Pubitemid 44665819)
15. Kreilgaard M. Influence of microemulsions on cutaneous drug delivery. Adv Drug Delivery Rev, 2002;54:77-98.
16. Kreilgaard M, Pedersen EJ, Jaroszewski JW. NMR characterisation and transdermal drug delivery potential of microemulsion systems. J Controlled Release, 2000;69:421-33.
17. Ktistis G. A viscosity study on oil-in-water microemulsions. Int J Pharm, 1990;61:213-18. (Pubitemid 20209076)
18. Lawrence MJ, Rees GD. Microemulsion-based media as novel drug delivery systems. Adv Drug Delivery Rev, 2000;45:89-121.
19. Lin CC, Lin HY, Chen HC, Yu MW, Lee MH. Stability and characterisation of phospholipid-based curcumin-encapsulated microemulsions. Food Chem, 2009;116:923-28.
20. Lundberg B. Preparation of drug-carrier emulsions stabilized with phosphatidylcholine- surfactant mixtures. J Pharm Sci, 1994;83:72-5. (Pubitemid 24233734)
21. Magdassi S, Siman-Tov A. Formation and stabilization of perfluorocarbon emulsions. Int J Pharm, 1990;59:69-72. (Pubitemid 20143173)
22. Malcolmson C, Satra C, Kantaria S, Sidhu A, Lawrence MJ. Effect of oil on the level of solubilization of testosterone propionate into nonionic oil-inwater microemulsions. J Pharm Sci, 1998;87:109-16. (Pubitemid 28079271)
23. Mohammed C, Manoj V. Aerosol-OT microemulsions as transdermal carriers of tatracaine hydrochloride. Drug Dev Ind Pharm, 2000;26:507-12.
24. Moreno MA, Ballesteros MP, Frutos P. Lecithin-based oil-in-water microemulsions for parenteral use: Pseudo ternary phase diagrams, characterization and toxicity studies. J Pharm Sci, 2003;92:1428-37. (Pubitemid 36792756)
25. Mustakalio KK. Irritation, staining and antipsoriatic activity of 10-acyl analogue of anthralin. Br J Dermatol, 1981;105:23-7.
26. Paolino D, Ventura CA, Nisticò S, Puglisi G, Fresta M. Lecithin microemulsions for the topical administration of ketoprofen: percutaneous adsorption through human skin and in vivo human skin tolerability. Int J Pharm, 2002;244:21-131.
27. Peltola S, Saarinen-Savolainen P, Kiesvaara J, Suhonen TM, Urtti A. Microemulsions for topical delivery of estradiol. Int J Pharm, 2003;254:99-107. (Pubitemid 36298819)
28. Ruth HS, Attwood D, Ktistis G, Taylor CJ. Phase studies and particle diameter analysis of oil-in-water phospholipid microemulsions. Int J Pharm, 1995;116:253-61.
29. Shinoda K, Kaneko TJ. Characteristic properties of lecithin as a surfactant. J Dispersion Sci Technol, 1988;5:555-9.
30. Singh B, Mehta G, Kumar R, Bhatia A, Ahuja N, Katare OP. Design, development and optimization of nimuslide-loaded liposomal systems for topical applications. Curr Drug Delivery, 2005;2:143-53. (Pubitemid 40488624)
31. Sintov AC, Shapiro L. New microemulsion vehicle facilitates percutaneous penetration in vitro and cutaneous drug bioavailability in vivo. J Controlled Release, 2004;95:173-83. (Pubitemid 38230033)
32. Skiba M, Duchene D, Puisieux F, Wouessidjewe D. Development of a new colloidal drug carrier from chemically-modified cyclodextrins: Nanospheres and influence of physicochemical and technological factors on particle size. Int J Pharm, 1996;129:113-21. (Pubitemid 26098736)
33. Stilbs P, Lindman B, Rapacki K. Effect of alcohol cosurfactant length on microemulsion structure. J Colloid Interface Sci, 1983;95:583-5.
34. Subramanium N, Ray S, Ghosal SK, Bhadra R, Moulik SP. Formulation design of self-microemulsifying drug delivery systems for improved oral bioavailability of Celecoxib. Biol Pharm Bull, 2004;27:1993-9. (Pubitemid 41701577)
35. Wang JCT, Patel BG, Ehman CW, Lowe N. The release and percutaneous permeation of anthralin products, using clinically involved and uninvolved psoriatic skin. J Am Acad Dermatol, 1987;16:812-20.
36. Williams AC, Barry BW. Penetration enhancers. Adv Drug Delivery Rev, 2004;56:603-18. (Pubitemid 38326936)
37. Yokomizo Y, Sagitani H. The effects of phospholipids on the percutaneous penetration of indomethacin through the dorsal skin of guinea pig in vitro. 2. The effects of the hydrophobic group in phospholipids and a comparison with general enhancers. J Controlled Release, 1996;42:37-46. (Pubitemid 26297874)
38. Yuan Y, Li SM, Mo FK, Zhang DF. Investigation of microemulsion system for transdermal delivery of meloxicam. Int J Pharm, 2006;321:117-23. (Pubitemid 44247427)
39. Zhang XC, Jackson JK, Burt HM. Development of amphiphilic diblock copolymers as micellar carriers of taxol. Int J Pharm, 1996;132:195-206. (Pubitemid 26158719)