-
1
-
-
79958814789
-
Cancer statistics in Korea: Incidence, mortality, survival, and prevalence in 2008
-
Jung KW, Park S, Kong HJ, et al.: Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2008. Cancer Res Treat 2011; 43:1-11.
-
(2011)
Cancer Res Treat
, vol.43
, pp. 1-11
-
-
Jung, K.W.1
Park, S.2
Kong, H.J.3
-
3
-
-
0033917229
-
Cellular phenotypes of differentiated-type adenocarcinomas and precancerous lesions of the stomach are dependent on the genetic pathways
-
DOI 10.1002/1096-9896(2000)9999:9999<::AID-PATH631
-
Endoh Y, Sakata K, Tamura G, et al.: Cellular phenotypes of differentiated-type adenocarcinomas and precancerous lesions of the stomach are dependent on the genetic pathways. J Pathol 2000; 191:257-263. (Pubitemid 30441248)
-
(2000)
Journal of Pathology
, vol.191
, Issue.3
, pp. 257-263
-
-
Endoh, Y.1
Sakata, K.2
Tamura, G.3
Ohmura, K.4
Ajioka, Y.5
Watanabe, H.6
Motoyama, T.7
-
4
-
-
0029882053
-
Bcl-2 expression and allelic loss of the p53 gene in gastric carcinomas
-
DOI 10.1007/BF01212883
-
Saegusa M, Takano Y, Kamata Y, Okayasu J: Bcl-2 expression and allelic loss of the p53 gene in gastric carcinomas. J Cancer Res Clin Oncol 1996; 122:427-432. (Pubitemid 26226269)
-
(1996)
Journal of Cancer Research and Clinical Oncology
, vol.122
, Issue.7
, pp. 427-432
-
-
Saegusa, M.1
Takano, Y.2
Kamata, Y.3
Okayasu, I.4
-
5
-
-
0030907987
-
PI3K: Downstream AKTion blocks apoptosis
-
DOI 10.1016/S0092-8674(00)81883-8
-
Franke TF, Kaplan DR, Cantley LC: PI3K: downstream AK-Tion blocks apoptosis. Cell 1997; 88:435-437. (Pubitemid 27154408)
-
(1997)
Cell
, vol.88
, Issue.4
, pp. 435-437
-
-
Franke, T.F.1
Kaplan, D.R.2
Cantley, L.C.3
-
6
-
-
0033551070
-
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
-
DOI 10.1073/pnas.96.8.4240
-
Cantley LC, Neel BG: New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci U S A 1999; 96:4240-4245. (Pubitemid 29190320)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.8
, pp. 4240-4245
-
-
Cantley, L.C.1
Neel, B.G.2
-
7
-
-
0037352170
-
Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: A target for cancer chemotherapy
-
DOI 10.1038/sj.leu.2402824
-
Chang F, Lee JT, Navolanic PM, et al.: Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. Leukemia 2003; 17:590-603. (Pubitemid 36395654)
-
(2003)
Leukemia
, vol.17
, Issue.3
, pp. 590-603
-
-
Chang, F.1
Lee, J.T.2
Navolanic, P.M.3
Steelman, L.S.4
Shelton, J.G.5
Blalock, W.L.6
Franklin, R.A.7
McCubrey, J.A.8
-
9
-
-
33747042840
-
AKT can be activated in the nucleus
-
DOI 10.1016/j.cellsig.2006.01.020, PII S0898656806000295
-
Wang R, Brattain MG: AKT can be activated in the nucleus. Cell Signal 2006; 18:1722-1731. (Pubitemid 44216128)
-
(2006)
Cellular Signalling
, vol.18
, Issue.10
, pp. 1722-1731
-
-
Wang, R.1
Brattain, M.G.2
-
10
-
-
0036094711
-
Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival
-
Ermoian RP, Furniss CS, Lamborn KR, et al.: Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival. Clin Cancer Res 2002; 8:1100-1106. (Pubitemid 34517646)
-
(2002)
Clinical Cancer Research
, vol.8
, Issue.5
, pp. 1100-1106
-
-
Ermoian, R.P.1
Furniss, C.S.2
Lamborn, K.R.3
Basila, D.4
Berger, M.S.5
Gottschalk, A.R.6
Nicholas, M.K.7
Stokoe, D.8
Haas-Kogan, D.A.9
-
11
-
-
11144354317
-
Prognostic Significance of Activated Akt Expression in Pancreatic Ductal Adenocarcinoma
-
DOI 10.1158/1078-0432.CCR-02-1441
-
Yamamoto S, Tomita Y, Hoshida Y, et al.: Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma. Clin Cancer Res 2004; 10:2846-2850. (Pubitemid 38509164)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.8
, pp. 2846-2850
-
-
Yamamoto, S.1
Tomita, Y.2
Hoshida, Y.3
Morooka, T.4
Nagano, H.5
Dono, K.6
Umeshita, K.7
Sakon, M.8
Ishikawa, O.9
Ohigashi, H.10
Nakamori, S.11
Monden, M.12
Aozasa, K.13
-
12
-
-
18644376449
-
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest
-
DOI 10.1038/nm761
-
Liang J, Zubovitz J, Petrocelli T, et al.: PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest Nat Med 2002; 8:1153-1160. (Pubitemid 35175971)
-
(2002)
Nature Medicine
, vol.8
, Issue.10
, pp. 1153-1160
-
-
Liang, J.1
Zubovitz, J.2
Petrocelli, T.3
Kotchetkov, R.4
Connor, M.K.5
Han, K.6
Lee, J.-H.7
Ciarallo, S.8
Catzavelos, C.9
Beniston, R.10
Franssen, E.11
Slingerland, J.M.12
-
13
-
-
0036799377
-
Kip1 at threonine 157 and modulation of its cellular localization
-
DOI 10.1038/nm759
-
Shin I, Yakes FM, Rojo F, et al.: PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. Nat Med 2002; 8:1145-1152. (Pubitemid 35175970)
-
(2002)
Nature Medicine
, vol.8
, Issue.10
, pp. 1145-1152
-
-
Shin, I.1
Yakes, F.M.2
Rojo, F.3
Shin, N.-Y.4
Bakin, A.V.5
Baselga, J.6
Arteaga, C.L.7
-
14
-
-
18644370396
-
kip1 by PKB/Akt-mediated phosphorylation in breast cancer
-
DOI 10.1038/nm762
-
Viglietto G, Motti ML, Bruni P, et al.: Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer. Nat Med 2002; 8:1136-1144. (Pubitemid 35175969)
-
(2002)
Nature Medicine
, vol.8
, Issue.10
, pp. 1136-1144
-
-
Viglietto, G.1
Motti, M.L.2
Bruni, P.3
Melillo, R.M.4
D'Alessio, A.5
Califano, D.6
Vinci, F.7
Chiappetta, G.8
Tsichliss, P.9
Bellacosa, A.10
Fusco, A.11
Santoro, M.12
-
16
-
-
12644292106
-
The two histological main types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma. an attempt at a histo-clinical classification
-
Lauren P: The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. an attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 1965; 64:31-49.
-
(1965)
Acta Pathol Microbiol Scand
, vol.64
, pp. 31-49
-
-
Lauren, P.1
-
18
-
-
0036632368
-
The phosphatidylinositol 3-kinase-AKT pathway in human cancer
-
Vivanco I, Sawyers CL: The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002; 2:489-501. (Pubitemid 37328931)
-
(2002)
Nature Reviews Cancer
, vol.2
, Issue.7
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
19
-
-
0035448879
-
Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 gene
-
DOI 10.1101/gad.913901
-
Chen WS, Xu PZ, Gottlob K, et al.: Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev 2001; 15:2203-2208. (Pubitemid 32843832)
-
(2001)
Genes and Development
, vol.15
, Issue.17
, pp. 2203-2208
-
-
Chen, W.S.1
Xu, P.-Z.2
Gottlob, K.3
Chen, M.-L.4
Sokol, K.5
Shiyanova, T.6
Roninson, I.7
Weng, W.8
Suzuki, R.9
Tobe, K.10
Kadowaki, T.11
Hay, N.12
-
20
-
-
0035914388
-
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
-
Cho H, Thorvaldsen JL, Chu Q, et al.: Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem 2001; 276:38349-38352.
-
(2001)
J Biol Chem
, vol.276
, pp. 38349-38352
-
-
Cho, H.1
Thorvaldsen, J.L.2
Chu, Q.3
-
21
-
-
0035368548
-
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBbeta)
-
DOI 10.1126/science.292.5522.1728
-
Cho H, Mu J, Kim JK, et al.: Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science 2001; 292:1728-1731. (Pubitemid 32506248)
-
(2001)
Science
, vol.292
, Issue.5522
, pp. 1728-1731
-
-
Cho, H.1
Mu, J.2
Kim, J.K.3
Thorvaldsen, J.L.4
Chu, Q.5
Crenshaw III, E.B.6
Kaestner, K.H.7
Bartolomei, M.S.8
Shulman, G.I.9
Birnbaum, M.J.10
-
22
-
-
85047693348
-
Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBbeta
-
DOI 10.1172/JCI200316885
-
Garofalo RS, Orena SJ, Rafidi K, et al.: Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta. J Clin Invest 2003; 112:197-208. (Pubitemid 38056356)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.2
, pp. 197-208
-
-
Garofalo, R.S.1
Orena, S.J.2
Rafidi, K.3
Torchia, A.J.4
Stock, J.L.5
Hildebrandt, A.L.6
Coskran, T.7
Black, S.C.8
Brees, D.J.9
Wicks, J.R.10
McNeish, J.D.11
Coleman, K.G.12
-
23
-
-
20044382806
-
Role for Akt3/protein kinase by in attainment of normal brain size
-
DOI 10.1128/MCB.25.5.1869-1878.2005
-
Easton RM, Cho H, Roovers K, et al.: Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Mol Cell Biol 2005; 25:1869-1878. (Pubitemid 40280150)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.5
, pp. 1869-1878
-
-
Easton, R.M.1
Cho, H.2
Roovers, K.3
Shineman, D.W.4
Mizrahi, M.5
Forman, M.S.6
Lee, V.M.-Y.7
Szabolcs, M.8
De Jong, R.9
Oltersdorf, T.10
Ludwig, T.11
Efstratiadis, A.12
Birnbaum, M.J.13
-
24
-
-
23144449547
-
Essential role of protein kinase Bgamma (PKBgamma/Akt3) in postnatal brain developmental but not in glucose homeostasis
-
DOI 10.1242/dev.01864
-
Tschopp O, Yang ZZ, Brodbeck D, et al.: Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis. Development 2005; 132:2943-2954. (Pubitemid 41086730)
-
(2005)
Development
, vol.132
, Issue.13
, pp. 2943-2954
-
-
Tschopp, O.1
Yang, Z.-Z.2
Brodbeck, D.3
Dummler, B.A.4
Hemmings-Mieszczak, M.5
Watanabe, T.6
Michaelis, T.7
Frahm, J.8
Hemmings, B.A.9
-
25
-
-
0037728809
-
The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines
-
Grille SJ, Bellacosa A, Upson J, et al.: The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. Cancer Res 2003; 63:2172-2178. (Pubitemid 36538623)
-
(2003)
Cancer Research
, vol.63
, Issue.9
, pp. 2172-2178
-
-
Grille, S.J.1
Bellacosa, A.2
Upson, J.3
Klein-Szanto, A.J.4
Van Roy, F.5
Lee-Kwon, W.6
Donowitz, M.7
Tsichlis, P.N.8
Larue, L.9
-
26
-
-
0037304479
-
Elevated Akt activation and its impact on clinicopathological features of renal cell carcinoma
-
DOI 10.1016/S0022-5347(05)63998-5
-
Horiguchi A, Oya M, Uchida A, et al.: Elevated Akt activation and its impact on clinicopathological features of renal cell carcinoma. J Urol 2003; 169:710-713. (Pubitemid 36133028)
-
(2003)
Journal of Urology
, vol.169
, Issue.2
, pp. 710-713
-
-
Horiguchi, A.1
Oya, M.2
Uchida, A.3
Marumo, K.4
Murai, M.5
-
27
-
-
4544231168
-
Prognostic relevance of activated Akt kinase in node-negative breast cancer: A clinicopathological study of 99 cases
-
DOI 10.1038/modpathol.3800002
-
Schmitz KJ, Otterbach F, Callies R, et al.: Prognostic relevance of activated Akt kinase in node-negative breast cancer: a clinicopathological study of 99 cases. Mod Pathol 2004; 17:15-21. (Pubitemid 41656447)
-
(2004)
Modern Pathology
, vol.17
, Issue.1
, pp. 15-21
-
-
Schmitz, K.J.1
Otterbach, F.2
Callies, R.3
Levkau, B.4
Holscher, M.5
Hoffmann, O.6
Grabellus, F.7
Kimmig, R.8
Schmid, K.W.9
Baba, H.A.10
-
28
-
-
44349163452
-
Akt1/protein kinase Balpha is involved in gastric cancer progression and cell proliferation
-
DOI 10.1007/s10620-007-9824-2
-
Han Z, Wu K, Shen H, et al.: Akt1/protein kinase B alpha is involved in gastric cancer progression and cell proliferation. Dig Dis Sci 2008; 53:1801-1810. (Pubitemid 351748978)
-
(2008)
Digestive Diseases and Sciences
, vol.53
, Issue.7
, pp. 1801-1810
-
-
Han, Z.1
Wu, K.2
Shen, H.3
Li, C.4
Han, S.5
Hong, L.6
Shi, Y.7
Liu, N.8
Guo, C.9
Xue, Y.10
Qiao, T.11
Fan, D.12
-
29
-
-
38849114939
-
A hypoxia-independent up-regulation of hypoxia-inducible factor-1 by AKT contributes to angiogenesis in human gastric cancer
-
DOI 10.1093/carcin/bgm232
-
Lee BL, Kim WH, Jung J, et al.: A hypoxia-independent upregulation of hypoxia-inducible factor-1 by AKT contributes to angiogenesis in human gastric cancer. Carcinogenesis 2008; 29:44-51. (Pubitemid 351201740)
-
(2008)
Carcinogenesis
, vol.29
, Issue.1
, pp. 44-51
-
-
Lee, B.I.1
Kim, W.H.2
Jung, J.3
Cho, S.J.4
Park, J.-W.5
Kim, J.6
Chung, H.-Y.7
Chang, M.S.8
Nam, S.Y.9
-
30
-
-
33847679524
-
Expression of phosphorylated Akt (pAkt) in gastric carcinoma predicts prognosis and efficacy of chemotherapy
-
DOI 10.1007/s10120-006-0410-7
-
Murakami D, Tsujitani S, Osaki T, et al.: Expression of phosphorylated Akt (pAkt) in gastric carcinoma predicts prognosis and efficacy of chemotherapy. Gastric Cancer 2007; 10:45-51. (Pubitemid 46356263)
-
(2007)
Gastric Cancer
, vol.10
, Issue.1
, pp. 45-51
-
-
Murakami, D.1
Tsujitani, S.2
Osaki, T.3
Saito, H.4
Katano, K.5
Tatebe, S.6
Ikeguchi, M.7
-
31
-
-
0031456578
-
Cell proliferation, cell death and angiogenesis in early and advanced gastric cancer of intestinal type
-
DOI 10.1002/(SICI)1097-0215(19971219)74:6<637::AID
-
Vindigni C, Miracco C, Spina D, et al.: Cell proliferation, cell death and angiogenesis in early and advanced gastric cancer of intestinal type. Int J Cancer 1997; 74:637-641. (Pubitemid 28037508)
-
(1997)
International Journal of Cancer
, vol.74
, Issue.6
, pp. 637-641
-
-
Vindigni, C.1
Miracco, C.2
Spina, D.3
Presenti, L.4
Gallorini, M.5
Vatti, R.6
De Stefano, A.7
Roviello, F.8
Pinto, E.9
Filipe, M.I.10
Tosi, P.11
-
32
-
-
36849015047
-
Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death
-
Yu HG, Ai YW, Yu LL, et al.: Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death. Int J Cancer 2008; 122:433-443.
-
(2008)
Int J Cancer
, vol.122
, pp. 433-443
-
-
Yu, H.G.1
Ai, Y.W.2
Yu, L.L.3
-
33
-
-
55849146269
-
Activated Akt as an indicator of prognosis in gastric cancer
-
Cinti C, Vindigni C, Zamparelli A, et al.: Activated Akt as an indicator of prognosis in gastric cancer. Virchows Arch 2008; 453:449-455.
-
(2008)
Virchows Arch
, vol.453
, pp. 449-455
-
-
Cinti, C.1
Vindigni, C.2
Zamparelli, A.3
-
34
-
-
84855178664
-
Targeting AKT Protein Kinase in Gastric Cancer
-
Almhanna K, Strosberg J, Malafa M: Targeting AKT Protein Kinase in Gastric Cancer. Anticancer Res 2011; 31:4387-4392.
-
(2011)
Anticancer Res
, vol.31
, pp. 4387-4392
-
-
Almhanna, K.1
Strosberg, J.2
Malafa, M.3
-
35
-
-
0028363519
-
p27, A novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
-
DOI 10.1016/0092-8674(94)90573-8
-
Toyoshima H, Hunter T: p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 1994; 78:67-74. (Pubitemid 24228301)
-
(1994)
Cell
, vol.78
, Issue.1
, pp. 67-74
-
-
Toyoshima, H.1
Hunter, T.2
-
36
-
-
0035092687
-
Skp2-mediated ubiquitinylation of p27
-
DOI 10.1038/35060126
-
Ganoth D, Bornstein G, Ko TK, et al.: The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27. Nat Cell Biol 2001; 3:321-324. (Pubitemid 32201330)
-
(2001)
Nature Cell Biology
, vol.3
, Issue.3
, pp. 321-324
-
-
Ganoth, D.1
Bornstein, G.2
Ko, T.K.3
Larsen, B.4
Tyers, M.5
Pagano, M.6
Hershko, A.7
-
37
-
-
0035265829
-
Kip1
-
DOI 10.1016/S1097-2765(01)00210-6
-
Spruck C, Strohmaier H, Watson M, et al.: A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1. Mol Cell 2001; 7:639-650. (Pubitemid 32706355)
-
(2001)
Molecular Cell
, vol.7
, Issue.3
, pp. 639-650
-
-
Spruck, C.1
Strohmaier, H.2
Watson, M.3
Smith, A.P.L.4
Ryan, A.5
Krek, W.6
Reed, S.I.7
-
38
-
-
0344198099
-
Cyclin-Dependent Kinase 1 Gene Expression Is Associated with Poor Prognosis in Gastric Carcinoma
-
Masuda TA, Inoue H, Nishida K, et al.: Cyclin-dependent kinase 1 gene expression is associated with poor prognosis in gastric carcinoma. Clin Cancer Res 2003; 9:5693-5698. (Pubitemid 37499492)
-
(2003)
Clinical Cancer Research
, vol.9
, Issue.15
, pp. 5693-5698
-
-
Masuda, T.-A.1
Inoue, H.2
Nishida, K.3
Sonoda, H.4
Yoshikawa, Y.5
Kakeji, Y.6
Utsunomiya, T.7
Mori, M.8
-
39
-
-
15744382959
-
The prognostic impact of the ubiquitin ligase subunits Skp2 and Cks1 in colorectal carcinoma
-
DOI 10.1002/cncr.20917
-
Shapira M, Ben-Izhak O, Linn S, et al.: The prognostic impact of the ubiquitin ligase subunits Skp2 and Cks1 in colorectal carcinoma. Cancer 2005; 103:1336-1346. (Pubitemid 40410727)
-
(2005)
Cancer
, vol.103
, Issue.7
, pp. 1336-1346
-
-
Shapira, M.1
Ben-Izhak, O.2
Linn, S.3
Futerman, B.4
Minkov, I.5
Hershko, D.D.6
-
40
-
-
33644875101
-
The expression of the ubiquitin ligase subunit Cks1 in human breast cancer
-
Slotky M, Shapira M, Ben-Izhak O, et al.: The expression of the ubiquitin ligase subunit Cks1 in human breast cancer. Breast Cancer Res 2005; 7:R737-744.
-
(2005)
Breast Cancer Res
, vol.7
-
-
Slotky, M.1
Shapira, M.2
Ben-Izhak, O.3
|