-
1
-
-
72849146885
-
Challenging the current approaches to multiple myeloma-related bone disease: From bisphosphonates to target therapy
-
Tassone P, Tagliaferri P, Rossi M, et al. Challenging the current approaches to multiple myeloma-related bone disease: from bisphosphonates to target therapy. Curr Cancer Drug Targets 2009;9:854-70
-
(2009)
Curr Cancer Drug Targets
, vol.9
, pp. 854-870
-
-
Tassone, P.1
Tagliaferri, P.2
Rossi, M.3
-
2
-
-
84863607209
-
Multiple myeloma and its therapies: To what extent do they contribute to the increased incidence of second malignant neoplasms?
-
Dasanu CA, Mewawalla P, Grabska J. Multiple myeloma and its therapies: to what extent do they contribute to the increased incidence of second malignant neoplasms? Curr Med Res Opin 2012;28:1129-40
-
(2012)
Curr Med Res Opin
, vol.28
, pp. 1129-1140
-
-
Dasanu, C.A.1
Mewawalla, P.2
Grabska, J.3
-
3
-
-
84858824788
-
Second malignancies after multiple myeloma: From 1960s to 2010s
-
Thomas A, Mailankody S, Korde N, et al. Second malignancies after multiple myeloma: from 1960s to 2010s. Blood 2012;119:2731-7
-
(2012)
Blood
, vol.119
, pp. 2731-2737
-
-
Thomas, A.1
Mailankody, S.2
Korde, N.3
-
4
-
-
22544458771
-
Human dendritic cells: Potent antigen-presenting cells at the crossroads of innate and adaptive immunity
-
Rossi M, Young JW. Human dendritic cells: potent antigen-presenting cells at the crossroads of innate and adaptive immunity. J Immunol 2005;175:1373-81
-
(2005)
J Immunol
, vol.175
, pp. 1373-1381
-
-
Rossi, M.1
Young, J.W.2
-
5
-
-
61349100687
-
Myeloid-derived suppressor cells as regulators of the immune system
-
Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 2009;9:162-74
-
(2009)
Nat Rev Immunol
, vol.9
, pp. 162-174
-
-
Gabrilovich, D.I.1
Nagaraj, S.2
-
6
-
-
0043268854
-
Understanding the cell biology of antigen presentation: The dendritic cell contribution
-
Gatti E, Pierre P. Understanding the cell biology of antigen presentation: the dendritic cell contribution. Curr Opin Cell Biol 2003;15:468-73
-
(2003)
Curr Opin Cell Biol
, vol.15
, pp. 468-473
-
-
Gatti, E.1
Pierre, P.2
-
7
-
-
84872175112
-
Dendritic cells a double-edge sword in autoimmune responses
-
Amodio G, Gregori S. Dendritic cells a double-edge sword in autoimmune responses. Front Immunol 2012;3:233
-
(2012)
Front Immunol
, vol.3
, pp. 233
-
-
Amodio, G.1
Gregori, S.2
-
8
-
-
77956538422
-
Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway
-
Gregori S, Tomasoni D, Pacciani V, et al. Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway. Blood 2010;116:935-44
-
(2010)
Blood
, vol.116
, pp. 935-944
-
-
Gregori, S.1
Tomasoni, D.2
Pacciani, V.3
-
9
-
-
0036659945
-
Dendritic cells are functionally defective in multiple myeloma: The role of interleukin-6
-
Ratta M, Fagnoni F, Curti A, et al. Dendritic cells are functionally defective in multiple myeloma: the role of interleukin-6. Blood 2002;100:230-7
-
(2002)
Blood
, vol.100
, pp. 230-237
-
-
Ratta, M.1
Fagnoni, F.2
Curti, A.3
-
10
-
-
61649125595
-
The dysfunction and abnormal signaling pathway of dendritic cells loaded by tumor antigen can be overcome by neutralizing VEGF in multiple myeloma
-
Yang DH, Park JS, Jin CJ, et al. The dysfunction and abnormal signaling pathway of dendritic cells loaded by tumor antigen can be overcome by neutralizing VEGF in multiple myeloma. Leuk Res 2009;33:665-70
-
(2009)
Leuk Res
, vol.33
, pp. 665-670
-
-
Yang, D.H.1
Park, J.S.2
Jin, C.J.3
-
11
-
-
3042691752
-
Either interleukin-12 or interferon-gamma can correct the dendritic cell defect induced by transforming growth factor beta in patients with myeloma
-
Brown R, Murray A, Pope B, et al. Either interleukin-12 or interferon-gamma can correct the dendritic cell defect induced by transforming growth factor beta in patients with myeloma. Br J Haematol 2004;125:743-8
-
(2004)
Br J Haematol
, vol.125
, pp. 743-748
-
-
Brown, R.1
Murray, A.2
Pope, B.3
-
12
-
-
0037033448
-
Antitumor monoclonal antibodies enhance cross-presentation ofcCellular antigens and the generation of myeloma-specific killer T cells by dendritic cells
-
Dhodapkar KM, Krasovsky J, Williamson B, et al. Antitumor monoclonal antibodies enhance cross-presentation ofcCellular antigens and the generation of myeloma-specific killer T cells by dendritic cells. J Exp Med 2002;195:125-33
-
(2002)
J Exp Med
, vol.195
, pp. 125-133
-
-
Dhodapkar, K.M.1
Krasovsky, J.2
Williamson, B.3
-
13
-
-
84856332921
-
Cetuximab +/-chemotherapy enhances dendritic cell-mediated phagocytosis of colon cancer cells and ignites a highly efficient colon cancer antigen-specific cytotoxic T-cell response in vitro
-
Correale P, Botta C, Cusi MG, et al. Cetuximab +/-chemotherapy enhances dendritic cell-mediated phagocytosis of colon cancer cells and ignites a highly efficient colon cancer antigen-specific cytotoxic T-cell response in vitro. Int J Cancer 2012;130:1577-89
-
(2012)
Int J Cancer
, vol.130
, pp. 1577-1589
-
-
Correale, P.1
Botta, C.2
Cusi, M.G.3
-
14
-
-
84861235490
-
Immune-modulating effects of the newest cetuximab-based chemoimmunotherapy regimen in advanced colorectal cancer patients
-
Botta C, Bestoso E, Apollinari S, et al. Immune-modulating effects of the newest cetuximab-based chemoimmunotherapy regimen in advanced colorectal cancer patients. J Immunother 2012;35:440-7
-
(2012)
J Immunother
, vol.35
, pp. 440-447
-
-
Botta, C.1
Bestoso, E.2
Apollinari, S.3
-
16
-
-
77951820013
-
Dysregulation in T helper 1/T helper 2 cytokine ratios in patients with multiple myeloma
-
Sharma A, Khan R, Joshi S, et al. Dysregulation in T helper 1/T helper 2 cytokine ratios in patients with multiple myeloma. Leuk Lymphoma 2010;51:920-7
-
(2010)
Leuk Lymphoma
, vol.51
, pp. 920-927
-
-
Sharma, A.1
Khan, R.2
Joshi, S.3
-
17
-
-
0038268128
-
Viral antigen-specific CD8+ T-cell responses are impaired in multiple myeloma
-
Maecker B, Anderson KS, von Bergwelt-Baildon MS, et al. Viral antigen-specific CD8+ T-cell responses are impaired in multiple myeloma. Br J Haematol 2003;121:842-8
-
(2003)
Br J Haematol
, vol.121
, pp. 842-848
-
-
Maecker, B.1
Anderson, K.S.2
Von Bergwelt-Baildon, M.S.3
-
18
-
-
78049386125
-
Immunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma
-
Gorgun G, Calabrese E, Soydan E, et al. Immunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma. Blood 2010;116:3227-37
-
(2010)
Blood
, vol.116
, pp. 3227-3237
-
-
Gorgun, G.1
Calabrese, E.2
Soydan, E.3
-
19
-
-
0036849109
-
A regulatory role for suppressor of cytokine signaling-1 in T(h) polarization in vivo
-
Fujimoto M, Tsutsui H, Yumikura-Futatsugi S, et al. A regulatory role for suppressor of cytokine signaling-1 in T(h) polarization in vivo. Int Immunol 2002;14:1343-50
-
(2002)
Int Immunol
, vol.14
, pp. 1343-1350
-
-
Fujimoto, M.1
Tsutsui, H.2
Yumikura-Futatsugi, S.3
-
20
-
-
28044461950
-
Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK-STAT
-
Kimura A, Naka T, Muta T, et al. Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK-STAT. Proc Natl Acad Sci USA 2005;102:17089-94
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 17089-17094
-
-
Kimura, A.1
Naka, T.2
Muta, T.3
-
21
-
-
16844365788
-
Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
-
Sakaguchi S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 2005;6:345-52
-
(2005)
Nat Immunol
, vol.6
, pp. 345-352
-
-
Sakaguchi, S.1
-
23
-
-
70149093957
-
Indoleamine 2, 3-dioxygenase-expressing mature human monocyte-derived dendritic cells expand potent autologous regulatory T cells
-
Chung DJ, Rossi M, Romano E, et al. Indoleamine 2, 3-dioxygenase- expressing mature human monocyte-derived dendritic cells expand potent autologous regulatory T cells. Blood 2009;114:555-63
-
(2009)
Blood
, vol.114
, pp. 555-563
-
-
Chung, D.J.1
Rossi, M.2
Romano, E.3
-
24
-
-
20144368637
-
Dendritic cells have the option to express IDO-mediated suppression or not
-
Munn DH, Mellor AL, Rossi M, et al. Dendritic cells have the option to express IDO-mediated suppression or not. Blood 2005;105:2618
-
(2005)
Blood
, vol.105
, pp. 2618
-
-
Munn, D.H.1
Mellor, A.L.2
Rossi, M.3
-
25
-
-
34547894233
-
Induction of immunosuppressive functions of dendritic cells in vivo by CD4+CD25+ regulatory T cells: Role of B7-H3 expression and antigen presentation
-
Mahnke K, Ring S, Johnson TS, et al. Induction of immunosuppressive functions of dendritic cells in vivo by CD4+CD25+ regulatory T cells: role of B7-H3 expression and antigen presentation. Eur J Immunol 2007;37:2117-26
-
(2007)
Eur J Immunol
, vol.37
, pp. 2117-2126
-
-
Mahnke, K.1
Ring, S.2
Johnson, T.S.3
-
26
-
-
27644449311
-
The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs
-
Allan SE, Passerini L, Bacchetta R, et al. The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs. J Clin Invest 2005;115:3276-84
-
(2005)
J Clin Invest
, vol.115
, pp. 3276-3284
-
-
Allan, S.E.1
Passerini, L.2
Bacchetta, R.3
-
27
-
-
53749094183
-
CTLA-4 control over Foxp3+ regulatory T cell function
-
Wing K, Onishi Y, Prieto-Martin P, et al. CTLA-4 control over Foxp3+ regulatory T cell function. Science 2008;322:271-5
-
(2008)
Science
, vol.322
, pp. 271-275
-
-
Wing, K.1
Onishi, Y.2
Prieto-Martin, P.3
-
28
-
-
49149125958
-
Expression of ICOS on human melanoma-infiltrating CD4 +CD25highFoxp3+ T regulatory cells: Implications and impact on tumor-mediated immune suppression
-
Strauss L, Bergmann C, Szczepanski MJ, et al. Expression of ICOS on human melanoma-infiltrating CD4 +CD25highFoxp3+ T regulatory cells: implications and impact on tumor-mediated immune suppression. J Immunol 2008;180:2967-80
-
(2008)
J Immunol
, vol.180
, pp. 2967-2980
-
-
Strauss, L.1
Bergmann, C.2
Szczepanski, M.J.3
-
29
-
-
82755184094
-
Two modes of immune suppression by Foxp3(+) regulatory T cells under inflammatory or non-inflammatory conditions
-
Yamaguchi T, Wing JB, Sakaguchi S. Two modes of immune suppression by Foxp3(+) regulatory T cells under inflammatory or non-inflammatory conditions. Semin Immunol 2011;23:424-30
-
(2011)
Semin Immunol
, vol.23
, pp. 424-430
-
-
Yamaguchi, T.1
Wing, J.B.2
Sakaguchi, S.3
-
30
-
-
77954959667
-
Regulatory (FoxP3+) T-cell tumor infiltration is a favorable prognostic factor in advanced colon cancer patients undergoing chemo or chemoimmunotherapy
-
Correale P, Rotundo MS, Del Vecchio MT, et al. Regulatory (FoxP3+) T-cell tumor infiltration is a favorable prognostic factor in advanced colon cancer patients undergoing chemo or chemoimmunotherapy. J Immunother 2010;33:435-41
-
(2010)
J Immunother
, vol.33
, pp. 435-441
-
-
Correale, P.1
Rotundo, M.S.2
Del Vecchio, M.T.3
-
31
-
-
84879187714
-
Tumor infiltration by chemokine receptor 7 (CCR7)(+) T-lymphocytes is a favorable prognostic factor in metastatic colorectal cancer
-
Correale P, Rotundo MS, Botta C, et al. Tumor infiltration by chemokine receptor 7 (CCR7)(+) T-lymphocytes is a favorable prognostic factor in metastatic colorectal cancer. Oncoimmunology 2012;1:531-2
-
(2012)
Oncoimmunology
, vol.1
, pp. 531-532
-
-
Correale, P.1
Rotundo, M.S.2
Botta, C.3
-
32
-
-
84856545781
-
Tumor infiltration by T lymphocytes expressing chemokine receptor 7 (CCR7) is predictive of favorable outcome in patients with advanced colorectal carcinoma
-
Correale P, Rotundo MS, Botta C, et al. Tumor infiltration by T lymphocytes expressing chemokine receptor 7 (CCR7) is predictive of favorable outcome in patients with advanced colorectal carcinoma. Clin Cancer Res 2012;18:850-7
-
(2012)
Clin Cancer Res
, vol.18
, pp. 850-857
-
-
Correale, P.1
Rotundo, M.S.2
Botta, C.3
-
33
-
-
30144444962
-
Dysfunctional T regulatory cells in multiple myeloma
-
Prabhala RH, Neri P, Bae JE, et al. Dysfunctional T regulatory cells in multiple myeloma. Blood 2006;107:301-4
-
(2006)
Blood
, vol.107
, pp. 301-304
-
-
Prabhala, R.H.1
Neri, P.2
Bae, J.E.3
-
34
-
-
58149241014
-
Generation of antitumor invariant natural killer T cell lines in multiple myeloma and promotion of their functions via lenalidomide: A strategy for immunotherapy
-
Song W, van der Vliet HJ, Tai YT, et al. Generation of antitumor invariant natural killer T cell lines in multiple myeloma and promotion of their functions via lenalidomide: a strategy for immunotherapy. Clin Cancer Res 2008;14:6955-62
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6955-6962
-
-
Song, W.1
Van Der Vliet, H.J.2
Tai, Y.T.3
-
35
-
-
33646575622
-
In vivo peripheral expansion of naive CD4+CD25high FoxP3+ regulatory T cells in patients with multiple myeloma
-
Beyer M, Kochanek M, Giese T, et al. In vivo peripheral expansion of naive CD4+CD25high FoxP3+ regulatory T cells in patients with multiple myeloma. Blood 2006;107:3940-9
-
(2006)
Blood
, vol.107
, pp. 3940-3949
-
-
Beyer, M.1
Kochanek, M.2
Giese, T.3
-
36
-
-
84867372743
-
Increased T regulatory cells are associated with adverse clinical features and predict progression in multiple myeloma
-
Muthu Raja KR, Rihova L, Zahradova L, et al. Increased T regulatory cells are associated with adverse clinical features and predict progression in multiple myeloma. PloS One 2012;7:e47077
-
(2012)
PloS One
, vol.7
-
-
Muthu Raja, K.R.1
Rihova, L.2
Zahradova, L.3
-
37
-
-
53449089919
-
Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma
-
Dhodapkar KM, Barbuto S, Matthews P, et al. Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma. Blood 2008;112:2878-85
-
(2008)
Blood
, vol.112
, pp. 2878-2885
-
-
Dhodapkar, K.M.1
Barbuto, S.2
Matthews, P.3
-
38
-
-
77955862810
-
Elevated IL-17 produced by TH17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma
-
Prabhala RH, Pelluru D, Fulciniti M, et al. Elevated IL-17 produced by TH17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma. Blood 2010;115:5385-92
-
(2010)
Blood
, vol.115
, pp. 5385-5392
-
-
Prabhala, R.H.1
Pelluru, D.2
Fulciniti, M.3
-
39
-
-
78149322663
-
A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma
-
Noonan K, Marchionni L, Anderson J, et al. A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma. Blood 2010;116:3554-63
-
(2010)
Blood
, vol.116
, pp. 3554-3563
-
-
Noonan, K.1
Marchionni, L.2
Anderson, J.3
-
40
-
-
0033134608
-
IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
-
Kotake S, Udagawa N, Takahashi N, et al. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest 1999;103:1345-52
-
(1999)
J Clin Invest
, vol.103
, pp. 1345-1352
-
-
Kotake, S.1
Udagawa, N.2
Takahashi, N.3
-
41
-
-
84861572331
-
Myeloid-derived suppressor cell measurements in fresh and cryopreserved blood samples
-
Kotsakis A, Harasymczuk M, Schilling B, et al. Myeloid-derived suppressor cell measurements in fresh and cryopreserved blood samples. J Immunol Methods 2012;381:14-22
-
(2012)
J Immunol Methods
, vol.381
, pp. 14-22
-
-
Kotsakis, A.1
Harasymczuk, M.2
Schilling, B.3
-
42
-
-
4344590947
-
High-dose granulocyte-macrophage colony-stimulating factor-producing vaccines impair the immune response through the recruitment of myeloid suppressor cells
-
Serafini P, Carbley R, Noonan KA, et al. High-dose granulocyte-macrophage colony-stimulating factor-producing vaccines impair the immune response through the recruitment of myeloid suppressor cells. Cancer Res 2004;64:6337-43
-
(2004)
Cancer Res
, vol.64
, pp. 6337-6343
-
-
Serafini, P.1
Carbley, R.2
Noonan, K.A.3
-
43
-
-
35448954376
-
Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression
-
Bunt SK, Yang L, Sinha P, et al. Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression. Cancer Res 2007;67:10019-26
-
(2007)
Cancer Res
, vol.67
, pp. 10019-10026
-
-
Bunt, S.K.1
Yang, L.2
Sinha, P.3
-
44
-
-
79959271214
-
Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells
-
Hoechst B, Gamrekelashvili J, Manns MP, et al. Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells. Blood 2011;117:6532-41
-
(2011)
Blood
, vol.117
, pp. 6532-6541
-
-
Hoechst, B.1
Gamrekelashvili, J.2
Manns, M.P.3
-
45
-
-
84879452593
-
Tumor promoting immune suppressive myeloid derived suppressor cells in multiple myeloma microenvironment
-
Gorgün GT, Whitehill G, Anderson JL, et al. Tumor promoting immune suppressive myeloid derived suppressor cells in multiple myeloma microenvironment. Blood 2013;121:2975-87
-
(2013)
Blood
, vol.121
, pp. 2975-2987
-
-
Gorgün, G.T.1
Whitehill, G.2
Anderson, J.L.3
-
46
-
-
84872087150
-
Analysis of the immune system of multiple myeloma patients achieving long-term disease control by multidimensional flow cytometry
-
Pessoa de Magalhaes RJ, Vidriales MB, Paiva B, et al. Analysis of the immune system of multiple myeloma patients achieving long-term disease control by multidimensional flow cytometry. Haematologica 2013;98:79-86
-
(2013)
Haematologica
, vol.98
, pp. 79-86
-
-
Pessoa De Magalhaes, R.J.1
Vidriales, M.B.2
Paiva, B.3
-
47
-
-
79954445562
-
Competition between clonal plasma cells and normal cells for potentially overlapping bone marrow niches is associated with a progressively altered cellular distribution in MGUS vs myeloma
-
Paiva B, Perez-Andres M, Vidriales MB, et al. Competition between clonal plasma cells and normal cells for potentially overlapping bone marrow niches is associated with a progressively altered cellular distribution in MGUS vs myeloma. Leukemia 2011;25:697-706
-
(2011)
Leukemia
, vol.25
, pp. 697-706
-
-
Paiva, B.1
Perez-Andres, M.2
Vidriales, M.B.3
-
48
-
-
11144299492
-
NK cell recognition
-
Lanier LL. NK cell recognition. Annu Rev Immunol 2005;23:225-74
-
(2005)
Annu Rev Immunol
, vol.23
, pp. 225-274
-
-
Lanier, L.L.1
-
49
-
-
19944428928
-
HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells
-
Carbone E, Neri P, Mesuraca M, et al. HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells. Blood 2005;105:251-8
-
(2005)
Blood
, vol.105
, pp. 251-258
-
-
Carbone, E.1
Neri, P.2
Mesuraca, M.3
-
50
-
-
0037086131
-
Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
-
Ruggeri L, Capanni M, Urbani E, et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 2002;295:2097-100
-
(2002)
Science
, vol.295
, pp. 2097-2100
-
-
Ruggeri, L.1
Capanni, M.2
Urbani, E.3
-
51
-
-
0038543513
-
A reversible defect in natural killer T cell function characterizes the progression of premalignant to malignant multiple myeloma
-
Dhodapkar MV, Geller MD, Chang DH, et al. A reversible defect in natural killer T cell function characterizes the progression of premalignant to malignant multiple myeloma. J Exp Med 2003;197:1667-76
-
(2003)
J Exp Med
, vol.197
, pp. 1667-1676
-
-
Dhodapkar, M.V.1
Geller, M.D.2
Chang, D.H.3
-
52
-
-
79960454502
-
Harnessing natural killer T (NKT) cells in human myeloma: Progress and challenges
-
Dhodapkar MV, Richter J. Harnessing natural killer T (NKT) cells in human myeloma: progress and challenges. Clin Immunol 2011;140:160-6
-
(2011)
Clin Immunol
, vol.140
, pp. 160-166
-
-
Dhodapkar, M.V.1
Richter, J.2
-
53
-
-
51649127569
-
Inflammation-associated lysophospholipids as ligands for CD1d-restricted T cells in human cancer
-
Chang DH, Deng H, Matthews P, et al. Inflammation-associated lysophospholipids as ligands for CD1d-restricted T cells in human cancer. Blood 2008;112:1308-16
-
(2008)
Blood
, vol.112
, pp. 1308-1316
-
-
Chang, D.H.1
Deng, H.2
Matthews, P.3
-
54
-
-
70350508581
-
Linking inflammation to natural killer T cell activation
-
Salio M, Cerundolo V. Linking inflammation to natural killer T cell activation. PLoS Biol 2009;7:e1000226
-
(2009)
PLoS Biol
, vol.7
-
-
Salio, M.1
Cerundolo, V.2
-
55
-
-
2342613652
-
The proteasome: A suitable antineoplastic target
-
Adams J. The proteasome: a suitable antineoplastic target. Nat Rev Cancer 2004;4:349-60
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 349-360
-
-
Adams, J.1
-
56
-
-
0346122900
-
Proteasome inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple myeloma
-
Hideshima T, Chauhan D, Hayashi T, et al. Proteasome inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple myeloma. Oncogene 2003;22:8386-93
-
(2003)
Oncogene
, vol.22
, pp. 8386-8393
-
-
Hideshima, T.1
Chauhan, D.2
Hayashi, T.3
-
57
-
-
0242496212
-
Molecular sequelae of proteasome inhibition in human multiple myeloma cells
-
Mitsiades N, Mitsiades CS, Poulaki V, et al. Molecular sequelae of proteasome inhibition in human multiple myeloma cells. Proc Natl Acad Sci USA 2002;99:14374-9
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 14374-14379
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Poulaki, V.3
-
58
-
-
84866183414
-
Immune mechanism of the antitumor effects generated by bortezomib
-
Chang CL, Hsu YT, Wu CC, et al. Immune mechanism of the antitumor effects generated by bortezomib. J Immunol 2012;189:3209-20
-
(2012)
J Immunol
, vol.189
, pp. 3209-3220
-
-
Chang, C.L.1
Hsu, Y.T.2
Wu, C.C.3
-
59
-
-
34249650184
-
Bortezomib enhances dendritic cell (DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: Therapeutic implications
-
Spisek R, Charalambous A, Mazumder A, et al. Bortezomib enhances dendritic cell (DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications. Blood 2007;109:4839-45
-
(2007)
Blood
, vol.109
, pp. 4839-4845
-
-
Spisek, R.1
Charalambous, A.2
Mazumder, A.3
-
60
-
-
33645776929
-
Immunosensitization of tumor cells to dendritic cell-activated immune responses with the proteasome inhibitor bortezomib (PS-341, Velcade)
-
Schumacher LY, Vo DD, Garban HJ, et al. Immunosensitization of tumor cells to dendritic cell-activated immune responses with the proteasome inhibitor bortezomib (PS-341, Velcade). J Immunol 2006;176:4757-65
-
(2006)
J Immunol
, vol.176
, pp. 4757-4765
-
-
Schumacher, L.Y.1
Vo, D.D.2
Garban, H.J.3
-
61
-
-
33845668472
-
Proteasomal chymotrypsin-like peptidase activity is required for essential functions of human monocyte-derived dendritic cells
-
Naujokat C, Berges C, Hoh A, et al. Proteasomal chymotrypsin-like peptidase activity is required for essential functions of human monocyte-derived dendritic cells. Immunology 2007;120:120-32
-
(2007)
Immunology
, vol.120
, pp. 120-132
-
-
Naujokat, C.1
Berges, C.2
Hoh, A.3
-
62
-
-
70350509121
-
Proteasome inhibition activates the mitochondrial pathway of apoptosis in human CD4+ T cells
-
Berges C, Haberstock H, Fuchs D, et al. Proteasome inhibition activates the mitochondrial pathway of apoptosis in human CD4+ T cells. J Cell Biochem 2009;108:935-46
-
(2009)
J Cell Biochem
, vol.108
, pp. 935-946
-
-
Berges, C.1
Haberstock, H.2
Fuchs, D.3
-
63
-
-
0033168605
-
Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha
-
Corral LG, Haslett PA, Muller GW, et al. Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha. J Immunol 1999;163:380-6
-
(1999)
J Immunol
, vol.163
, pp. 380-386
-
-
Corral, L.G.1
Haslett, P.A.2
Muller, G.W.3
-
64
-
-
0038476461
-
Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs
-
Schafer PH, Gandhi AK, Loveland MA, et al. Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs. J Pharmacol Exp Ther 2003;305:1222-32
-
(2003)
J Pharmacol Exp Ther
, vol.305
, pp. 1222-1232
-
-
Schafer, P.H.1
Gandhi, A.K.2
Loveland, M.A.3
-
65
-
-
0037444106
-
Thalidomide and a thalidomide analogue drug costimulate virus-specific CD8+ T cells in vitro
-
Haslett PA, Hanekom WA, Muller G, et al. Thalidomide and a thalidomide analogue drug costimulate virus-specific CD8+ T cells in vitro. J Infect Dis 2003;187:946-55
-
(2003)
J Infect Dis
, vol.187
, pp. 946-955
-
-
Haslett, P.A.1
Hanekom, W.A.2
Muller, G.3
-
66
-
-
33745961875
-
Enhancement of ligand-dependent activation of human natural killer T cells by lenalidomide: Therapeutic implications
-
Chang DH, Liu N, Klimek V, et al. Enhancement of ligand-dependent activation of human natural killer T cells by lenalidomide: therapeutic implications. Blood 2006;108:618-21
-
(2006)
Blood
, vol.108
, pp. 618-621
-
-
Chang, D.H.1
Liu, N.2
Klimek, V.3
-
67
-
-
19944430437
-
Molecular mechanisms whereby immunomodulatory drugs activate natural killer cells: Clinical application
-
Hayashi T, Hideshima T, Akiyama M, et al. Molecular mechanisms whereby immunomodulatory drugs activate natural killer cells: clinical application. Br J Haematol 2005;128:192-203
-
(2005)
Br J Haematol
, vol.128
, pp. 192-203
-
-
Hayashi, T.1
Hideshima, T.2
Akiyama, M.3
-
68
-
-
0015353478
-
Myeloma proteins as tumor-specific transplantation antigens
-
Lynch RG, Graff RJ, Sirisinha S, et al. Myeloma proteins as tumor-specific transplantation antigens. Proc Natl Acad Sci USA 1972;69:1540-4
-
(1972)
Proc Natl Acad Sci USA
, vol.69
, pp. 1540-1544
-
-
Lynch, R.G.1
Graff, R.J.2
Sirisinha, S.3
-
69
-
-
0034667620
-
Tumor-specific recognition of human myeloma cells by idiotype-induced CD8 (+) T cells
-
Li Y, Bendandi M, Deng Y, et al. Tumor-specific recognition of human myeloma cells by idiotype-induced CD8 (+) T cells. Blood 2000;96:2828-33
-
(2000)
Blood
, vol.96
, pp. 2828-2833
-
-
Li, Y.1
Bendandi, M.2
Deng, Y.3
-
70
-
-
0037804767
-
Idiotype vaccination in multiple myeloma induced a reduction of circulating clonal tumor B cells
-
Rasmussen T, Hansson L, Osterborg A, et al. Idiotype vaccination in multiple myeloma induced a reduction of circulating clonal tumor B cells. Blood 2003;101:4607-10
-
(2003)
Blood
, vol.101
, pp. 4607-4610
-
-
Rasmussen, T.1
Hansson, L.2
Osterborg, A.3
-
71
-
-
0033566327
-
Idiotype vaccination in human myeloma: Generation of tumor-specific immune responses after high-dose chemotherapy
-
Massaia M, Borrione P, Battaglio S, et al. Idiotype vaccination in human myeloma: generation of tumor-specific immune responses after high-dose chemotherapy. Blood 1999;94:673-83
-
(1999)
Blood
, vol.94
, pp. 673-683
-
-
Massaia, M.1
Borrione, P.2
Battaglio, S.3
-
72
-
-
0034025657
-
Vaccination of multiple myeloma patients with idiotype-pulsed dendritic cells: Immunological and clinical aspects
-
Titzer S, Christensen O, Manzke O, et al. Vaccination of multiple myeloma patients with idiotype-pulsed dendritic cells: immunological and clinical aspects. Br J Haematol 2000;108:805-16
-
(2000)
Br J Haematol
, vol.108
, pp. 805-816
-
-
Titzer, S.1
Christensen, O.2
Manzke, O.3
-
73
-
-
79953324723
-
Peptide-loaded Langerhans cells, despite increased IL15 secretion and T-cell activation in vitro, elicit antitumor T-cell responses comparable to peptide-loaded monocyte-derived dendritic cells in vivo
-
Romano E, Rossi M, Ratzinger G, et al. Peptide-loaded Langerhans cells, despite increased IL15 secretion and T-cell activation in vitro, elicit antitumor T-cell responses comparable to peptide-loaded monocyte-derived dendritic cells in vivo. Clin Cancer Res 2011;17:1984-97
-
(2011)
Clin Cancer Res
, vol.17
, pp. 1984-1997
-
-
Romano, E.1
Rossi, M.2
Ratzinger, G.3
-
74
-
-
0036529823
-
Immunization against murine multiple myeloma with fusions of dendritic and plasmacytoma cells is potentiated by interleukin 12
-
Gong J, Koido S, Chen D, et al. Immunization against murine multiple myeloma with fusions of dendritic and plasmacytoma cells is potentiated by interleukin 12. Blood 2002;99:2512-17
-
(2002)
Blood
, vol.99
, pp. 2512-2517
-
-
Gong, J.1
Koido, S.2
Chen, D.3
-
76
-
-
0037455013
-
Human T cell receptor gammadelta cells recognize endogenous mevalonate metabolites in tumor cells
-
Gober HJ, Kistowska M, Angman L, et al. Human T cell receptor gammadelta cells recognize endogenous mevalonate metabolites in tumor cells. J Exp Med 2003;197:163-8
-
(2003)
J Exp Med
, vol.197
, pp. 163-168
-
-
Gober, H.J.1
Kistowska, M.2
Angman, L.3
-
77
-
-
80051944692
-
Immune modulation by zoledronic acid in human myeloma: An advantageous cross-talk between Vgamma9Vdelta2 T cells, alphabeta CD8+ T cells, regulatory T cells, and dendritic cells
-
Castella B, Riganti C, Fiore F, et al. Immune modulation by zoledronic acid in human myeloma: an advantageous cross-talk between Vgamma9Vdelta2 T cells, alphabeta CD8+ T cells, regulatory T cells, and dendritic cells. J Immunol 2011;187:1578-90
-
(2011)
J Immunol
, vol.187
, pp. 1578-1590
-
-
Castella, B.1
Riganti, C.2
Fiore, F.3
-
78
-
-
51649083849
-
Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu
-
Tai YT, Dillon M, Song W, et al. Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu. Blood 2008;112:1329-37
-
(2008)
Blood
, vol.112
, pp. 1329-1337
-
-
Tai, Y.T.1
Dillon, M.2
Song, W.3
-
79
-
-
70349481310
-
Combinatorial efficacy of anti-CS1 monoclonal antibody elotuzumab (HuLuc63) and bortezomib against multiple myeloma
-
van Rhee F, Szmania SM, Dillon M, et al. Combinatorial efficacy of anti-CS1 monoclonal antibody elotuzumab (HuLuc63) and bortezomib against multiple myeloma. Mol Cancer Ther 2009;8:2616-24
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 2616-2624
-
-
Van Rhee, F.1
Szmania, S.M.2
Dillon, M.3
-
80
-
-
84863919927
-
Elotuzumab in combination with lenalidomide and low-dose dexamethasone in relapsed or refractory multiple myeloma
-
Lonial S, Vij R, Harousseau JL, et al. Elotuzumab in combination with lenalidomide and low-dose dexamethasone in relapsed or refractory multiple myeloma. J Clin Oncol 2012;30:1953-9
-
(2012)
J Clin Oncol
, vol.30
, pp. 1953-1959
-
-
Lonial, S.1
Vij, R.2
Harousseau, J.L.3
-
81
-
-
0036207926
-
PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2
-
Carter L, Fouser LA, Jussif J, et al. PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2. Eur J Immunol 2002;32:634-43
-
(2002)
Eur J Immunol
, vol.32
, pp. 634-643
-
-
Carter, L.1
Fouser, L.A.2
Jussif, J.3
-
82
-
-
79957891364
-
PD-1 blockade by CT-011, anti-PD-1 antibody, enhances ex vivo T-cell responses to autologous dendritic cell/myeloma fusion vaccine
-
Rosenblatt J, Glotzbecker B, Mills H, et al. PD-1 blockade by CT-011, anti-PD-1 antibody, enhances ex vivo T-cell responses to autologous dendritic cell/myeloma fusion vaccine. J Immunother 2011;34:409-18
-
(2011)
J Immunother
, vol.34
, pp. 409-418
-
-
Rosenblatt, J.1
Glotzbecker, B.2
Mills, H.3
-
83
-
-
77957701558
-
The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: A therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody
-
Benson DM Jr, Bakan CE, Mishra A, et al. The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody. Blood 2010;116:2286-94
-
(2010)
Blood
, vol.116
, pp. 2286-2294
-
-
Benson Jr., D.M.1
Bakan, C.E.2
Mishra, A.3
-
84
-
-
84864061825
-
The therapeutic human CD38 antibody daratumumab improves the anti-myeloma effect of newly emerging multi-drug therapies
-
van der Veer MS, de Weers M, van Kessel B, et al. The therapeutic human CD38 antibody daratumumab improves the anti-myeloma effect of newly emerging multi-drug therapies. Blood Cancer J 2011;1:e41
-
(2011)
Blood Cancer J
, vol.1
-
-
Van Der Veer, M.S.1
De Weers, M.2
Van Kessel, B.3
-
85
-
-
84878159958
-
Daratumumab, a CD38 monoclonal antibody in patients with multiple myeloma-data from a dose-escalation phase I/II study
-
Plesner T, Lokhorst H, Gimsing P, et al. Daratumumab, a CD38 monoclonal antibody in patients with multiple myeloma-data from a dose-escalation phase I/II study. ASH Annu Meet Abstr 2012;120:73
-
(2012)
ASH Annu Meet Abstr
, vol.120
, pp. 73
-
-
Plesner, T.1
Lokhorst, H.2
Gimsing, P.3
-
86
-
-
84872068442
-
Results from AMBER, a randomized phase 2 study of bevacizumab and bortezomib versus bortezomib in relapsed or refractory multiple myeloma
-
White D, Kassim A, Bhaskar B, et al. Results from AMBER, a randomized phase 2 study of bevacizumab and bortezomib versus bortezomib in relapsed or refractory multiple myeloma. Cancer 2013;119:339-47
-
(2013)
Cancer
, vol.119
, pp. 339-347
-
-
White, D.1
Kassim, A.2
Bhaskar, B.3
-
87
-
-
0036782532
-
The IL-6 receptor super-antagonist Sant7 enhances antiproliferative and apoptotic effects induced by dexamethasone and zoledronic acid on multiple myeloma cells
-
Tassone P, Galea E, Forciniti S, et al. The IL-6 receptor super-antagonist Sant7 enhances antiproliferative and apoptotic effects induced by dexamethasone and zoledronic acid on multiple myeloma cells. Int J Oncol 2002;21:867-73
-
(2002)
Int J Oncol
, vol.21
, pp. 867-873
-
-
Tassone, P.1
Galea, E.2
Forciniti, S.3
-
88
-
-
84862291416
-
Novel strategies for immunotherapy in multiple myeloma: Previous experience and future directions
-
Danylesko I, Beider K, Shimoni A, et al. Novel strategies for immunotherapy in multiple myeloma: previous experience and future directions. Clin Dev Immunol 2012;2012:753407
-
(2012)
Clin Dev Immunol
, vol.2012
, pp. 753407
-
-
Danylesko, I.1
Beider, K.2
Shimoni, A.3
-
89
-
-
84866425349
-
Editorial: New approaches in the treatment of multiple myeloma: From target-based agents to the new era of microRNAs (dedicated to the memory of Prof. Salvatore Venuta)
-
Tassone P, Tagliaferri P. Editorial: new approaches in the treatment of multiple myeloma: from target-based agents to the new era of microRNAs (dedicated to the memory of Prof. Salvatore Venuta). Curr Cancer Drug Targets 2012;12:741-2
-
(2012)
Curr Cancer Drug Targets
, vol.12
, pp. 741-742
-
-
Tassone, P.1
Tagliaferri, P.2
-
90
-
-
84866410501
-
Promises and challenges of microRNA-based treatment of multiple myeloma
-
Tagliaferri P, Rossi M, Di Martino MT, et al. Promises and challenges of microRNA-based treatment of multiple myeloma. Curr Cancer Drug Targets 2012;12:838-46
-
(2012)
Curr Cancer Drug Targets
, vol.12
, pp. 838-846
-
-
Tagliaferri, P.1
Rossi, M.2
Di Martino, M.T.3
-
91
-
-
84875764502
-
MiR-29b negatively regulates human osteoclastic cell differentiation and function: Implications for the treatment of multiple myeloma-related bone disease
-
[Epub ahead of print]
-
Rossi M, Pitari MR, Amodio N, et al. miR-29b negatively regulates human osteoclastic cell differentiation and function: implications for the treatment of multiple myeloma-related bone disease. J Cell Physiol 2012; [Epub ahead of print]
-
(2012)
J Cell Physiol
-
-
Rossi, M.1
Pitari, M.R.2
Amodio, N.3
-
92
-
-
84869238270
-
Synthetic miR-34a mimics as a novel therapeutic agent for multiple myeloma: In vitro and in vivo evidence
-
Di Martino MT, Leone E, Amodio N, et al. Synthetic miR-34a mimics as a novel therapeutic agent for multiple myeloma: in vitro and in vivo evidence. Clin Cancer Res 2012;18:6260-70
-
(2012)
Clin Cancer Res
, vol.18
, pp. 6260-6270
-
-
Di Martino, M.T.1
Leone, E.2
Amodio, N.3
-
93
-
-
84871694384
-
DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma
-
Amodio N, Leotta M, Bellizzi D, et al. DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma. Oncotarget 2012;3:1246-58
-
(2012)
Oncotarget
, vol.3
, pp. 1246-1258
-
-
Amodio, N.1
Leotta, M.2
Bellizzi, D.3
-
94
-
-
84870543762
-
MiR-29b sensitizes multiple myeloma cells to bortezomib-induced apoptosis through the activation of a feedback loop with the transcription factor Sp1
-
Amodio N, Di Martino MT, Foresta U, et al. miR-29b sensitizes multiple myeloma cells to bortezomib-induced apoptosis through the activation of a feedback loop with the transcription factor Sp1. Cell Death Disease 2012;3:e436
-
(2012)
Cell Death Disease
, vol.3
-
-
Amodio, N.1
Di Martino, M.T.2
Foresta, U.3
-
95
-
-
84877100047
-
Targeting miR-21 inhibits in vitro and in vivo multiple myeloma cell growth
-
Leone E, Morelli E, Di Martino MT, et al. Targeting miR-21 inhibits in vitro and in vivo multiple myeloma cell growth. Clin Cancer Res 2013;19(8):2096-106
-
(2013)
Clin Cancer Res
, vol.19
, Issue.8
, pp. 2096-2106
-
-
Leone, E.1
Morelli, E.2
Di Martino, M.T.3
-
96
-
-
84875766140
-
In vitro and in vivo anti-tumor activity of miR-221/222 inhibitors in multiple myeloma
-
Di Martino MT, Gulla A, Cantafio ME, et al. In vitro and in vivo anti-tumor activity of miR-221/222 inhibitors in multiple myeloma. Oncotarget 2013;4:242-55
-
(2013)
Oncotarget
, vol.4
, pp. 242-255
-
-
Di Martino, M.T.1
Gulla, A.2
Cantafio, M.E.3
-
97
-
-
20344381988
-
A clinically relevant SCID-hu in vivo model of human multiple myeloma
-
Tassone P, Neri P, Carrasco DR, et al. A clinically relevant SCID-hu in vivo model of human multiple myeloma. Blood 2005;106:713-16
-
(2005)
Blood
, vol.106
, pp. 713-716
-
-
Tassone, P.1
Neri, P.2
Carrasco, D.R.3
-
98
-
-
84866434864
-
Mouse models as a translational platform for the development of new therapeutic agents in multiple myeloma
-
Tassone P, Neri P, Burger R, et al. Mouse models as a translational platform for the development of new therapeutic agents in multiple myeloma. Curr Cancer Drug Targets 2012;12:814-22
-
(2012)
Curr Cancer Drug Targets
, vol.12
, pp. 814-822
-
-
Tassone, P.1
Neri, P.2
Burger, R.3
-
99
-
-
79954436115
-
A unique three-dimensional SCID-polymeric scaffold (SCID-synth-hu) model for in vivo expansion of human primary multiple myeloma cells
-
Calimeri T, Battista E, Conforti F, et al. A unique three-dimensional SCID-polymeric scaffold (SCID-synth-hu) model for in vivo expansion of human primary multiple myeloma cells. Leukemia 2011;25:707-11
-
(2011)
Leukemia
, vol.25
, pp. 707-711
-
-
Calimeri, T.1
Battista, E.2
Conforti, F.3
-
100
-
-
54849407184
-
In vivo anti-myeloma activity and modulation of gene expression profile induced by valproic acid, a histone deacetylase inhibitor
-
Neri P, Tagliaferri P, Di Martino MT, et al. In vivo anti-myeloma activity and modulation of gene expression profile induced by valproic acid, a histone deacetylase inhibitor. Br J Haematol 2008;143:520-31
-
(2008)
Br J Haematol
, vol.143
, pp. 520-531
-
-
Neri, P.1
Tagliaferri, P.2
Di Martino, M.T.3
|