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Volumn 394, Issue 6, 2013, Pages 729-739

The human Ah receptor: Hints from dioxin toxicities to deregulated target genes and physiological functions

Author keywords

Ah receptor target genes; Cell cycle progression; Cell differentiation; Dioxin mediated toxicities; Human Ah receptor

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A1; DIOXIN; KYNURENINE;

EID: 84879555576     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/hsz-2012-0340     Document Type: Review
Times cited : (36)

References (100)
  • 2
    • 80051531363 scopus 로고    scopus 로고
    • Notch signaling: Simplicity in design, versatility in function
    • Andersson, E.R., Sandberg, R., and Lehndahl, U. (2011). Notch signaling: simplicity in design, versatility in function. Development 138, 3593-3612.
    • (2011) Development , vol.138 , pp. 3593-3612
    • Andersson, E.R.1    Sandberg, R.2    Lehndahl, U.3
  • 3
    • 4944239129 scopus 로고    scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin blocks androgen-dependent cell proliferation of LNCaP cells through modulation of pRB phosphorylation
    • DOI 10.1124/mol.104.000356
    • Barnes-Ellerbe, S., Knutsen, K.E., and Puga, A. (2004). 2,3,7,8-Tetrachlorodibenzo- p -dioxin blocks androgendependent cell proliferation of LNCaP cells through modulation of pRB phosphorylation. Mol. Pharmacol. 66, 502-511. (Pubitemid 39329248)
    • (2004) Molecular Pharmacology , vol.66 , Issue.3 , pp. 502-511
    • Barnes-Ellerbe, S.1    Knudsen, K.E.2    Puga, A.3
  • 4
    • 34447511096 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor, more than a xenobiotic-interacting protein
    • DOI 10.1016/j.febslet.2007.03.046, PII S0014579307003171, Cellular Stress
    • Barouki, R., Coumoul, X., and Fernandez-Salguero, P. (2007). The aryl hydrocarbon receptor, more than a xenobiotic-interacting protein. FEBS Lett. 581, 3608-3615. (Pubitemid 47080995)
    • (2007) FEBS Letters , vol.581 , Issue.19 , pp. 3608-3615
    • Barouki, R.1    Coumoul, X.2    Fernandez-Salguero, P.M.3
  • 6
    • 6344220202 scopus 로고    scopus 로고
    • Metabolic fate of the Ah receptor ligand 6-formylindolo[3,2-b]carbazole
    • DOI 10.1016/j.cbi.2004.08.005, PII S0009279704001061
    • Bergander, L., Wincent, E., Rannug, A., Foroozesh, M., Alworth, W., and Rannug, U. (2004). Metabolic fate of the Ah receptor ligand 6-formylindolo[3,2- b]carbazole. Chem. Biol. Interact. 149, 151-164. (Pubitemid 39402931)
    • (2004) Chemico-Biological Interactions , vol.149 , Issue.2-3 , pp. 151-164
    • Bergander, L.1    Wincent, E.2    Rannug, A.3    Foroozesh, M.4    Alworth, W.5    Rannug, U.6
  • 7
    • 84865589572 scopus 로고    scopus 로고
    • Tryptamine serves as a proligand of the AhR transcriptional pathway whose activation is dependent of monoamine oxidases
    • Bergander, L.V., Cai, W., Klocke, B., Seifert, M., and Pongratz, I. (2012). Tryptamine serves as a proligand of the AhR transcriptional pathway whose activation is dependent of monoamine oxidases. Mol. Endocrinol. 26, 1542-1551.
    • (2012) Mol. Endocrinol , vol.26 , pp. 1542-1551
    • Bergander, L.V.1    Cai, W.2    Klocke, B.3    Seifert, M.4    Pongratz, I.5
  • 9
    • 79954512528 scopus 로고    scopus 로고
    • In vivo dioxin favors interleukin-22 production by human CD4 + T cells in an aryl hydrocarbon receptor(AhR)-dependent manner
    • Brembilla, N.C., Ramirez, J.M., Chicheportiche, R., Sorg, O., Saurat, J.H., and Chizzolini, C. (2011). In vivo dioxin favors interleukin-22 production by human CD4 + T cells in an aryl hydrocarbon receptor(AhR)-dependent manner. PloS One 6, e18741.
    • (2011) PloS One , vol.6
    • Brembilla, N.C.1    Ramirez, J.M.2    Chicheportiche, R.3    Sorg, O.4    Saurat, J.H.5    Chizzolini, C.6
  • 11
    • 54349090870 scopus 로고    scopus 로고
    • Abnormal liver development and resistance to 2,3,7,8-tetrachloro- p -dioxin toxicity in mice carrying a mutation in the DNA-binding domain of the aryl hydrocarbon receptor
    • Bunger, M.K., Glover, E., Moran, S.M., Walisser, J.A., Lahvis, G.P., Hsu, E.L., and Bradfield, C.A. (2008). Abnormal liver development and resistance to 2,3,7,8-tetrachloro- p -dioxin toxicity in mice carrying a mutation in the DNA-binding domain of the aryl hydrocarbon receptor. Toxicol. Sci. 106, 83-92.
    • (2008) Toxicol Sci , vol.106 , pp. 83-92
    • Bunger, M.K.1    Glover, E.2    Moran, S.M.3    Walisser, J.A.4    Lahvis, G.P.5    Hsu, E.L.6    Bradfield, C.A.7
  • 12
    • 47949125557 scopus 로고    scopus 로고
    • Characterization of bipotential epidermal progenitors derived from human sebaceous gland: Contrasting roles of c-myc and α -catenin
    • Celso, C.L., Berta, M.A., Braun, K.M., Frye, M., Lyle, S., Zouboulis C.C., and Watt, F.M. (2008). Characterization of bipotential epidermal progenitors derived from human sebaceous gland: Contrasting roles of c-myc and α -catenin. Stem Cells 26; 1241-1252.
    • (2008) Stem Cells , vol.26 , pp. 1241-1252
    • Celso, C.L.1    Berta, M.A.2    Braun, K.M.3    Frye, M.4    Lyle, S.5    Zouboulis, C.C.6    Watt, F.M.7
  • 14
    • 84155196846 scopus 로고    scopus 로고
    • Exactly the same but different: Promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor
    • Denison, M.S., Soshilov, A.A., He, G., DeGroot, D.E., and Zhao, B. (2011). Exactly the same but different: Promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor. Toxicol. Sci. 124, 1-22.
    • (2011) Toxicol. Sci , vol.124 , pp. 1-22
    • Denison, M.S.1    Soshilov, A.A.2    He, G.3    Degroot, D.E.4    Zhao, B.5
  • 15
    • 77955362056 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor (AhR) in the regulation of cell-cell contact and tumor growth
    • Dietrich, C. and Kaina, B. (2010). The aryl hydrocarbon receptor (AhR) in the regulation of cell-cell contact and tumor growth. Carcinogenesis 31, 1319-1328.
    • (2010) Carcinogenesis , vol.31 , pp. 1319-1328
    • Dietrich, C.1    Kaina, B.2
  • 16
    • 0036404933 scopus 로고    scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin-dependent release from contact inhibition in WB-F344 cells: Involvement of cyclin A
    • DOI 10.1016/S0041-008X(02)99475-5
    • Dietrich, C., Faust, D., Budt, S., Moskwa, M., Kunz, A., Bock, K.W., and Oesch, F. (2002). 2,3,7,8-Tetrachlorodibenzo- p -dioxindependent release from contact inhibition in WB-F344 cells: Involvement of cyclin A. Toxicol. Appl. Pharmacol. 183, 117-126. (Pubitemid 35286140)
    • (2002) Toxicology and Applied Pharmacology , vol.183 , Issue.2 , pp. 117-126
    • Dietrich, C.1    Faust, D.2    Budt, S.3    Moskwa, M.4    Kunz, A.5    Bock, K.-W.6    Oesch, F.7
  • 17
    • 79551688725 scopus 로고    scopus 로고
    • Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling
    • DiNatale, B.C., Murray, I.A., Schroeder, J.C., Flaveny, C.A., Lahoti, T.S., Laurenzana, E.M., Omiecinski, C.J., and Perdew, G.H. (2010). Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling. Toxicol. Sci. 115, 89-97.
    • (2010) Toxicol. Sci , vol.115 , pp. 89-97
    • Dinatale, B.C.1    Murray, I.A.2    Schroeder, J.C.3    Flaveny, C.A.4    Lahoti, T.S.5    Laurenzana, E.M.6    Omiecinski, C.J.7    Perdew, G.H.8
  • 18
    • 33748422203 scopus 로고    scopus 로고
    • Activation of the dioxin/aryl hydrocarbon receptor (AhR) modulates cell plasticity through a JNK-dependent mechanism
    • DOI 10.1038/sj.onc.1209553, PII 1209553
    • Diry, M., Tomkiewicz, C., Koehle, C., Coumoul, X., Bock, K.W., Barouki, R., and Transy, C. (2006). Activation of the dioxin/aryl hydrocarbon receptor (AhR) modulates cell plasticity through a JNK-dependent mechanism. Oncogene 25, 5570-5574. (Pubitemid 44344107)
    • (2006) Oncogene , vol.25 , Issue.40 , pp. 5570-5574
    • Diry, M.1    Tomkiewicz, C.2    Koehle, C.3    Coumoul, X.4    Bock, K.W.5    Barouki, R.6    Transy, C.7
  • 19
    • 0030598390 scopus 로고    scopus 로고
    • Identification of c-Src as the integral component of the cytosolic Ah receptor complex, transducing the signal of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) through the protein phosphorylation pathway
    • DOI 10.1016/S0006-2952(96)00566-7, PII S0006295296005667
    • Enan, E. and Matsumura, F. (1996). Identification of c-Src as the integral component of the cytosolic Ah receptor complex, transducing the signal of 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD) through the protein phosphorylation pathway. Biochem. Pharmacol. 52, 1599-1612. (Pubitemid 26375466)
    • (1996) Biochemical Pharmacology , vol.52 , Issue.10 , pp. 1599-1612
    • Enan, E.1    Matsumura, F.2
  • 20
    • 68949172534 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor in immunity
    • Esser, C., Rannug, A. and Stockinger, B. (2009). The aryl hydrocarbon receptor in immunity. Trends Immunol. 30, 447-454.
    • (2009) Trends Immunol , vol.30 , pp. 447-454
    • Esser, C.1    Rannug, A.2    Stockinger, B.3
  • 21
    • 75149115740 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor functions as a tumor suppressor in liver carcinogenesis
    • Fan, Y., Boivin, G.P., Knudsen, E.S., Nebert, D.W., Xia, Y., and Puga, A. (2010). The aryl hydrocarbon receptor functions as a tumor suppressor in liver carcinogenesis. Cancer Res. 70, 212-220.
    • (2010) Cancer Res , vol.70 , pp. 212-220
    • Fan, Y.1    Boivin, G.P.2    Knudsen, E.S.3    Nebert, D.W.4    Xia, Y.5    Puga, A.6
  • 23
    • 0035816183 scopus 로고    scopus 로고
    • Use of cDNA microarrays to analyze dioxin-induced changes in human liver gene expression
    • DOI 10.1016/S0378-4274(01)00364-2, PII S0378427401003642
    • Frueh, F.W., Hayashibara, K.C., Brown, P.O., and Whitlock, J.P. (2001). Use of cDNA microarrays to analyze dioxin-induced changes in human liver gene expression. Toxicol. Lett. 122, 189-203. (Pubitemid 32727282)
    • (2001) Toxicology Letters , vol.122 , Issue.3 , pp. 189-203
    • Frueh, F.W.1    Hayashibara, K.C.2    Brown, P.O.3    Whitlock Jr., J.P.4
  • 24
    • 0029919538 scopus 로고    scopus 로고
    • TCDD-inducible plasminogen activator inhibitor type 2 (PAI-2) in human hepatocytes, HepG2 and monocytic U937 cells
    • Gohl, G., Lehmköster, T., Mü nzel, P.A., Schrenk, D., Viehbahn, R., and Bock, K.W. (1996). TCDD-inducible plasminogen activator inhibitor type 2 (PAI-2) in human hepatocytes, HepG2 and monocytic U937 cells. Carcinogenesis 17, 443-449.
    • (1996) Carcinogenesis , vol.17 , pp. 443-449
    • Gohl, G.1    Lehmköster, T.2    Münzel, P.A.3    Schrenk, D.4    Viehbahn, R.5    Bock, K.W.6
  • 25
    • 75149130980 scopus 로고    scopus 로고
    • Activation of the aryl-hydrocarbon receptor inhibits invasive and metastatic features of human breast cancer cells and promotes breast cancer cell differentiation
    • Hall, J.M., Barhoover, M.A., Kazmin, D., McDonnell, D.P., Greenlee, W.F., and Thomas, R.S. (2010). Activation of the aryl-hydrocarbon receptor inhibits invasive and metastatic features of human breast cancer cells and promotes breast cancer cell differentiation. Mol. Endocrinol. 24, 359-369.
    • (2010) Mol. Endocrinol , vol.24 , pp. 359-369
    • Hall, J.M.1    Barhoover, M.A.2    Kazmin, D.3    McDonnell, D.P.4    Greenlee, W.F.5    Thomas, R.S.6
  • 26
    • 0028987872 scopus 로고
    • The aryl hydrocarbon receptor complex
    • Hankinson, O. (1995). The aryl hydrocarbon receptor complex. Ann. Rev. Pharmacol. Toxicol. 35, 307-340.
    • (1995) Ann. Rev. Pharmacol. Toxicol , vol.35 , pp. 307-340
    • Hankinson, O.1
  • 27
    • 0025061540 scopus 로고
    • Inhibition of high-density growth arrest in human squamous carcinoma cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
    • Hebert, C.D., Cao, Q.L., and Birnbaum, L.S. (1990). Inhibition of high-density growth arrest in human squamous carcinoma cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Carcinogenesis 11, 1335-1342. (Pubitemid 20245706)
    • (1990) Carcinogenesis , vol.11 , Issue.8 , pp. 1335-1342
    • Hebert, C.D.1    Cao, Q.-L.2    Birnbaum, L.S.3
  • 28
    • 11244353490 scopus 로고    scopus 로고
    • Multiple mechanisms are involved in Ah receptor-mediated cell cycle arrest
    • DOI 10.1124/mol.104.002410
    • Huang, G. and Elferink, C.J. (2005). Multiple mechanisms are involved in Ah receptor-mediated cell cycle arrest. Mol. Pharmacol. 67, 88-96. (Pubitemid 40069969)
    • (2005) Molecular Pharmacology , vol.67 , Issue.1 , pp. 88-96
    • Huang, G.1    Elferink, C.J.2
  • 29
    • 33749133802 scopus 로고    scopus 로고
    • Zinc finger transcription factor Slug is a novel target gene of aryl hydrocarbon receptor
    • DOI 10.1016/j.yexcr.2006.08.002, PII S0014482706003120
    • Ikuta, T. and Kawajiri, K. (2006). Zinc finger transcription factor Slug is a novel target of aryl hydrocarbon receptor. Exp. Cell Res. 312, 3585-3594. (Pubitemid 44470776)
    • (2006) Experimental Cell Research , vol.312 , Issue.18 , pp. 3585-3594
    • Ikuta, T.1    Kawajiri, K.2
  • 30
    • 77953136147 scopus 로고    scopus 로고
    • B lymphocyte-induced maturation protein 1 is a novel target gene of aryl hydrocarbon receptor
    • Ikuta, T., Ohba, M., Zouboulis, C.C., Fujii-Kuriyama, Y., and Kawajiri, K.B. (2010). B lymphocyte-induced maturation protein 1 is a novel target gene of aryl hydrocarbon receptor. J. Dermatol. Sci. 58, 211-216.
    • (2010) J. Dermatol. Sci , vol.58 , pp. 211-216
    • Ikuta, T.1    Ohba, M.2    Zouboulis, C.C.3    Fujii-Kuriyama, Y.4    Kawajiri, K.B.5
  • 31
    • 79952731890 scopus 로고    scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin alters sebaceous gland cell differentiation in vitro
    • Ju, Q., Fimmel, S., Hinz, N., Stahlmann. R., Xia, L., and Zouboulis, C.C. (2011). 2,3,7,8-Tetrachlorodibenzo-p-dioxin alters sebaceous gland cell differentiation in vitro. Exp. Dermatol. 20, 320-325.
    • (2011) Exp Dermatol , vol.20 , pp. 320-325
    • Ju, Q.1    Fimmel, S.2    Hinz, N.3    Stahlmann, R.4    Xia, L.5    Zouboulis, C.C.6
  • 32
    • 78650288912 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor mediated UVB radiation-induced skin tanning
    • Jux, B., Kadow, S., Luecke, S., Rannug, A., Krutmann, J., and Esser, C. (2011). The aryl hydrocarbon receptor mediated UVB radiation-induced skin tanning. J. Invest. Dermatol. 131, 203-210.
    • (2011) J. Invest. Dermatol , vol.131 , pp. 203-210
    • Jux, B.1    Kadow, S.2    Luecke, S.3    Rannug, A.4    Krutmann, J.5    Esser, C.6
  • 33
    • 59149104736 scopus 로고    scopus 로고
    • AHR-mediated immunomodulation: The role of altered gene transcription
    • Kerkvliet, N.I. (2009). AHR-mediated immunomodulation: the role of altered gene transcription. Biochem. Pharmacol. 77, 746-760.
    • (2009) Biochem. Pharmacol , vol.77 , pp. 746-760
    • Kerkvliet, N.I.1
  • 34
    • 84961028063 scopus 로고
    • Berufliche Akne (sog. Chlorakne) durch chlorierte aromatische zyklischeÄther
    • Kimmig, J. and Schulz, K.H. (1957). Berufliche Akne (sog. Chlorakne) durch chlorierte aromatische zyklischeÄther. Dermatologica 115, 540-546.
    • (1957) Dermatologica , vol.115 , pp. 540-546
    • Kimmig, J.1    Schulz, K.H.2
  • 36
    • 83855160821 scopus 로고    scopus 로고
    • Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles
    • Kiss, E.A., Vonarbourg, C., Kopfmann, S., Hobeika, E., Finke, D., Esser, C., and Diefenbach A. (2011). Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles. Science 334, 1561-1565.
    • (2011) Science , vol.334 , pp. 1561-1565
    • Kiss, E.A.1    Vonarbourg, C.2    Kopfmann, S.3    Hobeika, E.4    Finke, D.5    Esser, C.6    Diefenbach, A.7
  • 37
    • 59149090185 scopus 로고    scopus 로고
    • Coordinate regulation of human drug-metabolizing enzymes, and conjugate transporters by the Ah receptor, pregnane X receptor, and constitutive androstane receptor
    • Köhle, C. and Bock, K.W. (2009). Coordinate regulation of human drug-metabolizing enzymes, and conjugate transporters by the Ah receptor, pregnane X receptor, and constitutive androstane receptor. Biochem. Pharmacol. 77, 689-699.
    • (2009) Biochem. Pharmacol , vol.77 , pp. 689-699
    • Köhle, C.1    Bock, K.W.2
  • 38
    • 0033003606 scopus 로고    scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-mediated membrane translocation of c-Src protein kinase in liver WB-F344 cells
    • DOI 10.1007/s002040050600
    • Köhle, C., Gschaidmeier, H., Lauth, D., Topell, S., Zitzer, H., and Bock, K.W. (1999). 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)- mediated membrane translocation of c-Src protein kinase in liver WB-F344 cells. Arch. Toxicol. 73, 152-158. (Pubitemid 29279501)
    • (1999) Archives of Toxicology , vol.73 , Issue.3 , pp. 152-158
    • Kohle, C.1    Gschaidmeier, H.2    Lauth, D.3    Topell, S.4    Zitzer, H.5    Bock, K.W.6
  • 39
    • 50649098449 scopus 로고    scopus 로고
    • Promotion of hepatocarcinogenesis in humans and animal models
    • Köhle, C., Schwarz, M., and Bock, K.W. (2008). Promotion of hepatocarcinogenesis in humans and animal models. Arch. Toxicol. 82, 623-631.
    • (2008) Arch. Toxicol , vol.82 , pp. 623-631
    • Köhle, C.1    Schwarz, M.2    Bock, K.W.3
  • 40
    • 0033166447 scopus 로고    scopus 로고
    • P27(Kip1) induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells
    • Kolluri, S.K., Weiss, K., Koff, A., and Göttlicher, M. (1999). P27/KIP1 induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells. Genes Dev. 13, 1742-1753. (Pubitemid 29325878)
    • (1999) Genes and Development , vol.13 , Issue.13 , pp. 1742-1753
    • Kolluri, S.K.1    Weiss, C.2    Koff, A.3    Gottlicher, M.4
  • 41
    • 78650542988 scopus 로고    scopus 로고
    • How T cells take developmental decisions by using the aryl hydrocarbon receptor to sense the environment
    • Korn, T. (2010). How T cells take developmental decisions by using the aryl hydrocarbon receptor to sense the environment. Proc. Natl. Acad. Sci. USA 107, 20597-20598.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 20597-20598
    • Korn, T.1
  • 42
    • 84855916261 scopus 로고    scopus 로고
    • You AhR what you eat?
    • Lawrence, B.P. and Sherr, D.H. (2012). You AhR what you eat? Nat Immunol. 13, 117-119.
    • (2012) Nat Immunol , vol.13 , pp. 117-119
    • Lawrence, B.P.1    Sherr, D.H.2
  • 45
    • 0035449670 scopus 로고    scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin alters the differentiation pattern of human keratinocytes in organotypic culture
    • DOI 10.1006/taap.2001.9202
    • Loertscher, J.A., Sattler, C.A., and Allen-Hoffmann, B.l. (2001). 2,3,7,8-Tetrachlorodibenzo- p -dioxin alters the differentiation pattern of human keratinocytes in organotypic culture. Toxicol. Appl. Pharmacol. 175, 121-129. (Pubitemid 32848503)
    • (2001) Toxicology and Applied Pharmacology , vol.175 , Issue.2 , pp. 121-129
    • Loertscher, J.A.1    Sattler, C.A.2    Allen-Hoffmann, B.L.3
  • 47
    • 0029963257 scopus 로고    scopus 로고
    • The aromatic hydrocarbon receptor modulates the Hepa 1c1c7 cell cycle and differentiated state independently of dioxin
    • Ma, Q. and Whitlock, J.P. (1996). The aromatic hydrocarbon receptor modulates the hepa1c1c7 cell cycle and differentiated state independently of dioxin. Mol. Cell. Biol. 16, 2144-2150. (Pubitemid 26123735)
    • (1996) Molecular and Cellular Biology , vol.16 , Issue.5 , pp. 2144-2150
    • Ma, Q.1    Whitlock Jr., J.P.2
  • 48
    • 33644831336 scopus 로고    scopus 로고
    • 4 and aspirin-triggered lipoxin are SOCS-2 dependent
    • DOI 10.1038/nm1355, PII N1355
    • Machado, F.S., Johndrow, J.E., Esper, L., Dias, A., Bafica, A., Sherhan, C.N., and Aliberti, J. (2006). Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent. Nature 12, 330-334. (Pubitemid 43355082)
    • (2006) Nature Medicine , vol.12 , Issue.3 , pp. 330-334
    • Machado, F.S.1    Johndrow, J.E.2    Esper, L.3    Dias, A.4    Bafica, A.5    Serhan, C.N.6    Aliberti, J.7
  • 49
    • 54249157595 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor binds to E2F1 and inhibits E2F1-induced apoptosis
    • Marlowe, J.L., Fan, Y., Chang, X., Peng, L., Knutsen, E.S., Xia, Y., and Puga, A. (2008). The aryl hydrocarbon receptor binds to E2F1 and inhibits E2F1-induced apoptosis. Mol. Pharmacol. 19, 3263-3271.
    • (2008) Mol. Pharmacol , vol.19 , pp. 3263-3271
    • Marlowe, J.L.1    Fan, Y.2    Chang, X.3    Peng, L.4    Knutsen, E.S.5    Xia, Y.6    Puga, A.7
  • 51
    • 77951921902 scopus 로고    scopus 로고
    • Mammalian Per-Arnt-Sim proteins in environmental adaptation
    • McIntosh, B.E., Hogenesch, J.B., and Bradfield, C.A. (2010). Mammalian Per-Arnt-Sim proteins in environmental adaptation. Ann. Rev. Physiol. 72, 625-645.
    • (2010) Ann. Rev. Physiol , vol.72 , pp. 625-645
    • McIntosh, B.E.1    Hogenesch, J.B.2    Bradfield, C.A.3
  • 52
    • 78649880396 scopus 로고    scopus 로고
    • An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells
    • Mezrich, J.D., Fechner, J.H., Zhang, X., Johnson, B.P., Burlingham, W.J., and Bradfield, C.A. (2010). An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells. J. Immunol. 185, 3190-3198.
    • (2010) J. Immunol , vol.185 , pp. 3190-3198
    • Mezrich, J.D.1    Fechner, J.H.2    Zhang, X.3    Johnson, B.P.4    Burlingham, W.J.5    Bradfield, C.A.6
  • 53
    • 60649095638 scopus 로고    scopus 로고
    • Timing is everything: Consequences of transient and sustained AhR activity
    • Mitchell, K.A. and Elferink, C.J. (2009). Timing is everything: Consequences of transient and sustained AhR activity. Biochem. Pharmacol. 77, 947-956.
    • (2009) Biochem. Pharmacol , vol.77 , pp. 947-956
    • Mitchell, K.A.1    Elferink, C.J.2
  • 54
    • 79959918506 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract
    • Monteleone, I., Rizzo, A., Sarra, M., Sica, G., Sileri, P., Biancone, L., MacDonald, T.T., Pallone F., and Monteleone, G. (2011). Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract. Gastroenterol. 141, 237-248.
    • (2011) Gastroenterol , vol.141 , pp. 237-248
    • Monteleone, I.1    Rizzo, A.2    Sarra, M.3    Sica, G.4    Sileri, P.5    Biancone, L.6    Macdonald, T.T.7    Pallone, F.8    Monteleone, G.9
  • 56
    • 0029878852 scopus 로고    scopus 로고
    • Growth modulation of hepatocytes and rat liver epithelial cells (WB-F344) by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
    • DOI 10.1093/carcin/17.2.197
    • Mü nzel, P., Bock-Hennig, B., Schieback, S., Gschaidmeier, H., Beck-Gschaidmeier, S., and Bock, K.W. (1996). Growth modulation of hepatocytes and rat liver epithelial cells (WB-F344) by 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD). Carcinogenesis 17, 197-202. (Pubitemid 26091294)
    • (1996) Carcinogenesis , vol.17 , Issue.2 , pp. 197-202
    • Munzel, P.1    Bock-Hennig, B.2    Schieback, S.3    Gschaidmeier, H.4    Beck-Gschaidmeier, S.5    Bock, K.W.6
  • 57
    • 2642510760 scopus 로고    scopus 로고
    • Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer
    • DOI 10.1074/jbc.R400004200
    • Nebert, D.W., Dalton, T.P., Okey, A.B., and Gonzalez, F.J. (2004). Role of aryl hydrocarbon receptor-mediated induction of CYP1 enzymes in environmental toxicity and cancer. J. Biol. Chem. 279, 23847-23850. (Pubitemid 38725238)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.23 , pp. 23847-23850
    • Nebert, D.W.1    Dalton, T.P.2    Okey, A.B.3    Gonzalez, F.J.4
  • 58
    • 38949097735 scopus 로고    scopus 로고
    • The search for endogenous activators of the aryl hydrocarbon receptor
    • DOI 10.1021/tx7001965
    • Nguyen, L.P. and Bradfield, C.A. (2008). The search for endogenous activators of the aryl hydrocarbon receptor. Chem. Res. Toxicol. 21, 102-116. (Pubitemid 351219712)
    • (2008) Chemical Research in Toxicology , vol.21 , Issue.1 , pp. 102-116
    • Nguyen, L.P.1    Bradfield, C.A.2
  • 60
    • 34447530842 scopus 로고    scopus 로고
    • An aryl hydrocarbon receptor odyssey to the shores of toxicology: The Deichmann Lecture, International Congress of Toxicology-XI
    • DOI 10.1093/toxsci/kfm096
    • Okey, A.B. (2007). An aryl hydrocarbon receptor Odyssey to the shores of toxicology: The Deichmann lecture, International Congress of Toxicology-XI. Toxicol. Sci. 98, 5-38. (Pubitemid 47078751)
    • (2007) Toxicological Sciences , vol.98 , Issue.1 , pp. 5-38
    • Okey, A.B.1
  • 62
    • 33746622171 scopus 로고    scopus 로고
    • Dioxin-induced chloracne - Reconstructing the cellular and molecular mechanisms of a classic environmental disease
    • DOI 10.1111/j.1600-0625.2006.00476.x
    • Pantelejev, A.A. and Bickers, D.R. (2006). Dioxin-induced chloracne - reconstructing the cellular and molecular mechanisms of a classic environmental disease. Exp. Dermatol. 15, 705-730. (Pubitemid 44145241)
    • (2006) Experimental Dermatology , vol.15 , Issue.9 , pp. 705-730
    • Panteleyev, A.A.1    Bickers, D.R.2
  • 63
    • 14944348442 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor predisposes hepatocytes to Fas-mediated apoptosis
    • DOI 10.1124/mol.104.005223
    • Park, K.T., Mitchell, K.A., Huang, G., and Elferink, C.J. (2005). The aryl hydrocarbon receptor predisposes hepatocytes to Fas-mediated apoptosis. Mol. Pharmacol. 67, 612-622. (Pubitemid 40365308)
    • (2005) Molecular Pharmacology , vol.67 , Issue.3 , pp. 612-622
    • Park, K.-T.1    Mitchell, K.A.2    Huang, G.3    Elferink, C.J.4
  • 64
    • 0018932459 scopus 로고
    • Quantitative evaluation of the promotion by 2,3,7,8-tetrachlorodibenzo-p- dioxin of hepatocarcinogenesis from diethylnitrosamine
    • Pitot, H.C., Goldsworthy, T.L., Campbell, H.A., and Poland, A. (1980). Quantitative evaluation of the promotion by 2,3,7,8-tetrachlorodibenzo- p -dioxin of hepatocarcinogenesis from diethylnitrosamine. Cancer Res. 40, 3616-3620. (Pubitemid 10003760)
    • (1980) Cancer Research , vol.40 , Issue.10 , pp. 3616-3620
    • Pitot, H.C.1    Goldsworthy, T.2    Campbell, H.A.3    Poland, A.4
  • 65
    • 68949110244 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor activation inhibits in vitro differentiation of human monocytes and Langerhans dendritic cells
    • Platzer, B., Richter, S., Kneidinger, D., Waltenberger, D., Woisetschläger, M., and Strobl, H. (2009). Aryl hydrocarbon receptor activation inhibits in vitro differentiation of human monocytes and Langerhans dendritic cells. J. Immunol. 183, 66-74.
    • (2009) J. Immunol , vol.183 , pp. 66-74
    • Platzer, B.1    Richter, S.2    Kneidinger, D.3    Waltenberger, D.4    Woisetschläger, M.5    Strobl, H.6
  • 66
    • 46249124461 scopus 로고    scopus 로고
    • Immune escape as a fundamental trait of cancer: Focus on IDO
    • DOI 10.1038/onc.2008.35, PII ONC200835
    • Prendergast, G.C. (2008). Immune escape as a fundamental trait of cancer: focus on IDO. Oncogene 27, 3889-3900. (Pubitemid 351913639)
    • (2008) Oncogene , vol.27 , Issue.28 , pp. 3889-3900
    • Prendergast, G.C.1
  • 67
    • 0034723264 scopus 로고    scopus 로고
    • Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest
    • DOI 10.1074/jbc.275.4.2943
    • Puga, A., Barnes, S.J., Dalton, T.P., Chang, C.Y., Knutsen, E.S., and Maier, M.A. (2000). Aromatic hydrocarbon receptor interactions with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest. J. Biol. Chem. 275, 2943-2950. (Pubitemid 30082071)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.4 , pp. 2943-2950
    • Puga, A.1    Barnes, S.J.2    Dalton, T.P.3    Chang, C.-Y.4    Knudsen, E.S.5    Maier, M.A.6
  • 68
    • 59149097969 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways
    • Puga, A., Ma, C. and Marlowe, J.L. (2009). The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways. Biochem. Pharmacol. 77, 713-722.
    • (2009) Biochem. Pharmacol , vol.77 , pp. 713-722
    • Puga, A.1    Ma, C.2    Marlowe, J.L.3
  • 70
    • 0023616773 scopus 로고
    • Certain photooxidized derivatives of tryptophan bind with very high affinity to the Ah receptor and are likely to be endogenous signal substances
    • Rannug, A., Rannug, U., Rosenkranz, H.S., Winqvist, L., Westerholm, R., Agurell, E., and Grafström, A.K. (1987). Certain photooxidized derivatives of tryptophan bind with very high affinity to the Ah receptor and are likely to be endogenous signal substances. J. Biol. Chem. 262, 15422-15427.
    • (1987) J. Biol. Chem , vol.262 , pp. 15422-15427
    • Rannug, A.1    Rannug, U.2    Rosenkranz, H.S.3    Winqvist, L.4    Westerholm, R.5    Agurell, E.6    Grafström, A.K.7
  • 73
    • 0033535843 scopus 로고    scopus 로고
    • Lipoxin A4: A new class of ligand for the Ah receptor
    • Schaldach, C.M., Riby, J., and Bjeldanes, L.F. (1999). Lipoxin A4: a new class of ligand for the Ah receptor. Biochemistry 38, 7594-7600.
    • (1999) Biochemistry , vol.38 , pp. 7594-7600
    • Schaldach, C.M.1    Riby, J.2    Bjeldanes, L.F.3
  • 74
    • 0030758669 scopus 로고    scopus 로고
    • Tryptanthrins: A novel class of agonists of the aryl hydrocarbon receptor
    • DOI 10.1016/S0006-2952(97)00150-0, PII S0006295297001500
    • Schrenk, D., Riebnicker, D., Till, M., Vetter, S., and Fiedler, H.P. (1997). Tryptanthrins: a novel class of agonists of the aryl hydrocarbon receptor. Biochem. Pharmacol. 54, 165-171. (Pubitemid 27353234)
    • (1997) Biochemical Pharmacology , vol.54 , Issue.1 , pp. 165-171
    • Schrenk, D.1    Riebniger, D.2    Till, M.3    Vetter, S.4    Fiedler, H.-P.5
  • 77
    • 59149086493 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor has a normal function in the regulation of hematopoietic and other stem/progenitor cell populations
    • Singh, K.P., Casado, F.L., Opanashuk, L.A., and Gasiewicz, T.A. (2009). The aryl hydrocarbon receptor has a normal function in the regulation of hematopoietic and other stem/progenitor cell populations. Biochem. Pharmacol. 77, 577-587.
    • (2009) Biochem. Pharmacol , vol.77 , pp. 577-587
    • Singh, K.P.1    Casado, F.L.2    Opanashuk, L.A.3    Gasiewicz, T.A.4
  • 79
    • 78650310810 scopus 로고    scopus 로고
    • The expanding family of innate lymphoid cells: Regulators and effectors of immunity and tissue remodeling
    • Spits, H. and Di Santo, J.P. (2011). The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling. Nature Immunol. 12, 21-27.
    • (2011) Nature Immunol , vol.12 , pp. 21-27
    • Spits, H.1    Di Santo, J.P.2
  • 80
    • 66549106623 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor: A perspective on potential roles in the immune system
    • Stevens, E.A., Mezrich, J.D., and Bradfield, C.A. (2009). The aryl hydrocarbon receptor: a perspective on potential roles in the immune system. Immunol. 127, 299-311.
    • (2009) Immunol , vol.127 , pp. 299-311
    • Stevens, E.A.1    Mezrich, J.D.2    Bradfield, C.A.3
  • 81
    • 0029010526 scopus 로고
    • Inhibition of apoptosis during 2,3,7,8-tetrachlorodibenzo- p -dioxin-mediated tumour promotion in rat liver
    • Stinchcombe, S., Buchmann, A., Bock, K.W., and Schwarz, M. (1995). Inhibition of apoptosis during 2,3,7,8-tetrachlorodibenzo- p -dioxin-mediated tumour promotion in rat liver. Carcinogenesis 16, 1271-1275.
    • (1995) Carcinogenesis , vol.16 , pp. 1271-1275
    • Stinchcombe, S.1    Buchmann, A.2    Bock, K.W.3    Schwarz, M.4
  • 82
    • 0021844262 scopus 로고
    • Chloracne, 'the hallmark of dioxin intoxication'
    • Suskind, R.R. (1985). Chloracne,'the hallmark of dioxin intoxication'. Scand. J. Work. Environ. Health 11, 165-171.
    • (1985) Scand. J. Work. Environ. Health , vol.11 , pp. 165-171
    • Suskind, R.R.1
  • 83
    • 0025934316 scopus 로고
    • Targets for dioxin: Genes for plasminogen activator inhibitor-2 and interleukin-1β
    • Sutter, T.R., Guzman, K., Dold, K.M., and Greenlee, W.F. (1991). Targets for dioxin: genes for plasminogen activator inhibitor-2 and interleukin-1. Science 254, 415-418. (Pubitemid 21917355)
    • (1991) Science , vol.254 , Issue.5030 , pp. 415-418
    • Sutter, T.R.1    Guzman, K.2    Dold, K.M.3    Greenlee, W.F.4
  • 84
    • 84155187508 scopus 로고    scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo- p -dioxin increases the expression of genes in the human epidermal differentiation complex and accelerates epidermal barrier function
    • Sutter, C.H., Bodreddigari, S., Campion, C., Wible, R.S., and Sutter, T.R. (2011). 2,3,7,8-Tetrachlorodibenzo- p -dioxin increases the expression of genes in the human epidermal differentiation complex and accelerates epidermal barrier function. Toxicol. Sci. 124, 128-137.
    • (2011) Toxicol Sci , vol.124 , pp. 128-137
    • Sutter, C.H.1    Bodreddigari, S.2    Campion, C.3    Wible, R.S.4    Sutter, T.R.5
  • 86
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • DOI 10.1038/nrm1835, PII NRM1835
    • Thiery, J.P. and Sleeman, J.P. (2006). Complex networks orchestrate epithelial-mesenchymal transitions. Nature Rev. Mol. Biol. 7, 131-142. (Pubitemid 43278296)
    • (2006) Nature Reviews Molecular Cell Biology , vol.7 , Issue.2 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 87
    • 1642495627 scopus 로고    scopus 로고
    • HES-1, a Novel Target Gene for the Aryl Hydrocarbon Receptor
    • DOI 10.1124/mol.65.1.165
    • Thomsen, J.S., Kietz, S., Ström, A., and Gustafsson, J.A. (2004). Hes-1, a novel target gene for aryl hydrocarbon receptor. Mol. Pharmacol. 65, 165-171. (Pubitemid 38113897)
    • (2004) Molecular Pharmacology , vol.65 , Issue.1 , pp. 165-171
    • Thomsen, J.S.1    Kietz, S.2    Strom, A.3    Gustafsson, J.-A.4
  • 88
    • 30044452058 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteries
    • DOI 10.1124/mol.105.018705
    • Tijet, N., Boutros, P.C., Moffat, I.D., Okey, A.B., Tuomisto, J., and Pohjanvirta, R. (2006). Aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteries. Mol. Pharmacol. 69, 140-153. (Pubitemid 43048901)
    • (2006) Molecular Pharmacology , vol.69 , Issue.1 , pp. 140-153
    • Tijet, N.1    Boutros, P.C.2    Moffat, I.D.3    Okey, A.B.4    Tuomisto, J.5    Pohjanvirta, R.6
  • 89
    • 67651171182 scopus 로고    scopus 로고
    • Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from Th-17, Th1 and Th2 cells
    • Trifari, S., Kaplan, C.D., Tran, E.H., Crellin, N.K., and Spits, H. (2009). Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from Th-17, Th1 and Th2 cells. Nature Immunol. 10, 864-871.
    • (2009) Nature Immunol , vol.10 , pp. 864-871
    • Trifari, S.1    Kaplan, C.D.2    Tran, E.H.3    Crellin, N.K.4    Spits, H.5
  • 90
    • 0028012079 scopus 로고
    • Dioxin-responsive genes: Examination of dose-response relationships using quantitative reverse transcriptase-polymerase chain reaction
    • Vanden Heuvel, J.P., Clark, G.C., Kohn, M.C., Tritscher, A.M., Greenlee, W.F., Lucier G.W., and Bell D.A. (1994). Dioxinresponsive genes: examination of dose-response relationships using quantitative reverse transcriptase-polymerase chain reaction. Cancer Res. 54, 62-68. (Pubitemid 24042089)
    • (1994) Cancer Research , vol.54 , Issue.1 , pp. 62-68
    • Vanden Heuvel, J.P.1    Clark, G.C.2    Kohn, M.C.3    Tritscher, A.M.4    Greenlee, W.F.5    Lucier, G.W.6    Bell, D.A.7
  • 91
    • 42649106556 scopus 로고    scopus 로고
    • H17-cell-mediated autoimmunity to environmental toxins
    • DOI 10.1038/nature06881, PII NATURE06881
    • Veldhoen, M., Hirota, K., Westendorf, A.M., Buer, J., Dumoutier, L., Renauld, J.C., and Stockinger, B. (2008). The aryl hydrocarbon receptor links Th17-cell-mediated autoimmunity to environmental toxins. Nature 453, 106-109. (Pubitemid 351630329)
    • (2008) Nature , vol.453 , Issue.7191 , pp. 106-109
    • Veldhoen, M.1    Hirota, K.2    Westendorf, A.M.3    Buer, J.4    Dumoutier, L.5    Renauld, J.-C.6    Stockinger, B.7
  • 92
    • 36849010739 scopus 로고    scopus 로고
    • RelB, a new partner of aryl hydrocarbon receptor-mediated transcription
    • DOI 10.1210/me.2007-0211
    • Vogel, C.F.A., Sciullo, E., Li, W., Wong, P., Lazennec, G., and Matsumura, F. (2007a). RelB, a new partner of aryl hydrocarbon receptor-mediated transcription. Mol. Endocrinol. 21, 2941-2955. (Pubitemid 350223506)
    • (2007) Molecular Endocrinology , vol.21 , Issue.12 , pp. 2941-2955
    • Vogel, C.F.A.1    Sciullo, E.2    Li, W.3    Wong, P.4    Lazennec, G.5    Matsumura, F.6
  • 93
    • 36348988444 scopus 로고    scopus 로고
    • Pathogenesis of aryl hydrocarbon receptor-mediated development of lymphoma is associated with increased cyclooxygenase-2 expression
    • DOI 10.2353/ajpath.2007.070406
    • Vogel, C.F.A., Li, W., Sciullo, E., Newman, J., Hammock, B., Reader, J.R., Tuscano, J., and Matsumura, F. (2007b). Pathogenesis of aryl hydrocarbon receptor-mediated development of lymphoma is associated with increased cyclooxygenase-2 expression. Am. J. Pathol. 171, 1538-1548. (Pubitemid 350158315)
    • (2007) American Journal of Pathology , vol.171 , Issue.5 , pp. 1538-1548
    • Vogel, C.F.A.1    Li, W.2    Sciullo, E.3    Newman, J.4    Hammock, B.5    Reader, J.R.6    Tuscano, J.7    Matsumura, F.8
  • 94
    • 50949098849 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase
    • Vogel, C.F.A., Goth, S.R., Dong, B., Pessah, I.N., and Matsumura, F. (2008). Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase. Biochem. Biophys. Res. Commun. 375, 331-335.
    • (2008) Biochem. Biophys. Res. Commun , vol.375 , pp. 331-335
    • Vogel, C.F.A.1    Goth, S.R.2    Dong, B.3    Pessah, I.N.4    Matsumura, F.5
  • 98
  • 99
    • 59149105791 scopus 로고    scopus 로고
    • The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-folmylindolo [3,2-b]carbazole is present in humans
    • Wincent, E., Amini, N., Luecke, S., Glatt, H., Bergman, J., Crescenzi, C., Rannug, A., and Rannug, U. (2009). The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-folmylindolo[3,2-b]carbazole is present in humans. J. Biol. Chem. 284, 2690-2696.
    • (2009) J. Biol. Chem , vol.284 , pp. 2690-2696
    • Wincent, E.1    Amini, N.2    Luecke, S.3    Glatt, H.4    Bergman, J.5    Crescenzi, C.6    Rannug, A.7    Rannug, U.8
  • 100
    • 84858626055 scopus 로고    scopus 로고
    • Inhibition of cytochrome P4501-dependent clearance of the endogenous agonist FICZ as a mechanism for activation of the aryl hydrocarbon receptor
    • Wincent, E., Bengtsson, J., Bardbori, A.M., Alsberg, T., Luecke, S., Rannug, U., and Rannug, A. (2012). Inhibition of cytochrome P4501-dependent clearance of the endogenous agonist FICZ as a mechanism for activation of the aryl hydrocarbon receptor. Proc. Natl. Acad. Sci. USA 109, 4479-4484.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 4479-4484
    • Wincent, E.1    Bengtsson, J.2    Bardbori, A.M.3    Alsberg, T.4    Luecke, S.5    Rannug, U.6    Rannug, A.7


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