The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor

Biochemistry

Volumn 49, Issue 2, 2010, Pages 393-400

  Schroeder, Jennifer C ^a   DiNatale, Brett C ^a   Murray, Iain A ^a   Flaveny, Colin A ^a   Liu, Qiang ^a   Laurenzana, Elizabeth M ^a   Lin, Jyh Ming ^b   Strom, Stephen C ^c   Omiecinski, Curtis J ^a   Amin, Shantu ^b   Perdew, Gary H ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARYL HYDROCARBON RECEPTOR; BINDING ASSAYS; CELL DIFFERENTIATION; CELLULAR PATHWAY; DRUG METABOLISMS; HIGH POTENCY; HUMAN DISEASE; HUMAN HEPATOCYTES; IN-CELL; INDOXYL SULFATE; KIDNEY DIALYSIS PATIENTS; MECHANISM OF ACTION; MICROMOLAR CONCENTRATION; MULTIPLE GENES; NANOMOLAR CONCENTRATION; PHASE II; STRUCTURE-FUNCTION STUDIES; SULFATE GROUPS; THERAPEUTIC TARGETS; TRANSCRIPTIONAL ACTIVATIONS; UREMIC TOXINS; XENOBIOTIC METABOLISM;

CELL CULTURE; DIALYSIS; HYDROCARBONS; METABOLISM; TRANSCRIPTION; TRANSCRIPTION FACTORS;

LIGANDS;

AROMATIC HYDROCARBON RECEPTOR; CAR PROTEIN; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A6; INDICAN; INDOLE DERIVATIVE; INTERLEUKIN 6; LIGAND; PROTEIN; PXR PROTEIN; SULFATE; UNCLASSIFIED DRUG; UREMIC TOXIN; AHR PROTEIN, HUMAN; COMPLEMENTARY DNA; RNA;

ANIMAL CELL; ARTICLE; BINDING ASSAY; CELL LINE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYP1A1 GENE; CYP1A2 GENE; CYP1B1 GENE; DISEASE COURSE; DRUG POTENCY; GENE; GENETIC TRANSCRIPTION; HEMODIALYSIS PATIENT; HUMAN; HUMAN CELL; IL6 GENE; LIVER CELL; MOUSE; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; RENAL REPLACEMENT THERAPY; SAA1 GENE; SCREENING; TRANSCRIPTION INITIATION; UGT1A1 GENE; UGT1A6 GENE; CELL STRAIN HEPG2; CHEMISTRY; DRUG POTENTIATION; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC TRANSFECTION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; PLASMID; POLYMERASE CHAIN REACTION; REPORTER GENE; TUMOR CELL LINE;

CELL LINE; CELL LINE, TUMOR; DNA, COMPLEMENTARY; GENE EXPRESSION REGULATION; GENE SILENCING; GENES, REPORTER; HEP G2 CELLS; HEPATOCYTES; HUMANS; INDICAN; LIGANDS; PLASMIDS; POLYMERASE CHAIN REACTION; RECEPTORS, ARYL HYDROCARBON; RNA; RNA, NEOPLASM; TRANSFECTION;

EID: 75349102699     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi901786x     Document Type: Article

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