Anti-Inflammation of Spirocyclopiperazinium Salt Compound LXM-10 Targeting α7 nAChR and M4 mAChR and Inhibiting JAK2/STAT3 Pathway in Rats

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Zhang, Weiwei ^a,b   Sun, Qi ^b   Gao, Xiaoli ^b   Jiang, Yimin ^a   Li, Runtao ^a,b   Ye, Jia ^a,b  

^a PEKING UNIVERSITY   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIMETHYL 9 BETA PHENYLETHYL 3 OXO 6,9 DIAZASPIROUNDECANE CHLORIDE; ACETYLSALICYLIC ACID; ANTIINFLAMMATORY AGENT; BUNGAROTOXIN RECEPTOR; DICLOFENAC; INTERLEUKIN 6; JANUS KINASE 2; MUSCARINIC M4 RECEPTOR; SPIROCYCLOPIPERAZINIUM SALT COMPOUND; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; CHRONIC INFLAMMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG EFFECT; DRUG TARGETING; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IN VIVO STUDY; INFLAMMATION; MALE; NONHUMAN; PAW EDEMA; RAT; TRANSCRIPTION REGULATION;

ACONITINE; ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; EDEMA; INFLAMMATION MEDIATORS; INTERLEUKIN-6; JANUS KINASE 2; MALE; MUSCARINIC ANTAGONISTS; NICOTINIC ANTAGONISTS; PHOSPHORYLATION; PIPERAZINES; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, MUSCARINIC M4; SIGNAL TRANSDUCTION; SPIRO COMPOUNDS; STAT3 TRANSCRIPTION FACTOR; TROPICAMIDE; TUMOR NECROSIS FACTOR-ALPHA;

RATTUS;

EID: 84879539142     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066895     Document Type: Article

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