메뉴 건너뛰기




Volumn 95, Issue 2, 2010, Pages 192-197

Antinociceptive mechanism of the spirocyclopiperazinium compound LXM-10 in mice and rats

Author keywords

7 Nicotinic acetylcholine receptor; Antinociception; LXM 10; M4 muscarine acetylcholine receptor

Indexed keywords

2,4 DIMETHYL 9 BETA PHENYLETHYL 3 OXO 6,9 DIAZASPIRO[5.5]UNDECANE CHLORIDE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR; ANTINOCICEPTIVE AGENT; ATROPINE METHYL NITRATE; BICUCULLINE; BUNGAROTOXIN RECEPTOR; HEXAMETHONIUM; LXM 10; METHYLLYCACONITINE; METHYLLYCACONITINE CITRATE; MUSCARINIC RECEPTOR; PHACLOFEN; TROPICAMIDE; UNCLASSIFIED DRUG;

EID: 76949086441     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2010.01.004     Document Type: Article
Times cited : (7)

References (34)
  • 1
    • 0028230727 scopus 로고
    • Epibatidine, a potent analgetic and nicotinic agonist
    • Badio B., and Daly J.W. Epibatidine, a potent analgetic and nicotinic agonist. Mol Pharmacol 45 4 (1994) 563-569
    • (1994) Mol Pharmacol , vol.45 , Issue.4 , pp. 563-569
    • Badio, B.1    Daly, J.W.2
  • 2
    • 0032568302 scopus 로고    scopus 로고
    • Spinal and supraspinal antinociceptive action of dipyrone in formalin, capsaicin and glutamate tests. Study of the mechanism of action
    • Beirith A., Santos A.R., Rodrigues A.L., Creczynski-Pasa T.B., and Calixto J.B. Spinal and supraspinal antinociceptive action of dipyrone in formalin, capsaicin and glutamate tests. Study of the mechanism of action. Eur J Pharmacol 345 3 (1998) 233-245
    • (1998) Eur J Pharmacol , vol.345 , Issue.3 , pp. 233-245
    • Beirith, A.1    Santos, A.R.2    Rodrigues, A.L.3    Creczynski-Pasa, T.B.4    Calixto, J.B.5
  • 3
    • 0035094199 scopus 로고    scopus 로고
    • Peripheral group I metabotropic glutamate receptors modulate nociception in mice
    • Bhave G., Karim F., Carlton S.M., and Gereau R.T. Peripheral group I metabotropic glutamate receptors modulate nociception in mice. Nat Neurosci 4 4 (2001) 417-423
    • (2001) Nat Neurosci , vol.4 , Issue.4 , pp. 417-423
    • Bhave, G.1    Karim, F.2    Carlton, S.M.3    Gereau, R.T.4
  • 4
    • 0035812899 scopus 로고    scopus 로고
    • Memory improving actions of gabapentin in mice: possible involvement of central muscarinic cholinergic mechanism
    • Boccia M.M., Acosta G.B., and Baratti C.M. Memory improving actions of gabapentin in mice: possible involvement of central muscarinic cholinergic mechanism. Neurosci Lett 311 3 (2001) 153-156
    • (2001) Neurosci Lett , vol.311 , Issue.3 , pp. 153-156
    • Boccia, M.M.1    Acosta, G.B.2    Baratti, C.M.3
  • 5
    • 0027208248 scopus 로고
    • Muscarinic receptors-characterization, coupling and function
    • Caulfield M.P. Muscarinic receptors-characterization, coupling and function. Pharmacol Ther 58 3 (1993) 319-379
    • (1993) Pharmacol Ther , vol.58 , Issue.3 , pp. 319-379
    • Caulfield, M.P.1
  • 6
    • 0033626562 scopus 로고    scopus 로고
    • The antinociceptive effects of alpha7 nicotinic agonists in an acute pain model
    • Damaj M.I., Meyer E.M., and Martin B.R. The antinociceptive effects of alpha7 nicotinic agonists in an acute pain model. Neuropharmacology 39 13 (2000) 2785-2791
    • (2000) Neuropharmacology , vol.39 , Issue.13 , pp. 2785-2791
    • Damaj, M.I.1    Meyer, E.M.2    Martin, B.R.3
  • 7
    • 0032586785 scopus 로고    scopus 로고
    • Characterisation of the binding of [3H]methyllycaconitine: a new radioligand for labelling α7-type neuronal nicotinic acetylcholine receptors
    • Davies A.R.L., Hardick D.J., Blagbrough I.S., Potter B.V.L., Wolstenholme A.J., and Wonnacott S. Characterisation of the binding of [3H]methyllycaconitine: a new radioligand for labelling α7-type neuronal nicotinic acetylcholine receptors. Neuropharmacology 38 5 (1999) 679-690
    • (1999) Neuropharmacology , vol.38 , Issue.5 , pp. 679-690
    • Davies, A.R.L.1    Hardick, D.J.2    Blagbrough, I.S.3    Potter, B.V.L.4    Wolstenholme, A.J.5    Wonnacott, S.6
  • 8
    • 0032478589 scopus 로고    scopus 로고
    • Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice
    • Decker M.W., Bannon A.W., Buckley M.J., Kim D.J., Holladay M.W., Ryther K.B., et al. Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice. Eur J Pharmacol 346 1 (1998) 23-33
    • (1998) Eur J Pharmacol , vol.346 , Issue.1 , pp. 23-33
    • Decker, M.W.1    Bannon, A.W.2    Buckley, M.J.3    Kim, D.J.4    Holladay, M.W.5    Ryther, K.B.6
  • 9
    • 0346724925 scopus 로고    scopus 로고
    • Cholinergic modulation of nociceptive responses in vivo and neuropeptide release in vitro at the level of the primary sensory neuron
    • Dussor G.O., Helesic G., Hargreaves K.M., and Flores C.M. Cholinergic modulation of nociceptive responses in vivo and neuropeptide release in vitro at the level of the primary sensory neuron. Pain 107 1-2 (2004) 22-32
    • (2004) Pain , vol.107 , Issue.1-2 , pp. 22-32
    • Dussor, G.O.1    Helesic, G.2    Hargreaves, K.M.3    Flores, C.M.4
  • 10
    • 0036841143 scopus 로고    scopus 로고
    • Evaluation of muscarinic agonist-induced analgesia in muscarinic acetylcholine receptor knockout mice
    • Duttaroy A., Gomeza J., Gan J.W., Siddiqui N., Basile A.S., Harman W.D., et al. Evaluation of muscarinic agonist-induced analgesia in muscarinic acetylcholine receptor knockout mice. Mol Pharmacol 62 5 (2002) 1084-1093
    • (2002) Mol Pharmacol , vol.62 , Issue.5 , pp. 1084-1093
    • Duttaroy, A.1    Gomeza, J.2    Gan, J.W.3    Siddiqui, N.4    Basile, A.S.5    Harman, W.D.6
  • 11
    • 0025632856 scopus 로고
    • Regional distribution of M1, M2 and non-M1, non-M2 subtypes of muscarinic binding sites in rat brain
    • Ehlert F.J., and Tran L.P. Regional distribution of M1, M2 and non-M1, non-M2 subtypes of muscarinic binding sites in rat brain. J Pharmacol Exp Ther 255 3 (1990) 1148-1157
    • (1990) J Pharmacol Exp Ther , vol.255 , Issue.3 , pp. 1148-1157
    • Ehlert, F.J.1    Tran, L.P.2
  • 12
    • 0029805769 scopus 로고    scopus 로고
    • Hippocampal synaptic transmission enhanced by low concentrations of nicotine
    • Gray R., Rajan A.S., Radcliffe K.A., Yakehiro M., and Dani J.A. Hippocampal synaptic transmission enhanced by low concentrations of nicotine. Nature 383 6602 (1996) 713-716
    • (1996) Nature , vol.383 , Issue.6602 , pp. 713-716
    • Gray, R.1    Rajan, A.S.2    Radcliffe, K.A.3    Yakehiro, M.4    Dani, J.A.5
  • 13
    • 3543104904 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptor subtypes in nociceptive dorsal root ganglion neurons of the adult rat
    • Haberberger R.V., Bernardini N., Kress M., Hartmann P., Lips K.S., and Kummer W. Nicotinic acetylcholine receptor subtypes in nociceptive dorsal root ganglion neurons of the adult rat. Autonom Neurosci 113 (2007) 32-42
    • (2007) Autonom Neurosci , vol.113 , pp. 32-42
    • Haberberger, R.V.1    Bernardini, N.2    Kress, M.3    Hartmann, P.4    Lips, K.S.5    Kummer, W.6
  • 14
    • 0035059685 scopus 로고    scopus 로고
    • The antinociceptive effect of intrathecal administration of epibatidine with clonidine or neostigmine in the formalin test in rats
    • Hama A.T., Lloyd G.K., and Menzaghi F. The antinociceptive effect of intrathecal administration of epibatidine with clonidine or neostigmine in the formalin test in rats. Pain 91 4 (2001) 131-138
    • (2001) Pain , vol.91 , Issue.4 , pp. 131-138
    • Hama, A.T.1    Lloyd, G.K.2    Menzaghi, F.3
  • 15
    • 33750002031 scopus 로고    scopus 로고
    • The antinociceptive effects of centrally administered CDP-choline on acute pain models in rats: the involvement of cholinergic system
    • Hamurtekin E., and Gurun M.S. The antinociceptive effects of centrally administered CDP-choline on acute pain models in rats: the involvement of cholinergic system. Brain Res 1117 1 (2006) 92-100
    • (2006) Brain Res , vol.1117 , Issue.1 , pp. 92-100
    • Hamurtekin, E.1    Gurun, M.S.2
  • 16
    • 34547552883 scopus 로고    scopus 로고
    • Targeting the cholinergic system as a therapeutic strategy for the treatment of pain
    • Jones P.G., and Dunlop J. Targeting the cholinergic system as a therapeutic strategy for the treatment of pain. Neuropharmacology 53 2 (2007) 197-206
    • (2007) Neuropharmacology , vol.53 , Issue.2 , pp. 197-206
    • Jones, P.G.1    Dunlop, J.2
  • 17
    • 0030827378 scopus 로고    scopus 로고
    • A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional pain syndromes
    • Kingery W.S. A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional pain syndromes. Pain 73 2 (1997) 123-139
    • (1997) Pain , vol.73 , Issue.2 , pp. 123-139
    • Kingery, W.S.1
  • 18
    • 0037106432 scopus 로고    scopus 로고
    • Role of presynaptic muscarinic and GABA(B) receptors in spinal glutamate release and cholinergic analgesia in rats
    • Li D.P., Chen S.R., Pan Y.Z., Levey A.I., and Pan H.L. Role of presynaptic muscarinic and GABA(B) receptors in spinal glutamate release and cholinergic analgesia in rats. J Physiol 543 Pt 3 (2002) 807-818
    • (2002) J Physiol , vol.543 , Issue.PART 3 , pp. 807-818
    • Li, D.P.1    Chen, S.R.2    Pan, Y.Z.3    Levey, A.I.4    Pan, H.L.5
  • 19
    • 0035477336 scopus 로고    scopus 로고
    • Regulation of GABA release by nicotinic acetylcholine receptors in the neonatal rat hippocampus
    • Maggi L., Sher E., and Cherubini E. Regulation of GABA release by nicotinic acetylcholine receptors in the neonatal rat hippocampus. J Physiol 536 Pt 1 (2001) 89-100
    • (2001) J Physiol , vol.536 , Issue.PART 1 , pp. 89-100
    • Maggi, L.1    Sher, E.2    Cherubini, E.3
  • 20
    • 0036277865 scopus 로고    scopus 로고
    • Descending control of pain
    • Millan M.J. Descending control of pain. Prog Neurobiol 66 6 (2002) 355-474
    • (2002) Prog Neurobiol , vol.66 , Issue.6 , pp. 355-474
    • Millan, M.J.1
  • 21
    • 0142102404 scopus 로고    scopus 로고
    • Loss of muscarinic M4 receptors in spinal cord of arthritic rats: implications for a role of M4 receptors in pain response
    • Mulugeta E., El-Bakri N., Karlsson E., Elhassan A., and Adem A. Loss of muscarinic M4 receptors in spinal cord of arthritic rats: implications for a role of M4 receptors in pain response. Brain Res 982 2 (2003) 284-287
    • (2003) Brain Res , vol.982 , Issue.2 , pp. 284-287
    • Mulugeta, E.1    El-Bakri, N.2    Karlsson, E.3    Elhassan, A.4    Adem, A.5
  • 22
    • 46149126361 scopus 로고    scopus 로고
    • Synthesis, trafficking, and localization of muscarinic acetylcholine receptors
    • Nathanson N.M. Synthesis, trafficking, and localization of muscarinic acetylcholine receptors. Pharmacol Ther 119 1 (2008) 33-43
    • (2008) Pharmacol Ther , vol.119 , Issue.1 , pp. 33-43
    • Nathanson, N.M.1
  • 23
    • 0016671314 scopus 로고
    • Quantification of the analgesic activity of narcotic antagonists by a modified hot-plate procedure
    • O'Callaghan J.P., and Holtzman S.G. Quantification of the analgesic activity of narcotic antagonists by a modified hot-plate procedure. J Pharmacol Exp Ther 192 3 (1975) 497-505
    • (1975) J Pharmacol Exp Ther , vol.192 , Issue.3 , pp. 497-505
    • O'Callaghan, J.P.1    Holtzman, S.G.2
  • 24
    • 0035865020 scopus 로고    scopus 로고
    • The effects of GABA(B) agonists and gabapentin on mechanical hyperalgesia in models of neuropathic and inflammatory pain in the rat
    • Patel S., Naeem S., Kesingland A., Froestl W., Capogna M., Urban L., et al. The effects of GABA(B) agonists and gabapentin on mechanical hyperalgesia in models of neuropathic and inflammatory pain in the rat. Pain 90 3 (2001) 217-226
    • (2001) Pain , vol.90 , Issue.3 , pp. 217-226
    • Patel, S.1    Naeem, S.2    Kesingland, A.3    Froestl, W.4    Capogna, M.5    Urban, L.6
  • 26
    • 0023137280 scopus 로고
    • GABAergic mechanisms of analgesia: an update
    • Sawynok J. GABAergic mechanisms of analgesia: an update. Pharmacol Biochem Behav 26 2 (1987) 463-474
    • (1987) Pharmacol Biochem Behav , vol.26 , Issue.2 , pp. 463-474
    • Sawynok, J.1
  • 27
    • 35048845088 scopus 로고    scopus 로고
    • Unique spirocyclopiperazinium salt III: further investigation of monospirocyclopiperazinium (MSPZ) salts as potential analgesics
    • Sun Q., Yue C., Ye J., Li C., Cheng T., and Li R. Unique spirocyclopiperazinium salt III: further investigation of monospirocyclopiperazinium (MSPZ) salts as potential analgesics. Bioorg Med Chem Lett 17 22 (2007) 6245-6249
    • (2007) Bioorg Med Chem Lett , vol.17 , Issue.22 , pp. 6245-6249
    • Sun, Q.1    Yue, C.2    Ye, J.3    Li, C.4    Cheng, T.5    Li, R.6
  • 28
    • 0035141558 scopus 로고    scopus 로고
    • Cholinergic modulation of excitatory synaptic transmission in the CA3 area of the hippocampus
    • Vogt K.E., and Regehr W.G. Cholinergic modulation of excitatory synaptic transmission in the CA3 area of the hippocampus. J Neurosci 21 1 (2001) 75-83
    • (2001) J Neurosci , vol.21 , Issue.1 , pp. 75-83
    • Vogt, K.E.1    Regehr, W.G.2
  • 29
    • 15044360252 scopus 로고    scopus 로고
    • Antinociceptive effects of choline against acute and inflammatory pain
    • Wang Y., Su D.M., Wang R.H., Liu Y., and Wang H. Antinociceptive effects of choline against acute and inflammatory pain. Neuroscience 132 1 (2005) 49-56
    • (2005) Neuroscience , vol.132 , Issue.1 , pp. 49-56
    • Wang, Y.1    Su, D.M.2    Wang, R.H.3    Liu, Y.4    Wang, H.5
  • 30
    • 0037470642 scopus 로고    scopus 로고
    • Muscarinic receptor subtypes mediating central and peripheral antinociception studied with muscarinic receptor knockout mice: a review
    • Wess J., Duttaroy A., Gomeza J., Zhang W., Yamada M., Felder C.C., et al. Muscarinic receptor subtypes mediating central and peripheral antinociception studied with muscarinic receptor knockout mice: a review. Life Sci 72 18-19 (2003) 2047-2054
    • (2003) Life Sci , vol.72 , Issue.18-19 , pp. 2047-2054
    • Wess, J.1    Duttaroy, A.2    Gomeza, J.3    Zhang, W.4    Yamada, M.5    Felder, C.C.6
  • 31
    • 34249696025 scopus 로고    scopus 로고
    • Antinociceptive effects of the novel spirocyclopiperazinium salt compound LXM-10 in mice
    • Yue C.Q., Ye J., Li C.L., Li R.T., and Sun Q. Antinociceptive effects of the novel spirocyclopiperazinium salt compound LXM-10 in mice. Pharmacol Biochem Behav 86 4 (2007) 643-650
    • (2007) Pharmacol Biochem Behav , vol.86 , Issue.4 , pp. 643-650
    • Yue, C.Q.1    Ye, J.2    Li, C.L.3    Li, R.T.4    Sun, Q.5
  • 32
    • 18044366205 scopus 로고    scopus 로고
    • M2, M3, and M4 receptor subtypes contribute to muscarinic potentiation of GABAergic inputs to spinal dorsal horn neurons
    • Zhang H.M., Li D.P., Chen S.R., and Pan H.L. M2, M3, and M4 receptor subtypes contribute to muscarinic potentiation of GABAergic inputs to spinal dorsal horn neurons. J Pharmacol Exp Ther 313 2 (2005) 697-704
    • (2005) J Pharmacol Exp Ther , vol.313 , Issue.2 , pp. 697-704
    • Zhang, H.M.1    Li, D.P.2    Chen, S.R.3    Pan, H.L.4
  • 33
    • 33846464673 scopus 로고    scopus 로고
    • Regulation of glutamate release from primary afferents and interneurons in the spinal cord by muscarinic receptor subtypes
    • Zhang H.M., Chen S.R., and Pan H.L. Regulation of glutamate release from primary afferents and interneurons in the spinal cord by muscarinic receptor subtypes. J Neurophysiol 97 1 (2007) 102-109
    • (2007) J Neurophysiol , vol.97 , Issue.1 , pp. 102-109
    • Zhang, H.M.1    Chen, S.R.2    Pan, H.L.3
  • 34
    • 0020525719 scopus 로고
    • Ethical guidelines for investigations of experimental pain in conscious animals
    • Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16 2 (1983) 109-110
    • (1983) Pain , vol.16 , Issue.2 , pp. 109-110
    • Zimmermann, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.