Inhibition of Janus kinase 2 and signal transduction and activator of transcription 3 protect against cecal ligation and puncture-induced multiple organ damage and mortality

Journal of Trauma - Injury, Infection and Critical Care

Volumn 66, Issue 3, 2009, Pages 859-865

  Hui, Liu ^a   Yao, Yongming ^a   Wang, Songbai ^a   Yu, Yan ^a   Dong, Ning ^a   Li, Hongyun ^a   Sheng, Zhiyong ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

High mobility group box 1 protein; Janus kinase; Sepsis; Signal transducer and transcription activator

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; HIGH MOBILITY GROUP B1 PROTEIN; JANUS KINASE 2; MYELOPEROXIDASE; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; RAPAMYCIN; STAT3 PROTEIN; ALPHA CYANO (3,4 DIHYDROXY) N BENZYLCINNAMIDE; ALPHA-CYANO-(3,4-DIHYDROXY)-N-BENZYLCINNAMIDE; ENZYME INHIBITOR; HBP1 PROTEIN, RAT; JAK2 PROTEIN, RAT; PEROXIDASE; STAT3 PROTEIN, RAT; TYRPHOSTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CECUM; CHRONOTHERAPY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; EXPERIMENTAL LIGATION; GEL MOBILITY SHIFT ASSAY; LIVER INJURY; LIVER PROTECTION; LUNG INJURY; MALE; MORTALITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PUNCTURE; RAT; SEPSIS; SIGNAL TRANSDUCTION; SURVIVAL; TISSUE LEVEL; WESTERN BLOTTING; ANIMAL; BLOOD; COMPARATIVE STUDY; DRUG ADMINISTRATION; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; INJURY; MULTIPLE ORGAN FAILURE; SURVIVAL RATE; WISTAR RAT;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; CECUM; DRUG ADMINISTRATION SCHEDULE; ENZYME INHIBITORS; HMGB1 PROTEIN; JANUS KINASE 2; MALE; MULTIPLE ORGAN FAILURE; PEROXIDASE; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; SIROLIMUS; STAT3 TRANSCRIPTION FACTOR; SURVIVAL RATE; TYRPHOSTINS;

EID: 68149163946     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e318164d05f     Document Type: Article

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