메뉴 건너뛰기




Volumn 86, Issue 4, 2007, Pages 643-650

Antinociceptive effects of the novel spirocyclopiperazinium salt compound LXM-10 in mice

Author keywords

Antinociception; LXM 10

Indexed keywords

2,4 DIMETHYL 9 BETA PHENYLETHYL 3 OXO 6,9 DIAZASPIRO[5.5]UNDECANE CHLORIDE; ACETIC ACID; ANTINOCICEPTIVE AGENT; ATROPINE; ATROPINE METHYL NITRATE; DIAZEPAM; HEXAMETHONIUM; LXM 10; MECAMYLAMINE; MORPHINE; NALOXONE; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG; YOHIMBINE;

EID: 34249696025     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2007.02.009     Document Type: Article
Times cited : (13)

References (39)
  • 1
    • 0028997458 scopus 로고
    • Is epibatidine really analgesic? Dissociation of the activity, temperature, and analgesic effects of (+)-epibatidine
    • Bannon A.W., Gunther K.L., and Decker M.W. Is epibatidine really analgesic? Dissociation of the activity, temperature, and analgesic effects of (+)-epibatidine. Brain Res 51 4 (1995) 693-698
    • (1995) Brain Res , vol.51 , Issue.4 , pp. 693-698
    • Bannon, A.W.1    Gunther, K.L.2    Decker, M.W.3
  • 2
    • 15144343497 scopus 로고    scopus 로고
    • Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors
    • Bannon A.W., Decker M.W., Holladay M.W., Curzon P., Donnelly-Roberts D., Puttfarcken P.S., et al. Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors. Science 279 (1998) 77-81
    • (1998) Science , vol.279 , pp. 77-81
    • Bannon, A.W.1    Decker, M.W.2    Holladay, M.W.3    Curzon, P.4    Donnelly-Roberts, D.5    Puttfarcken, P.S.6
  • 3
    • 7044228051 scopus 로고    scopus 로고
    • Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil
    • Barocelli E., Calcina F., and Chiavarini M. Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil. Life Sci 76 (2004) 213-223
    • (2004) Life Sci , vol.76 , pp. 213-223
    • Barocelli, E.1    Calcina, F.2    Chiavarini, M.3
  • 5
    • 0035828131 scopus 로고    scopus 로고
    • 2 receptors inhibit heat-induced CGRP release from isolated rat skin, in vitro
    • 2 receptors inhibit heat-induced CGRP release from isolated rat skin, in vitro. NeuroReport 2 (2001) 2457-2460
    • (2001) NeuroReport , vol.2 , pp. 2457-2460
    • Bernardini, N.1    Reeh, P.W.2    Sauer, S.K.3
  • 8
    • 0028209148 scopus 로고
    • Differential effects of pretreatment with nicotine and lobeline on nicotine-induced changes in body temperature and locomotor activity in mice
    • Decker M.W., Buckley M.J., and Brioni J.D. Differential effects of pretreatment with nicotine and lobeline on nicotine-induced changes in body temperature and locomotor activity in mice. Drug Devel Res 31 (1994) 52-58
    • (1994) Drug Devel Res , vol.31 , pp. 52-58
    • Decker, M.W.1    Buckley, M.J.2    Brioni, J.D.3
  • 9
    • 0032977664 scopus 로고    scopus 로고
    • Hybridized and isosteric analogues of N1-acetyl-N4-dimethyl-piperazinium iodide (ADMP) and N1-phenyl-N4-dimethyl-piperazinium iodide (DMPP) with central nicotinic action
    • Dina M., Alessandro B., Pier A.B., Cristina B., Silvia D., Carla G., et al. Hybridized and isosteric analogues of N1-acetyl-N4-dimethyl-piperazinium iodide (ADMP) and N1-phenyl-N4-dimethyl-piperazinium iodide (DMPP) with central nicotinic action. Bioorganic Med. Chem 7 (1999) 457-465
    • (1999) Bioorganic Med. Chem , vol.7 , pp. 457-465
    • Dina, M.1    Alessandro, B.2    Pier, A.B.3    Cristina, B.4    Silvia, D.5    Carla, G.6
  • 10
    • 84935383230 scopus 로고
    • Synthetic analgesics: II. dithienylbutenyl and dithienylbutylamines
    • Eddy N.B., and Leimbach D. Synthetic analgesics: II. dithienylbutenyl and dithienylbutylamines. J Pharmacol Exp Ther 107 (1953) 385-393
    • (1953) J Pharmacol Exp Ther , vol.107 , pp. 385-393
    • Eddy, N.B.1    Leimbach, D.2
  • 11
    • 0035793826 scopus 로고    scopus 로고
    • Mariannina I. Evidence for specific analgesic activity of a muscarinic agonist selected among a new series of acetylenic derivatives
    • Elisabetta B., Vigilio B., Simona B., and Marco D.A. Mariannina I. Evidence for specific analgesic activity of a muscarinic agonist selected among a new series of acetylenic derivatives. Life Sci 68 (2001) 1775-1785
    • (2001) Life Sci , vol.68 , pp. 1775-1785
    • Elisabetta, B.1    Vigilio, B.2    Simona, B.3    Marco, D.A.4
  • 12
    • 0037420769 scopus 로고    scopus 로고
    • Unique spirocyclopiperazinium salt I: synthesis and structure-activity relationship of spirocyclopiperazinium salts as analgesics
    • Gao F.L., Wang X., Zhang H.M., Cheng T.M., and Li R.T. Unique spirocyclopiperazinium salt I: synthesis and structure-activity relationship of spirocyclopiperazinium salts as analgesics. Bioorg Med Chem Lett 13 (2003) 1535-1537
    • (2003) Bioorg Med Chem Lett , vol.13 , pp. 1535-1537
    • Gao, F.L.1    Wang, X.2    Zhang, H.M.3    Cheng, T.M.4    Li, R.T.5
  • 13
    • 11844276603 scopus 로고    scopus 로고
    • Neuronal nicotinic receptors: from structure to pathology
    • Gotti C., and Clementi F. Neuronal nicotinic receptors: from structure to pathology. Prog Neurobiol 74 (2004) 363-396
    • (2004) Prog Neurobiol , vol.74 , pp. 363-396
    • Gotti, C.1    Clementi, F.2
  • 15
    • 0027359663 scopus 로고
    • Characterization of the antinociception produced by intrathecally administered muscarinic agonists in rats
    • Iwamoto E.T., and Marion L. Characterization of the antinociception produced by intrathecally administered muscarinic agonists in rats. J Pharmacol Exp Ther 266 (1993) 329-338
    • (1993) J Pharmacol Exp Ther , vol.266 , pp. 329-338
    • Iwamoto, E.T.1    Marion, L.2
  • 16
    • 0033534711 scopus 로고    scopus 로고
    • Muscarinic-induced analgesia
    • James C.E. Muscarinic-induced analgesia. Life Sci 64 6/l (1999) 549-554
    • (1999) Life Sci , vol.64 , Issue.6 -l , pp. 549-554
    • James, C.E.1
  • 17
    • 0037470642 scopus 로고    scopus 로고
    • Muscarinic receptor subtypes mediating central and peripheral antinociception studied with muscarinic receptor knockout mice: a review
    • Jürgen W., Alokesh D., and Jesus G. Muscarinic receptor subtypes mediating central and peripheral antinociception studied with muscarinic receptor knockout mice: a review. Life Sci 72 (2003) 2047-2054
    • (2003) Life Sci , vol.72 , pp. 2047-2054
    • Jürgen, W.1    Alokesh, D.2    Jesus, G.3
  • 18
    • 0242300269 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptor distribution in relation to spinal neurotransmission pathways
    • Khan I.M., Osaka H., Stanislaus S., Calvo R.M., Deenrinc T., Yaksh T.L., et al. Nicotinic acetylcholine receptor distribution in relation to spinal neurotransmission pathways. J Comp Neurol 467 (2003) 44-59
    • (2003) J Comp Neurol , vol.467 , pp. 44-59
    • Khan, I.M.1    Osaka, H.2    Stanislaus, S.3    Calvo, R.M.4    Deenrinc, T.5    Yaksh, T.L.6
  • 19
    • 0030827378 scopus 로고    scopus 로고
    • A critical review of control clinical trials for peripheral neuropathic pain and complex regional pain syndromes
    • Kingery W.S. A critical review of control clinical trials for peripheral neuropathic pain and complex regional pain syndromes. Pain 7 (1997) 123-139
    • (1997) Pain , vol.7 , pp. 123-139
    • Kingery, W.S.1
  • 20
    • 0000680650 scopus 로고
    • Acetic acid for analgesic screening
    • Koster R., Anderson M., and De Beer E.J. Acetic acid for analgesic screening. Fed Proc 18 (1959) 412
    • (1959) Fed Proc , vol.18 , pp. 412
    • Koster, R.1    Anderson, M.2    De Beer, E.J.3
  • 21
    • 0028922693 scopus 로고
    • Molecular evolution of the nicotinic acetylcholine receptor: an example of multigene family in excitable cells
    • Le Novere N., and Changeux J.P. Molecular evolution of the nicotinic acetylcholine receptor: an example of multigene family in excitable cells. J Mol Evol 40 (1995) 155-172
    • (1995) J Mol Evol , vol.40 , pp. 155-172
    • Le Novere, N.1    Changeux, J.P.2
  • 22
    • 0000110445 scopus 로고    scopus 로고
    • The structures of neuronal nicotinic receptors
    • Clementi F., Fornasari D., and Gotti C. (Eds), Springer, Berlin
    • Lindstrom J. The structures of neuronal nicotinic receptors. In: Clementi F., Fornasari D., and Gotti C. (Eds). Handbook of experimental pharmacology vol. neuronal nicotinic receptors (2000), Springer, Berlin 101-162
    • (2000) Handbook of experimental pharmacology vol. neuronal nicotinic receptors , pp. 101-162
    • Lindstrom, J.1
  • 23
    • 0033614401 scopus 로고    scopus 로고
    • Reduced antinociception in mice lacking neuronal nicotinic receptor subunits
    • Marubio L.M. Reduced antinociception in mice lacking neuronal nicotinic receptor subunits. Nature 398 (1999) 805-810
    • (1999) Nature , vol.398 , pp. 805-810
    • Marubio, L.M.1
  • 25
    • 0032478589 scopus 로고    scopus 로고
    • Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice
    • Michael W.D., Anthony W.B., Michael J.B., David J.B.K., Mark W.H., Keith B.R., et al. Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice. Euro J Pharmacol 346 (1998) 23-33
    • (1998) Euro J Pharmacol , vol.346 , pp. 23-33
    • Michael, W.D.1    Anthony, W.B.2    Michael, J.B.3    David, J.B.K.4    Mark, W.H.5    Keith, B.R.6
  • 26
    • 1642340652 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptor agonists: a potential new class of analgesics
    • Michael W.D., Lynne E.R., and Scott Bitner R. Nicotinic acetylcholine receptor agonists: a potential new class of analgesics. Curr Top Med Chem 4 (2004) 369-384
    • (2004) Curr Top Med Chem , vol.4 , pp. 369-384
    • Michael, W.D.1    Lynne, E.R.2    Scott Bitner, R.3
  • 27
    • 0032890162 scopus 로고    scopus 로고
    • The induction of pain: an integrative review
    • Millan M.J. The induction of pain: an integrative review. Prog Neurobiol 57 (1999) 1-64
    • (1999) Prog Neurobiol , vol.57 , pp. 1-64
    • Millan, M.J.1
  • 28
    • 0036277865 scopus 로고    scopus 로고
    • Descending control of pain
    • Millan M.J. Descending control of pain. Prog Neurobiol 66 (2002) 355-474
    • (2002) Prog Neurobiol , vol.66 , pp. 355-474
    • Millan, M.J.1
  • 29
    • 0030809983 scopus 로고    scopus 로고
    • Characterization of muscarinic receptor subtypes that mediate antinociception in the rat spinal cord
    • Naguib M., and Yaksh T.L. Characterization of muscarinic receptor subtypes that mediate antinociception in the rat spinal cord. Anesth Analg 85 (1997) 847-853
    • (1997) Anesth Analg , vol.85 , pp. 847-853
    • Naguib, M.1    Yaksh, T.L.2
  • 31
    • 0037040031 scopus 로고    scopus 로고
    • Involvement of monoaminergic system in the antidepressant-like effect of the hydroalcoholic extract of Siphocampylus verticillatus
    • Rodrigues A.L.S., Da Silva G.L., Mateussi A.S., Fernandes E.S., Miguel O.G., Yunes R.A., et al. Involvement of monoaminergic system in the antidepressant-like effect of the hydroalcoholic extract of Siphocampylus verticillatus. Life Sci 70 (2002) 1347-1358
    • (2002) Life Sci , vol.70 , pp. 1347-1358
    • Rodrigues, A.L.S.1    Da Silva, G.L.2    Mateussi, A.S.3    Fernandes, E.S.4    Miguel, O.G.5    Yunes, R.A.6
  • 32
    • 0035829401 scopus 로고    scopus 로고
    • Structure-affinity relationships of a unique nicotinic ligand: N-1-dimethyl-N-4-phenylpiperazinium iodide (DMPP)
    • Romanelli M.N., Manetti D., Scapecchi S., Borea P.A., Dei S., Bartolini A.G., et al. Structure-affinity relationships of a unique nicotinic ligand: N-1-dimethyl-N-4-phenylpiperazinium iodide (DMPP). J Med Chem 44 (2001) 3946-3955
    • (2001) J Med Chem , vol.44 , pp. 3946-3955
    • Romanelli, M.N.1    Manetti, D.2    Scapecchi, S.3    Borea, P.A.4    Dei, S.5    Bartolini, A.G.6
  • 33
    • 0025175424 scopus 로고
    • Diazepam attenuates morphine antinociception test-dependently in mice
    • Rosland J.H., Hunskaar S., and Hole K. Diazepam attenuates morphine antinociception test-dependently in mice. Pharmacol Toxicol 66 (1990) 382-386
    • (1990) Pharmacol Toxicol , vol.66 , pp. 382-386
    • Rosland, J.H.1    Hunskaar, S.2    Hole, K.3
  • 34
    • 15444351510 scopus 로고    scopus 로고
    • ABT-089 [2-methyl-3(2-(S)-pyrrolidinylmethoxy) pyridine]: a potent and selective cholinergic channel modulator with neuroprotective properties
    • Sullivan J.P., Donnelly-Roberts D., and Briggs C.A. ABT-089 [2-methyl-3(2-(S)-pyrrolidinylmethoxy) pyridine]: a potent and selective cholinergic channel modulator with neuroprotective properties. J Pharmacol Exp Ther 283 (1997) 235-246
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 235-246
    • Sullivan, J.P.1    Donnelly-Roberts, D.2    Briggs, C.A.3
  • 36
    • 34249685742 scopus 로고    scopus 로고
    • Evaluation of anti-nociceptive effects of neuronal nicotinic acetylcholine receptor
    • Tadimeti S.R., Lucia D.C., Richard T.R., and Kennethlloyd G. Evaluation of anti-nociceptive effects of neuronal nicotinic acetylcholine receptor. Neurophamacology 35 4 (1996) 393-405
    • (1996) Neurophamacology , vol.35 , Issue.4 , pp. 393-405
    • Tadimeti, S.R.1    Lucia, D.C.2    Richard, T.R.3    Kennethlloyd, G.4
  • 37
    • 0037687838 scopus 로고    scopus 로고
    • Unique spirocyclopiperazinium salt. Part 2: synthesis and structure-activity relationship of dispirocyclopiperazinium salts as analgesics
    • Wang X., Gao F.L., Piao H.B., Cheng T.M., and Li R.T. Unique spirocyclopiperazinium salt. Part 2: synthesis and structure-activity relationship of dispirocyclopiperazinium salts as analgesics. Bioorg Med Chem Lett 13 (2003) 1729-1732
    • (2003) Bioorg Med Chem Lett , vol.13 , pp. 1729-1732
    • Wang, X.1    Gao, F.L.2    Piao, H.B.3    Cheng, T.M.4    Li, R.T.5
  • 38
    • 3042581465 scopus 로고    scopus 로고
    • Fragmentation patterns of novel dispirocyclopiperazinium dibromides with strong analgesic activity under electrospray ionization tandem mass spectrometry conditions
    • Wang X., Sha Y.W., and Li R.T. Fragmentation patterns of novel dispirocyclopiperazinium dibromides with strong analgesic activity under electrospray ionization tandem mass spectrometry conditions. Int J Mass Spectrom 235 (2004) 111-115
    • (2004) Int J Mass Spectrom , vol.235 , pp. 111-115
    • Wang, X.1    Sha, Y.W.2    Li, R.T.3
  • 39
    • 0020525719 scopus 로고
    • Ethical guidelines for investigations of experimental pain in conscious animals
    • Zimmermann P. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16 (1983) 109-110
    • (1983) Pain , vol.16 , pp. 109-110
    • Zimmermann, P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.